研究成果

[学会発表] Nuclear signaling of membrane-anchored growth factors and cell growth regulation

Shigeki Higashiyama 2009

[学会発表] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation

Shigeki Higashiyama 2009

[雑誌論文] Insufficient shedding of proHB-EGF enhances hypoxic cell death in H9c2 cardiomyoblasts via activation of Caspase-3 and c-Jun N-terminal kinase

Uetani, T., Nakayama, H., Okayama, H.,Okura T., Higaki, J., Inoue, H., &Higashiyama, S. 2009

[雑誌論文] Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury

Oya S, Yoshikawa G, Takai K, Tanaka JI,Higashiyama, S., Saito N, Kirino T,Kawahara N. 2009

[雑誌論文] Region-specific proliferative response of neural progenitors to exogenous stimulation by growth factors following ischemia

Oya S, Yoshikawa G, Takai K, Tanaka JI,Higashiyama, S., Saito N, Kirino T,Kawahara N. 2008

[学会発表] The plasma membrane-anchored growth factor, amphiregulin, binds A-type lamin and regulates global transcription

Mayumi Isokane, Miki Hieda, Satoshi Hirakawa, Koichi Nakashiro, Koji Hashimoto, Hiroyuki Hamakawa and Shigeki Higashiyama 2008

[学会発表] 膜型増殖因子の核膜内膜移行とがん細胞特性の変化

東山繁樹 2008

[雑誌論文] Aberrant Expression of Connexin 26 Is Associated with Lung Metastasis of Colorectal Cancer

Ezumi, K., Yamamoto, H., Murata, K.,Higashiyama, M., Damdinsuren, B.,Nakamura, Y., Kyo, N., Okami, J., Ngan,C.Y., Takemasa, I., Ikeda, M., Sekimoto,M., Matsuura, N., Nojima, H., Monden, M. 2008

[雑誌論文] Membrane-anchored growth factors, the EGF tamily. Beyond receptor ligands.

Higashiyama, et al. 2008

[雑誌論文] Membrane-anchored growth factors,the EGF family.Beyond receptor lig ands

Higashiyama, et. al. 2008

[学会発表] Intracellular transport of membrane-anchored EGF family growth factor from the plasma membrane to the inner nuclear membrane 「膜型増殖因子EGF ファミリー分子は細胞膜から核膜へ局在変化する」

檜枝美紀、礒兼真由美、東山繁樹 2008

[雑誌論文] Membrane-anchored growth factor,HB-EGF, on the cell surface targeted to the inner nuclear membrane

Hieda, M., Isokane, M., Koizumi, M.,Higashi, C., Tachibana, T., Shudou, M.,Taguchi, T., Hieda, Y., and Higashiyama, S. 2008

[学会発表] Inner nuclear membrane targeting of pro-amphiregulin regulates oral squamous cell carcinoma cell viability

Mayumi Isokane, Miki Hieda, Eriko Koya, Koichi Nakashiro, Hiroyuki Hamakawa and Shigeki Higashiyama 2008

[学会発表] Plasma membrane anchored growth factors HB-EGF and mamphiregulin targeted to the inner nuclear membrane and regulate gene expression

Mayumi Isokane, Miki Hieda, and Shigeki Higashiyama 2008

[雑誌論文] The plasma membrane-anchored growth factor, pro-amphiregulin, binds A-type lamin and regulates global transcription

Isokane, M., Hieda, M., Hirakawa, S.,Shudou, M., Nakashiro, K., Hashimoto, K., Hamakawa, H., and Higashiyama, S. 2008

[学会発表] The plasma membrane-anchored growth factor, amphiregulin, binds A-type lamin and regulates global transcription 「膜型増 殖因子amphiregulin の細胞内輸送経路およびその機能解析」

礒兼真由美、檜枝美紀、東山繁樹 2008

[学会発表] 膜型増殖因子の核膜内膜移行による転写調節

東山繁樹 2008

[雑誌論文] Membrane-anchored Growth Factors, The EGF Family : Beyond receptor ligands

Higashiyama, S., Iwabuki, H., Morimoto,C., Hieda, M., Inoue, H., and Matsushita, N. 2008

[学会発表] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression

Miki Hieda and Shigeki Higashiyama 2007

[学会発表] 癌微小環境における細胞特性の変化-膜型増殖因子の役割(招待講演)

東山繁樹 2007

[学会発表] Membrance-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression

Hieda M, and Higashiyama S. 2007

[学会発表] Membrane-anchored growth factor, HB-EGF targets tothe nuclear membrane and regulates gene expression

Hieda M, Kinugasa Y, Higashi C., Tachibana T, Taguchi T., and Higashiyama S. 2007

[学会発表] 「膜型増殖因子HB-EGFは核膜内膜に移行し転写を調節する

檜枝美紀、衣笠由美、東山繁樹 2007

[学会発表] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression

Miki Hieda and Shigeki Higashiyama 2007

[雑誌論文] Pbx1is a major target of PLZF-mediated melanoma cell growth suppression

Shiraishi, K., Yamasaki, K., Nanba, D.,Inoue, H., Hanakawa, Y., Shirakata, Y.,Hashimoto, K., and Higashiyama, S. 2007

[雑誌論文] The carboxyl-terminal fragment of proHB-EGF reverses Bcl6-mediated gene repression

Kinugasa, Y., Hieda, M., Hori, M., and Higashiyama, S. 2007

[学会発表] Membrane-anchored growth factor, HB-EGF targets to the nuclear membrane and regulates gene expression

Miki Hieda, Yumi Kinugasa, Chizuru Higashi, Taro Tachibana, Tomohiko Taguchi, and Shigeki Higashiyama 2007

[学会発表] 膜型増殖因子による遺伝子転写制御機構(招待講演)

東山繁樹 2007

[雑誌論文] An intermediary role of proHB-EGF shedding in growth factor-induced c-myc expression

Nanba, D., Inoue, Y., Shigemi, Y., Shirakata, Y., Hashimoto, K., and Higashiyama, S. 2007

[雑誌論文] Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts

Furochi, H., Tamura, S., Mameoka, M.,Yamada, C., Ogawa, T., Hirasaka, K.,Okumura, Y., Imagawa, T., Oguri, S.,Ishidoh, K., Kishi, K., Higashiyama, S.Nikawa, T. 2007

[雑誌論文] Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members

Morita, S., Shirakata, Y., Shiraishi, A.Kadota, Y., Hashimoto , K., Higashiyama,S., Ohashi, Y. 2007

[雑誌論文] Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding

Ikin, A.F., Causevic, M., Pedrini, S.,Lyndsey S. Bensonl, L.S., Buxbaum, J.D.,Suzuki, T., Simon Lovestone, S.,Higashiyama, S., Mustelin, T., Burgoyne, R.D., and Gandy, S. 2007

[学会発表] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membra ne and regulates gene expression

Hieda M, and Higashiyama S. 2007