トップ研究者を探す運動器固有の機械的ストレス感知機構:筋・骨萎縮遺伝子の発現調節の分子システムから

運動器固有の機械的ストレス感知機構:筋・骨萎縮遺伝子の発現調節の分子システムから

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19500564
研究種目 基盤研究(C)
研究分野 総合・新領域系
総合領域
健康・スポーツ科学
スポーツ科学
研究機関 徳島大学
代表研究者 二川 健
研究分担者 安井 夏生
研究分担者 中屋 豊
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額(合計) 4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額(履歴) 2008年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
2007年度:2,860,000 (直接経費 :2,200,000、間接経費 :660,000)
キーワード ユビキチンリガーゼ
機械的ストレスの感知
IGF-1シグナル
運動器(筋・骨)
蛋白質分解酵素

研究成果

[雑誌論文] Glucose infusion suppresses surgery-induced muscle protein breakdown by inhibiting ubiquitin-proteasome pathway in rats

Mikura M, Yamaoka I, Doi M, Kawano Y, Nakayama M, Nakao R, Hirasaka K, Okumura Y, Nikawa T 2009

[雑誌論文] Polyphenols prevent clinorotation-induced expression of atrogenes in mouse C2C12 skeletal myotubes

Hemdan DII, Hirasaka K, Nakao R, Kohno S, Kagawa S, Abe T, Harada-Sukeno A, Okumura Y, Nakaya Y, Terao J, Nikawa T 2009

[雑誌論文] Awa(Tokushima)lactate-fermented tea as well as green tea enhance the effect of diet restriction on obesity in rats

Sogawa M, Seura T, Kohno S, Hirasaka K, Yamaguchi Y, Takagi R, Harada A, Okumura Y, Yamamoto S, Kishi K, Nikawa T 2009

[雑誌論文] Effects of Dimethy1 Sulfoxide and Dexamethasone on mRNA Expression of Housekeeping Genes in Cultures of C2C12 Myotubes

Masuhiro Nishimura M, Nikawa T, Kawano Y, Nakayama M, Muneharu Ikeda M 2008

[雑誌論文] Effects of Dimethyl Sulphoxide and Dexamethasone on mRNA Expression of Myogenesis- and Muscle Proteolytic System-related Genes in Mouse Myoblastic C2C12 Cells

Nishimura M, Mikura M, Hirasaka K, Okumura Y, Nikawa T, Kawano Y, Nakayama M, Ikeda M 2008

[雑誌論文] Effects of dietary fish oil on lipid peroxidation and serum triacylglycerol levels in psychologically stressed mice

Oarada M, Tsuzuki T, Gonoi T, Igarashi H, Kamei K, Nikawa T, Hirasaka K, Ogawa T, Miyazawa T, Nakagawa K, Kurita N 2008

[雑誌論文] Subcutaneous injection, from birth, of epigallocatechin-3-gallate, a component of green tea, limits the onset of muscular dystrophy in mdx mice : a quantitative histological, immunohistochemical and electrophysiological study

Nakae Y, Hirasaka K, Goto J, Nikawa T, Shono M, Yoshida M, Stoward PJ 2008

[雑誌論文] Effects of dietary fish oil on lipid peroxidation and serum triacylglycerol levels in psychologically stressed mice

Oarada M, Tsuzuki T, Gonoi T, Igarashi H, Kamei K, Nikawa T, Hirasaka K, Ogawa T, Miyazawa T, Nakagawa K, Kurita N 2008

[雑誌論文] athepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells

Hirasaka K, Tokuoka K, Nakao R, Yamada C, Oarada M, Imagawa T, Ishidoh K, Okumura Y, Kishi K, Nikawa T 2008

[雑誌論文] Peroxidized cholesterol-induced matrix metalloproteinase-9 activation and its suppression by dietary beta-carotene in photoaging of hairless mouse skin

Minami Y, Kawabata K, Kubo Y, Arase S, Hirasaka K, Nikawa T, Banda N, Kawai Y, Terao J 2008

[図書] 最新整形外科学大系(1)運動器の生物学と生体力学各組織の力学特性と病態-骨格筋

二川 健, 安井夏生(分担) 2008

[学会発表] Sensing mechanism of unloading stress in skeletal muscle cells

二川健 2008

[図書] 最新整形外科学大系(1)運動器の生物学と生体力学筋・腱-構造と筋収縮の生理学

松浦哲也, 二川 健(分担) 2008

[学会発表] Development of a functional food or drug against unloading-mediated muscle atrophy

二川健 2008

[図書] 運動器の生物学と生体力学筋・腱-構造と筋収縮の生理学

松浦哲也、二川健(分担) 2008

[図書] 運動器の生物学と生体力学各組織の力学特性と病態-骨格筋

二川健、安井夏生(分担) 2008

[雑誌論文] Deficiency of Cb1-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice

Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, Hamada N, Hosaka T, Nakaya Y, Ishidoh K, Obata T, Ebina Y, Gu H, Takeda S, Kishi K, Nikawa T 2007

[雑誌論文] Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts

Furochi H, Tamura S, Mameoka M, Yamada C, Ogawa T, Hirasaka K, Okumura Y, Imagawa T, Oguri S, Ishidoh K, Kishi K, Higashiyama S, Nikawa T 2007

[学会発表] 宇宙における細胞培養実験の必要性と問題点

二川 健 2007

[学会発表] Unloadingによる筋萎縮の主要な制御因子

二川 健 2007

[雑誌論文] istinct effects of anterior pyriform cortex and the lateral hypothalamus lesions on protein intake in rats

Nakao R, Ozaki E, Hasegawa M, Kondo A, Uezu K, Hirasaka K, Nikawa T, Kishi K 2007

[学会発表] Unloadingによる筋萎縮の主要な制御因子

二川健 2007

[図書] 栄養・食糧学会語辞典

二川 健(分担) 2007

[雑誌論文] Overexpression of osteoactivin protects skeletal muscle from severe degeneration caused by long-term denervation in mice

urochi H, Tamura S, Takeshima K, Hirasaka K, Nakao R, Kishi K, Nikawa T 2007

[図書] 栄養・食糧学用語辞典

二川健(分担) 2007

[雑誌論文]

Nakano S, Mishiro T, Takahara S, Yokoi H, Hamada D, Yukata K, Takata Y, Goto T, Egawa H, Yasuoka S, Furouchi H, Hirasaka K, Nikawa T, Yasui N. Nakano S, Mishiro T, Takahara S, Yokoi H, Hamada D, Yukata K, Takata Y, Goto T, Egawa H, Yasuoka S, Furouchi H, Hirasaka K, Nikawa T, Yasui N 2007

[雑誌論文] Effect of dietary oils on lymphocyte immunological activity in psychologically stressed mice

Oarada M, Gonoi T, Tsuzuki T, Igarashi M, Hirasaka K, Nikawa T, Onishi Y, Toyotome T, Kamei K, Miyazawa T, Nakagawa K, Kashima M, Kurita N 2007

[学会発表] 宇宙における細胞培養実験の必要性と問題点

二川健 2007

[雑誌論文] Effects of single administration of Rokumi-gan (TJ-87) on serum amino acid concentration of 6 healthy Japanese male volunteers

akahashi H, Nakao R, Hirasaka K, Kishi K, Nikawa T 2007