新規ワクチンのスクリーニングに有用なマラリア防御血清の探索

トップ›研究者を探す›新規ワクチンのスクリーニングに有用なマラリア防御血清の探索

代表研究者	坪井敬文
研究課題番号	KAKENHI-PROJECT-19406009
研究種目	基盤研究(B)
研究分野	生物系医歯薬学基礎医学寄生虫学(含衛生動物学)
研究機関	愛媛大学
研究分担者	竹尾暁
研究期間開始年月日	2007/4/1
研究期間終了年度	2009
研究ステータス	完了 (2009/4/1)
配分額（合計）	16,770,000 (直接経費 :12,900,000、間接経費 :3,870,000)
配分額（履歴）	2009年度：4,940,000 (直接経費 :3,800,000、間接経費 :1,140,000) 2008年度：4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000) 2007年度：7,020,000 (直接経費 :5,400,000、間接経費 :1,620,000)
キーワード	感染症マラリアワクチンゲノムタイバイオテクノロジー国際研究者交流

研究成果

[雑誌論文] Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence.

Otsuki H, Kaneko O, Thongkukiatkul A, Tachibana M, Iriko H, Takeo S, Tsuboi T, Torii M. 2009

[雑誌論文] A small-scale systematic analysis of alternative splicing in Plasmodium falciparum.

Iriko H, Jin L, Kaneko O, Takeo S, Han ET, Tachibana M, Otsuki H, Torii M, Tsuboi T. 2009

[雑誌論文] Pyruvate kinase type-II isozyme in Plasmodium falciparum localizes to the apicoplast.

Maeda T, Saito T, Harb OS, Roos DS, Takeo S, Suzuki H, Tsuboi T, Takeuchi T, Asai T. 2009

[学会発表] Wheat germ cell-free protein synthesis system: a breakthrough for the post-genome malaria vaccine candidate discovery.

Tsuboi T. 2009

[雑誌論文] Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites.

Cao J, Kaneko O, Thongkukiatkul A, Tachibana M, Otsuki H, Gao Q, Tsuboi T, Torii M. 2009

[学会発表] Wheat germ cell-free protein synthesis system : a breakthrough for the post-genome malaria vaccine candidate discovery

Tsuboi T 2009

[雑誌論文] Malaria ookinete surface protein-based vaccination via the intranasal route completely blocks parasite transmission in both passive and active vaccination regimens in a rodent model of malaria infection.

Arakawa T, Tachibana M, Miyata T, Harakuni T, Kohama H, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Torii M, Tsuboi T. 2009

[雑誌論文] Sterile protection against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: comparison of heterologous prime boost strategies.

Jiang G, Shi M, Conteh S, Richie N, Banania G, Geneshan H, Valencia A, Singh P, Aguiar J, Limbach K, Kamrud KI, Rayner J, Smith J, Bruder JT, King CR, Tsuboi T, Takeo S, Endo Y, Doolan DL, Richie TL, Weiss WR. 2009

[雑誌論文] Wheat germ cell-free technology for accelerating the malaria vaccine research.

Takeo S, Arumugam TU, Torii M, Tsuboi T. 2009

[雑誌論文] Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design.

VanBuskirk KM, O'Neill MT, De La Vega P, Maier AG, Krzych U, Williams J, Dowler MG, Sacci, Jr. JB, Kangwanrangsan N, Tsuboi T, Kneteman NM, Heppner, Jr. DG, Murdock BA, Mikolajczak SA, Aly ASI, Cowman AF Kappe SHI. 2009

[学会発表] fs230: Prefertilization Transmission-blocking Vaccine Candidate.

Tsuboi T. 2009

[雑誌論文] Enzymatic characterization of the Plasmodium vivax chitinase, a potential malaria transmission-blocking target.

Takeo S, Hisamori D, Matsuda S, Vinetz J, Sattabongkot J, Tsuboi T. 2009

[雑誌論文] Evidence for the transmission of Plasmodium vivax in the Republic of the Congo, west central Africa.

Culleton R, Ndounga M, Zeyrek FY, Coban C, Casimiro PN, Takeo S, Tsuboi T, Yadava A, Carter R, Tanabe K. 2009

[学会発表] Wheat germ eel1-free system : A breakthrough in malaria vaccine candidate discovery.

Tsuboi T 2008

[学会発表] Wheat germ cell-free system: A breakthrough in malaria vaccine candidate discovery.

Tsuboi T, Takeo S, Otsuki H, Torii M. 2008

[学会発表] Novel antigens at Plasmodium falciparum schizont-merozoite stages as potential vaccine candidates.

Tsuboi T. 2008

[学会発表] Expression of malaria vaccine candidates using a wheat germ cell-free protein synthesis system without codon optimization.

Tsuboi T. 2008

[雑誌論文] Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates.

Tsuboi T, Takeo S, Iriko H, Jin L, Tsuchimochi M, Matsuda S, Han ET, Otsuki H, Kaneko O, Sattabongkot J, Udomsangpetch R, Sawasaki T, Torii M, Endo Y. 2008

[雑誌論文] Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates.

Tsuboi T 2008

[雑誌論文] Diversity and evolution of the rhoph1/clag multigene family of Plasmodium falciparum.

Iriko H, Kaneko O, Otsuki H, Tsuboi T, Su XZ, Tanabe K, Torii M. 2008

[学会発表] Wheat germ cell-free protein synthesis system: a key tool for novel malaria vaccine candidate discovery.

Tsuboi T. 2008

[学会発表] Genome-wide malaria vaccine candidate discovery using wheat germ cell-free system.

Tsuboi T. 2008

[学会発表] Novel sporozoite antigen discovery of Plasmodium falciparum screened using human immunesera

Tsuboi T. 2007

[雑誌論文] Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.

Mudeppa DG, Pang CKT, Tsuboi T, Endo Y, Buckner FS, Varani G, Rathod PK. 2007

[雑誌論文] Detection of four Plasmodium species by genus-and species-specific loop-mediated isothermal amplification for clinical diagnosis.

Han ET, Watanabe R, Sattabongkot J, Khuntirat B, Sirichaisinthop J, Iriko H, Jin L, Takeo S, Tsuboi T. 2007

[学会発表] Novel sporozoite antigen discoverly of Plasmodium falciparum screened using human antisera.

Tsuboi T. 2007

[雑誌論文] The Plasmodium falciparum RhopH2 promoter and first 24 amino acids are sufficient to target proteins to the rhoptries.

Ghoneim A, Kaneko O, Tsuboi T, Torii M. 2007

[学会発表] Novel sporozoite antigen discovery of Plasmodium falciparum screened using human immunesera

Tsuboi T 2007