トップ研究者を探すメチル化DNAマーカーと血清腫瘍マーカー併用によるヒト腎癌の早期診断法の開発

メチル化DNAマーカーと血清腫瘍マーカー併用によるヒト腎癌の早期診断法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19390417
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
外科系臨床医学
泌尿器科学
研究機関 高知大学
代表研究者 執印 太郎
代表研究者 執印 太郎
研究分担者 蘆田 真吾
研究分担者 井上 啓史
連携研究者 蘆田 真吾
連携研究者 井上 啓史
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額(合計) 18,850,000 (直接経費 :14,500,000、間接経費 :4,350,000)
配分額(履歴) 2008年度:8,710,000 (直接経費 :6,700,000、間接経費 :2,010,000)
2007年度:10,140,000 (直接経費 :7,800,000、間接経費 :2,340,000)
キーワード 腎細胞癌
腫瘍マーカー
HIG2
Hoxb13
メチル化
HOXB13
メチル化DNA

研究成果

[雑誌論文] Involvement of TMEM22 overexpressionin the growth of renal cell carcinomacells

Dobashi S, Katagiri T, Hirota E, Ashida S, Daigo Y, Shuin T, Fujioka T, Miki T, Nakamura Y 2009

[雑誌論文] Evidence-based clinical practice guidelines for renal cel carcinoma(Summary-JUA 2007 Edition)

Fujioka T, Obara W, Miki Hara I, Hirao Y, Kakehi Y, Kanayama HO, Naito S, Nonomura N, Ogawa Y, Ozono S, Shimazui T, Shinohara N, Shuin T, Takahashi S, Tomita Y, Eto M, Inoue K, Kato T, Kinouchi T, Konda R, Mugiya S, Nagamori S, Nakazawa H, Nishitani MA, Oikawa T, Sugimoto M, Takahashi M, Mizutani Y, Obara W. 2009

[雑誌論文] Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.

Dobashi S, Shuin T, et al. 2009

[雑誌論文] Sarcomatoid acquired cystic disease-associated renal cell carcinoma.

Kuroda N, Shuin T, et al. 2008

[雑誌論文] Acute inactivation of the VHL gene contributes to protective effects of ischemic preconditioning in the mouse kidney

Iguchi M, Kakinuma Y, Kurabayashi A, Sato T, Shuin T, Hong SB, Schmidt LS, Furihata M. 2008

[雑誌論文] Sarcomatoid acquired cystic disease-associated renal cell carcinoma

Kuroda N, Tamura M, Taguchi T, Tominaga A, Hes O, Michal M, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Shuin T, Lee GH. 2008

[雑誌論文] Chromophobe renal cell carcinoma: useful diagnostic application imprinttology and fluorescence in situ hybridization of chromosomes 10 and 21 in two cases of typical and eosinophilic variants

Kuroda N, Katto K, Yamaguchi T, KaT, Imamura Y, Hes O, Michal M, Shuin T, Lee GH. 2008

[雑誌論文] Promoter methylation of the bone morphogenetic protein-6 gene in association with adult T-cll leukemia

Taniguchi A, Nemoto Y, Yokoyama AKotani N, Imai S, Shuin T, Daibata M. 2008

[雑誌論文] Prospective study of combined treatment with interferon-alpha and active vitamin D3 for Japanese patients with metastatic renal cellcarcinoma

Obara W, Mizutani Y, Oyama C, Akaza HIshii N, Kohri K, Namiki M, Okuyama A, Shima H, Yokoyama M, Shuin T, Miki T, Watanabe Y Fujioka T. 2008

[雑誌論文] Renal leiomyoma : an immunohistochemical, ultrastructural and comparative genomic hybridizion study Histol Histopathol

Kuroda N, Inoue Y, Taguchi T, Tominaga A, Hes O, Michal M, Hayashi Y, Hiroi M, Shuin T, Lee GH. 2007

[雑誌論文] Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude mice

Karashima T, Inoue K, Fukata S, Iiyama T, Kurabayashi A, Kawada C, Shuin T. 2007

[雑誌論文] KTernary complex formation of pVHL, elongin B and elongin C visualized in living cells by a fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy technique

Kinoshita K, Coryo K, Takada M, Tomokuni Y, Aso T, Okuda H, Shuin T, Fukumura H, Sogawa 2007

[雑誌論文] Promoter hypermethylation of the bone morphogenetic protein-6 gene in malignant lymphoma

Daibata M, Nemoto Y, BandobashiKotani N, Kuroda M, Tsuchiya M, Okuda H, Takakuwa T, Imai S, Shuin T, Taguchi H. 2007

[雑誌論文] WT1(Wilms' tumor 1)peptide immunotherapy for renal cell carcinoma

Iiyama T, Udaka K, Takeda S, Takeuchi T, Adachi YC, Ohtsuki Y, Tsuboi A, Nakatsuka S, Elisseeva OA, Oji Y, Kawakami M, Nakajima H, Nishida S, Shirakata T, Oka Y, Shuin T, Sugiyama H. 2007

[雑誌論文] Modification in the von Hippel-Lindau protein is involved in the progression of experimentally induced rat glomrulonephritis

Kudo Y, Kakinuma Y, Iguchi M, Sato TSugiura T, Furihata M, Shuin T. 2007