自然免疫の新たな制御因子Ubc13による表皮の分化・自然免疫制御機構の研究

トップ›研究者を探す›自然免疫の新たな制御因子Ubc13による表皮の分化・自然免疫制御機構の研究

自然免疫の新たな制御因子Ubc13による表皮の分化・自然免疫制御機構の研究

代表研究者	佐山浩二
研究課題番号	KAKENHI-PROJECT-19390297
研究種目	基盤研究(B)
研究分野	生物系医歯薬学内科系臨床医学皮膚科学
研究機関	愛媛大学
研究分担者	平川聡史
研究分担者	花川靖
研究期間開始年月日	2007/4/1
研究期間終了年度	2009
研究ステータス	完了 (2009/4/1)
配分額（合計）	18,460,000 (直接経費 :14,200,000、間接経費 :4,260,000)
配分額（履歴）	2009年度：5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000) 2008年度：5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000) 2007年度：8,060,000 (直接経費 :6,200,000、間接経費 :1,860,000)
キーワード	皮膚感染症自然免疫角化細胞細胞内シグナル Ubc13 NF-kB ノックアウトマウスアポトーシス分化 MAP kinase NF-кB ユビキチン TAK1 cre-recombinase 皮膚

研究成果

[学会発表] Inflammatory mediator TAK1 regulates hair follicle cycling

Sayama K, et al. 2009

[雑誌論文] Nodal lymphangiogenesis and metastasis: Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease Am J Pathol

Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, Kamata N, Higashikawa K, Okazaki H, Kameda K, Nishida-Fukuda H, Mori H, Hanakawa Y, Sayama K, Shirakata Y, Tohyama M, Tokumaru S, Katayama I, Hashimoto K. 2009

[雑誌論文] Malignant acanthosis nigricans with enhanced expression of fibroblast growth factor receptor 3 Acta Derm Venereol

Hida Y, Kubo Y, Nishio Y, Murakami S, Fukumoto D, Sayama K, Hashimoto K, Arase S 2009

[学会発表] Inflammatory mediator TAK1 regulates hair follicle cycling The 69th Annual Meeting of Society for Investigative Dermatology

Sayama K, Shirakata Y, Ishimatsu-Tsuji Y, Kajiya K, Hirakawa S, Sugawara K, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K. 2009

[雑誌論文] Living skin equivalents constructed using human amnions as a matrix J Dermatol Sci

Yang L, Shirakata Y, Tokumaru S, Xiuju D, Tohyama M, Hanakawa Y, Hirakawa S, Sayama K Hashimoto K. 2009

[雑誌論文] IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression Eur J Immunol

Tohyama M, Hanakawa Y, Shirakata Y, Dai X, Yang L, Hirakawa S, Tokumaru S, Okazaki H, Sayama K, Hashimoto K. 2009

[雑誌論文] The influence of hepatic damage on serum soluble Fas ligand levels of patients with drug rashes

Tohyama M, Shirakata Y, Sayama K, Hashimoto K. 2009

[学会発表] Conditional ablation of Ubc 13, a mediator of innate immunity, in keratinocytes induces abnomaldifferentiation, decreased proliferation, and apoptosis.

Sayama, K. Yamamoto, M. Hanakawa, Y. Shirakata, Y. Akira, S., Hashimoto, K. 2008

[雑誌論文] Increased resistance to cationic antimicrobial peptide LL-37 in methicillin-resistant strains of staphylococcus aureus J Antimicrob Chemother

Ouhara K, Komatsuzawa H, Kawai T, Nishi H, Fujiwara T, Fujiue Y, Kuwabara M, Sayama K, Hashimoto K, Sugai M. 2008

[雑誌論文] The NF-kappaB, P38 MAPK and STAT1 pathways differentially regulate the dsRNA-mediated innate immune responses of epidermal keratinocytes.

Dai X, Sayama K, Tohyama M, Shirakata Y, Yang L, Hirakawa S, Tokumaru S, Hashimoto K. 2008

[雑誌論文] PPARgamma is an important transcription factor in 1 alpha

Dai X, Sayama K, Shirakata Y, Tokumaru S, Yang L, Tohyama M, Hirakawa S, Hanakawa Y, Hashimoto K. 2008

[学会発表] The innate immunity mediator Ubc13-TAK1 is a master regulator of epidermal structure and apoptosis

Sayama, K. 2008

[雑誌論文] PPARgamma is an important transcription factor in 1alpha, 25-dihydroxyvitamin D3-induced involucrin expression

Dai, X. Sayama, K. Shirakata, Y. Tokumaru, S. YangL. Tohyama, M. Hirakawa, S. Hanakawa, Y., Hashimoto, K. 2008

[雑誌論文] A marked increase in serum soluble Fas ligand in drug-induced hypersensitivity syndrome.

Tohyama M, Shirakata Y, Sayama K, Hashimoto K. 2008

[雑誌論文] The NF-kappaB, P38MAPK and STAT1 pathways differentially regulate the dsRNA-mediated innate immune responses of epidemal keratinocytes.

Dai, X. Sayama, K. Tohyama. M. Shirakata, Y. Yang, L. Hirakawa, S, Todumaru, S., Hashimoto, K. 2008

[学会発表] Conditional ablation of Ubc 13, a mediator of innate immunity, in keratinocytes induces abnormal differentiation

Sayama, K. Yamamoto, M. Hanakawa, Y. Shirakata, Y. Akira, S., Hashimoto, K. 2008

[雑誌論文] STAT5a/PPAR gamma pathway regulates involucrin expression in keratinocyte differentiation J Invest Dermato

Dai, X. Sayama, K. Shirakata, Y. Hanakawa, Y. Yamasaki, K. Tokumaru, S. Yang, L. Wang, X. Hirakawa, S. Tohyama, M. Yamauchi, T. Takashi, K. Kagechika, H., Hashimoto, K. 2007

[学会発表] Ablation of TAK1 in mouse keratinocytes disturbed hair follicle development

Sayama, K.Kajiya, K.Shirakata, Y.Hanakawa, Y.Hirakawa, S.Dai, X.Nagai, H.Akira, S.Kishimoto, J.and Hashimoto, K. 2007

[雑誌論文] STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiation

Dai X, Sayama K, Shirakata Y, Hanakawa Y, Yamasaki K, Tokumaru S, Yang L, Wang X, Hirakawa S, Tohyama M, Yamauchi T, Takashi K, Kagechika H, Hashimoto K. 2007

[学会発表] TAK1 regulates hair follicle development in EDA receptor signaling 37th Annual European Society for Dermatological Research(ESDR)Meeting

Sayama, K. Kajiya, K. Shirakata, Y. Hanakawa, Y. Hirakawa, S. Akira, S. Kishimoto, J. Hashimoto, K. 2007

[雑誌論文] Suppressor of cytokine signaling 3 negative regulation of signal transducer and activator of transcription 3 in platelet-derived growth factor-induced fibroblast migration J Dermatol

Nagai, H. Tokumaru, S. Sayama, K. Shirakata, Y. Hanakawa, Y. Hirakawa, S. Dai, X. Tohyama, M. Yang, L. Hashimoto, K. 2007

[雑誌論文] CXCL 16 is a novel mediator of the innate immunity of epidermal keratinocytes Int Immunol

Tohyma, M. Sayama, K. Komatsuzawa, H. Hanakawa, Y. Shirakata, Y. Dai, X. Yang, L. Tokumaru, S. Nagai, H. Hirakawa, S. Sugai, M., Hashimoto, K. 2007

[学会発表] Ablation of TAK1 in mouse keratinocytes disturbed hair follicle development 68th Annual Meeting of the Society for Investigative Dermatology

Sayama, K. Kajiya, K. Shirakata, Y. Hanakawa, Y. Hirakawa, S. Dai, X. Nagai, H. Akira, S. Kishimoto, J., Hashimoto, K. 2007

[雑誌論文] CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes

Tohyama M, Sayama K, Komatsuzawa H, Hanakawa Y, Shirakata Y, Dai X, Yang L, Tokumaru S, Nagai H, Hirakawa S, Sugai M, Hashimoto K 2007