トップ研究者を探す再生医療技術を応用した腎尿細管の再生・修復による急性腎不全の新規治療法の開発

再生医療技術を応用した腎尿細管の再生・修復による急性腎不全の新規治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-19390229
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
腎臓内科学
研究機関 高知大学
東京医科歯科大学
代表研究者 寺田 典生
研究協力者 井下 聖司
研究期間 開始年月日 2007/4/1
研究期間 終了年度 2010
研究ステータス 完了 (2010/4/1)
配分額(合計) 18,330,000 (直接経費 :14,100,000、間接経費 :4,230,000)
配分額(履歴) 2010年度:2,600,000 (直接経費 :2,000,000、間接経費 :600,000)
2009年度:4,420,000 (直接経費 :3,400,000、間接経費 :1,020,000)
2008年度:4,420,000 (直接経費 :3,400,000、間接経費 :1,020,000)
2007年度:6,890,000 (直接経費 :5,300,000、間接経費 :1,590,000)
キーワード 腎臓
再生医学
急性腎不全
尿細管
オートファジー
アポトーシス
虚血
慢性腎障害
腎尿細管
幹細胞
血液透析
透析療法
再生
ES細胞
糸球体
脱分化
増殖
急性腎障害
尿細管細胞
胎生期
Deddiferentiation
Wnt4
Etsl

研究成果

[雑誌論文] F-18 FDG PET/CT provides the earliest findings of enthesitis in reactive arthritis.

Taniguchi Y, Kumon Y, Nakayama S, Arii K, Ohnishi T, Ogawa Y, Kobayashi S, Terada Y. 2011

[雑誌論文] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo

Inoue K, Kuwana H, Shinahara Y, Ogata K, Taniguchi Y, Kagawa T, Horino T, Takada T, Morita T, Sasaki S, Mizushima N, Terada Y 2010

[雑誌論文] A case of post-streptococcal reactive arthritis in which lesions were detected with [18F]-fluorodeoxyglucose positron emission tomography-CT imaging and magnetic resonance imaging.

Horino T, Takao T, Terada Y. 2010

[雑誌論文] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo.

Inoue K, Kuwana H, Shimamura Y, Ogata K, Taniguchi Y, Kagawa T, Horino T, Takao T, Morita T, Sasaki S, Mizushima N, Terada Y. 2010

[雑誌論文] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo

Inoue K, Terada Y., et al 2010

[雑誌論文] IgA nephropathy in a patient with systemic lupus erythematosus

Horino T, Takao T, Terada Y 2010

[雑誌論文] Rapid recurrence of craniopharyngioma following recombinant human growth hormone replacement.

Taguchi T, Takao T, Iwasaki Y, Pooh K, Okazaki M, Hashimoto K, Terada Y. 2010

[雑誌論文] A case of post-streptococcal reactive arthritis in which lesions were detected with[18F]-fluorodeoxyglucose positron emission tomography-CT imaging and magnance imaging

Horino T, Takao T, Terada Y 2010

[雑誌論文] Hypoglycemic encephalopathy as a result of an attempted suicide.

Taguchi T, Mizobuchi M, Terada Y. 2010

[雑誌論文] Diagnostic value of 18F-dihydroxyphenylalanine positron emission tomography for growth hormone-producing pituitary adenoma.

Taguchi T, Takao T, Iwasaki Y, Oyama K, Yamada S, Inoue M, Terada Y. 2010

[雑誌論文] IgA nephropathy in a patient with systemic lupus erythematosus.

Horino T, Takao T, Terada Y. 2010

[雑誌論文] Acute pulmonary arterial hypertension associated with anti-synthetase syndrome.

Taniguchi Y, Horino T, Kato T, Terada Y. 2010

[雑誌論文] Serum fetuin-A is an independent marker of insulin resistance in Japanese men.

Ishibashi A, Ikeda Y, Ohguro T, Kumon Y, Yamanaka S, Takata H, Inoue M, Suehiro T, Terada Y 2010

[雑誌論文] The activity of carotidynia syndrome is correlated with the soluble intracellular adhesion molecule-1 (sICAM-1) level.

Taniguchi Y, Horino T, Terada Y, Jinnouchi Y. 2010

[雑誌論文] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo

Inoue K, Terada Y, et al 2010

[雑誌論文] Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.

Zhao LF, Iwasaki Y, Zhe W, Nishiyama M, Taguchi T, Tsugita M, Kambayashi M, Hashimoto K, Terada Y. 2010

[雑誌論文] Clinical implication of 18F- fluorodeoxyglucose PET/CT in monitoring disease activity in spondyloarthritis.

Taniguchi Y, Kumon Y, Arii K, Tsugita M, Fukumoto M, Ohnishi T, Kobayashi S, Terada Y. 2010

[雑誌論文] HLA-B51-related seronegative spondyloarthropathy associated with membranous nephropathy.

Horino T, Nakayama S, Takao T, Terada Y. 2010

[雑誌論文] Regulation of glucocorticoid receptor transcription and nuclear translocation during single and repeated immobilization stress.

Noguchi T, Makino S, Matsumoto R, Nakayama S, Nishiyama M, Terada Y, Hashimoto K. 2010

[雑誌論文] Coincidental double erythema caused by Vibrio vulnificus.

Taguchi T, Mizobuchi M, Terada Y. 2010

[雑誌論文] Positron emission tomography/computed tomography : a clinical tool for evaluation of enthesitis in patients with spondyloarthritides.

Taniguchi Y, Arii K, Kumon Y, Fukumoto M, Ohnishi T, Horino T, Kagawa T, Kobayashi S, Ogawa Y, Terada Y. 2010

[雑誌論文] Possible involvement of intracellular angiotensin II receptor in high-glucose-induced damage in renal proximal tubular cells.

Takao T, Horino T, Kagawa T, Matsumoto R, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Taguchi T, Morita T, Terada Y. 2010

[雑誌論文] Glucocorticoid receptor-β and receptor-γ exert dominant negative effect on gene repression but not on gene induction.

Taniguchi Y, Iwasaki Y, Tsugita M, Nishiyama M, Taguchi T, Okazaki M, Nakayama S, Kambayashi M, Hashimoto K, Terada Y 2010

[雑誌論文] Role of protein kinase C in pitavastatin-induced human paraoxonase I expression in Huh7 cells.

Arii K, Suehiro T, Ikeda Y, Kumon Y, Inoue M, Inada S, Takata H, Ishibashi A, Hashimoto K, Terada Y. 2010

[学会発表] 尿細管再生における脱分化

寺田典生 2010

[雑誌論文] PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1.

Okazaki M, Iwasaki Y, Nishiyama M, Taguchi T, Tsugita M, Nakayama S, Kambayashi M, Hashimoto K, Terada Y. 2010

[図書] 急性腎不全・AKIハンドブック

香川亨, 寺田典生(菱田明:編集) 2010

[図書] 専門医のための腎臓病学 第2版(電解質異常.高・低Na血症,高・低Cl血症)(内山聖, 富野康日己, 今井裕一編)

堀野太郎, 寺田典生 2009

[雑誌論文]

堀野太郎, 寺田典生 2009

[雑誌論文] Cutaneous amyloidosis associated with amyopathic dermatomyositis.

Taniguchi Y, Horino T, Terada Y. 2009

[雑誌論文] Insulin exhibits short-term antiinflammatory but long-term proinflammatory effects in vitro.

Iwasaki Y, Nishiyama M, Taguchi T, Asai M, Yoshida M, Kambayashi M, Terada Y, Hashimoto K. 2009

[学会発表] Aldosterone Stimulates NF-κB Activity and Transcription of ICAM-1 via SGK-1 in Rat Mesangial Cells in vivo and in vitro

Terada Y 2009

[雑誌論文] Hormonal regulation of glycolytic enzyme gene and pyruvate dehydrogenase dinase/phosphatase gene transcription.

Wang Z, Iwasaki Y, Zhao LF, Nishiyama M, Taguchi T, Tsugita M, Kambayashi M, Hashimoto K, Terada Y 2009

[図書] 輸液療法パーフェクト(電解質異常.高ナトリウム血症)(飯野靖彦編)

堀野太郎, 寺田典生 2009

[雑誌論文] 急性腎障害とは(特集腎疾患-最近の進展)

堀野太郎, 寺田典生 2009

[図書] 電解質異常. 高・低Na血症, 高・低Cl血症. 専門医のための腎臓病学 第2版(内山聖, 富野康日己, 今井裕一編)

堀野太郎, 寺田典生 2009

[雑誌論文] Plasma adiponectin level is increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome.

Shinahara M, Nishiyama M, Iwasaki Y, Nakayama S, Noguchi T, Kambayashi M, Okada Y, Tuda M, Stenzel-Poore MP, Hashimoto K, Terada Y 2009

[雑誌論文] 酸塩基平衡(産生量,肺・腎での調節,腎のトランスポーターなど)

森田達仁, 寺田典生 2009

[雑誌論文] A case with spontaneous bladder rupture mimicking acute kidney injury.

Horino T, Okazaki M, Nishikawa H, Takao T, Taniguchi Y, Morita T, Terada Y 2009

[雑誌論文] ネフローゼ症候群:診断と治療の進歩.II.一次性ネフローゼ症候群の病態・診断・治療. 5.メサンギウム増殖性糸球体腎炎,管内増殖性糸球体腎炎,半月体形成性糸球体腎炎

堀野太郎, 寺田典生 2009

[雑誌論文] Pitavastation induces PON1 expression through P44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells.

Arii K, Suehiro T, Ikeda Y, Kumon Y, Osaki F, Inoue M, Inada S, Ogami N, Takada H, Hashimoto K, Terada Y 2009

[雑誌論文] Glucocorticoid receptor plays an indispensable role in mineralocorticoid receptor-dependent transcription in GR-deficient BE(2)C and T84 cells in vitro.

Tsugita M, Iwasaki Y, Nishiyama M, Taguchi T, Shinahara M, Taniguchi Y, Kambayashi M, Nishiyama A, Gomez-Sanchez CE, Terada Y, Hashimoto K. 2009

[雑誌論文] Effects of angiotensin II type 1 receptor blocker on albumin-induced cell damage in human renal proximal tubular epithelial cells

Takao T, Terada Y, et al. 2009

[学会発表] Cisplatin-Induced Macroautophagy Occurs Prior to Apoptosis in Proximal Tubules In Vivo.

Inoue K, Kuwana H, Shimamura Y, Ogata K, Taniguchi Y, Kagawa T, Horino T, Takao T, Morita T, Ikeda Y, Sasaki S, Terada Y 2009

[雑誌論文] Glucocorticoid receptor plays an indispensable role in mineralocorticoid receptor-dependent transcription in GR-deficient BE(2)C and T84 cells in vitro

Tsugita M, Terada Y, et al. 2009

[雑誌論文] 食塩の吸収・調節と排泄、その異常

次田誠、寺田典生 2009

[雑誌論文] Effects of angiotensin II type 1 receptor blocker on albumin-induced cell damage in human renal proximal tubular epithelial cells.

Takao T, Horino T, Kagawa T, Matsumoto R, Inoue K, Taguchi T, Morita T, Iwasaki Y, Hashimoto K, Terada Y 2009

[雑誌論文] Visceral obesity is associated with the metabolic syndrome and elevated plasma retinol binding protein-4 level in obstructive sleep apnea syndrome.

Makino S, Fujiwara M, Suzukawa K, Handa H, Fujie T, Ohtaka Y, Komatsu Y, Aoki Y, Maruyama H, Terada Y, Hashimoto K, Sugimoto T 2009

[図書] 内分泌代謝専門医ガイドブック(Bartter症候群)(成瀬光栄、平田結喜緒、島津章編)

香川亨, 寺田典生 2009

[雑誌論文] Effect of Sevelamer Hydrochloride on Bone in Experimental Uremic Rats.

Kuwahara M, Inoshita S, Terada Y, Sasaki S 2009

[雑誌論文] Symmetric giant xanthogranulomas in Erdheim-Chester disease.

Taguchi T, Sano S, Iwasaki Y, Terada Y 2009

[学会発表] Aldosterone Stimulates NF-κ B Activity and Transcription of ICAM-1 via SGK-1 in Rat Mesangial Cells in vivo and in vitro

Terada Y 2009

[雑誌論文] Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury.

Kobayashi T, Terada Y, et al 2008

[雑誌論文] A familial case of mitochondrial disease resembling Alport syndrome.

Fujii H, Terada Y., et al. 2008

[雑誌論文] A familial case of mitochondrial disease resembling Alport syndrome.

Fujii H, Mori Y, Kayamori K, Igari T, Ito E, Akashi T, Noguchi Y, Kitamura K, Okado T, Terada Y, Kanda E, Rai T, Uchida S, Sasaki S. 2008

[雑誌論文] Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium

Terada Y, Kuwana H, et al. 2008

[雑誌論文] The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity.

Kuwana H, Terada Y, Kobayashi T, Okado T, Penninger JM, Irie-Sasaki J, Sasaki T, Sasaki S. 2008

[学会発表] Aldosterone Stimulates NF-kB Activity and Transcription of ICAM-1 via Serum and Glucocorticoid-inducible Protein Kinase (SGK) in Rat Mesangial Cells

Yoshio Terada 2008

[雑誌論文] Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium.

Terada Y, Kuwana H, Kobayashi T, Okado T, Suzuki N, Yoshimoto T, Hirata Y, Sasaki S. 2008

[雑誌論文] The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity

Kuwana H, Terada Y, Kobayashi T, Okado T, Penninger JM, Irie-Sasaki J, Sasaki T, Sasaki S. 2008

[雑誌論文] Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury

Kobayashi T, Terada Y, Kuwana H, Tanaka H, Okado T, Kuwahara M, Tohda S, Sakano S, Sasaki S. 2008

[雑誌論文] Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury.

Kobayashi T, Terada Y, Kuwana H, Tanaka H, Okado T, Kuwahara M, Tohda S, Sakano S, Sasaki S. 2008

[雑誌論文] Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury.

Terada Y, et. al. 2007

[雑誌論文] Expression of bone type 1 PTH receptor in rats with chronic rena 1 failure.

Kuwahara M, Terada Y, et. al. 2007

[雑誌論文] Expression of bone type 1 PTH receptor in rats with chronic renal failure.

Kuwahara M, Inoshita S, Nakao Y, Terada Y, Takano Y, Sasaki S 2007

[雑誌論文] Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury.

Terada Y, Inoshita S, Kuwana H, Kobayashi T, Okado T, Ichijo H, Sasaki S. 2007