トップ研究者を探すTAK1-Pim-2経路がもたらす骨髄腫の難治性と骨破壊の役割とその克服法の開発

TAK1-Pim-2経路がもたらす骨髄腫の難治性と骨破壊の役割とその克服法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18K08329
研究種目 基盤研究(C)
研究分野
研究機関 徳島大学
代表研究者 安倍 正博
研究期間 開始年月日 2018/4/1
研究期間 終了年度 2021
研究ステータス 完了 (2021/4/1)
配分額(合計) 4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
配分額(履歴) 2021年度:390,000 (直接経費 :300,000、間接経費 :90,000)
2020年度:1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
2019年度:1,170,000 (直接経費 :900,000、間接経費 :270,000)
2018年度:1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
キーワード 多発性骨髄腫
骨髄微小環境
薬剤耐性
骨破壊
TAK1
PIM2
阻害薬
破骨細胞
骨形成
骨髄腫
TAK-1
骨病変
TAK1
Pim-2
骨髄間質細胞

研究成果

[雑誌論文] Mechanical unloading aggravates bone destruction and tumor expansion in myeloma

Tanimoto K, Hiasa M, Tenshin H, Teramachi J, Oda A, Harada T, Higa Y, Sogabe K, Oura M, Sumitani R, Hara T, Endo I, Matsumoto T, Tanaka E, Abe M 2022

[雑誌論文] Basal insulin requirement in patients with type 1 diabetes depends on the age and body mass index

Mitsui Y, Kuroda A, Ishizu M, Mori H, Kurahashi K, Kondo T, Yoshida S, Akehi Y, Aihara KI, Endo I, Abe M, Matsuhisa M 2022

[雑誌論文] A Genome-Wide Association Study Predicts the Onset of Dysgeusia Due to Anti-cancer Drug Treatment

Takei M, Okada N, Nakamura S, Kagawa K, Fujii S, Miki H, Ishizawa K, Abe M, Sato Y. 2022

[雑誌論文] Skeletal FGFR1 signaling is necessary for regulation of serum phosphate level by FGF23 and normal life span

Takashi Y, Sawatsubashi S, Endo I, Ohnishi Y, Abe M, Matsuhisa M, Kawanami D, Matsumoto T, Fukumoto S 2021

[雑誌論文] Development of a novel antioxidant based on a dimeric dihydroisocoumarin derivative

Nakayama A, Nakamura T, Ara T, Fukuta T, Karanjit S, Harada T, Oda A, Sato H, Abe M, Kogure K, Namba K 2021

[雑誌論文] Plasma heparin cofactor II activity is inversely associated with albuminuria and its annual deterioration in patients with diabetes.

Hara T, Uemoto R, Sekine A, Mitsui Y, Masuda S, Kurahashi K, Yoshida S, Otoda T, Yuasa T, Kuroda A, Ikeda Y, Endo I, Honda S, Yoshimoto K, Kondo A, Tamaki T, Matsumoto T, Matsuhisa M, Abe M, Aihara KI 2021

[雑誌論文] Management of bone metastasis and cancer treatment-induced bone loss during the COVID-19 pandemic: An international perspective and recommendations

Brown JE, Wood SL, Confavreux C, Abe M, Weilbaecher K, Hadji P, Johnson RW, Rhoades JA, Edwards CM, Croucher PI, Juarez P, El Badri S, Ariaspinilla G, D'Oronzo S, Guise TA, Van Poznak C 2021

[雑誌論文] Pathogenesis and treatment of multiple myeloma bone disease

2. Hiasa M, Harada T, Tanaka E, Abe M 2021

[雑誌論文] Myeloma-Bone Interaction: A Vicious Cycle via TAK1-PIM2 Signaling

1. Harada T, Hiasa M, Teramachi J, Abe M 2021

[雑誌論文] Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma.

Keiichiro Watanabe、Ariunzaya Bat-Erdene、Hirofumi Tenshin、Qu Cui、Jumpei Teramachi、Masahiro Hiasa、Asuka Oda、Takeshi Harada、Hirokazu Miki、Kimiko Sogabe、Masahiro Oura、Ryohei Sumitani、Yukari Mitsui、Itsuro Endo、Eiji Tanaka、Makoto Kawatani、Hiroyuki Osada、Toshio Matsumoto、Masahiro Abe 2020

[学会発表] 教育講演:多発性骨髄腫に対する治療の進歩と分子標的療法の開発

安倍正博 2020

[雑誌論文] Clinical utility of target capture‐based panel sequencing in hematological malignancies: A multicenter feasibility study

Yasuda T, Sanada M, Nishijima D, Kanamori T, Iijima Y, Hattori H, Saito A, Miyoshi H, Ishikawa Y, Asou N, Usuki K, Hirabayashi S, Kato M, Abe M. 2020

[雑誌論文] Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patients with hematological cancer

Sogawa Yuka、Fukui Makoto、Nakamura Shingen、Sogabe Kimiko、Sumitani Ryohei、Yoshioka Masami、Abe Masahiro、Hinode Daisuke 2020

[雑誌論文] PD-L1 upregulation in myeloma cells by panobinostat in combination with interferon-γ

Iwasa M, Harada T, Oda A, Bat-Erdene A, Teramachi J, TenshinT, Ashtar M, Oura M, Sogabe K, Udaka K, Fujii S, Nakamura S, Miki H, Kagawa K, Ozaki S and Abe M 2019

[雑誌論文] JSH practical guidelines for hematological malignancies, 2018: III. Myeloma-1. Multiple myeloma (MM)

Iida S, Ishida T, Murakami H, Ozaki S, Abe M, Hata H, Shimazaki C 2019

[雑誌論文] Correlation between high serum alkaline phosphatase levels and denosumab-related hypocalcemia in patients with multiple myeloma

Miki H, Nakamura S, Oura M, Hamano H, Ikuta K, Okada N, Okamoto Y, Sogabe K, Takahashi M, Iwasa M, Udaka K, Harada T, Kurahashi K, Fujii S, Yoshida S, Kagawa K, Endo I, Aihara K, Abe M 2019

[学会発表] 合同シンポジウム 6 癌と骨代謝 骨髄腫骨病変と腫瘍進展

安倍 正博 2019

[学会発表] シンポジウム2 骨髄腫骨病変治療の進歩と展望

安倍 正博 2019

[雑誌論文] Effect of serum concentration and concomitant drugs on vancomycin-induced acute kidney injury in haematologic patients: a single-centre retrospective study

Okada N, Chuma M, Azuma M, Nakamura S, Miki H, Hamano H, Goda M, Takechi K, Zamami Y, Abe M, Ishizawa K 2019

[雑誌論文] JSH practical guidelines for hematological malignancies, 2018: III. Myeloma-2. Related disorders of multiple myeloma.

Iida S, Shimazaki C, Abe M, Nakaseko C 2019

[雑誌論文] JSH practical guidelines for hematological malignancies, 2018: III. Myeloma-1. Multiple myeloma (MM)

Iida S, Ishida T, Murakami H, Ozaki S, Abe M, Hata H, Shimazaki C 2019

[雑誌論文] Polyclonal immunoglobulin recovery after autologous stem cell transplantation is an independent prognostic factor for survival outcome in patients with multiple myeloma

Ozaki S, Harada T, Yagi H, Sekimoto E, Shibata H, Shigekiyo T, Fujii S, Nakamura S, Miki H, Kagawa K, Abe M 2019

[雑誌論文] Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation

Takashi Y, Kosako H, Sawatsubashi S, Kinoshita Y, Ito N, Tsoumpra MK, Nangaku M, Abe M, Matsuhisa M, Kato S, Matsumoto T, Fukumoto S 2019

[雑誌論文] Correlation between high serum alkaline phosphatase levels and denosumab-related hypocalcemia in patients with multiple myeloma

Miki H, Nakamura S, Oura M, Hamano H, Ikuta K, Okada N, Okamoto Y, Sogabe K, Takahashi M, Iwasa M, Udaka K, Harada T, Kurahashi K, Fujii S, Yoshida S, Kagawa K, Endo I, Aihara KI, Abe M. 2019

[学会発表] Development of novel therapeutic approaches targeting myeloma-bone marrow interplay

Masahiro Abe 2018

[学会発表] Management of patients with MGUS or multiple myeloma

Masahiro Abe 2018

PIM2阻害剤