腎臓が引き起こす生体老化の機序解明とその制御

トップ›研究者を探す›腎臓が引き起こす生体老化の機序解明とその制御

代表研究者	西山成
研究課題番号	KAKENHI-PROJECT-18H03191
研究種目	基盤研究(B)
研究分野
研究機関	香川大学
研究期間開始年月日	2018/4/1
研究期間終了年度	2021
研究ステータス	完了 (2021/4/1)
配分額（合計）	17,030,000 (直接経費 :13,100,000、間接経費 :3,930,000)
配分額（履歴）	2021年度：1,820,000 (直接経費 :1,400,000、間接経費 :420,000) 2020年度：5,850,000 (直接経費 :4,500,000、間接経費 :1,350,000) 2019年度：5,850,000 (直接経費 :4,500,000、間接経費 :1,350,000) 2018年度：3,510,000 (直接経費 :2,700,000、間接経費 :810,000)
キーワード	生体適応能力生体防御反応老化腎臓病異化反応カタボリズム（異化）腎機能生体老化体液保持サルコペニア健康長寿カタボリズム代謝異常尿素個体老化腎臓生活習慣病

研究成果

[学会発表] 肝細胞がんラットは，組織ナトリウム・体液貯留を伴う体質量の減少を示す.

北田研人，木戸口慧，中野大介，西山成． 2022

[雑誌論文] Protease-Activated Receptor 1 Contributes to Microcirculation Failure and Tubular Damage in Renal Ischemia-Reperfusion Injury in Mice

Guan Yu、Nakano Daisuke、Li Lei、Zheng Haofeng、Nishiyama Akira、Tian Ye、Zhang Lei 2021

[雑誌論文] New Concept of Onco-Hypertension and Future Perspectives

Kidoguchi Satoshi、Sugano Naoki、Tokudome Gorou、Yokoo Takashi、Yano Yuichiro、Hatake Kiyohiko、Nishiyama Akira 2021

[学会発表] 高血圧合併心不全ラットに対する新規の非ステロイド型MRブロッカーの薬効検討.

西山　成、澤野達哉、中野大介、北田研人、今村武史、ラフマンアサダ. 2021

[雑誌論文] New Concept of Onco-Hypertension and Future Perspectives

Kidoguchi Satoshi、Sugano Naoki、Tokudome Gorou、Yokoo Takashi、Yano Yuichiro、Hatake Kiyohiko、Nishiyama Akira 2021

[学会発表] デキサメタゾンは皮膚のナトリウム・水分含量を減少させる.

北田研人. 森澤紀彦. 中野大介. Jens T. 西山成. 2021

[雑誌論文] The angiotensin II receptor-neprilysin inhibitor LCZ696 attenuates the progression of proteinuria in type 2 diabetic rats

Rahman Asadur、Sherajee Shamshad J.、Rafiq Kazi、Kobara Hideki、Masaki Tsutomu、Nakano Daisuke、Morikawa Takashi、Konishi Yoshio、Imanishi Masahito、Nishiyama Akira 2020

[雑誌論文] Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease

Wan Ningning、Fujisawa Yoshihide、Kobara Hideki、Masaki Tsutomu、Nakano Daisuke、Rahman Asadur、Nishiyama Akira 2020

[雑誌論文] Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats

Sufiun Abu、Rahman Asadur、Rafiq Kazi、Fujisawa Yoshihide、Nakano Daisuke、Kobara Hideki、Masaki Tsutomu、Nishiyama Akira 2020

[学会発表] New concept of salt and water balance

Akira Nishiyama 2020

[雑誌論文] Esaxerenone, a novel nonsteroidal mineralocorticoid receptor blocker (MRB) in hypertension and chronic kidney disease

Wan Ningning、Rahman Asadur、Nishiyama Akira 2020

[雑誌論文] Partial Body Mass Recovery After Caloric Restriction Abolishes Improved Glucose Tolerance in Obese, Insulin Resistant Rats

Cornejo Manuel A.、Nguyen Julie、Cazares Joshua、Escobedo Benny、Nishiyama Akira、Nakano Daisuke、Ortiz Rudy M. 2020

[学会発表] 塩と病態生理・MR阻害薬

西山　成 2020

[学会発表] 皮膚におけるナトリウム貯留と電解質調節

西山　成 2020

[学会発表] DKD治療におけるRAS阻害剤とMR拮抗薬への期待

西山　成 2020

[雑誌論文] Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4?dependent pathway and limits sensitivity to fluid therapy in mice

Nakano Daisuke、Kitada Kento、Wan Ningning、Zhang Yahua、Wiig Helge、Wararat Kittikulsuth、Yanagita Motoko、Lee Syann、Jia Lin、Titze Jens M.、Nishiyama Akira 2020

[学会発表] （プロ）レニン受容体をターゲットとした癌に対する新規診断治療法の開発

西山　成 2020

[学会発表] SGLT2阻害薬の腎保護作用のメカニズム

西山　成 2020

[学会発表] ミネラルコルチコイド受容体ブロッカー

西山　成 2020

[雑誌論文] Nrf2-related gene expression is impaired during a glucose challenge in type II diabetic rat hearts

Thorwald Max A.、Godoy-Lugo Jose A.、Rodriguez Gema J.、Rodriguez Marco Antonio、Jamal Mostofa、Kinoshita Hiroshi、Nakano Daisuke、Nishiyama Akira、Forman Henry J.、Ortiz Rudy M. 2019

[雑誌論文] Diuretic Effects of Sodium Glucose Cotransporter 2 Inhibitors and Their Influence on the Renin-Angiotensin System

Ansary Tuba M.、Nakano Daisuke、Nishiyama Akira 2019

[雑誌論文] Effects of the novel nonsteroidal mineralocorticoid receptor blocker, esaxerenone (CS-3150), on blood pressure and urinary angiotensinogen in low-renin Dahl salt-sensitive hypertensive rats

Li Lei、Guan Yu、Kobori Hiroyuki、Morishita Asahiro、Kobara Hideki、Masaki Tsutomu、Nakano Daisuke、Nishiyama Akira 2019

[学会発表] 食塩感受性高血圧の新しい機序

西山　成 2019

[学会発表] Renal denervation attenuates a catabolic state in mice fed high salt

Yamazaki D, Kitada K, Morisawa N, Fujisawa Y, Nakano D, HItomi H, Titze J, Nishiyama A. 2019

[雑誌論文] Effect of a novel nonsteroidal selective mineralocorticoid receptor antagonist, esaxerenone (CS-3150), on blood pressure and renal injury in high salt-treated type 2 diabetic mice

Bhuiyan Abdus Sattar、Rafiq Kazi、Kobara Hideki、Masaki Tsutomu、Nakano Daisuke、Nishiyama Akira 2019

[雑誌論文] A mouse model of renal fibrosis to overcome the technical variability in ischaemia/reperfusion injury among operators

Guan Yu、Nakano Daisuke、Zhang Yifan、Li Lei、Tian Ye、Nishiyama Akira 2019

[雑誌論文] Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4?dependent pathway and limits sensitivity to fluid therapy in mice

Nakano Daisuke、Kitada Kento、Wan Ningning、Zhang Yahua、Wiig Helge、Wararat Kittikulsuth、Yanagita Motoko、Lee Syann、Jia Lin、Titze Jens M.、Nishiyama Akira 2019

[雑誌論文] Simultaneous angiotensin receptor blockade and glucagon‐like peptide‐1 receptor activation ameliorate albuminuria in obese insulin‐resistant rats

Rodriguez Ruben、Escobedo Benny、Lee Andrew Y.、Thorwald Max、Godoy‐Lugo Jose A.、Nakano Daisuke、Nishiyama Akira、Parkes David G.、Ortiz Rudy M. 2019

[学会発表] Renoprotective effects of nonsteroidal MR blockers.

Nishiyama A. 2019

[学会発表] Effects of the novel nonsteroidal mineralocorticoid receptor blocker, esaxerenone(CS-3150),on blood pressure and urinary angiotensinogen in low-renin dahl satl-sensitive hypertensive rats

Nishiyama A, Nakako D, Kobori H, Li L. 2019

[学会発表] Antiproliferative effects of monoclonal antibodies against (pro)renin receptor in pancreatic ductal adenocarcinoma.

Rahman A, Matsuyama M, Shibayama Y, Ebihara A, Nishiyama A. 2019

[学会発表] 食塩過剰摂取で生じるカタボリズム

西山　成 2019

[学会発表] Anemia Disrupts Renal Compensatory Responses After Uninephrectomy in Mice.

Nakano D, Nishiyama A. 2019

[雑誌論文] Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats

Rodriguez Ruben、Moreno Meagan、Lee Andrew Y.、Godoy-Lugo Jose A.、Nakano Daisuke、Nishiyama Akira、Parkes David、Awayda Mouhamed S.、Ortiz Rudy M. 2018

[雑誌論文] Pathophysiological mechanisms of mineralocorticoid receptor-dependent cardiovascular and chronic kidney disease

Nishiyama Akira 2018

[学会発表] High Salt Intake Induces Catabolism Accompanied　By Hepatic Urea Osmolyte Production And　Decreases Renal Sympathetic Nerve Activity

Morisawa N, Kitada K, Yamazaki D, Nakano D, Fujisawa Y, Nishiyama A. 2018

[雑誌論文] Independent regulation of renin?angiotensin?aldosterone system in the kidney

Nishiyama Akira、Kobori Hiroyuki 2018

[学会発表] Effects of a SGLT2　inhibitor on blood pressure and sympathetic nervous activity in salt-treated CKD rats.

Nakano D, Yifan Z, Nishiyama A 2018

[雑誌論文] Effects of the selective chymase inhibitor TEI-F00806 on the intrarenal renin-angiotensin system in salt-treated angiotensin I-infused hypertensive mice

Ansary Tuba M.、Urushihara Maki、Fujisawa Yoshihide、Nagata Sayaka、Urata Hidenori、Nakano Daisuke、Hirofumi Hitomi、Kitamura Kazuo、Kagami Shoji、Nishiyama Akira 2018

[雑誌論文] Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats

Rodriguez Ruben、Minas Jacqueline N、Vazquez-Medina Jose Pablo、Nakano Daisuke、Parkes David G、Nishiyama Akira、Ortiz Rudy M 2018

[雑誌論文] Angiotensin receptor and tumor necrosis factor-α activation contributes to glucose intolerance independent of systolic blood pressure in obese rats

Rodriguez Ruben、Lee Andrew、Mathis Keisa W.、Broome Hanna J.、Thorwald Max、Martinez Bridget、Nakano Daisuke、Nishiyama Akira、Ryan Michael J.、Ortiz Rudy M. 2018

[学会発表] (Pro)renin Receptor Promotes Colorectal Cancer through the Wnt/Beta-Catenin Signaling Pathway despite Constitutive Pathway Component Mutations.

Nishiyama A, Shibayama Y, Wang J. 2018

[図書] カラー　新しい薬理学

石井邦明、西山　成 2018