トップ研究者を探す虚血における自然免疫機構(Toll様受容体)の関与

虚血における自然免疫機構(Toll様受容体)の関与

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18659421
研究種目 萌芽研究
研究分野 生物系
医歯薬学
外科系臨床医学
脳神経外科学
研究機関 愛媛大学
代表研究者 朱 鵬翔
研究分担者 大西 丘倫
研究分担者 久門 良明
研究分担者 秦 龍二
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2007
研究ステータス 完了 (2007/4/1)
配分額(合計) 3,300,000 (直接経費 :3,300,000)
配分額(履歴) 2007年度:1,600,000 (直接経費 :1,600,000)
2006年度:1,700,000 (直接経費 :1,700,000)
キーワード TLR4
Cerebral ischemia
Neuronal cell death
cerebral ischemia
自然免疫
神経細胞死

研究成果

[学会発表] Upregulation of syntaxinl in the ischemic cortex fblowing permanent focal ischemia in rats

Cao F, Hata R, Zhu P, Sakanaka M. 2007

[雑誌論文] Hematopoietic stem cells prevent hair cell death after transient cochlear ischemia through paracrine effects

Yoshida T, Hakuba N, Morizane I, Fujita K, Cao F, Zhu P, Uchida N, Kameda K, Sakanaka M, Gyo K, Hata R 2007

[学会発表] α-synuclein promotes neuronal cell death through the activation of microglia

Hata R, Zhu P, Cao F, Sakanaka M, Tanabe H. 2007

[雑誌論文] Intravenous Infusion of Dihydroginsenoside Rb1 Prevents Compressive Spinal Cord Injury and Ischemic Brain Damage through Upregulation of VEGF and Bcl-xL

Sakanaka M, Zhu P, Zhang Bo, Wen TC, Cao F, Ma YJ, Samukawa K, Mitsuda N, Tanaka J, Kuramoto M, Uno H, Hata R. 2007

[学会発表] Microglia promotes astrogliogenesis of the neural stem cells through activating Jak/Stat signaling

Zhu P, Hata R, Cao F, Sakanaka M. 2007

[学会発表] Hematopoietic stem cells prevent hair cell death after transient cochlear ischemia through paracrine effects

Yoshida T, Hata R, Hakuba N, Cao F, Zhu P, Sakanaka M, Gyo K. 2007

[学会発表] Targeted disruption of organic cation transporter 3 in mice reducesischemic brain injury through down-regulation of IL-6 and MCP-1

Zhu P, Hata R, Ogasawara M, Cao F, Maeyama K, Sakanaka M. 2007

[学会発表] Overexpression of Stat3 promotes neuronal cell death through activation of microglia

Hata R, Cao F, Zhu P, Sakanaka M. 2007

[学会発表] Protective effects of dihydrogeninsenoside Rb1 on ischemic brain damage and compressive spinal cord injury through upregulation of VEGF and Bcl-XL

Hata R, Cao F, Zhu P, Samukawa K, Sakanaka M. 2007

[学会発表] Delayed neuronal cell death in the brain stem after transient ischemia in gerbils

Cao F, Hata R, Zhu P, Sakanaka M. 2007

[雑誌論文] Overexpression of SOCS3 inhibits astrogliogenesis and promotes maintenance of neural stem cells.

Cao F, Hata R, Zhu P, Ma YJ, Tanaka J, Hanakawa Y, Hashimoto K, Niinobe M, Yoshikawa K, Sakanaka M 2006

[雑誌論文] Prevention of ischemic neuronal death by intravenous infusion of a ginseng saponin, ginsenoside Rb(1), that upregulates Bcl-x(L) expression.

Zhang B, Hata R, Zhu P, Sato K, Wen TC, Yang L, Fujita H, Mitsuda N, Tanaka J, Samukawa K, Maeda N, Sakanaka M 2006