トップ研究者を探すヒト腎癌に対する共刺激分子発現増強を介した化学免疫療法の新展開

ヒト腎癌に対する共刺激分子発現増強を介した化学免疫療法の新展開

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18591757
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
泌尿器科学
研究機関 香川大学
代表研究者 呉 秀賢
研究分担者 筧 善行
研究分担者 乾 政志
研究分担者 田岡 利宜也
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2007
研究ステータス 完了 (2007/4/1)
配分額(合計) 3,870,000 (直接経費 :3,600,000、間接経費 :270,000)
配分額(履歴) 2007年度:1,170,000 (直接経費 :900,000、間接経費 :270,000)
2006年度:2,700,000 (直接経費 :2,700,000)
キーワード 腎癌細胞
PBL
TIL
LFA-3
ICAM-1
TRAIL
TRAIL-R2
Lexatumumab
共刺激分子
末梢血リンパ球
腫瘍浸潤リンパ球
抗癌剤
Renal cell carcinoma cells
PBL
TIL
LFA-3
ICAM-1
TRAIL
TRAIL-R2
Lexatumumab

研究成果

[学会発表] Enhancement of death receptor 4-mediated apoptosis in renal cell carcinoma cells by low concentrations of adriamycin

Xiuxian, Wu, Yoshiuki, Kakehi, Xinghua, Jin, Rikiya, Taoka, Mashashi, Inuiand, Mikio, Sugimoto 2007

[学会発表] Subtoxic concentrations of adriamycin sensitizes renal cell carcinoma cells to death receptor(DR4)-mediated apoptosis and cytotoxicity

Wu XX, Jin XJ, Nouh MA, Yoshiyuki Kakehi Y. 2007

[学会発表] Subtoxic concentrations of adriamycin sensitizes renal cell carcinoma cells to death receptor (DR4)-mediated apoptosis and cytotoxicity

Xiuxian, Wu, Xinghua, Jin, MA, Nouh, Yoshiyuki, Kakehi 2007

[雑誌論文] Human Agonistic Antibody to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2(Trail-R2)Induces Cytotoxicity and Apoptosis in Prostate Cancer and Bladder Cancer Cells

Shimada O, Wu XX, Jin XH, Nouh MA, Fiscella M, Albert V, Matsuda T and Kakehi Y. 2007

[学会発表] Anti-tumor effect of vitamin E succinate(VES) against renal cell carcinoma cells

Xiuxian, Wu, Yu, Zeng, Ahmed, Mamdouh Hamed, Rikiya, Taoka, Mashashi, Inui, Yoshiyuki, Kakehi 2007

[雑誌論文] Enhancement of death receptor 4-mediated apoptosis and cytotoxicity in renal cell carcinoma cells by subtoxic concentrations of doxorubicin

Jin XH, Wu XX, Nouh MA, and Kakehi Y. 2007

[学会発表] Uroplakin III-Delta4 Messenger RNA as A Promising Marker to Identify Non-Ulcerative Type Interstitial Cystitis

Yu, Zeng, Xiuxian, Wu, Yukio, Homma, Naoki, Yoshimura, Hideaki, Iwaki, Susumu, Kageyama, Tatsnhiro, Yoshiki, Yoshiyuki, Kakehi 2007

[学会発表] 非潰瘍型間質膀胱炎の分子マーカーとしてのウロプラキンIII-delta4メッセンジャーRNA

曽 宇、筧 善行、呉 秀賢、本間 之夫、吉村 直樹、影山 進、吉貴 達寛 2007

[雑誌論文] Low concentrations of adriamycin sensitizes human solid cancer cells to TRAIL-R2-mediated apoptosis by inducting TRAIL-R2 expression

Wu XX, Jin XH, Zeng Y, E1 Hamed AM and Kakehi Y. 2007

[雑誌論文] Enhanced susceptibility of adriamycin-treated human renal cell carcinoma cells to lysis by peripheral blood lymphocytes and tumor infiltrating lymphocytes

Wu XX, Zeng Y, Jin XH and Kakehi Y. 2007

[雑誌論文] Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis

Zeng, Y, Wu, XX, Homma, Y, Yoshimura, N, Iwaki, H, Kageyama, S, Yoshiki, T, Kakehi, Y 2007

[学会発表] Anticancer effect of agonistic antibodies for DR4 and DR5 Combined with subtoxic concentrations of anticancer agents in the human solid cancer cells

Xiuxian, Wu, Yoshiyuki, Kakehi 2007

[雑誌論文] Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis

Zeng Y, Wu XX, Homma Y, Yoshimura N, Iwaki H, Kageyama S, Yoshiki T and Kakehi Y. 2007

[学会発表] 固形癌におけるDR4、 DR5を標的とした抗腫瘍壊死因子関連アポトーシス誘導リガンド受容体抗体と低濃度抗癌剤併用による抗腫瘍効果

呉 秀賢、筧 善行 2007

[雑誌論文] Enhancement of death receptor 4-mediated apoptosis and cytotoxicity inrenal cell carcinoma cells by subtoxic concentrations of doxorubicin

Jin XH, Wu XX, Nouh MA, and Kakehi Y. 2007

[雑誌論文] Human Agonistic Antibody to Tumor Necrosis Factor-Related Apoptosis-lnducing Ligand Receptor 2(Trail-R2)Induces Cytotoxicity and Apoptosis in Prostate Cancer and Bladder Cancer Cells.

Shimada O, Wu XX, Jin XH, Nouh MA, Fiscella M, Albert V, Matsuda T and and Kakehi Y. 2007

[雑誌論文] Enhancement of death receptor 4-mediated apoptosis and cytotoxicity in renal cell carcinoma cells by subtoxic concentrations of doxorubicin

Jin, XH, Wu, XX, Nouh, MA, Kakehi, Y 2007

[学会発表] 腎癌細胞における低濃度アドリアマイシンによるDR4発現誘導を介したアポトーシス増強

呉 秀賢、筧 善行、金 星華、田岡 利宜也、乾 政志、杉元 幹史 2007

[雑誌論文] Human Agonistic Antibody to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2(Trail-R2) Induces Cytotoxicity and Apoptosis in Prostate Cancer and Bladder Cancer Cells

Shimada, O, Wu, XX, Jin, XH, Nouh, MA, Fiscella, M, Albert, V, Matsuda, T, Kakehi, Y 2007

[雑誌論文] Enhanced susceptibility of adriamycin-treated human renal cell carcinoma cells to lysis by peripheral blood lymphocytes and tumor infiltrating lymphocytes

Wu, XX, Zeng, Y, Jin, XH, Kakehi, Y 2007

[雑誌論文] Low concentrations of adriamycin sensitizes human solid cancer cells to TRAIL-R2-mediated apoptosis by inducting TRAIL-R2 expression

Wu,XX, Jin, XH, Zeng, Y, El Hamed, AM, Kakehi, Y 2007

[雑誌論文] Low concentrations of adriamycin sensitizes human solid cancer cells to TRAIL-R2-mediated apoptosis by inducting TRAIL-R2 expression

Wu XX, Jin XH, Zeng Y, El Hamed AM and Kakehi Y. 2007

[学会発表] 腎癌細胞に対するコハク酸ビタミンE(VES)による抗腫瘍効果の検討

呉 秀賢、曽 宇、アハメド マムド アプデリ ハメド、田岡 利宜也、乾 正志、筧 善行 2007

[学会発表] 固形癌におけるDR4、DR5を標的とした抗腫瘍壊死因子関連アポトーシス誘導リガンド受容体抗体と低濃度抗癌剤併用による抗腫瘍効果

呉 秀賢、筧 善行 2007

[雑誌論文] Monoclonal antibody to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2 (TRAIL-R2) induces apoptosis in primary renal cell carcinoma cells in vitro and inhibits the tumor growth in vivo

Yu Zeng, Xiu-Xian Wu, Michele Fiscella, Osamu Shimada, Robin Humphreys, Vivian Albert, Yoshiyuki Kakehi 2006

[雑誌論文] Treatment stategy for advanced prostate cancer with bone metastases

Sugimoto M, Kakehi Y 2006