トップ研究者を探すアルコール曝露による脳組織構築異常-ノッチシグナル伝達系遺伝子発現への影響-

アルコール曝露による脳組織構築異常-ノッチシグナル伝達系遺伝子発現への影響-

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18591292
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
精神神経科学
研究機関 香川大学
代表研究者 竹内 義喜
研究分担者 三木 崇範
研究分担者 松本 由樹
研究分担者 割田 克彦
研究分担者 中村 和彦
研究分担者 今川 智弘
研究分担者 横山 俊史
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2009
研究ステータス 完了 (2009/4/1)
配分額(合計) 4,080,000 (直接経費 :3,600,000、間接経費 :480,000)
配分額(履歴) 2009年度:650,000 (直接経費 :500,000、間接経費 :150,000)
2008年度:650,000 (直接経費 :500,000、間接経費 :150,000)
2007年度:780,000 (直接経費 :600,000、間接経費 :180,000)
2006年度:2,000,000 (直接経費 :2,000,000)
キーワード アルコール
ノッチシグナル
遺伝子発現
脳組織
神経機能
精神障害
アルコール曝露
神経回路綱形成
ノッチシグナル伝達
膜タンパク
神経ネットワーク
精神神経機能
ノッチシグナル伝達系
幹細胞性
細胞分化
神経幹細胞
ニューロスフェアー
カルシウム変動
星状膠細胞

研究成果

[学会発表] Non-vesicular synaptic transport: WGA- HRP and Rab3A-siRNA studies

Y akura T, Matsumoto Y, Miki T, Warita K, Wang ZY, Liu JQ, Mamoru F, Takeuchi Y 2010

[雑誌論文] Effects of short-term ethanol ingestion on the expression of neurotrophins and their receptors: No changes in the expression of the glial-derived neurotrophic factor in the mouse hippocampus

Ueno T, Miki T, Wang ZY, Yokoyama T, Lee KY, Kusaka T, Warita K, Sumitani K, Matsumoto Y, Yakura T, Liu JQ, Bedi KS, Takeuchi Y. 2010

[雑誌論文] Takeuch Y GABA expression in c-Fos immunoreactive neurons of the rat periaqueductal gray induced by electroacupuncture at the point of Zusanli.

Fusumada K, Yokoyama T, Miki T, Matsumoto Y, Warita K, Wang ZY, Yakura T, Liu JQ 2010

[雑誌論文] Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum

Wang ZY, Miki T, Lee KY, Yokoyama T, Kusaka T, Sumitani K, Warita K, Matsumoto Y, Yakura T, Hosomi N, Ameno K, Bedi KS, Takeuchi Y 2010

[学会発表] Revaluation of anterograde synaptic transport of WGA-HRP in the rat

竹内義喜、三木崇範、横山俊史、松本由樹、割田克彦、汪治宇、上野貴士、藤田守 2009

[学会発表] Modulation of hypothalamopituitary axis in Mini rat: further studies with hypophysiotropic somatostatin and gonadotroph

松本由樹 2009

[学会発表] WGA-HRPによる順行性シナプス輸送:ラット迷走神経へのRab3A-siRNA投与

竹内義喜、松本由樹、三木崇範、横山俊史、割田克彦、汪治宇、矢倉富子、藤田守 2009

[学会発表] A protein conjugation of WGA essential for transsynaptic tracer in neuronal system: application for Amyloid-βin vivo

Takeuchi Y, Matsumoto Y, Miki T, Warita K, Wang ZY, Yakura T, Liu JQ. 2009

[学会発表] WGA結合タンパクがもたらすシナプス膜輸送機構の新展開

松本由樹、三木崇範、割田克彦、汪治宇、矢倉富子、劉俊騫、竹内義喜 2009

[学会発表] WGA結合タンパクがもたらすシナプス膜輸送機構の新展開

松本由樹 2009

[学会発表] Modulation of hypothalamopituitary axis in Mini rat: further studies with hypophysiotropic somatostatin and gonadotroph

M atsumoto Y, Miki T, Tsukamoto Y, Warita K, Wang ZY, Yakura T, Karasawa S, Ueda S, Takeuchi Y. 2009

[雑誌論文] Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice.

Ishii Y, Matsumoto Y, et. al. 2008

[学会発表] Early postnatal ethanol exposure alters the BDNF and neural interactions in the olfactory bulb

松本 由樹 2008

[学会発表] Early postnatal ethanol exposure alters the BDNF and neural interactions in the olfactory bulb.

松本由樹、三木崇範、谷賀、割田克彦、汪治宇、竹内義喜 2008

[雑誌論文] Activin A and Equine Chorionic Gonadotropin Recover Reproductive Dysfunction Induced by Neonatal Exposure to an Estrogenic Endocrine Disruptor in Adult Male Mice

Warita K, Okamoto K, Mutoh KI, Hasegawa Y, Yue ZP, Yokoyama T, Matsumoto Y, Miki T, Takeuchi Y, Kitagawa H, Sugawara T, Hoshi N 2008

[雑誌論文] Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice

Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima YI, Sasahara M, Funa K 2008

[雑誌論文] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus Acta Neurobiol Exp

Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, Bedi KS, Itoh S, Nakamura Y and Takeuchi Y 2008

[雑誌論文] Ethanol neurotoxicity and dentate gyrus development

Miki t, Yokoyama T, Sumitani K, Kusaka T, Warita Y, Matsumoto Y, Wang ZY, Wilce PA, Bedi KS, Itoh, S, Takeuchi Y. 2008

[雑誌論文] Ethanol neurotoxicity and dentate gyrus development

Miki T, Yokoyama T, Sumitani K, Kusaka T, Warita Y, Matsumoto Y, Wang ZY, Wilce PA, Bedi KS, Itoh, S, Takeuchi Y 2008

[雑誌論文] Kinetics of repression by modified p53 on the PDGF beta-receptor promoter.

Yang W, Wetterskog D, Matsumoto Y, et al. 2008

[雑誌論文] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus.

Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, Bedi KS, Itoh S, Nakamura Y, Takeuchi Y 2008

[雑誌論文] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus.

Miki T, et al. 2008

[雑誌論文] Ethanol neurotoxicity and dentate gyrus development.

Miki T, et al. 2008

[雑誌論文] Takeuchi Y, The effect of prenatal X-irradiation on the developing cerebral cortex of rats.

Miki T, Yokoyama T, Sumitani K, Wang ZY, Yang W, Kusaka T, Matsumoto Y, Warita K, Lee NS, Fukui Y 2007

[学会発表] Takeuchi Y Short-term ethanol exposure caused changes in neurotrophins and its receptors expression in mice cerebellum

W ang ZY, Miki T, Yokoyama T, Matsumoto Y, Warita K, Sumitani K, Lu F 2007

[学会発表] A novel enhancer of the PDGF β-receptor gene activated during differentiation of neuroblastoma through Ets and GATA factor Italian Society of Neuroscience

Matsumoto Y, Kaneko M, Yang W, Watt F, Warita K, Miki T, Takeuchi Y, Funa K. 2007

[学会発表] Fos-immunoreactive neurons in the lateral central nucleus of amygdala activated by hypotension with special reference to the parabrachial nucleus in the rat

Takeuchi Y, Xie Q, Matsumoto Y, Warita K, Miki T. 2007

[学会発表] A nobel enhancer of the PDGF beta-receptor gene activated uring the differentiation of neuroblastoma through GATA factor

Yoshiki Matsumoto 2007

[雑誌論文] The effect of prenatal X-irradiation on the developing cerebral cortex of rats.II:A quantitative assessment of glial cells in the somatosensory cortex

Miki T, et. al. 2007

[学会発表] Funa K A nobel enhancer of the PDGF beta-receptor gene activated uring the differentiation of neuroblastoma through GATA factor

M atsumoto Y, Kaneko M, Yang W, Watt F, Warita K, Miki T, Takeuchi Y 2007

[雑誌論文] Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde

Jamal M, Ameno K, Ameno S, Morishita J, Wang W, Kumihashi M, Ikuo U, Miki T, Ijiri I 2007

[雑誌論文] Changes of parvalbumin immunoreactive neurons and GFAP immunoreactive astrocytes in the rat lateral geniculate nucleus following monocular enucleation

Gonzalez D, Satriotomo I, Miki T, Lee KY, Yokoyama T, Touge T, Matsumoto Y, Li HP, Kuriyama S, Takeuchi Y. 2006

[学会発表] Activity of a novel PDGF b-receptor enhancer during the cel1 cycle and upon differentiation of neuroblastoma

Y ang W, Kaneko M, Matsumoto Y, Wang ZY, Yokoyama T, Miki T, Watt F, Funa K, Takeuchi Y. 2006

[雑誌論文] Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption

Okamoto H, Miki T, Lee KY, Yokoyama T, Kuma H, Wang ZY, Gu H, Li HP, Matsumoto Y, Irawan S, Bedi KS, Nakamura Y, Takeuchi Y 2006

[学会発表] 母子間相互作用の発達神経科学解析;母性剥奪による脳発達への影響

三木崇範、横山俊史、日下隆、汪治宇、松本由樹、楊衛文、伊藤進、竹内義喜 2006

[雑誌論文] Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption

Okamoto H, Miki T, Lee KY, Yokoyama T, Kuma H, Wang ZY, Gu H, Li HP, Matsumoto Y, Irawan S, Bedi KS, Nakamura Y, Takeuchi Y. 2006

[学会発表] Activity of a novel PDGF beta-receptor enhancer during the cell cycle and upon differentiation of neuroblastoma.

K aneko M, Yang W, Matsumoto Y, Watt F, Funa K. 2006

[雑誌論文] Age-related changes in growth hormone-immunoreactive cells in the anterior pituitary gland of Jcl: Wistar-TgN (ARGHGEN) 1Nts rats (Mini rats)

Matsumoto Y, Tsukamoto Y, Miki T, Ogawa K, Lee KY, Yokoyama T, Satriotomo I, Li HP, Gu H, Wang ZY, Karasawa S, Ueda S, Sasaki F, Takeuchi Y. 2006

[学会発表] Neuroprotective Effects of Rare Sugar against Ethanol Toxicity; An Electron Microscopic Study in Mice Hippocampus. Rare Sugar Congress 2006 in Kagawa

Takeuchi Y, Yokoyama T, Miki T, Wang ZY, Yang W, Ueno M. 2006

[学会発表] 長期アルコール摂取によるラット海馬のミエリン構成たんぱく質mRNAの発現量変化

三木崇範、横山俊史、李京烈、岡本華代、山岡一平、襖田和敏、今川智敬、竹内義喜 2006