トップ研究者を探す養育環境が脳発達に及ぼす影響-母子間相互作用の発達神経科学的解明

養育環境が脳発達に及ぼす影響-母子間相互作用の発達神経科学的解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18591220
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
胎児・新生児医学
研究機関 香川大学
代表研究者 三木 崇範
研究分担者 横山 俊史
研究分担者 松本 由樹
研究分担者 割田 克彦
研究分担者 竹内 義喜
研究分担者 日下 隆
研究分担者 伊藤 進
研究分担者 李 京烈
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2009
研究ステータス 完了 (2009/4/1)
配分額(合計) 4,080,000 (直接経費 :3,600,000、間接経費 :480,000)
配分額(履歴) 2009年度:520,000 (直接経費 :400,000、間接経費 :120,000)
2008年度:780,000 (直接経費 :600,000、間接経費 :180,000)
2007年度:780,000 (直接経費 :600,000、間接経費 :180,000)
2006年度:2,000,000 (直接経費 :2,000,000)
キーワード 母仔分離
ストレス
養育環境
母子間相互作用
脆弱性分子基盤
神経栄養因子
脳・神経発達
精神神経機能
母仔分離ストレス
脳発達
脆弱性基盤
ミエリン関連たんぱく質
OMGp
神経回路網形成
エピジェネテック
脳の脆弱性基盤
発達
エネルギー代謝
Prohibitin (PHB)
脂肪
BDNF mRNA
サイトカイン
発達・成長
Real-time RT-PCR

研究成果

[学会発表] 短期間アルコール摂取マウス小脳の神経栄養因子リガンド/レセプター系の特異的応答性

三木崇範、汪治宇、横山俊史、日下隆、住谷和則、割田克彦、松本由樹、矢倉富子、劉俊騫、王朝暉、竹内義喜 2010

[雑誌論文] Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum

Wang ZY, Miki T, Lee KY, Yokoyama T, Kusaka T, Sumitani K, Warita K, Matsumoto Y, Yakura T, Hosomi N, Ameno K, Bedi KS, Takeuchi Y 2010

[雑誌論文] Effects of short-term ethanol ingestion on the expression of neurotrophins and their receptors: No changes in the expression of the glial-derived neurotrophic factor in the mouse hippocampus

Ueno T, Miki T, Wang ZY, Yokoyama T, Lee KY, Kusaka T, Warita K, Sumitani K, Matsumoto Y, Yakura T, Liu JQ, Bedi KS, Takeuchi Y. 2010

[学会発表] Non-vesicular synaptic transport: WGA- HRP and Rab3A-siRNA studies

Yakura T, Matsumoto Y, Miki T, Warita K, Wang ZY, Liu JQ, Mamoru F, Takeuchi Y. 2010

[雑誌論文] GABA expression in c-Fos immunoreactive neurons of the rat periaqueductal gray induced by electroacupuncture at the point of Zusanli.

Fusumada K, Yokoyama T, Miki T, Matsumoto Y, Warita K, Wang ZY, Yakura T, Liu JQ, Takeuch Y. 2010

[雑誌論文] Alcohol or Their Combination on Cholinergic Markers in the Frontal Cortex and Hippocampus of Rat.

Jamal M, Ameno K, Miki T, Tanaka N, Ohkubo E, Kinoshita H. Effects of Systemic Nicotine 2010

[学会発表] 短期間アルコール摂取マウス小脳の神経栄養因子リガンド/レセプター系の特異的応答性

三木崇範 2010

[雑誌論文] Relationship between cerebral oxygenation and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets

Kusaka T, Ueno M, Miki T, Kuboi T, Nakamura S, Koyano K, Ijichi S, Yasuda S, Okubo K, Kawada K, Namba M, Nishida T, Imai T, Isobe K, Itoh S 2009

[雑誌論文] Relationship between cerebral oxygenation and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets

Kusaka, et al. 2009

[雑誌論文] Relationship between cerebral oxygenation and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets

Kusaka T, Ueno M, Miki T, Kuboi T, Nakamura S, Koyano K, Ijichi S, Yasuda S, Okubo K, Kawada K, Namba M, Nishida T, Imai T, Isobe K, Itoh S. 2009

[学会発表] Revaluation of anterograde synaptic transport of WGA-HRP in the rat

竹内義喜、三木崇範、横山俊史、松本由樹、割田克彦、汪治宇、上野貴士、藤田守 2009

[学会発表] Modulation of hypothalamopituitary axis in Mini rat: further studies with hypophysiotropic somatostatin and gonadotroph

Matsumoto Y, Miki T, Tsukamoto Y, Warita K, Wang ZY, Yakura T, Karasawa S, Ueda S, Takeuchi Y. 2009

[学会発表] Revaluation of anterograde synaptic transport of WGA-HRP in the rat.

竹内義喜, 三木崇範, 横山俊史, 松本由樹, 割田克彦, 汪治宇, 上野貴士, 藤田守 2009

[学会発表] WGA-HRPによる順行性シナプス輸送:ラット迷走神経へのRab3A-siRNA投与

竹内義喜、松本由樹、三木崇範、横山俊史、割田克彦、汪治宇、矢倉富子、藤田守 2009

[学会発表] A protein conjugation of WGA essential for transsynaptic tracer in neuronal system: application for Amyloid-βin vivo

Takeuchi Y, Matsumoto Y, Miki T, Warita K, Wang ZY, Yakura T, Liu JQ. 2009

[学会発表] evaluation of anterograde synaptic transport of WGA-HRP in the rat

竹内義喜、三木崇範、横山俊史、松本由樹、割田克彦、汪治宇、上野貴士、藤田守 2009

[学会発表] WGA結合タンパクがもたらすシナプス膜輸送機構の新展開

松本由樹、三木崇範、割田克彦、汪治宇、矢倉富子、劉俊騫、竹内義喜 2009

[雑誌論文] Japan Standard Stroke Registry Study Group. Predictors of ntracerebral hemorrhage severity and its outcome in Japanese stroke patients

Hosomi N, Naya T, Ohkita H, Mukai M, Nakamura T, Ueno M, Dobashi H, Murao K, Masugata H, Miki T, Kohno M, Kobayashi S, Koziol JA 2009

[雑誌論文] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models

Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K, Ijiri I, Kinoshita H. 2009

[学会発表] 医学部における先天異常学教育-香川大学での試み-

三木崇範、割田克彦、松本由樹、日下隆、汪治宇、伊藤進、竹内義喜 2008

[雑誌論文] Ethanol neurotoxicity and dentate gyrus development.

Miki T, Yokoyama T, Sumitani K, Kusaka T, Warita Y, Matsumoto Y, Wang ZY, Wilce PA, Bedi KS, Itoh, S, Takeuchi Y 2008

[雑誌論文] Ethanol neurotoxicity and dentate gyrus development

Miki T, Yokoyama T, Sumitani K, Kusaka T, Warita K, Matsumoto Y, Wang ZY, Wilce PA, Bedi KS, Itoh S, Takeuchi Y. 2008

[雑誌論文] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus.

Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, Bedi KS, Itoh S, Nakamura Y, Takeuchi Y 2008

[学会発表] 医学部における先天異常学教育-香川大学での試み-

三木崇範, 割田克彦, 松本由樹, 日下隆, 汪治宇, 伊藤進, 竹内義喜 2008

[雑誌論文] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus

Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, S Bedi K, Itoh S, Nakamura Y, Takeuchi Y. 2008

[学会発表] Early postnatal ethanol exposure alters the BDNF and neural interactions in the olfactory bulb

松本由樹、三木崇範、谷賀、割田克彦、汪治宇、竹内義喜 2008

[雑誌論文] Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice

Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima YI, Sasahara M, Funa K 2008

[雑誌論文] Activin A and equine chorionic gonadotropin recover reproductive dysfunction induced by neonatal exposure to an estrogenic endocrine disruptor in adult male mice.

Warita K, Okamoto K, Mutoh KI, Hasegawa Y, Yue ZP, Yokoyama T, Matsumoto Y, Miki T, Takeuchi Y, Kitagawa H, Sugawara T, Hoshi N. 2008

[学会発表] ライディッヒ細胞株TTE1 におけるエストロゲン様化学物質曝露の影響 : ステロイドホルモン産生系遺伝子発現とヒストン修飾の変化

割田克彦、三觜友子、菅原照夫、田渕圭章、松本由樹、三木崇範ら 2008

[学会発表] エストロゲン様化学物質曝露によるエストロゲンホルモン産生系遺伝子の発現変化とヒストンアセチル化解析

割田克彦、三觜友子、菅原照夫、田渕圭章、松本由樹、三木崇範ら 2008

[学会発表] ライディッヒ細胞株TTE1におけるエストロゲン様化学物質曝露の影響 : ステロイドホルモン産生系遺伝子発現とヒストン修飾の変化

割田克彦, 三觜友子, 菅原照夫, 田渕圭章, 松本由樹, 三木崇範 ら 2008

[学会発表] Y染色体腕間逆位を有するXY女性におけるSRY遺伝子のエピジェネティック異常

三觜友子、割田克彦、菅原照夫、田渕圭章、高崎一郎、松本由樹、三木崇範ら 2008

[学会発表] Early postnatal ethanol exposure alters the BDNF and neural interactions in the olfactory bulb

松本 由樹、三木 崇範, ら 2008

[学会発表] Early postnatal ethanol exposure alters the BDNF and neural interactions in the olfactory bulb.

松本由樹、三木崇範、谷賀、割田克彦、汪治宇、竹内義喜 2008

[雑誌論文] Dietary protein modulates circadian changes in core body temperature and metabolic rate in rats.

Yamaoka I, Nakayama M, Miki T, Yokoyama T, Takeuchi Y. 2008

[雑誌論文] 母性剥奪症侯群(Maternal Deprivation Syndrome)の発達神経科学的アプローチ

三木 崇範 2008

[雑誌論文] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus.

Miki, et al. 2008

[雑誌論文] Ethanol neurotoxicity and dentate gyrus development

Miki, et al. 2008

[雑誌論文] Plasma brain natriuretic peptide as a surrogate marker for ardioembolic stroke

Yukiiri K, Hosomi N, Naya T, Takahashi T, Ohkita H, Mukai M, Masugata H, Murao K, Ueno M, Nakamura T, Dobashi H, Miki T, Kuroda Y, Kohno M. 2008

[雑誌論文] Dietary protein modulates circadian changes in core body temperature and metabolic rate in rats

Yamaoka I, Nakayama M, Miki T, Yokoyama T,Takeuchi Y. 2008

[雑誌論文] Accumulation of triosephosphate isomerase,with sequence homology to Beta amyloid,peptides in vessel walls of the newborn piglet hippocampus

Kusaka T, Ueno M, Miki T, et. al. 2007

[雑誌論文] The effect of prenatal X-irradiation on the developing cerebral cortex of rats.ll: A quantitative assessment of glial cells in the somatosensory cortex

Miki T, Yokoyama T, Sumitani K, Wang ZY, Yang W, Kusaka T, Matsumoto Y, Warita K, Lee NS, Fukui Y, Takeuchi Y. 2007

[雑誌論文] The effect of prenatal X-irradiation on the developing cerebral cortex of rats. A quantitative assessment of glial cells in the somatosensory cortex

Miki T, Yokoyama T, Sumitani K, Wang ZY, Yang W, Kusaka T, Matsumoto Y, Warita K, Lee NS, Fukui Y, Takeuchi Y 2007

[学会発表] 中枢神経発達時期におけるイソフルラン曝露の影響:嗅球における神経栄養因子の変化

三木崇範、横山俊史、植木正明、汪治宇、割田克彦、松本由樹、前川信博、竹内義喜 2007

[学会発表] Funa K A nobel enhancer of the PDGF beta-receptor gene activated uring the differentiation of neuroblastoma through GATA factor

Matsumoto Y, Kaneko M, Yang W, Watt F, Warita K, Miki T, Takeuchi Y 2007

[学会発表] Fos-immunoreactive neurons in the lateral central nucleus of amygdala activated by hypotension with special reference to the parabrachial nucleus in the rat

akeuchi Y, Xie Q, Matsumoto Y, Warita K, Miki T. 2007

[学会発表] Takeuchi Y Short-term ethanol exposure caused changes in neurotrophins and its receptors expression in mice cerebellum.

ang ZY, Miki T, Yokoyama T, Matsumoto Y, Warita K, Sumitani K, Lu F 2007

[図書] Effects of electric or magnetic brain stimulation on cortical and subcortical neuron functions in rats.

Touge T, Gonzalez D, Miki T, Hiramine C, Takeuchi H. 2007

[学会発表] 中枢神経発達時期におけるイソフルラン曝露の影響:臭球における神経栄養因子の変化

三木 崇範 2007

[図書] Complex Medical Engineering

Touge T, Gonzalez D, Miki T, Hiramine C, Takeuchi H 2007

[学会発表] 母性剥奪症侯群(Maternal Deprivation Syndrome)の発達神経科学的アプローチ

三木崇範 2007

[雑誌論文] c-Fos expression in the periaqueductal gray is induced by electroacupuncture in the rat,with possible reference to GABAergic neurons.

Fusumada K, Yokoyama T, Miki T, Wang ZY, Yang W, Lee NS, Endo Y, Takeuchi Y. 2007

[学会発表] 母性剥奪症侯群(Maternal Deprivation Syndrome)の発達神経科学的アプローチ

三木 崇範 2007

[学会発表] Short-term ethanol exposure caused changes in neurotrophins and its receptorexpressionin mice cerebellu.

Zhi-Yu Wang, Miki T, et. al. 2007

[雑誌論文] Changes in cholinergic function in the frontal cortex and hippocampus of ratexposed to ethanol and acetaldehyde.

Jamal M, Ameno K, Ameno S, Morishita J, Wang W, Kumihashi M, Ikuo U, Miki T, ljiri I 2007

[雑誌論文] Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde

Jamal M, Ameno K, Ameno S, Morishita J, Wang W, Kumihashi M, Ikuo U, Miki T, Ijiri I 2007

[学会発表] 母子間相互作用の発達神経科学解析;母性剥奪による脳発達への影響

三木崇範、横山俊史、日下隆、汪治宇、松本由樹、楊衛文、伊藤進、竹内義喜 2006

[雑誌論文] Age-related changes in growth hormone-immunoreactive cells in the anterior pituitary gland of Jcl: Wistar-TgN (ARGHGEN) 1Nts rats (Mini rats)

Matsumoto Y, Tsukamoto Y, Miki T, Ogawa K, Lee KY, Yokoyama T, Satriotomo I, Li HP, Gu H, Wang ZY, Karasawa S, Ueda S, Sasaki F, Takeuchi Y. 2006

[学会発表] Activity of a novel PDGF beta-receptor enhancer during the cell cycle and upon differentiation of neuroblastoma

Kaneko M, Yang W, Matsumoto Y, Watt F, Funa K. 2006

[雑誌論文] Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption

Okamoto H, Miki T, Lee KY, Yokoyama T, Kuma H, Wang ZY, Gu H, Li HP, Matsumoto Y, Irawan S, Bedi KS, Nakamura Y, Takeuchi Y 2006

[学会発表] Activity of a novel PDGF b-receptor enhancer during the cel1 cycle and upon differentiation of neuroblastoma

Yang W, Kaneko M, Matsumoto Y, Wang ZY, Yokoyama T, Miki T, Watt F, Funa K, Takeuchi Y. 2006

[雑誌論文] Age-related changes in growth hormone-immunoreactive cells in the anterior pituitary gland of Jcl : Wistar-TgN (ARGHGEN) 1Nts rats (Mini rats).

Matsumoto Y et al. 2006

[学会発表] 組織定量解析法(ステレオロジー)を用いた中枢神経系の機能解析

三木崇範 2006

[学会発表] 長期アルコール摂取によるラット海馬のミエリン構成たんぱく質mRNAの発現量変化

三木崇範、横山俊史、李京烈、岡本華代、山岡一平、襖田和敏、今川智敬、竹内義喜 2006

[学会発表] Neuroprotective Effects of Rare Sugar against Ethanol Toxicity; An Electron Microscopic Study in Mice Hippocampus.

Takeuchi Y, Yokoyama T, Miki T, Wang ZY, Yang W, Ueno M. 2006

[雑誌論文] 母性剥奪症候群(Maternal Deprivation Syndrome)の発達神経科学的アプローチ

三木崇範

[雑誌論文] 子供の脳発達と養育環境-母性剥奪症候群のエピジェネティック解析

三木崇範