トップ研究者を探すアルコールの脳神経伝達物質に及ぼす影響-ApoEとALDH2欠損マウスによる研究

アルコールの脳神経伝達物質に及ぼす影響-ApoEとALDH2欠損マウスによる研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18590637
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
社会医学
法医学
研究機関 香川大学
代表研究者 JAMAL MOSTOFA
研究分担者 飴野 清
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額(合計) 4,100,000 (直接経費 :3,800,000、間接経費 :300,000)
配分額(履歴) 2008年度:650,000 (直接経費 :500,000、間接経費 :150,000)
2007年度:650,000 (直接経費 :500,000、間接経費 :150,000)
2006年度:2,800,000 (直接経費 :2,800,000)
キーワード アルコール
アセトアルデヒド
コリン作動性神経系
前頭皮質
ALDH2ノックアウトマウス
ApoEノックアウトマウス
記憶の固定
8アームラジアル迷路
Alcohol
Acetaldehyde
Cholinergic function
Frontal Cortex
Aldh2(-
-)mice
ApoE(-
Memory consolidation
Eight-arm radial maze
frontal cortex
hippocampus
RT-PCR
Western blot
acetylcholinesterase
choline acetyltransferase
cholinergic function
エタノール
前頭葉

研究成果

[雑誌論文] Acetaldehyde-induce changes in cholinergic function in the frontal cortex of ALDH2 transgenic mice (3^<rd>)

Mostofa Jamal, Kiyoshi Ameno, Uekita Ikuo, Weihuan Wang, Mitsuru Kumihashi, Shiakh Badiuzzaman, Iwao Ijiri 2008

[雑誌論文] Cholinergic changes following exposure to nicotine, ethanol, or both combined in the frontal cortex and hippocampus of rat

Mostofa Jamal, Ikuo Uekita, Mitsuru Kumihashi, Iwao Ijiri, and Kiyoshi Ameno 2008

[学会発表] Acetaldehyde-induce changes in cholinergic function in the frontal cortex of ALDH2 transgenic mice

Mostofa Jamal, KiyoshiAmeno, Uekita Ikuo, Weihuan Wang, Mitsuru Kumihashi, Shiakh Badiuzzaman, Iwao Ijiri 2008

[学会発表] Role of catalase in mediating acetaldehyde production in the striatum of free-moving rats

Mostofa Jamal, Kiyoshi Ameno, Ikuo Uekita, Mitsuru Kumihashi, Weihuan Wang, Iwao Ijiri 2008

[学会発表] Cholinergic changes following exposure to nicotine, ethanol, or both combined in the frontal cortex and hippocampus of rat.

Mostofa Jamal, Ikuo Uekita, Mitsuru Kumihashi, Iwao Ijiri, and Kiyoshi Ameno. 2008

[雑誌論文] Chollnergic changes following exposure to nicotine, ethanol, or both combined in the frontal cortex and hippocampus of rat

Mostofa Jamal, Ikuo Dekita, Mitsuru Kumihashi, Iwao Ijiri, Kiyoshi Ameno 2008

[学会発表] Cholinergic changes following exposure to nicotine, ethanol, or both combined in the frontal cortex and hippocampus of rat

Mostofa Jamal, Ikuo Uekita, Mitsuru Kumihashi, Iwao Ijiri, Kiyoshi Ameno. 2008

[雑誌論文] Shiakh Badiuzzaman and Iwao Ijiri. Acetaldehyde-induce changes in cholinergic function in the frontal cortex of ALDH2 transgenic mice (3^<rd>)

Mostofa Jamal, Kiyoshi Ameno, Uekita Ikuo, Weihuan Wang, Mitsuru Kumihashi 2008

[学会発表] Acetaldehyde-induce changes in cholinergic function in the frontal cortex of ALDH2 transgenic mice (3^<rd>).

Mostofa Jamal, Kiyoshi Ameno, Uekita Ikuo, Weihuan Wang, Mitsuru Kumihashi, Shiakh Badiuzzaman and Iwao Ijiri. 2008

[学会発表] Nagasaki : Role of catalase in mediating acetaldehyde production in the striatum of free-moving rats

Mostofa Jamal, Kiyoshi Ameno, Ikuo Uekita, Mitsuru Kumihashi, Weihuan Wang, and Iwao Ijiri. 2008

[雑誌論文] Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde.

Mostofa Jamal, et al. 2007

[雑誌論文] Simultaneous determination of Metamphetamine and Amphetamine in urine using a high performance liquid chromatography co lumn switching method

Kumihashi M, Ameno K, Shibayama T, Suga K, Miyauchi H, Jamal M, Wang W, Uekita I, Ijiri I 2007

[雑誌論文] 瀬戸内海で発見された海中死体の手背部の状態による死後経過時間の推定

三澤 宏規、上北 郁男、王 威環、ジャマール モストファ、飴野 清、井尻 巖 2007

[図書] Acetaldehyde-Related Pathology : Bridging the Trans-Disciplinary Divide,Ed,Derek J. Chadwick and Jamie Goode

Mostofa Jamal, et al. 2007

[雑誌論文] Ethanol and aceta ldehyde: in vivo quantitation and effects on cholinergic function in ratbrain

Jamal M, Ameno K, Uekita I, Kumihashi M, Wang W, ljiri I. 2007

[雑誌論文] Changes in cholinergic funct ion in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde

Jamal M, Ameno K, Ameno S, Morishita J, Wang W, Kumihashi M, Uekito I, Miki T, Ijiri I 2007

[雑誌論文] Catalase mediates acetaldehyde formation in the striatum of free-moving rats

Jamal M, Ameno K, Uekita I, Kumihashi M, Wang W, ljiri I. 2007

[学会発表] Acetaldehyde-induce changes in cholinergic function in the frontal cortex of ALDH2 Transgenic Mice.

Mostofa Jamal, Kiyoshi Ameno, Weihuan Wang, Ikuo Uekita, Mitsuru Kumihashi, Masashi Higuchi, and Iwao Ijiri. 2007

[雑誌論文] Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde

Mostofa Jamal, Kiyoshi Ameno, Setsuko Ameno, Jun Morishita, Weihuan Wang, Mitsuru Kumihashi, Uekita Ikuo, Takanori Miki and Iwao Ijiri 2007

[学会発表] Acetaldehyde-induce changes in cholinergic function in the frontal cortex of ALDH2 transgenic mice

Mostofa Jamal, Kiyoshi Ameno, Weihuan Wang, Ikuo Uekita, Mitsuru Kumihashi and Iwao Ijiri 2007

[雑誌論文] Effect of direct Infusion of Acetaldehyde on Dopamine and Dopamine-derived Salsolinol in the striatum of free-moving rats using reverse microdialysis

Wang W, Ameno K, Jamal M, Kumihashi M, Uekita I, Ameno S, ljiri I. 2007

[学会発表] Acetaldehyde-induce changes in cholinergic function in the frontal cortex of ALDH2 trangenic mice

Jamal M, Ameno K, Wang W, Uekita I, Kumihashi M, lsse T, Kawamoto T, Kitagawa K, Nakayama K, ljiri I. 2007

[図書] Bridging the Trans-Disciplinary Divide Novartis Foundation 285(John Wiley & Sons Ltd, UK)

Mostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, Weihuan Wang, Uekita Ikuo and Iwao Ijiri 2007

[雑誌論文] Catalase mediates acetaldehyde formation in the striatum of free-moving rats

Mostofa Jamal, Kiyoshi Ameno, Ikuo Uekita, Mitsuru Kumihashi, Weihuan Wang and Iwao Ijiri 2007