尿路病原性大腸菌の産生するUSPの作用解析と粘膜ワクチンの開発

トップ›研究者を探す›尿路病原性大腸菌の産生するUSPの作用解析と粘膜ワクチンの開発

代表研究者	倉園久生
研究課題番号	KAKENHI-PROJECT-18590433
研究種目	基盤研究(C)
研究分野	生物系医歯薬学基礎医学細菌学(含真菌学)
研究機関	帯広畜産大学大阪府立大学
研究分担者	星英之
研究分担者	山本新吾
研究分担者	牧野壮一
研究期間開始年月日	2006/4/1
研究期間終了年度	2007
研究ステータス	完了 (2007/4/1)
配分額（合計）	4,010,000 (直接経費 :3,500,000、間接経費 :510,000)
配分額（履歴）	2007年度：2,210,000 (直接経費 :1,700,000、間接経費 :510,000) 2006年度：1,800,000 (直接経費 :1,800,000)
キーワード	尿路感染症尿路病原性大腸菌 USP 尿路病原因子 UPEC 粘膜ワクチン Urinary Tract Infection Escherichia coli Protein Toxin USP Mucosal Vaccine

研究成果

[雑誌論文] Molecular typing of Vibrio cholerae O1 isolates from Thailand by pulsed-field gel electrophoresis.

Tapchaisri P, Na-Ubol M, Nair GB, Kurazono H , et. al. 2008

[雑誌論文] Molecular typing of Vibrio cholerae O1 isolates from Thailand by pulsed-field gel electrophoresis.

Tapchaisri, P., Na-Ubol, M., Tiyasuttipan, W., Chaiyaroj, S.C., Yamasaki, S., Wongsaroj, T., Hayashi, H., Nair, G.B., Chongsa-nguan, M., Kurazono, H., Chaicumpa, W. 2008

[雑誌論文] Molecular characterization of Helicobacter pylori VacA-induction of IL-8 in U937 cells reveals a prominent role for p38 MAP kinase in ATF-2, CREB and NF-kappaB activation.

Hisatsune J, Nakayama M, Isomoto H, Kurazono H , et. al. 2008

[雑誌論文] Molecular characterization of Helicobacter pylori VacA-induction of IL-8 in U937 cells reveals a prominent role for p38MAP kinase in ATF-2, CREB and NF-κB activation.

Hisatsune, J., Nakayama, M., Isomoto. H., Kurazono, H., et. al. 2008

[雑誌論文] Molecular characterization of Helicobacter pylori VacA-induction of IL-8 in U937 cells reveals a prominent role for p38MAP kinase in ATF-2, CREB and NF- κB activation.

Hisatsune, J., Nakayama, M., Isomoto. H., Kurazono, H., Mukaida, N., Mukhopadhyay, A.K., Sap, J., Yamasaki, E., Yahiro, Y., Moss, J., and Hirayama, T. 2008

[雑誌論文] Virulence genes of clinicai Vibrio cholerae O1 isolates in Thailand and their ribotypes.

Tapchaisti, P., Na-Ubol, M., Jaipaew, J., Srimanote, P., Chongsa-Nguan, M., Yamasaki, S., Hayashi, H., Kurazono, H., Chaicumpa, W. 2007

[学会発表] Escherichia coli from uncomplicated cystitis and from asymptomatic bacteriuria possess similar phylogeny, virulence genes and O serogroup profiles.

Takahashi A, Kanamaru S, Kurazono H et al 2007

[学会発表] Purified Salmonella enterotoxin exoresses cytotoxic activity to CHO Cells.

H Kurazono, S Horie, H Hoshi, Y Seto, M Chongsa-nguan, et. al. 2007

[学会発表] Purified Salmonella enterotoxin expresses cytotoxic activity to CHO cells.

Hisao Kurazono Satomi Horie, Hidenobu Hoshi, Yoshiyuki Seto, Manas Chongsa-nguan, Wanpen Chaicumpa, G.B. Nair, Souichi Makino, Toshiya Hirayama 2007

[学会発表] サルモネラ・エンテロトキシン精製の試み

倉園久生、星英之、牧野壮一 2007

[学会発表] Purified Salmonella enterotoxin expresses cytotoxic activity to CHO Cells.

Hisao Kurazono, Satomi Horie, Hidenobu Hoshi, Yoshiyuki Seto, Manas Chongsa-nguan, Wanpen Chicumpa, G. B. Nair, Soichi Makino, Toshiya Hirayama 2007

[学会発表] Helicobacter pylori VacA Enhances PGE2 Production Through Induction of COX-2 Expression via a p38 MAP Kinase/ATF-2 Cascade in AZ-521 Cells.

Toshiya Hirayama, Jyunzo Hisatsune, Masaaki Nakayama, Hisao Kurazono, and Joel Moss: 2007

[学会発表] Helicobacter pylori VacA enhances PGE2 production through induction of COX-2 expression via a p38 MAP kinase/ATF-2 cascade in AZ-521 cells.

Toshiya Hirayama, Junzo Hisatsune, Masaaki Nakayama, Hisao Kurazono, and Joel Moss 2007

[雑誌論文] Helicobacter pylori VacA Enhances Prostaglanding E2 Production through Induction of Cyclooxygenase 2 Expression via a p38 Mitogen-Activated Protein Kinase/Activating Transcription Factor 2 Cascade in AZ-521 Cells.

Hisatsune, J., Yamasaki, E., Nakayama, M., Shirasaka, D., Kurazono, H, et. al. 2007

[雑誌論文] Virulence genes of clinical Vibrio cholerae O1 isolates in Thailand and their ribotypes.

Tapchaisri, P., Na-Ubol, M., Srimanote, P., Chongsa-Nguan, M., Kurazono, H., et. al. 2007

[学会発表] H. pylori VacAによるp38 MAP Kinase活性化依存COX-2発現誘導を介したPGE_2産生亢進作用

久恒順三、倉園久生、片方陽太郎、平山壽哉 2007

[雑誌論文] Virulence genes of clinical Vibrio cholerae O1 isolates in Thailand and their ribotypes.

Tapchaisri, P., Na-Ubol, M., Jaipaew, J., Srimanote, P., Chongsa-Nguan, M., Yamasaki, S., Hayashi, H., Kurazono, H., Chaicumpa, W. 2007

[学会発表] Helicobacter pylori VacA Enhances PGE2 Production Through Induction of COX-2 Expression via a p38 MAP Kinase/ATF-2 Cascade in AZ-521 Cells.

T Hirayama, J Hisatsune, M Nakayama, H Kurazono, and J Moss 2007

[学会発表] urified Salmonella enterotoxin expresses cytotxic activity to CHO Cells.

Hisao Kurazono, Satomi Horie, Hidenobu Hoshi, Yoshiyuki Seto, Manas Chongsa-nguan, Wanpen Chicumpa, G. B. Nair, Soichi Makino, Toshiya Hirayama 2007

[学会発表] Helicobacter pylori VacA Enhances PGE2 Production Through Inducti on of COX-2 Expression via a p38 MAP Kinase/ATF-2 Cascade in AZ-521 Cells

Toshiya Hirayama, Jyunzo Hisatsune, Masaaki Nakayama, Hisao Kurazono, and Joel Moss: 2007

[雑誌論文] Helicobacter pylori VacA Enhances Prostaglandin E2 Production through induction of Cyclooxygenase 2 Expression via a p38 Mitogen-Activated Protein Kinase/Activating Transcription Factor 2 Cascade in AZ-521 Cells.

Hisatsune, J., Yamasaki, E., Nakayama, M., Shirasaka, D., Kurazono, H., Katagata, Y., Inoue, H., Han, J., Sap, J., Yahiro, K., Moss, J., Hirayama, T. 2007

[雑誌論文] Helicobacter pylori VacA enhance PGE-2 production through induction of cyclooxygenase 2 expressionvia a p38 MAP kinase/ ATF-2 cascade in AZ-521 cells.

Hisatsune J, Yamasaki E, Nakayama M, Shirasaka D, Kurazono H , et. al. 2007

[雑誌論文] Increased biofilm formation in Escherichia coli isolated from acute prostatitis.

Kanamaru, S., Kurazono, H., et al. 2006

[学会発表] Patial Purification of Salmonella enterotoxin.

Yusuke Ohtani, Hidenobu Hoshi, Sou-ichi Makino, Manas Chongsa-nguan, Wanpen Chaicumpa, G.B. Nair, Hisao Kurazono 2006

[雑誌論文] Subtyping of uropathogenic Escherichia coli according to the pathogenicity island encoding uropathogenic-apecific protein : Comparison with phylogenetic groups.

Kanamaru, S., Kurazono, H., et al. 2006

[学会発表] Salmonella enterotoxin

Hisao Kurazono 2006

[学会発表] Helicobacter pylori VacA clustering in lipid rsfts, mediated by its receptor, RPTPbeta, is required for intoxication in AZ-521 cells.

Toshiya Hirayama, Akihiro Wada, Hisao Kurazono, and Joel Moss 2006

[学会発表] Clustering of Helicobacter pylori VacA in lipid rafts, mediated by its receptor, RPTPbeta, is required for intoxication and activation of intracellular signaling pathways in AZ-521 cells.

Toshiya Hirayama, Masaaki Nakayama, Hisao Kurazono and Joel Moss 2006