細菌性コラゲナーゼのカルシウム依存性コンフォメーション変換に係る学際的研究

トップ›研究者を探す›細菌性コラゲナーゼのカルシウム依存性コンフォメーション変換に係る学際的研究

細菌性コラゲナーゼのカルシウム依存性コンフォメーション変換に係る学際的研究

代表研究者	松下治
研究課題番号	KAKENHI-PROJECT-18590429
研究種目	基盤研究(C)
研究分野	生物系医歯薬学基礎医学細菌学(含真菌学)
研究機関	北里大学香川大学
研究分担者	宮由茂
研究期間開始年月日	2006/4/1
研究期間終了年度	2007
研究ステータス	完了 (2007/4/1)
配分額（合計）	3,930,000 (直接経費 :3,600,000、間接経費 :330,000)
配分額（履歴）	2007年度：1,430,000 (直接経費 :1,100,000、間接経費 :330,000) 2006年度：2,500,000 (直接経費 :2,500,000)
キーワード	細菌性コラゲナーゼ触媒ドメインコラーゲン結合ドメイン副甲状腺ホルモン薬物送達システム融合タンパク質骨粗鬆症薬物伝達システム clostridial collagenases catalytic domain collagen-binding domain parathyroid hormone drug delivery system fusion protein osteoporosis

研究成果

[学会発表] ガス壊疽菌群コラゲナーゼの基質認識機構と骨粗鬆症治療への応用

松下治 2008

[学会発表] Collagen binding mechanism of a novel osteoporosis drug.

PST Leena, O Matsushita, R Gensure, J Sakon 2008

[学会発表] Collagen binding mechanism of a novel osteoporosis drug

PST Leena, O Matsushita, R Ge nsure, J Sakon 2008

[学会発表] Vector construction for production and purification of clostridial collagenases. (in Japanese)

Y, Tanaka, E, Tamai, S, Miyata, A, Okabe, H, Hohchi, O, Matsushita 2008

[学会発表] Substrate recognition mechanism of clostridial collagenases and its application to the treatment of osteoporosis. (in Japanese)

O, Matsushita 2008

[学会発表] Collagen binding mechanism of a novel osteoporosis drug

PST, Leena, O, Matsushita, R, Gensure, J, Sakon 2008

[学会発表] A novel drug delivery system based on the substrate recognition mechanism of clostridial collagenases. (in Japanese)

O, Matsushita 2008

[学会発表] クロストリジウム菌コラゲナーゼの産生と精製用のベクターの構築

田中裕章、玉井栄治、宮田茂、岡部昭延、芳地一、松下治 2008

[学会発表] Weekly administration of a novel parathyroid hormone-Collagen-binding domain fusion protein increases bone mineral density by more than 15 percent in normal mouse.

T Ponnapakkam, O Matsushita, J Sakon, RC Censure 2007

[学会発表] Vibzlo alginolyticusのコラーゲン分解レギュロンの発現調節について

松下治、宮田茂、玉井栄治、岡部昭延 2007

[学会発表] Expression regulation of collagenolytic regulon in Vibrio altinolyticus. (in Japanese)

O, Matsushita, S, Miyata, E, Tamai, A, Okabe 2007

[学会発表] Weekly administration of a novel parathyroid hormone - Collagen-binding domain fusion protein increases bone mineral density by more than 15 percent in normal mouse

T Ponnapakkam, O Matsushita, J Sakon, RC Gensure 2007

[学会発表] ガス壊疽菌群コラゲナーゼの基質認識機構と薬物送達システムへの応用

松下治 2007

[学会発表] Weekly administration of a novel parathyroid hormone-Collagen-binding domain fusion protein increases bone mineral density by more than 15 percent in normal mouse

T, Ponnapakkam, O, Matsushita, J, Sakon, RC, Gensure 2007

[学会発表] Collagen binding characteristics of collagen-binding domain from Clostri dium histolyticum class I collagenase

J Sakon, PST Leena, O Matsushita 2007

[学会発表] Collagen binding charactehstics of collagen-binding dolmain from Clostridium histolvticum class I collagenase.

J Sakon, PST Leena, O Matsushita 2007

[学会発表] Collagen binding characteristics of collagen-binding domain from Clostridium histolyticum class I collagenase

J, Sakon, PST, Leena, O, Matsushita 2007

[学会発表] Vibrio alginolyticusコラゲナーゼの性状と発現調節

松下治、谷口有紀、宮田茂、玉井栄治、田中裕章、岡部昭延 2006

[学会発表] Characterization of Vibrio alginolyticus collagenase and its expression regulation. (in Japanese)

O, Matsushita, Y, Taniguchi, S, Miyata, E, Tamai, Y, Tanaka, A, Okabe 2006