トップ研究者を探す鳥類AHRアイソフォームを指標とした化学物質のリスク評価

鳥類AHRアイソフォームを指標とした化学物質のリスク評価

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18510059
研究種目 基盤研究(C)
研究分野 総合・新領域系
複合新領域
環境学
放射線・化学物質影響科学
研究機関 愛媛大学
代表研究者 金 恩英
研究分担者 岩田 久人
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2007
研究ステータス 完了 (2007/4/1)
配分額(合計) 4,110,000 (直接経費 :3,600,000、間接経費 :510,000)
配分額(履歴) 2007年度:2,210,000 (直接経費 :1,700,000、間接経費 :510,000)
2006年度:1,900,000 (直接経費 :1,900,000)
キーワード 環境
化学物質
感受性
AHR
ダイオキシン類
リスク評価
鳥類
核内受容体
有機塩素化合物
Environment
Chemicals
Sensitivity
AHR
Dioxins
Risk assessment
avian species

研究成果

[雑誌論文] Contamination and Effects of Perfluorochemicals in Baikal Seal(Pusasibirica). 2. Molecular Characterization,Expression Level,and Transcriptional Activation of Peroxisome Proliferator-Activated Receptor α.

Ishibashi, H., Iwata, H., Kim, E-Y., Tao, L., Kannan, K., Miyazaki, N., Tanabe, S., Batoev, V. B., Petrov, E.A. 2008

[雑誌論文] Potential effcts of perfluorinated compounds in common cormorants from Lake Biwa,Japan:An implication from the hepatic gene expression profiles by microarray

Nakayama, K., Iwata, H., Tao, L, Kannan, K., hnoto, M., Kim, E-Y., Tashiro, K., Tanabe, S. 2008

[学会発表] Inter-species and-isoform differences in functions of two aryl hydrocarbon receptors(AHR1 and AHR2)from avian species

E-Y Kim, H.Iwata, T.Yasui, N.Inoue, J-S Lee, D.G.Franks, S.I.Karchner, M.E.Hahn, S.Tanabe 2008

[学会発表] Inter-Species and _Isoform Differences in Functionis of Two Aryal Hydrocarbon Receptors (AHR1 and AHR2) from Avian Soecies.

Kim, E-Y., Iwata, H., Yasui, T., Inoue, N., Lee, J. S., Franks D. G., Karchner, S. I., Hahn, M. E., Tanabe, S. 2008

[学会発表] Molecular Basis for Differential Dioxoion Sensitivity in Birds: Characterization of Avian AHR Isoforms.

Kim, E-Y., Iwata, H., Yasui, T., Inoue, N., Lee, J.S., Franks, D. G., Karchner, S. L., Hahn, M. E. and Tanabe, S. 2008

[雑誌論文] Contamination and Effects of Perfluorochemicals in Baikal Seal(Pusa sibirica).1. Residue Level,Tissue Distribution,and Temporal Trend

Ishibashi, H., Iwata, H., Kim, E-Y., Tao, L., Kannan, K., Amano, M., Miyazaki, N., Tanabe, S., Batoev, V. B., Petrov, E. A. 2008

[雑誌論文] Catalytic function of avian cytochrome P450 1A4 and 1A5(CYP1A4 and CYP1A5)enzymes heterologously expressed using in vitro east system

Kubota, A., Iwata, H. and Kim, E. Y. 2008

[雑誌論文] Functional Characterization and Evolutionary History of two Aryl Hydrocarbon Receptor Isoforms(AhR1 and AhR2)from Avian Species

T. Yasui, E-Y. Kim, H. Iwata, D. G. Franks, S. I. Karchner, M. E.Hahn, S. Tanabe 2007

[雑誌論文] Molecular Characterization of Cytochrome P450 1A1,1A2,and 1B1,and Effects of Polychlorinated Dibenzo-p-dioxin,Dibenzofuran,and Biphenyl Congeners on Their Hepatic Expression in Baikal Seal (Pusa sibirica)

Hirakawa, S., Iwata, H., Takeshita, Y., Kim, E-Y., Sakamoto, T., Okajima, Y., Amano, M., Miyazaki, N., Petrov, E. A., Tanabe, S. 2007

[雑誌論文] Molecular Characterization and Tissue Distribution of Aryl Hydrocarbon Receptor Nuclear Translocator Isoforms,ARNTI and ARNT2,and Identification of Their Novel Splice Variants in Common Cormorant(Phalacrcorax carbo

J-S. Lee, E-Y. Kim, H. Iwata, S. Tanabe 2007

[雑誌論文] Molecular Chazacterization and Tissue Distribution of Aryl Hydrocarb on Receptor Nuclear Translocator Isoforms, ARNT1 and ARNT2,and Identification of Their Novel Splice Variants in Common Cormorant(Phalacrocorax carbo)

Lee, J-S., Kim, E-Y., Iwata, H., Tanabe, S. 2007

[学会発表] Molecular Basis for Differential Dioxin Sensitivity in Birds: Characterization of Avian AHR Isoforms.

Kim, E-Y, Iwata, H., Yasui, T., moue, N., Lee, J-S., Franks, D. G., Karchner, S. I., Hahn, M. E., Tanabe, S. 2007

[学会発表] Relative potencies for AHR-mediated toxicity of dioxins and related compounds in Baikal seal (Pusa sibirica) estimated by in vitro bioassay.

Kim, E-Y., Suda, T., Iwata, H. Petrov, E. And Tanabe, S. 2007

[雑誌論文] Functional Characterization and Evolutionary History of two Aryl Hydrocarbon Receptor Isoforms(AhR1 and AhR2)from Avian Species.

Yasui, T., Kim, E-Y., Iwata, H., Franks, D. G., Karchner, S. I., Hahn, M. E., Tanabe, S. 2007

[雑誌論文] Chemical Contamination in Aquatic Ecosystems

Iwata, H 2007

[雑誌論文] Molecular characterization of two metallothionein isoforms in avian species:evolutionary history,tissue distribution profile,and expression associated with metal accumulation

D-H. Nam, E-Y. Kim, H. Iwata, S. Tanabe 2007

[雑誌論文] Chemical Contamination in Aquatic Ecosystems (Review)

Iwata, H., Kim, E-Y., Yamauci, M., Inoue, S., Agusa, T., Tanabe, S. 2007

[雑誌論文] Molecular Characterization and Tissue Distribution of Aryl Hydrocarb on Receptor Nuclear Translocator Isoforms,ARNT1 and ARNT2,and Identification of Their Novel Splice Variants in Common Cormorant(Phalacrocorax carbo)

Nam, D-H., Kim, E-Y., Iwata, H., Tanabe, S. 2007

[学会発表] Inter-species and-isoform differences in functions of two aryl hydrocarbon receptors (AHRI and AHR2) from avian species.

Kim, E-Y, Iwata, H., Yasui, T., moue, N., Lee, J-S., Franks, D. G., Karchner, S. I., Hahn, M. E., Tanabe, S. 2007

[雑誌論文] Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales(Balaenoptera acutorostrata)

Niimi, S., Kim, E-Y., Iwata, H., Watanabe, M. X., Yasunaga, G., Fujise, Y., Tanabe, S. 2007

[雑誌論文] Constitutive Androstane Receptor(CAR)as a Potential Sensing Biomarker of Persistent Organic Pollutants(POPs)in Aquatic Mammal: Molecular Characterization,Expression Level,and Ligand Profiling in Baikal Seal(Pusa sibirica)

Sakai, H., Iwata, H., Kim, E-Y, Tsydenova, O., Miyazaki, N., Petrov, E. A., Batoev, V. B., Tanabe, S. 2006

[雑誌論文] Gene expression profiling in common cormorant liver with an oligo arra y: assessing the potential toxic effects of environmental contaminants

Nakayama, K., Iwata, H., Kim, E-Y., Tashiro, K., Tanabe, S. 2006

[雑誌論文] Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)in developing red seabream(Pagrus major)embryo:An association of morphological deformities with AHR1,AHR2 and CYP1A expressions

Yamauchi, M., Kim, E-Y., Iwata, H., Shima, Y., Tanabe, S. 2006

[雑誌論文] Cytochrome P450 1A4 and 1A5 in common cormorant(Phalacrocorax carbo):evolutionary relationships and functional implications associated with dioxin and related compounds

Kubota, A., Iwata, H., Goldstone, H. M. H., Kim, E-Y., Stegeman, J. J, Batoev, J., Tanabe, S. 2006