トップ›研究者を探す›骨・ミネラル代謝、およびその破綻による疾患における線維芽細胞増殖因子23の関与

骨・ミネラル代謝、およびその破綻による疾患における線維芽細胞増殖因子23の関与

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18390274
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
内分泌学
研究機関 東京大学
代表研究者 福本 誠二
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2008
研究ステータス 完了 (2008/4/1)
配分額（合計） 17,290,000 (直接経費 :14,800,000、間接経費 :2,490,000)
配分額（履歴） 2008年度：3,900,000 (直接経費 :3,000,000、間接経費 :900,000)
2007年度：6,890,000 (直接経費 :5,300,000、間接経費 :1,590,000)
2006年度：6,500,000 (直接経費 :6,500,000)
キーワード 骨軟化症
ホルモン
低リン血症
高リン血症
FGF
Klotho
FGF受容体
プロテアーゼ
FGF23
O型糖鎖
翻訳後修飾
腫瘍状石灰化症
腫瘍性骨軟化症

研究成果

[雑誌論文] Anti-FGF23 neutralizing antibodies demonstrate the physiological role and structural features of FGF23

Yamazaki Y, Tamada T, Kasai N, Urakawa I, Aono Y, Hasegawa H, Fujita T, Kuroki R, Yamashita T, Fukumoto S, Shimada T 2008

[雑誌論文] Clinical usefulness of measurement of fibroblast growth factor 23(FGF23)in hypophosphatemic patients-Proposal of diagnostic criteria using FGF23 measurement-

Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T 2008

[雑誌論文] Physiological regulation and disorders of phosphate metabolism-Pivotalrole of fibroblast growth factor 23-

Fukumoto S 2008

[雑誌論文] Actions and mode of actions of FGF19 subfamily members

Fukumoto S 2008

[学会発表] Rare cases of X-linked hypophosphatemic rickets/osteomalacia mimicking autosomal recessive hypophosphatemic rickets/osteomalacia

Saito T, Suzuki H, Ito N, Igarashi T, Fukumoto S, Fujita T 2008

[雑誌論文] Physiological regulation and disorders of phosphate metabolism-Pivotal role of fibroblast growth factor 23-

Fukumoto S 2008

[雑誌論文] FGF23 is a hormone regulating phosphate metabolism-Unique biological characteristics of FGF23-

Fukumoto S, et al. 2007

[雑誌論文] Fibroblast growth factor (FGF)23 in patients with acromegaly

Ito N, Fukumoto S, Taguchi M, Takeshita A, Takeuchi Y, Yamada S, Fujita T 2007

[雑誌論文] Hyperostosis-hyperphosphatemia syndrome : A congenital disorder of O-glycosylation associated with augmented processing of fibroblast growth factor 23

Frishberg Y, Ito N, Rinat C, Yamazaki Y, Feinstein S, Urakawa I, Navon-Elkan P, Becker-Cohen R, Yamashita T, Araya K, Igarashi T, Fujita T, Fukumoto S 2007

[雑誌論文] FGF23 is a hormone regulating phosphate metabolism-Unique biological characteristics of FGF23-

Fukumoto S, Yamashita T 2007

[学会発表] Analysis and importance of glycosylation status in FGF23 protein

Suzuki H, Fukumoto S, Ito N, Fujita T 2007

[雑誌論文] Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in human

Ito N, Fukumoto S, Takeuchi Y, Takeda S, Suzuki H, Yamashita T, Fujita T 2007

[雑誌論文] Fibroblast growth factor-23(FGF23)in patients with transient hypoparathyroidism : Its important role in serum phosphate regulation

Yamashita H, Yamazaki Y, Hasegawa H, Yamashita T, Fukumoto S, Shigematsu T, Kazama JJ, Fukagawa M, Noguchi S 2007

[雑誌論文] Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T 2006

[学会発表] O-Linked Glycosylation by ppGaNTase-T3 Prevents Processing of Fibroblast Growth Factor (FGF)23

Ito N, Fukumoto S, Yamashita T, Frishberg Y, Fujita T 2006

[雑誌論文] The role of bone in phosphate metabolism

Fukumoto S.

[雑誌論文] The role of bone in phosphate metabolism

Fukumoto S

[雑誌論文] Bone as an endocrine organ

Fukumoto S, Martin TJ