トップ›研究者を探す›腫瘍発生・進展における非定型的メチル化シトシンの病態学的意義についての網羅的解析

腫瘍発生・進展における非定型的メチル化シトシンの病態学的意義についての網羅的解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18390114
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
基礎医学
人体病理学
研究機関 神戸大学
代表研究者 前田 盛
研究分担者 北澤 荘平
研究分担者 北澤 理子
研究分担者 近藤 武史
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2009
研究ステータス 完了 (2009/4/1)
配分額（合計） 15,580,000 (直接経費 :13,900,000、間接経費 :1,680,000)
配分額（履歴） 2009年度：1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
2008年度：2,730,000 (直接経費 :2,100,000、間接経費 :630,000)
2007年度：2,730,000 (直接経費 :2,100,000、間接経費 :630,000)
2006年度：8,300,000 (直接経費 :8,300,000)
キーワード エピジェネティクス
in situ hybridization
非CpGアイランド
メチル化シトシン
遺伝子プロモータ
膀胱癌
BANBI
転写制御
BAMBI
非CpG-island
膵癌
TrkA

研究成果

[図書] 組織細胞化学2010-組織細胞化学イメージングの基礎と最前線:生体内分子局在と機能を探る-

北澤荘平,森清,近藤武史,北澤理子 2010

[学会発表] マウスRANK遺伝子転写におけるNFATの機能解析

北澤理子, 他 2009

[雑誌論文] BAMBI gene is epigenetically silenced in a subset of high-grade bladder cancer

Sann Sanda Khin, Kitazawa R, Win N, Than TA, Mori K, Kondo T, Kitazawa S 2009

[雑誌論文] Lipopolysaccharide Suppresses RANK Gene Expression in Macrophages by Down-Regulating PU. 1 and MITF

shii J, Kitazawa R, Mori K, McHugh K.P., Morii E, Kondo T, Kitazawa S 2008

[雑誌論文] FSP27 Contributes to Efficient Energy Storage in Murine White Adipocytes by Promoting the Formation of Unilocular Lipid Droplets

Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W,Inoue K, Kitazawa R, Kitazawa S,Matsuki Y, Hiramatsu R, Masubuchi S, Omachi A, Kimura K, Saito M, Amo T, Ohta S, Yamaguchi T, Osumi T, Cheng J, Fujimoto T, Nakao H, Nakao K, Aiba A, Okamura H, Fushiki T, Kasuga M 2008

[雑誌論文] Leopairat J, Hypermethylation of Epithelial-cadherin Gene Promoter is Associated with Epstein-Barr Virus in Nasopharyngeal Carcinoma

Niemhom S, Kitazawa S, Kitazawa R, Maeda S 2008

[雑誌論文] Lipopolysaccharide Suppresses RANK Gene Expression in Macrophages by Down-Regulating PU.1 and MITF

Ishii J, Kitazawa R, Mori K, McHugh K.P., Morii E, Kondo T, Kitazawa S 2008

[雑誌論文] MeCP2 Expression and Promoter Methylation of Cyclin D1 Gene are Associated with Cyclin D1 Expression in Developing Rat Epididymal Duct

Darwanto A, Kitazawa R, Kondo T, Kitazawa S 2008

[雑誌論文] MeCP2 Expression and Promoter Methylation of Cyclin D1 Gene Are Associated with Cyclin D1

Darwanto A, Kitazawa R, Kondo T, Kitazawa S 2008

[雑誌論文] Modulation of Mouse RANKL Gene Expression by Runx2 and Vitamin D3

Kitazawa R, Mori K, Yamaguchi A, Kondo T, Kitazawa S 2008

[雑誌論文] FSP27 Contributes to Efficient Energy Storage in Murine White Adipocytes by Promoting the Formation of Unilocular Lipid Droplets

Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, Hiramatsu R, Masubuchi S, Omachi A, Kimura K, Saito M, Amo T, Ohta S, Yamaguchi T, Osumi T, Cheng J, Fujimoto T, Nakao H, Nakao K, Aiba A, OkaNishino N, Tamori Y, Tateya 2008

[雑誌論文] Modulation of mouse RANKL gene expression by Runx2 and vitamin D3 pathway.

Kitazawa R., et al. 2008

[学会発表] 転写早期の新生mRNAの電子顕微鏡による動態解析

北澤荘平, 他 2008

[雑誌論文] Hypermethylation of Epithelial-cadherin Gene Promoter is Associated with Epstein-Barr Virus in Nasopharyngeal

Niemhom S, Kitazawa S, Kitazawa R, Maeda S, Leopairat J 2008

[雑誌論文] Hepatic failure and enhanced oxidative stress in mitochondrial diabetes

Takahashi Y, Iida K, Takeno R, Kitazawa R, Kitazawa S, Kitamura H, Fujioka Y, Yamada H, Kanda F, Ohta S, Nishimaki K, Fujimoto M, Kondo T, Iguchi G, Takahashi K, Kaji H, Okimura Y, Chihara K 2008

[雑誌論文] Dexamethasone Promotes Osteoclastogenesis by Inhibiting Osteoprotegerin through Multiple Levels

Kondo T, Kitazawa R, Yamaguchi A, Kitazawa S 2008

[雑誌論文] Modulation of Mouse RANKL Gene Expression by Runx2 and Vitamin D3

Kitazawa R, Mori K, Yamaguchi AKondo T, Kitazawa S 2008

[図書] DNA Methylation Research Trends, Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research

Kitazawa S, Mori K, kondo T, Fujimoto M, Kitazawa R 2007

[雑誌論文] Methylation status of a single CpG locus 3 bases upstream of TATA-box of RANKL gene promoter modulates cell- and tissue-specific RANKL expression and osteoclastogenesis

Kitazawa R, et al. 2007

[学会発表] タイタンエイ, ネウイン, 北澤荘平, 日本とミャンマーにおける膀胱腫瘍進展過程におけるBAMBI遺伝子のエピジェネティクス制御の変化

サンサンダキン, 北澤理子, 近藤武史, 森清 2007

[雑誌論文] Methylation Status of a Single CpG Locus 3 Bases Upstream of TATA-box of RANKL Gene Promoter Modulates Cell- and Tissue-specific RANKL Expression and Osteoclastogenesis

Kitazawa R, Kitazawa S, 2007

[雑誌論文] Methylation Status of a Single CpG Locus 3 Bases Upstream of TATA-box of RANKL Gene Promoter Modulates Cell-and Tissue-specific RANKL Expression and Osteoclastogenesis

Kitazawa R, Kitazawa S 2007

[図書] Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research. In ; DNA Methylation Research

Kitazawa S, et al. 2007

[学会発表] 日本とミャンマ-における膀胱腫瘍進展過程におけるBAMBI 遺伝子のエピジェネティクス制御の変化

サン サンダキン, 北澤理子, 近藤武史, 森清, タイタンエイ, ネウイン, 北澤荘平 2007

[図書] DNA Methylation Research Trends, Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research (Editor; Kobayashi TB)

Kitazawa S, Mori K, kondo T, Fujimoto M, Kitazawa R 2007

[雑誌論文] DNA Methylation of Multiple Tumor-related Genes in Association with Overexpression of DNA Methyltransferase 1 (DNMT1) during Multistage Carcinogenesis of the Pancreas

Peng DF, Kanai Y, Sawada M, UshijimaS, Hiraoka N, Kitazawa S, Hirohashi S 2006

[雑誌論文] In situ Detection of Specific Gene Expression During and Immediately After Transcription at Electron

Kitazawa S, Kitazawa R 2006

[学会発表] Regulation of Osteoclastogenesis by CpG Methylation of Mouse Receptor Activator of NF-kB Ligand(RANKL)Gene Promoter Region

Kitazawa R, Mori K, Kondo T, Kitazawa S 2006

[雑誌論文] Modulation of Mouse RANKL Gene Expression by Runx2 and PKA Pathway

Mori K, Kitazawa R, Kondo T, Maeda S, Yamaguchi A, Kitazawa S 2006

[雑誌論文] Lung carcinosarcoma with liposarcoma element. an autopsy case.

Kitazawa R, et al. 2006

[雑誌論文] Protruding disordered loop of gC1qR is specifically exposed and related to antiapoptotic property in germ cell lineage.

Kitazawa S, et al. 2006

[雑誌論文] DNA Methylation of Multiple Tumor-related Genes in Association with Overexpression of DNA Methyltransferase 1 (DNMT1) during Multistage Carcinogenesis of the Pancreas

Peng DF, Kanai Y, Sawada M, Ushijima S, Hiraoka N, Kitazawa S, Hirohashi S 2006

[学会発表] In Situ of Specific Gene Expression During and Immediately After Transcription at Electron Microscopic Level

Kitazawa S, Kitazawa R, Fujimoto M, Mori K, Sann Sanda Khin, Ishii J, Kondo T 2006

[雑誌論文] Modulation of Mouse RANKL Gene Expression by Runx2 and PKA Pathway

Mori K, Kitazawa R, Kondo T, Maeda S, Yamaguchi AKitazawa S 2006

[雑誌論文] MCP-1 Contributes to Macrophage Infiltration into Adipose Tissue, Insulin Resistance, and Hepatic Steatosis in Obesity

Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, Kasuga M 2006

[雑誌論文] Protruding Disordered Loop of gC1qR is Specifically Exposed and Related to Antiapoptotic Property in Germ Cell Lineage

Kitazawa S, Takenaka A, Kondo T, Mizoguchi A, Kitazawa R 2006

[雑誌論文] Miyachi H, Maeda S, Egashira K, KasugaM, MCP-1 Contributes to Macrophage Infiltration into Adipose Tissue, Insulin Resistance, and Hepatic Steatosis in Obesity

Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S 2006

[雑誌論文] Expression Profiles of Genes Related to Osteoclastogenesis in Mouse Growth Plate and Articular Cartilage

Kishimoto K, Kitazawa R, Kurosaka M, Maeda S, Kitazawa S 2006

[雑誌論文] In situ Detection of Specific Gene Expression During and Immediately After Transcription at Electron Microscopic Level

Kitazawa S, Kitazawa R 2006