アレイ技術を基盤としたオーミクス解析による口腔癌の診断・治療標的分子の探索

トップ›研究者を探す›アレイ技術を基盤としたオーミクス解析による口腔癌の診断・治療標的分子の探索

アレイ技術を基盤としたオーミクス解析による口腔癌の診断・治療標的分子の探索

代表研究者	天笠光雄
研究課題番号	KAKENHI-PROJECT-18209059
研究種目	基盤研究(A)
研究分野	生物系医歯薬学歯学外科系歯学
研究機関	東京医科歯科大学
研究分担者	稲澤譲治
研究分担者	鵜澤成一
研究分担者	橘逸勢
研究期間開始年月日	2006/4/1
研究期間終了年度	2008
研究ステータス	完了 (2008/4/1)
配分額（合計）	47,580,000 (直接経費 :36,600,000、間接経費 :10,980,000)
配分額（履歴）	2008年度：4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000) 2007年度：13,520,000 (直接経費 :10,400,000、間接経費 :3,120,000) 2006年度：29,250,000 (直接経費 :22,500,000、間接経費 :6,750,000)
キーワード	口腔扁平上皮癌前癌病変ゲノムエピゲノムアレイCGH 発現解析 Omics 口腔癌診断マーカー CGHアレイ分子標的癌遺伝子癌抑制遺伝子個別化医療上皮異形成細胞アレイCGH法 DNAメチル化扁平上皮癌

研究成果

[雑誌論文] Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome

Arai E, Ushijima S, Fujimoto H, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y 2009

[雑誌論文] Actinin-4 gene amplification in ovarian cancer : a candidate oncogene associated with poor patient prognosis and tumor chemoresistance

Yamamoto S, Tsuda H, Honda K, Onozato K, Takano M, Tamai S, Imoto I, Inazawa J, Yamada T, Matsubara O 2009

[図書] 造血器腫瘍アトラス-形態、免疫、染色体と遺伝子-改訂第4版

阿部達生、稲澤譲治、井本逸勢、井上純(分担) 2009

[雑誌論文] SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells

Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K, Imamura T 2009

[雑誌論文] ASK1 amd ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

Iriyama T, Takeda K, Nakamura H, Motimoto Y, Kuroiwa T, Mizukami J, Umeda T, Noguchi T, Naguro I, Nishitoh H, Saegusa K, Tobiume K, Homma T, Shimada Y, Tsuda H, Aiko S, Imoto I, Inazawa J, Chiba K, Kamei Y, Kozuma S, Taketani Y, Matsuzawa A, Ichijo H 2009

[雑誌論文] Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy

Tanaka S, Arii S, Yasen M, Moqushi K, Su NT, Zhao C, Imoto I, Eishi Y, Inazawa J, Miki Y, Tanaka H 2008

[雑誌論文] Frequent inactivation of a putative conditional tumor-suppressor gene,angiopoietin-like protein 2, in ovarian cancer

Kikuchi R, Tsuda H, Kozaki K, Kanai Y, Kasamatsu T, Sengoku K,Hirohashi S, Inazawa J, Imoto I 2008

[雑誌論文] POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17

Zhao C, Inoue J, Imoto I, Otsuki T, Iida S, Ueda R, Inazawa J 2008

[学会発表] ゲノム構造解析による食道扁平上皮癌の標的遺伝子探索

井本逸勢、稲澤譲治 2008

[雑誌論文] Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization : its association with DNA methylation alteration and patient outcome

Arai E, Ushijima S, Tsuda H, Fujimoto H,Hosoda F, Shibata T, Kondo T, Imoto I, Inazawa J, Hirohashi S, Kanai Y 2008

[雑誌論文] Frequent silencing of a putative tumor suppressor gene melatonin receptor 1A(MTNR1A)in oral squamous-cell carcinoma

Nakamura E, Kozaki K, Tsuda H, Suzuki, E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I 2008

[雑誌論文] Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas

Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, Kosuge T, Umaki T, Onozato K, Shitashige M, Yamaguchi U, Ono M, Tsuchida A, Aoki T, Inazawa J,Hirohashi S, Yamada T 2008

[学会発表] ヒト癌におけるゲノム一次構造異常領域から同定された増幅標的癌遺伝子候補としてのdual specificity phosphatase

井本逸勢、稲澤譲治 2008

[雑誌論文] Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue

Qi S, Mogi S, Tsuda H, Tanaka Y, Kozaki K, Imoto I, Inazawa J, Hasegawa S, Omura K 2008

[雑誌論文] Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization

Suzuki A, Shibata T, Murakami Y, Horii A, Shiratori K, Hirohashi S, Inazawa J, Imoto I 2008

[雑誌論文] Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer

Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J 2008

[雑誌論文] Overexpressed NF-{kappa}B inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells

Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez BVJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S 2008

[雑誌論文] Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes

Katsuki Y, Nakada S, Yokoyama T, Imoto I, Inazawa J, Nagasawa M, Mizutani S 2008

[雑誌論文] ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization

Ishihara T, Tsuda H, Hotta A, Kozaki K, Yoshida A, Jaeduk Yoshimura Noh, Ito K, Imoto I, Inazawa J 2008

[雑誌論文] Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma

Tanaka K, Imoto I, Inoue J, Kozaki K, Tsuda H, Shimada Y, Aiko S, Yoshizumi Y, Iwai T, Kawano T, Inazawa J 2007

[学会発表] RGC32, a novel p53-inducible tumor-suppressor gene, is located on centrosomes during mitosis and results in G2/M arrest.

Imoto I, Inazawa J, et. al. 2007

[雑誌論文] Epigenetic silencing of prostaglandin E receptor 2(PTGER2)is associated with progression of neuroblastomas

Sugino Y, Misawa A, Inoue J, KitagawaM, Hosoi H, Sugimoto T, Imoto I, Inazawa J 2007

[雑誌論文] Association of KLK5-overexpression with invasiveness of urinary bladder carcinoma cells

Shinoda Y, Kozaki K, Imoto I, Obara W, Tsuda H, Mizutani Y, Shuin T, Fujioka T, Miki T, Inazawa J 2007

[雑誌論文] Genetically distinct and clinically relevant classification of hepatocellular carcinoma : putative therapeutic targets

Katoh H, Ojima H, Kokubu A, Saito S, Kondo T, Kosuge T, Hosoda F, Imoto I, Inazawa J, Hirohashi S, Shibata T 2007

[雑誌論文] RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest

Saigusa K, Imoto I, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J 2007

[図書] 最新医学 62巻増刊号臨床遺伝学

井本逸勢、稲澤譲治 2007

[学会発表] Cancer genomic and epigenomic analyses on BAC-array platform

井本逸勢、小崎健一、稲澤譲治 2007

[雑誌論文] The suppression of aurora-A/STK15/BTAK expression enhances chemosensitivity to docetaxel in human esophageal squamous cell carcinoma

Tanaka E, Hashimoto Y, Ito T, Kondo K, Higashiyama M, Tsunoda S, Ortiz C, Sakai Y, Inazawa J, Shimada Y 2007

[雑誌論文] BCL2L2 is a probable target for novel 14q11.2 amplification detected in a non-small cell lung cancer cell line

Kawasaki T, Yokoi S, Tsuda H, Izumi H, Kozaki k, Aida S, Ozeki Y, Yoshizawa Y, Imoto I, Inazawa J 2007

[雑誌論文] Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer

Kikuchi R, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I 2007

[雑誌論文] Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation

Kawanishi H, Takahashi T, Ito M, Matsui Y, Watanabe J, Ito N, Kamoto T, Kadowaki T, Tsujimoto G, Imoto I, Inazawa J, Nishiyama H, Ogawa O 2007

[学会発表] Identification of novel amplification-taeget genes in oral squamous cell carcinoma using array-CGH-assisted strategy

Begum Asma、鈴木江美奈、中村恵理奈、井本逸勢、小崎健一、津田均、天笠光雄、稲澤譲治 2007

[図書] 細胞工学

井本逸勢、稲澤譲治 2007

[雑誌論文] PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation

Suzuki E, Imoto I, Pimkhaokham A, Nakagawa T, Kamata N, Kozaki K,Amagasa T, Inazawa J 2007

[学会発表] Epigenetic silencing of TSOC25 by hypermethylation of the CpG island in oral cancer

中村恵理奈、鈴木江美奈、中川貴之、津田均、山本剛、入江太朗、小崎健一、井本逸勢、立川哲彦、天笠光雄、稲澤譲治 2007

[雑誌論文] Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma : identification of genetic indicators that predict patient outcome

Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, Ohki M, Inazawa J, Hirohashi S 2007

[雑誌論文] PRTFDC1, a possible tmmor-suppressor gene, is frequently silenced in or al squamous-cell carcinomas by aberrant promoter hypermethylation.

Suzuki E, Imoto I, Pimkhaokham A, Nakagawa T, Kamata N, Kozaki K-I, Amagasa T, Inazawa J. 2007

[雑誌論文] Non-incidental coamplification of Myc and ERBB2, and Myc and EGFR, in gastric adenocarcinomas

Mitsui F, Dobashi Y, Imoto I, Inazawa J, Kono K, Fujii H, Ooi A 2007

[学会発表] RGC32, a novel p53-inducible tumor-suppressor gene, is located on centrosomes during mitosis and results in G2/M arrest

Imoto I, Saigusa K, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J 2007

[雑誌論文] Genomic loss and epigenetic silencing of very low density lipoprotein receptor involved in gastric carcinogenesis

Takada H, Imoto I, Tsuda H, Nakanishi Y, Sakakura C, Mitsufuji S, Hirohashi S, Inazawa J 2006

[雑誌論文] PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma

Kozaki K, Imoto I, Pimkhaokham A, Hasegawa S, Tsuda H, Omura K, Inazawa J 2006

[学会発表] In-house BACアレイを用いた癌のゲノム構造・機能異常解析からの分子標的探索

井本逸勢、稲澤譲治 2006

[雑誌論文] Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers

Imoto I, Izumi H, Yokoi S, Hosoda H, Shibata T, Hosoda F, Ohki M, Hirohashi S, Inazawa J 2006

[学会発表] In-house BACアレイを用いたゲノム一次構造解析によるがんと遺伝疾患の個別医療実現へのアプローチ

井本逸勢 2006

[雑誌論文] Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma

Nakagawa T, Pimkhaokham A, Suzuki E, Omura K, Inazawa J, Imoto I 2006

[雑誌論文] A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity

Yu W, Imoto I, Inoue J, Onda M, Emi M, Inazawa J 2006

[学会発表] 口腔癌のアレイCGH解析により検出した新規ホモ欠失領域の標的癌関連遺伝子候補の解析

中村恵理奈、鈴木江美奈、中川貴之、山本剛、入江太郎、小崎健一、井本逸勢、立川哲彦、天笠光雄、稲澤譲治 2006

[雑誌論文] Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers. Cancer Res.

Imoto I, Inazawa J, et al. 2006

[学会発表] DNAメチル化により発現制御をうける新規口腔癌関連遺伝子候補TSOC10の解析

鈴木江美奈、井本逸勢、井上純、中川貴之、Atiphan Pimkhaokham、細田文恵、大木操、天笠光雄、稲澤譲治 2006