トップ研究者を探す造血器腫瘍に対する新たな細胞免疫療法の開発

造血器腫瘍に対する新たな細胞免疫療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-18015037
研究種目 特定領域研究
研究分野
研究機関 愛媛大学
代表研究者 安川 正貴
研究分担者 羽藤 高明
研究分担者 東 太地
研究期間 開始年月日 2006/4/1
研究期間 終了年度 2007
研究ステータス 完了 (2007/4/1)
配分額(合計) 10,500,000 (直接経費 :10,500,000)
配分額(履歴) 2007年度:5,300,000 (直接経費 :5,300,000)
2006年度:5,200,000 (直接経費 :5,200,000)
キーワード 造血器腫瘍
細胞傷害性T細胞
細胞免疫療法
T細胞エピトープ
CML66
Aurora Kinase
GVHD
がん免疫
細胞障害性T細胞
がんペプチドワクチン
遺伝子治療

研究成果

[雑誌論文] Cooperative role of the membrane-proximal and distal residues of the intergrin beta 3 cytoplasmic domain in regulation of talin-mediated alpha IIbbeta 3 activation.

Hato T, Yasukawa M, et. al. 2008

[雑誌論文] Identification of an epitope derived from CML66, a novel tumor-associated antigen broadly expressed in human leukemia, recognized by HLA-A^*2402-restricted

Suemori K, Yasukawa M, et. al. 2008

[雑誌論文] Therapeutic effect of accumulation of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model.

Hasegawa H, Yasukawa M, et. al. 2008

[雑誌論文] Identification and characterization of a WT1(Wilms' tumor gene)protein-derived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes.

Fujiki F, Yasukawa M, et. al. 2007

[学会発表] Therapeutic effect of CXCR3-expressing regulatory T cells on liver and intestinal dameges in a murine acute GVHD model

Yamanouchi J, Yasukawa M, et. al. 2007

[雑誌論文] The role of Wilms' tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone.

Ikeda K, Yasukawa M, et. al. 2007

[雑誌論文] Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+regulatory T cells in MRL/Lpr mice.

Hasegawa H, Yasukawa M, et. al. 2007

[図書] 造血器腫瘍「細胞免疫療法(各論)」

安川正貴 2007

[図書] 造血器腫瘍「細胞免疫療法各論」

安川正貴 2007

[学会発表] 腫瘍関連抗原CML66特異的細胞傷害性T細胞の誘導と機能解析

末盛浩一郎、安川正貴、他 2007

[学会発表] Identification of an epitope derived from Aurora-a kinase which induces leukemia-specific CTL

Ochi T, Yasukawa M, et. al. 2007

[雑誌論文] Wilms tumor gene Wt1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma.

Tsuboi A, Yasukawa M, et. al. 2007

[図書] 造血器腫瘍「細胞免疫療法総論」

安川正貴 2007

[学会発表] Cytotoxic T-lymphocytes harnessing CML66 can kill human myeloid leukemia cells in vitro.

Suemori K, Yasukawa M, et. al. 2007

[学会発表] Induction and functional analysis of CML66-specific cytotoxic T lymphocytes

Suemori K, Yasukawa M, et. al. 2007

[学会発表] Aurora-A kinase: A novel target for the immunotherapy against human leukemias

Ochi T, Yasukawa M, et. al. 2007

[雑誌論文] The role of Wilms' tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone.

Ikeda K, Yasukawa M, et al. 2007

[学会発表] ヒト細胞傷害性T細胞カミ認識するAurora・A由来エピトープの同定

越智俊元、安川正貴、他 2007

[雑誌論文] A mitotic kinase TOPK enhances cdkl/cyclin B1-dependent phosphorylation of PRC1 and promotes cytokinesis.

Abe Y, Yasukawa M, et. al. 2007

[雑誌論文] Identification of critical residues for regulation of integrin activation in the beta6-alpha7 loop of the integrin beta3 I-like domain.

Hato T, Yasukawa M, et al. 2006

[雑誌論文] Antagosist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL/lpr mice.

Hasegawa H, Yasukawa M, et al. 2006

[雑誌論文] Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells.

Niiya H, Yasukawa M, et al. 2006

[雑誌論文] IK cytokine ameliorates the progression of lupus nephritis in MRL/lpr mice.

Muraoka M, Yasukawa M, et al. 2006

[雑誌論文] Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.

Kohno M, Yasukawa M, et al. 2006