研究成果

[雑誌論文] Pathophysiological changes of the lower urinary tract behind voiding dysfunction in streptozotocin-induced long-term diabetic rats.

Masuda K, Aizawa N, Watanabe D, Okegawa T, Kume H, Igawa Y, Fukuhara H. 2020

[学会発表] 膀胱伸展受容一次求心性神経活動の直接測定法による排尿知覚の評価 ―カラゲニン誘発慢性前立腺炎モデルでの検討―

相澤直樹、藤田朋恵 2020

[雑誌論文] KPR-5714, a Novel Transient Receptor Potential Melastatin 8 (TRPM8) Antagonist, Improves Overactive Bladder via Inhibition of Bladder Afferent Hyperactivity in Rats.

Nakanishi O, Fujimori Y, Aizawa N, Hayashi T, Matsuzawa A, Kobayashi JI, Hirasawa H, Mutai Y, Tanada F, Igawa Y. 2020

[雑誌論文] RQ-00434739, a novel TRPM8 antagonist, inhibits prostaglandin E2-induced hyperactivity of the primary bladder afferent nerves in rats

Aizawa Naoki、Ohshiro Hiroyuki、Watanabe Shuzo、Kume Haruki、Homma Yukio、Igawa Yasuhiko 2019

[学会発表] 下部尿路閉塞ラットの膀胱における微小収縮に同期した一次求心性神経活動におよぼす タダラフィルの作用

相澤直樹, 井川靖彦, 藤田朋恵 2019

[学会発表] Effects of RQ-00434739, a transient receptor potential Melastatin 8 (TRPM8) channel antagonist, on deep body temperature and on bladder function in rats

Aizawa N, Ohshiro H, Watanabe S, Kume H, Igawa Y 2018

[学会発表] Comparison of clinical characteristics between interstitial cystitis and hypersensitive bladder

Watanabe D, Akiyama Y, Nomiya A, Niimi A, Aizawa N, Kume H, Igawa Y, Homma Y 2018

[学会発表] 難治性過活動膀胱の治療戦略, 基礎研究からみた新規治療

相澤直樹, 井川靖彦 2018

[雑誌論文] KPR-2579, a novel TRPM8 antagonist, inhibits acetic acid-induced bladder afferent hyperactivity in rats

Aizawa Naoki、Fujimori Yoshikazu、Kobayashi Jun-ichi、Nakanishi Osamu、Hirasawa Hideaki、Kume Haruki、Homma Yukio、Igawa Yasuhiko 2018

[学会発表] BPH薬物療法：今後の展開は？基礎研究の観点より

相澤直樹、井川靖彦 2018

[雑誌論文] Inhibitory effects of silodosin on the bladder mechanosensitive afferent activities and their relation with bladder myogenic contractions in male rats with bladder outlet obstruction

Aizawa Naoki、Watanabe Daiji、Fukuhara Hiroshi、Fujimura Tetsuya、Kume Haruki、Homma Yukio、Igawa Yasuhiko 2018

[学会発表] Involvement of transient receptor aotential ankyrin 1 (TRPA1) in the lipopolysaccharide (LPS)-induced inflammatory bladder hypersensitivity in mice.

Kamei J, Aizawa N, Nakagawa T, Kaneko S, Homma Y, Igawa Y. 2018

[学会発表] RQ-00434739, a novel TRPM8 antagonist, inhibits prostaglandin-E2-induced hyperactivity of the primary bladder afferent nerves in rats.

Aizawa N, Ohshiro H, Watanabe S, Homma Y, Igawa Y. 2018

[学会発表] Preoperative ultrasound-guided pelvic floor muscle training facilitates continence recovery in the early phase after robot assisted radical prostatectomy

Yoshida M, Matsunaga A, Fijimura T, Sato Y, Kamei J, Watanabe D, Aizawa N, Shinoda Y, Haga N, Kume H, Igawa Y, Sanada H 2018

[雑誌論文] May perioperative ultrasound-guided pelvic floor muscle training promote early recovery of urinary continence after robot-assisted radical prostatectomy?

Yoshida Mikako、Matsunaga Akiko、Igawa Yasuhiko、Fujimura Tetsuya、Shinoda Yusuke、Aizawa Naoki、Sato Yusuke、Kume Haruki、Homma Yukio、Haga Nobuhiko、Sanada Hiromi 2018

[雑誌論文] Attenuated lipopolysaccharide-induced inflammatory bladder hypersensitivity in mice deficient of transient receptor potential ankilin1

Kamei Jun、Aizawa Naoki、Nakagawa Takayuki、Kaneko Shuji、Kume Haruki、Homma Yukio、Igawa Yasuhiko 2018

[学会発表] 自発収縮と求心性シグナル （Mechanosensitive bladder afferent activities in relation with spontaneous microcontractions）

相澤直樹、井川靖彦 2017

[学会発表] Functional role of Transient Receptor Potential Melastatin 8 (TRPM8) channel in the rat urinary bladder assessed by using a novel potent antagonist.

Aizawa N, Ohshiro H, Watanabe S, Homma Y, Igawa Y. 2017

[学会発表] Effects of tadalafil, a PDE type 5 inhibitor, on the bladder mechanosensitive afferent activities related to microcontractions in male rats with bladder outlet obstruction.

Aizawa N, Fukuhara H, Fujimura T, Homma Y, Igawa Y. 2017

[学会発表] ラット膀胱におけるTRPM8チャネルの機能的役割：新規TRPM8拮抗薬を用いた検討

相澤直樹、大城博行、渡邉修造、藤村哲也、 福原　浩、本間之夫、井川靖彦 2017

[学会発表] KPR-2579, a novel TRPM8 antagonist, inhibits acetic-acid-induced bladder hyperactivity via mechanosensitive afferent C-fibers in rats.

Aizawa N, Fujimori Y, Kobayashi J, Nakanishi O, Hirasawa H, Homma Y, Igawa Y. 2017

[学会発表] 排尿知覚の薬理学・生理学的機能解析

相澤直樹、井川靖彦 2017

[学会発表] Preoperative ultrasound-guided pelvic floor muscle training promotes early recovery of urinary continence after robot assisted radical prostatectomy.

Yoshida M, Matsunaga A, Fujimura T, Shinoda Y, Niimi A, Aizawa N, Homma Y, Sanada H, Igawa Y. 2017