トップ研究者を探す造血器腫瘍のBCL-2特性に基づくp53依存+非依存性ミトコンドリア死の分子誘導

造血器腫瘍のBCL-2特性に基づくp53依存+非依存性ミトコンドリア死の分子誘導

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17K09928
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
血液内科学
研究機関 高知大学
佐賀大学
代表研究者 小島 研介
研究期間 開始年月日 2017/4/1
研究期間 終了年度 2020
研究ステータス 完了 (2020/4/1)
配分額(合計) 4,680,000 (直接経費 :3,600,000、間接経費 :1,080,000)
配分額(履歴) 2019年度:1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
2018年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2017年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
キーワード 造血器腫瘍
分子標的治療
BCL-2
薬剤耐性
MCL-1
p53
耐性
シグナル伝達
細胞死

研究成果

[雑誌論文] Prophylactic antiviral therapy for hepatitis B virus surface antigen‐positive patients with diffuse large B‐cell lymphoma treated with rituximab‐containing chemotherapy

Yamauchi Nobuhiko、Maruyama Dai、Choi Ilseung、Atsuta Yoshiko、Sakai Rika、Miyashita Kazuho、Moriuchi Yukiyoshi、Tsujimura Hideki、Kubota Nobuko、Yamamoto Go、Igarashi Tadahiko、Izutsu Koji、Yoshida Shinichiro、Kojima Kensuke、・・・、Kusumoto Shigeru 2021

[雑誌論文] Central Nervous System Involvement in Mantle Cell Lymphoma Presenting Magnetic Resonance Imaging Features of Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion

Nakamura Makoto、Iwasa Hitomi、Kojima Kensuke 2021

[雑誌論文] 良好なABL1チロシンキナーゼ阻害薬感受性を示したバリアントe13a3(b2a3)<i>BCR-ABL1</i>慢性骨髄性白血病

砥谷 和人、朝霧 正、上岡 樹生、小島 研介 2021

[雑誌論文] Clinical impact of the CONUT score in patients with multiple myeloma

Okamoto S, Ureshino H*, Kidoguchi K, Kusaba K, Kizuka-Sano H, Sano H, Nishioka A, Yamaguchi K, Kamachi K, Itamura H, Yoshimura M, Yokoo M, Shindo T, Kubota Y, Ando T, Kojima K, Kawaguchi A, Sueoka E, Kimura S. 2020

[雑誌論文] 分子標的治療時代の慢性リンパ性白血病治療戦略

小島 研介 2020

[雑誌論文] Gastric emphysema in chemosensitive gastric diffuse large B cell lymphoma

Nakamura Makoto、Saeki Kyosuke、Egashira Ryoko、Egashira Yoshiaki、Kojima Kensuke 2020

[雑誌論文] Treatment algorithm for Japanese patients with chronic lymphocytic leukemia in the era of novel targeted therapies

Kojima Kensuke、Burger Jan A. 2020

[雑誌論文] Primary pulmonary diffuse large B cell lymphoma presenting as bulky bilateral lung tumors

Saeki Kyosuke、Nakamura Makoto、Egashira Ryoko、Kojima Kensuke 2020

[雑誌論文] Is clinicopathological distinction of mucosa-associated lymphoid tissue lymphoma from Waldenstrom macroglobulinemia essential in MYD88 L265P mutation-positive cases?

Kidoguchi K, Kojima K, Seki R, Nagafuji K, Ohshima K, Kimura S. 2019

[雑誌論文] Feasibility of the imatinib stop study in the Japanese clinical setting: delightedly overcome CML expert stop TKI trial (DOMEST Trial).

Fujisawa S, Ueda Y, Usuki K, Kobayashi H, Kondo E, Doki N, ..., Kojima K, Morita S, Komukai S, Kawaguchi A, Sakamoto J, Kimura S. 2019

[雑誌論文] Locally distributed multicentric plasmacytomas in the ileum secondary to lymphoma chemoimmunotherapy

Yokoo M, Kojima K, Sano H, Kai K, Arakawa F, Ohshima K, Matsunaga T, Kimura S. 2019

[雑誌論文] BCR-ABL1- and CBFB-MYH11-positive chronic myeloid leukemia presenting with primary blast crisis and marrow fibrosis.

Kidoguchi K, Kojima K*, Yokoo M, Kimura S. 2019

[雑誌論文] Oral ulceration: an unusual manifestation of lymphomatoid granulomatosis.

Kidoguchi K, Yoshimura M, Kojima K*, Ureshino H, Egashira R, Yokoo M, Kai K, Egashira Y, Ohshima K, Ando T, Kimura S. 2019

[雑誌論文] ipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia

Nii T, Prabhu VV, Ruvolo V, Madhukar N, Zhao R, Mu H, Heese L, Nishida Y, Kojima K, Garnett MJ, McDermott U, Benes CH, Charter N, Deacon S, Elemento O, Allen JE, Oster W, Stogniew M, Ishizawa J, Andreeff M. 2019

[雑誌論文] Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.

Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Andreeff M 2019

[雑誌論文] Predictive Gene Signatures Determine Tumor Sensitivity to MDM2 Inhibition.

Ishizawa J, Nakamaru K, Seki T, Tazaki K, Kojima K, Chachad D, Zhao R, Heese L, Ma W, Ma MCJ, DiNardo C, Pierce S, Patel KP, Tse A, Davis RE, Rao A, Andreeff M. 2018

[学会発表] FLT3阻害

小島研介 2018

[雑誌論文] Oral ulceration: an unusual manifestation of lymphomatoid granulomatosis.

Kidoguchi K, Yoshimura M, Kojima K, Ureshino H, Egashira R, Yokoo M, Kai K, Egashira Y, Ohshima K, Ando T, Kimura S. 2018

[雑誌論文] Targeting of BMI-1 expression by the novel small molecule PTC596 in mantle cell lymphoma.

Maeda A, Nishida Y, Weetall M, Cao L, Branstrom A, Ishizawa J, Nii T, Schober WD, Abe Y, Matsue K, Yoshimura M, Kimura S, Kojima K. 2018

[雑誌論文] Predictive gene signatures determine tumor sensitivity to MDM2 inhibition.

Ishizawa J, Nakamaru K, Seki T, Tazaki K, Kojima K, Chachad D, Zhao R, Heese LE, Ma W, Ma MCJ, DiNardo CD, Pierce SA, Patel KP, Tse A, Davis RE, Rao A, Andreeff M. 2018

[学会発表] The novel imipridone ONC212 highly synergizes with the BCL-2 inhibitor ABT-199 in AML and activates orphan receptor GPR132.

Nii T, Ishizawa J, Prabhu VV, Ruvolo V, Madhukar N, Zhao R, Mu H, Heese L, Kojima K, Garnett M, McDermott U, Benes C, Charter N, Deacon S, Elemento O, Allen J, Oster W, Stogniewand M, Andreeff M. 2018

[学会発表] The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199

Takenobu Nii, Jo Ishizawa, Varun Vijay Prabhu, Vivian Ruvolo, Neel Madhukar, Ran Zhao, Hong Mu, Lauren Heese, Kensuke Kojima, Mathew Garnett, Ultan McDermott, Cyril H Benes, Neil Charter, Sean Deacon, Olivier Elemento, Joshua E. Allen, Wolfgang Oster, Martin Stogniew and Michael Andreeff 2017

[学会発表] PTC299 Is a Novel DHODH Inhibitor That Modulates VEGFA mRNA Translation and Inhibits Proliferation of a Broad Range of Leukemia Cells

Liangxian Cao, Arthur Branstrom, John Baird, Christopher Trotta, Joseph Colacino, Marianne T. Santaguida, Diane Heiser, Mark Ma, Kensuke Kojima, Stuart Peltz, Edward O'Mara, Robert Spiegel and Marla Weetall 2017

[雑誌論文] Automatic digital quantification of bone marrow myeloma volume in appendicular skeletons - clinical implications and prognostic significance

Nishida Yuki、Kimura Shinya、Mizobe Hideaki、Yamamichi Junta、Kojima Kensuke、Kawaguchi Atsushi、Fujisawa Manabu、Matsue Kosei 2017

[学会発表] Inhibition of Translation Initiation and Heat Shock Factor 1 (HSF1): A Novel Strategy Targeting FLT3 Double Mutant and Non-FLT3 Mutant AML Progenitor/Stem Cells

Jo Ishizawa, Ran Zhao, Lauren Heese, Alex Jaeger, Yuki Nishida, Rodrigo Jacamo, Kensuke Kojima, Man Chun John MA, Vivian Ruvolo, Dhruv Chachad, R. Eric Davis, William Devine, John A Porco Jr., Luke Whitesell and Michael Andreeff 2017

[学会発表] Downregulation of BMI-1 By the Small Molecule PTC596 Induces Mitochondrial Apoptosis in Mantle Cell Lymphoma

Kensuke Kojima, Aya Maeda, Sho Okamoto, Yuki Nishida, Cao Liangl, Marla Weetall, Art Branstrom and Shinya Kimura 2017

[学会発表] Targeting of BMI-1 in mantle cell lymphoma

Aya Maeda, Shinya Kimura, Kensuke Kojima 2017

[学会発表] Automatic Digital Quantification of Bone Marrow Myeloma Volume in Appendicular Skeletons ― Clinical Implications and Prognostic Significance

Yuki Nishida, Shinya Kimura, Hideaki Mizobe, Junta Yamamichi, Kensuke Kojima, Atsushi Kawaguchi, Manabu Fujisawa and Kosei Matsue 2017