トップ研究者を探す感染および慢性炎症関連リンパ腫の腫瘍化機構の解明と新たな制御法開発への展開

感染および慢性炎症関連リンパ腫の腫瘍化機構の解明と新たな制御法開発への展開

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17K09927
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
血液内科学
研究機関 高知大学
代表研究者 大畑 雅典
研究分担者 松崎 茂展
研究分担者 樋口 智紀
研究分担者 橋田 裕美子
研究期間 開始年月日 2017/4/1
研究期間 終了年度 2019
研究ステータス 完了 (2019/4/1)
配分額(合計) 4,680,000 (直接経費 :3,600,000、間接経費 :1,080,000)
配分額(履歴) 2019年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2018年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2017年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
キーワード 悪性リンパ腫
ウイルス
感染症
微生物

炎症
感染

研究成果

[雑誌論文] Human polyomavirus 6 with the Asian/Japanese genotype in cases of Kimura disease and angiolymphoid hyperplasia with eosinophilia.

Yumiko Hashida, Tomonori Higuchi, Kimiko Nakajima, Takako Ujihara, Ichiro Murakami, Mikiya Fujieda, Shigetoshi Sano, Masanori Daibata. 2020

[学会発表] RNA-seq analysis identified candidate pathogens for prostate cancer.

Shingo Ashida, Chiaki Kawada, Keiji Inoue, Masanori Daibata, Hidewaki Nakagawa. 2020

[雑誌論文] Is There an Entity of Radiation-Induced Chronic Myeloid Leukemia? Report of a Case and Brief Review of the Literature

Isao Miyoshi, Masakazu Mori, IchiroYamasaki, Masanori Daibata. 2020

[学会発表] Expression of CCL17 and CCL22 chemokines in EBV-positive pyothorax-associated lymphoma attracts CCR4-expressing regulatory T cells.

Tomonori Higuchi, Yumiko Hashida, Tomohiro Nishimori and Masanori Daibata. 2019

[学会発表] Epidemiological study of human polyomavirus 6 and human polyomavirus 7 in normal skin of healthy individuals.

Yumiko Hashida, Tomonori Higuchi, Tomohiro Nishimori, Masanori Daibata. 2019

[学会発表] revalence and viral loads of cutaneous human polyomaviruses in the skin of patients with chronic inflammatory skin diseases.

Yuka Shibata, Yumiko Hashida, Tomonori Higuchi, Moe Tanaka, Kimiko Nakajima, Masanori Daibata, Shigetoshi Sano. 2019

[学会発表] Epidemiological investigation of Merkel cell polyomavirus infection levels in the human skin.

Yumiko Hashida, Tomonori Higuchi, Masanori Daibata. 2019

[学会発表] EBV+ pyothorax-associated lymphoma expresses CCL17 and CCL22 chemokines that recruit CCR4+ regulatory T cells.

Tomonori Higuchi, Yumiko Hashida, Takako Ujihara, Ayuko Taniguchi, Takashi Nakayama and Masanori Daibata. 2019

[学会発表] Activity situation of Japanese encephalitis virus in Kochi prefecture from 2016 to 2018.

Kiyohiko Matsui, Chang-Kweng Lim, Shigeru Tajima, Masanori Daibata. 2019

[雑誌論文] Prevalence and Genetic Variability of Human Polyomaviruses 6 and 7 in Healthy Skin Among Asymptomatic Individuals

Hashida Yumiko、Higuchi Tomonori、Matsuzaki Shigenobu、Nakajima Kimiko、Sano Shigetoshi、Daibata Masanori 2018

[学会発表] Antiproliferative effects of MYC/PLK1 inhibitions in a cell line derived from lymphoma with MYC/BCL6 rearrangements.

Tomonori Higuchi, Hiroaki Kikuchi, Yumiko Hashida, Ayuko Taniguchi, Mikio Kamioka, Takahiro Taguchi, Ichiro Murakami, Masanori Daibata. 2018

[雑誌論文] Genetic Variability of the Noncoding Control Region of Cutaneous Merkel Cell Polyomavirus: Identification of Geographically-Related Genotypes.

Yumiko Hashida, Tomonori Higuchi, Kiyohiko Matsui, Yuka Shibata, Kimiko Nakajima, Shigetoshi Sano, Masanori Daibata. 2018

[学会発表] Genetic variability of the noncoding control region of cutaneous Merkel cell polyomavirus.

Yumiko Hashida, Tomonori Higuchi, Kiyohiko Matsui, Masanori Daibata. 2018

[学会発表] Quantification of MCPyV DNA loads in the tumor tissues and nonlesional skins of patients with Merkel cell carcinoma.

Yumiko Hashida, Tomonori Higuchi, Shigenobu Matsuzaki, Masanori Daibata. 2018

[雑誌論文] Generation and characteristics of a novel "double-hit" high grade B-cell lymphoma cell line DH-My6 with MYC/IGH and BCL6/IGH gene arrangements and potential molecular targeted therapies.

Hiroaki Kikuchi, Tomonori Higuchi, Yumiko Hashida, Ayuko Taniguchi, Mikio Kamioka, Takahiro Taguchi, Akihito Yokoyama, Ichiro Murakami, Mikiya Fujieda, Masanori Daibata. 2018

[学会発表] PLK1 upregulation promotes cell proliferation and survival in advanced splenic marginal zone lymphoma

Higuchi Tomonori, Hashida Yumiko, Kamioka Mikio, Taniguchi Ayuko, Daibata Masanori 2017

[学会発表] The relationship between loads of Merkel cell polyomavirus and carcinogenesis

Hashida Yumiko, Higuchi Tomonori, Matsuzaki Shigenobu, Daibata Masanori 2017

[学会発表] High load of MCPyV in the nonlesional skin of patients with Merkel cell carcinoma and among a cohort of asymptomatic elderly individuals

Hashida Yumiko, Higuchi Tomonori, Matsuzaki Shigenobu, Nakajima Kimiko, Sano Shigetoshi, Daibata Masanori 2017

[雑誌論文] Differential gene expression profiling linked to tumor progression of splenic marginal zone lymphoma

Higuchi Tomonori、Hashida Yumiko、Taniguchi Ayuko、Kamioka Mikio、Daibata Masanori 2017