トップ研究者を探す胸腺髄質上皮細胞の分化制御に機能するAIRE遺伝子発現ネットワークの解明

胸腺髄質上皮細胞の分化制御に機能するAIRE遺伝子発現ネットワークの解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17K08885
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
基礎医学
免疫学
研究機関 徳島大学
代表研究者 西嶋 仁
研究期間 開始年月日 2017/4/1
研究期間 終了年度 2019
研究ステータス 完了 (2019/4/1)
配分額(合計) 4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額(履歴) 2019年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
2018年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2017年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
キーワード Aire
胸腺上皮細胞
負の選択
遺伝子発現
mTEC
RNA-seq
AIRE
自己免疫疾患
1型糖尿病
Xcr1陽性樹状細胞
胸腺髄質上皮細胞
免疫学

研究成果

[雑誌論文] AIRE - The Autoimmune Regulator

Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Tsuneyama Koichi、Matsumoto Mitsuru 2019

[学会発表] Aireを高発現する胸腺髄質上皮細胞の免疫学的機能とトランスクリプトーム解析

Nishijima Hitoshi, Sugita Mizuki, Morimoto Junko, Matsumoto Minoru, Matsumoto Mitsuru 2019

[学会発表] Aire-dependent establishment of self-tolerance

Matsumoto Mitsuru, Morimoto Junko, Matsumoto Minoru, Tsuneyama Koichi, Miyazawa Ryuichiro, Nishijima Hitoshi 2019

[学会発表] Aire-dependent establishment of self-tolerance studied by genetically modified mice.

Matsumoto Mitsuru, Morimoto Junko, Matsumoto Minoru, Tsuneyama Koichi, Miyazawa Ryuichiro, Nishijima Hitoshi 2019

[学会発表] Acquisition of the resistance to autoimmune diabetes by the expression of human AIRE in BM-derived APCs in NOD

Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Tsuneyama Koichi、Matsumoto Mitsuru 2018

[学会発表] A novel Aire-dependent subset of mTECs with tolerogenic functions is defined by Ly6 family protein expression

Matsumoto Mitsuru、Morimoto Junko、Matsumoto Minoru、 Tsuneyama Koichi、Nishijima Hitoshi 2018

[雑誌論文] Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE)

Nishijima Hitoshi、Kajimoto Tatsuya、Matsuoka Yoshiki、Mouri Yasuhiro、Morimoto Junko、Matsumoto Minoru、Kawano Hiroshi、Nishioka Yasuhiko、Uehara Hisanori、Izumi Keisuke、Tsuneyama Koichi、Okazaki Il-mi、Okazaki Taku、Hosomichi Kazuyoshi、Shiraki Ayako、Shibutani Makoto、Mitsumori Kunitoshi、Matsumoto Mitsuru 2018

[雑誌論文] Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G

Morimoto Junko、Nishikawa Yumiko、Kakimoto Takumi、Furutani Kohei、Kihara Naoki、Matsumoto Minoru、Tsuneyama Koichi、Kozono Yuko、Kozono Haruo、Hozumi Katsuto、Hosomichi Kazuyoshi、Nishijima Hitoshi、Matsumoto Mitsuru 2018

[学会発表] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells

Morimoto Junko、Nishikawa Yumiko、Kihara Naoki、Hosomichi Kazuyoshi、Nishijima Hitoshi、Matsumoto Mitsuru 2018

[学会発表] Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity

Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Tsuneyama Koichi、Matsumoto Mitsuru 2018

[学会発表] Transcriptomic analysis of medullary thymic epithelial cells with augmented Aire expression

Nishijima Hitoshi、Morimoto Junko、Matsumoto Minoru、Matsumoto Mitsuru 2018

[学会発表] 胸腺髄質上皮細胞におけるAire発現レベルと組織特異的自己抗原遺伝子発現との関連性に関する検討

Nishijima Hitoshi、Morimoto Junko、Matsumoto Minoru、Matsumoto Mitsuru 2018

[学会発表] Distinct tissue-specific immune response revealed by manipulation of thymic and peripheral tolerance by Aire

Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Matsumoto Mitsuru 2018

[学会発表] Analysis of the role of thymic APCs and Aire in the production of thymic Tregs

Morimoto Junko、Nishijima Hitoshi、Matsumoto Minoru、Matsumoto Mitsuru 2018

[学会発表] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells

Morimoto Junko、Nishikawa Yumiko、Kihara Naoki、Hosomichi Kazuyoshi、Nishijima Hitoshi、Matsumoto Mitsuru 2017

[学会発表] Transgenic human AIRE expression in NOD acquired resistance to the diabetes due to the impaired presentation of self-antigens in the pancreas

Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Tsuneyama Koichi、Matsumoto Mitsuru 2017