トップ研究者を探すアルツハイマー病の早期発見:軽度認知機能障害の臨床的病因論的多様性の検討

アルツハイマー病の早期発見:軽度認知機能障害の臨床的病因論的多様性の検討

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17700345
研究種目 若手研究(B)
研究分野 総合・新領域系
総合領域
神経科学
神経化学・神経薬理学
研究機関 独立行政法人放射線医学総合研究所
東北大学
代表研究者 丸山 将浩
研究期間 開始年月日 2005/4/1
研究期間 終了年度 2006
研究ステータス 完了 (2006/4/1)
配分額(合計) 3,400,000 (直接経費 :3,400,000)
配分額(履歴) 2006年度:1,100,000 (直接経費 :1,100,000)
2005年度:2,300,000 (直接経費 :2,300,000)
キーワード アルツハイマー病治療薬
micro PET scan
病理学的変化を描出
アルツハイマー病
軽度認知機能障害
客観的予測診断法

研究成果

[雑誌論文] 2-(2-[2-Dimethylaminothiazol-5-y1]Ethenyl)-6- (2-[Fluoro]Ethoxy)Benzoxazble : A Novel PET Agent for In Vivo Detection of Dense Amyloid Plaques in Alzheimer's Disease Patients.

Kudo Y, Okamura N, Furumoto S, Tashiro M, Furukawa K, Maruyama M, Itoh M, Iwata R, Yanai K, Arai H 2007

[雑誌論文] ACE activity in CSF of patients with mild cognitive impairment and Alzheimer disease.

He M, Ohrui T, Maruyama M, Tomita N, Nakayama K, Higuchi M, Furukawa K, Arai H 2006

[雑誌論文] A randomized trial of olfactory stimulation using black pepper oil in older people with swallowing dysfunction.

Ebihara T, Ebihara S, Maruyama M, Kobayashi M, Itou A, Arai H, Sasaki H 2006

[雑誌論文] Predicting human performance by channelized Hotelling observer in discriminating between Alzheimer's dementia and controls using statistically processed brain perfusion SPECT.

Shidahara M, Inoue K, Maruyama MWatabe H, Taki Y, Goto R, Okada K, Kinomura S, Osawa S, Onishi Y, Ito H, Arai H, Fukuda H 2006

[雑誌論文] Benefits of combining donepezil plus traditional Japanese herbal medicine on cognition and brain perfusion in Alzheimer's disease : a 12-week observer-blind, donepezil monotherapy controlled trial.

Maruyama M, Tomita N, Iwasaki K, Ootsuki M, Matsui T, Nemoto M, Okamura N, Higuchi M, Tsutsui M, Suzuki T, Seki T, Kaneta T, Furukawa K, Arai H 2006

[雑誌論文] Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.

Fujiwara H, Iwasaki K, Furukawa K, Seki T, He M, Maruyama M, Tomita N, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Ohizumi Y, Arai H 2006

[雑誌論文] Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease.

Hamaguchi T, Kitamoto T, Sato T, Mizusawa H, Nakamura Y, Noguchi M, Furukawa Y, Ishida C, Kuji I, Mitani K, Murayama S, Kohriyama T, Katayama S, Yamashita M, Yamamoto T, Udaka F, Kawakami A, Ihara Y, Nishinaka T, Kuroda S, Suzuki N, Shiga Y, Arai H, Maruyama M, Yamada M. 2005

[雑誌論文] Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.

Maruyama M, Higuchi M, Takaki Y, Matsuba Y, Tanji H, Nemoto K, Tomita N, Matsui T, Iwata N, Mizukami H, Muramatsu S, 0zawa K, Saido TC, Arai H, Sasaki H. 2005

[雑誌論文] A randomized observer-blind controlled trial of a traditional Chinese medicine, Yi-Gan San, on behabioral and psychological symptoms and activities of daily living in dementia patients.

Iwasaki K, Satoh-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Arai H, Sasaki H. 2005

[雑誌論文] Quinoline and benzimidazole derivatives : candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.

Okamura N, Suemoto T, Furumoto S, Suzuki M, Shimadzu H, Akatsu H, Yamamoto T, Fujiwara H, Nemoto M, Maruyama M, Arai H, Yamai K, Sawada T, Kudo Y. 2005

[雑誌論文] Lithium therapy and CSF biomarker levels in Alzheimer's disease.

Maruyama M, Ishizawa K, Tomita N, Nemoto M, Yasuda H, Ebihara S, Ohrui T, Seki T, Iwasaki K, Okamura N, Higuchi M, Yoshida H, Kudo Y, Arai H, Sasaki H. 2005

[雑誌論文] Effects of the Traditional Chinese Herbal Medicine Yi-Gen San for Cholinesterase Inhibitor-Resistant Visual Hallucinations and Neuropsychiatric Symptoms in Patients With Dementia With Lewy Bodies.

Iwasaki K, Maruyama M, Tomita N, Furukawa K, Nemoto M, Fujiwara H, Seki T, Fujii M, Kodama M, Arai H 2005