血管病変部の緊張異常と増殖性亢進におけるプロテイナーゼ活性化型受容体の役割

トップ›研究者を探す›血管病変部の緊張異常と増殖性亢進におけるプロテイナーゼ活性化型受容体の役割

血管病変部の緊張異常と増殖性亢進におけるプロテイナーゼ活性化型受容体の役割

代表研究者	平野勝也
研究課題番号	KAKENHI-PROJECT-17590744
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学循環器内科学
研究機関	九州大学
研究分担者	平野真弓
研究期間開始年月日	2005/4/1
研究期間終了年度	2006
研究ステータス	完了 (2006/4/1)
配分額（合計）	3,500,000 (直接経費 :3,500,000)
配分額（履歴）	2006年度：1,700,000 (直接経費 :1,700,000) 2005年度：1,800,000 (直接経費 :1,800,000)
キーワード	トロンビンプロテイナーゼ受容体血管内皮細胞血管平滑筋細胞血管トーヌス一酸化窒素血管病プラスミン発現血管スパズム血管平滑筋プロテアーゼ増殖シグナル伝達 THROMBIN PROTEINASE RECEPTOR VASCULAR ENDOTHELIAL CELLS VASCULAR SMOOTH MUSCLE VASCULAR TONE NITRIC OXIDE VASCULAR DISEASES

研究成果

[雑誌論文] Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery.

Fujiyoshi T, Hirano K, Hirano M, Nishimura J, Takahashi S, Kanaide H 2007

[雑誌論文] The roles of proteinase-activated receptors in the vascular physiology and pathophysiology.

Hirano K 2007

[雑誌論文] Involvement of Na^+-Ca^2+ exchanger in cAMP-mediatpd relaxation in mice aorta : Evaluation using transgenic mice

Karashima E, Nishimura J, Iwamoto T, Hirano K, Hirano M, Kita S, Harada M, Kanaide H 2007

[雑誌論文] The roles of proteinase-activated receptors in the vascular physiology and pathophysiology

Hirano K 2007

[雑誌論文] Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery

Fujiyoshi T, Hirano K, Hirano M, Nishimura J, Takahashi S, Kanaide H 2007

[雑誌論文] Plasmin induces endothelium-dependent nitric oxide- mediated relaxation in the porcine coronary artery.

Fujiyoshi T, Hirano K, Hirano M, Nishimura J, Takahashi S, Kanaide H 2007

[雑誌論文] Distinct Ca^<2+> requirement for NO production between proteinase-activated receptor 1 and 4 (PAR_1 and PAR_4) in vascular endothelial cells.

Hirano K, Nomoto N, Hirano M, Momota F, Hanada A, Kanaide H 2007

[雑誌論文] Involvement of G_<i/o>in the PAR-4-induced NO production in endothelial cells.

Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H 2006

[雑誌論文] Involvement of Gi_i/o in the PAR-4-induced NO production in endothelial cells

Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H 2006

[雑誌論文] Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury.

Fukunaga R, Hirano K, Hirano M, Niiro N, Nishimura J, Maehara Y, Kanaide H 2006

[雑誌論文] Involvement of G_<i/o> in the PAR-4-induced NO production in endothelial cells.

Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H 2006

[雑誌論文] Involvement of Gi/o in the PAR-4-induced NO production in endothelial cells.

Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H 2006

[雑誌論文] Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury

Fukunaga R, Hirano K, Hirano M, Niiro N, Nishimura J, Maehara Y, Kanaide H 2006

[雑誌論文] Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits

Furuyama T, Komori K, Shimokawa H, Matsumoto Y, Uwatoku T, Hirano K, Maehara Y 2006

[雑誌論文] Enhancement of trypsin-induced contraction by in vivo treatment with 17β-estradiol and progesterone in rat myometrium

Aman M, Hirano K, Nishimura J, Nakano H, Kanaide H 2005

[雑誌論文] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery

Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H 2005

[雑誌論文] Contractile properties of the cultured vascular smooth muscle cells : The crucial role played by RhoA in the regulation of contractility

Bi D, Nishimura J, Niiro N, Hirano K, Kanaide H 2005

[雑誌論文] Rac1 regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells

Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H 2005

[雑誌論文] Racl regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells.

Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H 2005

[雑誌論文] Rac1 regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells.

Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H 2005

[雑誌論文] Distinct Ca^<2+> requirement for NO production between proteinase-activated receptor 1 and 4 (PAR_1 and PAR_4) in vascular endothelial cells.

Hirano K, Nomoto N, Hirano M, Momota F, Hanada A, Kanaide H