トップ研究者を探す心筋受容体-受容体相互作用による活性酸素依存性細胞内情報伝達と心不全

心筋受容体-受容体相互作用による活性酸素依存性細胞内情報伝達と心不全

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17590220
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
基礎医学
薬理学一般
研究機関 香川大学
代表研究者 木村 正司
研究分担者 大森 浩二
研究分担者 西山 成
研究分担者 宮武 明
研究期間 開始年月日 2005/4/1
研究期間 終了年度 2006
研究ステータス 完了 (2006/4/1)
配分額(合計) 3,600,000 (直接経費 :3,600,000)
配分額(履歴) 2006年度:1,100,000 (直接経費 :1,100,000)
2005年度:2,500,000 (直接経費 :2,500,000)
キーワード アンジオテンシン
アドレナリン作用薬
心肥大
酸化ストレス
Angiotensin
Adrenergic receptor

研究成果

[雑誌論文] Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice.

Zhang G, Ohmori K, Nagai Y, Fujisawa Y, Nishiyama A, Abe Y, Kimura S. 2007

[雑誌論文] Effects of adrenomedullin 2 on regional hemodynamics in conscious rats.

Fujisawa Y, Nagai Y, Miyatake A, Miura K, Nishiyama A, Kimura S, Abe Y. 2007

[雑誌論文] Contribution of reactive oxygen species to the pathogenesis of left ventricular failure in Dahl salt-sensitive hypertensive rats : effects of angiotensin II blockade.

Guo P, Nishiyama A, Rahman M, Nagai Y, Noma T, Namba T, Ishizawa M, Murakami K, Miyatake A, Kimura S, Mizushige K, Abe Y, Ohmori K, Kohno M. 2006

[雑誌論文] Roles of adrenomedullin2 in regulating the cardiovascular and sympathetic nervous systems in conscious rats.

Fujisawa Y, Nagai Y, Miyatake A, Miura K, Shokoji T, Nishiyama A, Kimura S, Abe Y. 2006

[雑誌論文] Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury.

Sun GP, Kohno M, Guo P, Nagai Y, Miyata K, Fan YY, Kimura S, Kiyomoto H, Ohmori K, Li DT, Abe Y, Nishiyama A. 2006

[雑誌論文] Effects of adrenomedullin on cardiac oxidative stress and collagen accumulation in aldosterone-dependent malignant hypertensive rats.

Rahman M, Nishiyama A, Guo P, Nagai Y, Zhang GX, Fujisawa Y, Fan YY, Kimura S, Hosomi N, Omori K, Abe Y, Kohno M. 2006

[雑誌論文] Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/salt-treated hypertensive rats; renoprotective effects of an ultrahigh dose of olmesartan.

Fan YY, Baba R, Nagai Y, Miyatake A, Hosomi N, Kimura S, Sun GP, Kohno M, Fujita M, Abe Y, Nishiyama A. 2006

[雑誌論文] Synergistic effect of mechanical stretch and angiotensin II on superoxide production via NADPH oxidase in vascular smooth muscle cells.

Hitomi H, Fukui T, Moriwaki K, Matsubara K, Sun GP, Rahman M, Nishiyama A, Kiyomoto H, Kimura S, Ohmori K, Abe Y, Kohno M. 2006

[雑誌論文] RAA系 AIIの多面作用 活性酸素産生

木村 正司 2006

[雑誌論文] [Angiotensin II and superoxide production] Review in Japanese.

Kimura S 2006

[雑誌論文] D-allose, an all-cis aldo-hexose, suppresses development of salt induced hypertension in Dahl rats.

Kimura S, Zhang GX, Nishiyama A, Nagai Y, Nakagawa T, Miyanaka H, Fujisawa Y, Miyatake A, Nagai T, Tokuda M, Abe Y. 2005

[雑誌論文] Role of NAD(P)H oxidase-and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II.

Kimura S, Zhang GX, Nishiyama A, Shokoji T, Yao L, Fan YY, Rahman M, Suzuki T, Maeta H, Abe Y. 2005

[雑誌論文] Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in renal fibroblasts.

Nagai Y, Miyata K, Sun GP, Rahman M, Kimura S, Miyatake A, Kiyomoto H, Kohno M, Abe Y, Yoshizumi M, Nishiyama A. 2005

[雑誌論文] Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability.

Nishiyama Akira 2005

[雑誌論文] 心筋酸化ストレス:アンジオテンシン受容体とβアドレナリン受容体の相互作用

木村正司 2005

[雑誌論文] Role of NAD(P)H oxidase-and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II.

Kimura Shoji 2005

[雑誌論文] Mitochondria-derived reactive oxygen species and vascular MAP kinases: Comparison of angiotensin II and diazoxide.

Kimura Shoji 2005

[雑誌論文] D-allose, an all-cis aldo-hexose, suppresses development of salt-induced hypertension in Dahl rats.

Kimura Shoji 2005

[雑誌論文] Role of NAD(P)H oxidase- and mitochondrial-derived reactive oxygen species in cardioprotection of ischemic reperfuion injury by angiotensin II.

Kimura Shoji 2005

[雑誌論文] 心筋酸化ストレス : アンジオテンシン受容体とβアドレナリン受容体の相互作用

木村 正司 2005