トップ研究者を探すNox1遺伝子の発現異常の分子機構と遺伝子改変マウスを用いた病態解析

Nox1遺伝子の発現異常の分子機構と遺伝子改変マウスを用いた病態解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17390218
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 徳島大学
代表研究者 六反 一仁
研究分担者 大谷 直子
研究期間 開始年月日 2005/4/1
研究期間 終了年度 2007
研究ステータス 完了 (2007/4/1)
配分額(合計) 17,020,000 (直接経費 :16,000,000、間接経費 :1,020,000)
配分額(履歴) 2007年度:4,420,000 (直接経費 :3,400,000、間接経費 :1,020,000)
2006年度:3,300,000 (直接経費 :3,300,000)
2005年度:9,300,000 (直接経費 :9,300,000)
キーワード NADPH oxidase 1
Nox organizer 1
遺伝子改変マウス
消化管粘膜
自然免疫応答
炎症
発がん
TNF-α
NADPH oxidase 1
Nox organizer 1
Gene-targeted mice
Gastrointestinal mucosa
Innate immunity
Inflammation
Carcinogenesis
tumor necrosis factor-alpha

研究成果

[雑誌論文] Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract

Rokutan, K, et. al. 2008

[雑誌論文] Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract

Rokutan K, et. al. 2008

[雑誌論文] Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract

Rokutan K, et. al. 2008

[学会発表] Potential roles of the Nox family in intestinal inflammation in symposium on intestinal inflammation

Rokutan, K, et. al. 2007

[学会発表] TNF-α Is a Potent Activator for the Nox1-Based Oxidase System in Large Intestinal Epithelial Cells

Rokutan K, et. al. 2007

[学会発表] TNF-α,Is a Potent Activator for the Noxl-Based Oxidase System in Large Intestinal Epithelial Cells.

Rokutan K, et. al. 2007

[学会発表] Potential roles of the Nox family in intestinal inflammation in symposium on intestinal inflammation.

Rokutan K, et. al. 2007

[学会発表] Dysregulated expression of NADPH oxidase 1(Nox1) in gastric cancer

Rokutan, K., et. al. 2006

[学会発表] Pathophysiology of NAPHH oxidase I in the gut

Rokutan, K 2006

[雑誌論文] NADPH Oxidase in the gastrointestinal tract: A potential role of Noxl in innate immune response and carcinogenesis.

Rokutan K, et. al. 2006

[雑誌論文] NADPH Oxidase in the gastrointestinal tract : A potential role of Noxl in innate immune response and carcinogenesis.

Rokutan K, et al. 2006

[学会発表] Pathophysiology of NAPHH oxidase 1 in the gut.

Rokutan K. 2006

[学会発表] Dysregulated expression of NADPH oxidase 1 (Noxl)in gastric cancer.

Rokutan K., et. al. 2006

[雑誌論文] NADPH Oxidases in the gastrointestinal tract : A potential role of Noxl in innate immune response and carcinogenesis

Rokutan, K, et. al. 2006

[学会発表] Nox enzymes in the gastrointestinal tract: a potential role in inflammation-associated disorders.

Rokutan K. 2006

[学会発表] Nox enzymes in the gastrointestinal tract : a potential role in inflammation-associated disorders

Rokutan, K, et. al.