トップ›研究者を探す›高脂血症病態のマクロファージに出現する新しい小胞状オルガネラの同定とその機能解析

高脂血症病態のマクロファージに出現する新しい小胞状オルガネラの同定とその機能解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17390115
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
基礎医学
実験病理学
研究機関 熊本大学
代表研究者 坂下 直実
研究分担者 竹屋 元裕
研究期間 開始年月日 2005/4/1
研究期間 終了年度 2007
研究ステータス 完了 (2006/4/1)
配分額（合計） 14,800,000 (直接経費 :14,800,000)
配分額（履歴） 2006年度：3,500,000 (直接経費 :3,500,000)
2005年度：11,300,000 (直接経費 :11,300,000)
キーワード マクロファージ
コレステロール
小胞体オルガネラ
ACAT
コレステロールエステル
トランスゴルジネットワーク
syntaxin6
小胞体
小胞状オルガネラ
syntaxin 6
Macrophage
Cholesterol
Vesicular organelle
ACAT
Cholesteryl ester
trans-Golgi network
syntaxin 6
endoplasmic reticulum

研究成果

[雑誌論文] Class A scavenger receptor (CD204) attenuates hyperoxia-induced lung injury by reducing oxidative stress.

Kobayashi H, Sakashita N, Okuma T, Terasaki Y, Tsujita K, Suzuki H, Kodama T, Nomori H, Kawasuji M, Takeya M 2007

[雑誌論文] Class A scavenger receptor (CD204) attenuates hyperoxia-induced lung injury by reducing oxidative stress.

Kobayashi H, Sakashita N, Okuma T, Terasaki Y, Tsujita K, Suzuki H, Kodama T, Nomori H, Kawasuji M, Takeya M 2007

[雑誌論文] Class A scavenger receptor (CD204) attenuates hyperoxia-induced lung injury by reducing oxidative stress.

Kobayashi H, Sakashita N, Okuma T, Terasaki Y, Tsujita K, Suzki H, Kodama T, Nomori H, Kawasuji M, Takeya M 2007

[雑誌論文] Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardia infarction.

Tujita K, Kaikita K, Hayasaki T, Honda T, Kobayashi H, Sakashita N, Suzuki H, Kodama T, Ogawa H, Takeya M 2007

[雑誌論文] Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardial infarction.

Tujita K, Kaikita K, Hayasaki T, Honda T, Kobayashi H, Sakashita N, Suzuki H, Kodama T, Ogawa H, Takeya M 2007

[雑誌論文] AM-3K, an Anti-macrophage Antibody, Recognizes CD 163, a Molecule Associated with an Anti-inflammatory Macrophage Phenotype.

Komohara Y, Hirahara J, Horikawa T, Kawamura K, Kiyota E, Sakashita N, Araki N, Takeya M 2006

[雑誌論文] AM-3K, an Anti-macrophage Antibody, Recognizes CD163, a Molecule Associated with an Anti-inflammatory Macrophage Phenotype.

Komohara Y, Hirahara J, Horikawa T, Kawamura K, Kiyota E, Sakashita N, Araki N, Takeya M 2006

[雑誌論文] Human acyl-CoA : cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis.

Chang C, Dong R, Miyazaki A, Sakashita N, Zhang Y, Liu J, Guo M, Li BL, Chang TY 2006

[雑誌論文] Human Acyl-CoA : cholesterol Acyltransferase(ACAT) and its Potential as a Target for Pharmaceutical Intervention against Atherosclerosis.

Chang C, Dong R, Miyazaki A, Sakashita N et al. 2006

[雑誌論文] MCP- 1/CCR2 signaling pathway regulates hyperoxia-induced acute lung injury via nitric oxide production.

Okuma T, Terasaki Y, Sakashita N, Kaikita K, Kobayashi H, Hayasaki T, Kuziel WA, Baba H, Takeya M 2006

[雑誌論文] AM-3K, an Anti-macrophage Antibody, Recognizes CD163, a Molecule Associated with an Anti-inflammatory Macrophage Phenotype.

Komohara Y, Hirahara J, Horikawa T, Kawamura K, Kiyota E, Sakashita N, Araki N, Takeya M. 2006

[雑誌論文] Severe congestive heart failure with cardiac liver cirrhosis 10 years after orthotopic liver transplantation for familial amyloidotic polyneuropathy

Sakashita N, Ando Y, Haraoka K, Terazaki H, Yamashita T, Nakamura M, Takeya M 2006

[雑誌論文] MCP-1/CCR2 signaling pathway regulates hyperoxia-induced acute lung injury via nitric oxide production.

Okuma T, Terasaki Y, Sakashita N, Kaikita K, Kobayashi H, Hayasaki T, Kuziel WA, Baba H, Takeya M 2006

[雑誌論文] MCP-1/CCR2 singnaling pathway regulates hyperoxia-induced acute lung injury via nitric oxide production.

Okuma T, Terasaki Y, Sakashita N, Kaikita K, Kobayashi H, Hayasaka T, Kuziel WA, Baba H, Takeya M 2006

[雑誌論文] Severe congestive heart failure with cardiac liver cirrhosis 10 years after orthotopic liver transplantation for familial amyloidotic polyneuropathy.

Sakashita N, Ando Y, Haraoka K, Terazaki H, Yamashita T, Nakamura M, Takeya M 2006

[雑誌論文] Human acyl-CoA: cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis.

Chang C, Dong R, Miyazaki A, Sakashita N, Zhang Y, Liu J, Guo M, Li BL, Chang TY 2006

[雑誌論文] Severe congestive heart failure with cardiac liver cirrhosis 10 years after orthotopic liver transplantation for familial amyloidotic polyneuropathy.

Sakashita N, Ando Y, Haraoka K, Terazaki H et al. 2006

[雑誌論文] Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis.

Chang C, Dong R, Miyazaki A, Sakashita N, Zhang Y, Liu J, Guo M, Li BL, Chang TY 2006

[学会発表] Mechanism of foam cell formation of macrophages in hyperlipidemic condition: generation of an endoplasmic reticulunrderived vesicular structure.

Sakashita N, Chang CCY, Chang TY, Takeya M 0

[学会発表] Changes in endoplasmic reticulum of the macrophages, formation of a novel cholesterol-rich vesucular organelle.

Sakashita N, Chang CCY, Takeya M, Chang TY 0