トップ›研究者を探す›ヒトゲノム構造解析ツールとしての高密度ゲノムDNAマイクロアレイの開発と応用

ヒトゲノム構造解析ツールとしての高密度ゲノムDNAマイクロアレイの開発と応用

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-17019014
研究種目 特定領域研究
研究分野
研究機関 東京医科歯科大学
代表研究者 橘 逸勢
研究分担者 稲澤 譲治
研究分担者 蒔田 芳男
連携研究者 蒔田 芳男
研究期間 開始年月日 2005/4/1
研究期間 終了年度 2009
研究ステータス 完了 (2009/4/1)
配分額（合計） 63,700,000 (直接経費 :63,700,000)
配分額（履歴） 2009年度：11,500,000 (直接経費 :11,500,000)
2008年度：11,500,000 (直接経費 :11,500,000)
2007年度：13,500,000 (直接経費 :13,500,000)
2006年度：13,600,000 (直接経費 :13,600,000)
2005年度：13,600,000 (直接経費 :13,600,000)
キーワード ヒトゲノム
アレイCGH
ゲノム構造異常
先天異常
染色体
ゲノム
アレイCGH法
BACアレイ
潜在的コピー数異常
Copy-number variation (CNV)
遺伝疾患
ゲノムコピー数異常
Copy number variation
ゲノム一次構造異常
癌

研究成果

[雑誌論文] Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.

Honda S, Orii KO, Kobayashi J, Hayashi S, Imamura A, Imoto I, Nakagawa E, Goto Y, Inazawa J. 2010

[雑誌論文] Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma.

Arai E, Ushijima S, Gotoh M, Ojima H, Kosuge T, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y. 2009

[図書] アレイCGH法による腫瘍の微細染色体コピー数異常の検出. 造血器腫瘍アトラス-形態, 免疫, 染色体と遺伝子-改訂第4版

井本逸勢, 稲澤譲治 2009

[雑誌論文] Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas.

Inoue J, Misawa A, Tanaka Y, Ichinose S, Sugino Y, Hosoi H, Sugimoto T, Imoto I, Inazawa J. 2009

[学会発表] Integrative genomics and epigenomics in cancer.

Imoto I 2009

[学会発表] がんの統合的ゲノム・エピゲノム解析.

井本逸勢、稲澤譲治 2009

[図書] 染色体と遺伝子の異常. 臨床病態学

井本逸勢 2009

[学会発表] Integrative genomics and epigenomics in cancer

Imoto I 2009

[雑誌論文] Heterozygous deletion at 14q22. 1-q22. 3 including the BMP4 gene in a patient with psychomotor petardation, congenital corneal opacity and feet polysyndactyly.

Hayashi S, Okamoto N, Makita Y, Hata A, Imoto I, Inazawa J. 2008

[雑誌論文] The CASK gene harbored in a deletion detected by array-CGH as a potential candidate for a gene causative of X-linked dominant mental retardation.

Hayashi S, Mizuno S, Migita O, Okuyama T, Makita Y, Hata A, Imoto I, Inazawa J. 2008

[図書] ゲノムコピー数変化(CNV), BACアレイを用いたアレイCGHと他のマイクロアレイとの比較. アレイCGH診断活用ガイドブック-知っておきたい染色体微細構造異常症-

井本逸勢 2008

[学会発表] ゲノムアレイプラットフォームを用いた遺伝疾患研究の進展と臨床応用.

井本逸勢、林深、本田尚三、稲澤譲治 2008

[学会発表] ゲノムアレイプラットフォームを用いた遺伝疾患研究の進展と臨床応用

井本逸勢 2008

[図書] アレイUGH診断活用ガイドブック(共著)

井本 逸勢 2007

[雑誌論文] Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma.

Tanaka K, Imoto I, Inoue J, Kozaki K, Tsuda H, Shimada Y, Aiko S, Yoshizumi Y, Iwai T, Kawano T, Inazawa J. 2007

[雑誌論文] A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.

Yu W, Imoto I, Inazawa J, et al. 2007

[学会発表] RGC32, a novel p53-inducible tumor-suppressor gene, is located on centrosomes during mitosis and results in G2/M arrest.

Imoto I, et. al. 2007

[雑誌論文] Fortuitous Detection of a Submicroscopic Deletion at 1q25 in a girl with Cornelia-de Lange syndrome carrying t(5;13)(p13. 1;q12. 1) by array-based comparative genomic hybridization.

Hayashi S, Ono M, Makita Y, Imoto I, Mizutani S, Inazawa J. 2007

[雑誌論文] Clinical and molecular cytogenetic characterization of two patients with non-mutational aberrations of the FMR2 gene.

Honda S, Hayashi S, Kato M, Niida I, Okuyama T, Imoto I, Mizutani S, Inazawa J. 2007

[雑誌論文] Construction of a high-density and high-resolution human chromosome X array for comparative genomic hybridization analysis.

Hayashi S, Honda S, Minaguchi M, Makita Y, Okamoto N, Kosaki R, Okuyama T, Imoto I, Mizutani S, Inazawa J. 2007

[雑誌論文] RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.

Saigusa K, Imoto I, Inazawa J, et al. 2007

[学会発表] Cancer genomic and epigenomic analyses on BAC-array platform.

井本逸勢、小崎健一、稲澤譲治 2007

[雑誌論文] 22q13 microduplication in two patients with common clinical manifestations: A recognizable syndrome?

Okamoto N, Kubota T, Nakamura Y, Murakami R, Nishikubo T, Tanaka I, Takahashi Y, Hayashi S, Imoto I, Inazawa J, Hosokai N, Kohsaka S, Uchino S. 2007

[雑誌論文] Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers.

Imoto I, Inazawa J, et al. 2006

[雑誌論文] Frequent silencing of the candidate tumor-suppressor PCDH20 by epigenetic mechanism in non-small cell lung cancers.

Imoto I, Izumi H, Yokoi S, Hosoda H, Shibata T, Hosoda F, Hirohashi S, Inazawa J. 2006

[学会発表] Detecting copy-number variation in the human genome using BAC-array based comparative genomic hybridization.

井本逸勢、林深、本田尚三、稲澤譲治 2006

[雑誌論文] Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.

Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N. 2006

[雑誌論文] Detection of cryptic chromosome aberrations in a patient with a balanced t(1;9)(p34. 2;p24) by array-based comparative genomic hybridization.

Hayashi S, Kurosawa K, Imoto I, Mizutani S, Inazawa J. 2005

[雑誌論文] Detection of cryptic chromosome aberrations in a patient with a balanced t(1;9) (p34.2;p24) by array-based comparative genomic hybridization.

Hayashi S, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.

Izumi H, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis.

Tanami H, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification.

Misawa A, Imoto I, Inazawa J, et al. 2005

[雑誌論文] ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation.

Takada H, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Saigusa K, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Construction of a High-density and High-resolution Human Chromosome X Array for Comparative Genomic Hybridization Analysis.

Hayashi S, Imoto I, Inazawa J, et al.

[雑誌論文] Clinical and molecular cytogenetic characterization of two patients with non-mutational aberrations of the FMR2 gene.

Honda S, Imoto I, Inazawa J, et al.

[雑誌論文] Fortuitous Detection of a Submicroscopic Deletion at 1q25 in a Girl With Cornelia-de Lange Syndrome Carrying t(5;13)(p13.1;q12.1) by Array-based Comparative Genomic Hybridization.

Hayashi S, Imoto I, Inazaw J, et al.

先天性異常症の染色体欠失の検出方法