研究成果

[雑誌論文] Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.

Yamada T, Matsumoto K, Wang W, Li Q, Nishioka Y, Sekido Y, Sone S, Yano S. 2010

[図書] がん分子標的治療研究実践マニュアル

曽根三郎, ら 2009

[学会発表] Lung cancer: Update from early diagnosis to molecular -targeted and individualized therapy.

Sone S, et al. 2009

[雑誌論文] Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors

Wang W, Li Q, Yamada T, Matsumoto K, Matsumoto I, Oda M, Watanabe G, Kayano Y, Nishioka Y, Sone S, Yano S. 2009

[雑誌論文] Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.

Kishuku M, Nishioka Y, Abe S, Kishi J, Ogino H, Aono Y, Azuma M, Kinoshita K, Rentsenh, B, Makino H, Ranjan P, Minakuchi K, Sone S. 2009

[雑誌論文] HM1. 24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1. 24 antibody.

Wang W, Nishioka Y, Ozaki S, Jalili A, Abe S, Kakiuchi S, Kishuku M, Minakuchi K, Matsumoto T, Sone S. 2009

[雑誌論文] Intensification therapy with anti-parathyroid hormonerelated protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice.

Yamada T, Muguruma H, Yano S, Ikuta K, Ogino H, Kakiuchi S, Hanibuchi M, Uehara H, Nishioka Y, Sone S. 2009

[雑誌論文] A Bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone2 in natural killer cell-depleted severe combined immunodeficient mice.

Otsuka S, Hanibuchi M, Ikuta K, Yano S, Goto H, Ogino H, Yamada T, Kakiuchi S, Nishioka Y, Takahashi T, Sone S. 2009

[雑誌論文] Chimeric and humanized anti-HM1. 24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancer cells.

Wang W, Nishioka Y, Ozaki S, Jalili A, Verma VK, Hanibushi M, Abe S, Minakuchi K, Matsumoto T, Sone S. 2009

[学会発表] Lung cancer : Update from early diagnosis to molecular-targeted and individualized therapy.

Saburo Sone, et al. 2009

[雑誌論文] E7080, a multi-tyrosine kinase inhibitor, suppresses the progression of malignant pleural mesothelioma with different proangiogenic cytokine production profiles.

Ikuta K, Yano S, Trung VT, Hanibuchi M, Goto H, Li Q, Wang W, Yamada T, Ogino H, Kakiuchi S, Uehara H, Sekido Y, Uenaka T, Nishioka Y, Sone S. 2009

[学会発表] Validation of Molecular -targeted Therapy in Bone Metastasis Models of Lung Cancer.

Sone S, et al. 2009

[図書] がん分子標的治療研究 実践マニュアル

曽根三郎, 他 2009

[学会発表] Multi-tyrosine kinase inhibitor.

西岡安彦 2009

[学会発表] ヒト肺癌多臓器転移モデルにおけるマルチキナーゼ阻害薬E7080の転移抑制効果.

西岡安彦, 他 2009

[学会発表] らヒト肺癌多臓器転移モデルにおけるマルチキナーゼ阻害薬E7080の転移抑制効果.

西岡安彦 2009

[雑誌論文] Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto M, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K. 2008

[雑誌論文] Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2.

Yamada T, Yano S, Ogino H, Ikuta K, Kakiuchi S, Hanibuchi M, Kanematsu T, Taniguchi T, Sekido Y, Sone S. 2008

[雑誌論文] Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations.

Yano S, Wang W, Li Q, Matsumoto K, Sakurama H, Nakmura T, Ogino H, Kakiuchi S, Hanibuchi M, Nishioka Y, Uehara H, Mitsudomi T, Yatabe Y, Nakamura T, Sone S. 2008

[学会発表] Molecular mechanism of malignant pleural mesothelioma progression and its therapeutic implication

Saburo Sone, et.al. 2008

[雑誌論文] Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement.

Ogino H, Yano S, Kakiuchi S, Yamada T, Ikuta K, Nakataki E, Goto H, Hanibuchi M, Nishioka Y, Ryan A, Sone S. 2008

[雑誌論文] Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice.

Ogino H, Yano S, Kakiuchi S, Muguruma H, Ikuta K, Hanibuchi M, Uehara H, Tsuchida K, Sugino H, Sone S. 2008

[学会発表] 分子標的治療

曽根三郎 2008

[学会発表] 呼吸器学-疾患モデルから分子標的治療への橋渡し研究-

曽根三郎 2008

[学会発表] 悪性胸膜中皮腫の制御に向けたトランスレーショナルリサーチ

曽根三郎ら 2008

[学会発表] 樹状細胞を用いた肺癌に対する免疫療法の現状と課題

西岡安彦ら 2008

[学会発表] 骨髄由来丘fibrocyteとPDGFシグナル

西岡安彦ら 2008

[学会発表] Novel therapeutic efficacy of E 7080 for controlling experimental metastases of human lung cancer cells in natural killer cell-depleted severe combined immunodeficient mice

Masaki Hanibuchi, et.al. 2008

[学会発表] 低分子化合物による肺がんの分子標的治療

埴淵昌毅ら 2008

[雑誌論文] CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages.

Nishioka Y, Manabe K, Kishi J, Wang W, Inayama M, Azuma M, Sone S. 2007

[雑誌論文] Molecular pathogenesis and its therapeutic modalities of lung cancer metastasis to bone.

Sone S, Yano S. 2007

[雑誌論文] The therapeutic efficacy of anti-vascular endothelial growth factor antibody, bevacizumab, and pemetrexed against orthotopically implanted human pleural mesothelioma cells in SCID mice.

Li Q, Yano S, Ogino H, Wang W, Uehara H, Nishioka Y, Sone S. 2007

[学会発表] Disease models to identify and validate molecular targets in lung cancer progression.

Sone S. 2007

[雑誌論文] Molecular pathogenesis and its therapeutic modalities of lung cancer metastasis to bone.

Sone, S., et. al. 2007

[学会発表] Disease models to identify and validate molecular targets in lung cancer progression.

Saburo Sone 2007

[学会発表] Induction of antibody-dependent cellular cytotoxicity by chimeric and humanized anti-HM1.24 (CD317) antibody against human lung cancercells.

Yasuhiko Nishioka 2007

[学会発表] Induction of antibody -dependent cellular cytotoxicity by chimeric and humanized anti-HM1. 24 (CD317) antibody against human lung cancer cells.

Nishioka Y. 2007

[雑誌論文] Autofluorescence bronchoscopy, a novel modality for the early detection of bronchial premalignant and malignant lesions.

Hanibuchi, N., et. al. 2007

[雑誌論文] Novel orthotopic implantation model of human malignant pleural mesothelioma (EHMES-10 cells) highly expressing vascular endothelial growth factor and its receptor.

Nakataki E, Yano S, Matsumori Y, Goto H, Kakiuchi S, Muguruma H, Bando Y, Uehara H, Hamada H, Kito E, Yokoyama A, Sone S. 2006

[雑誌論文] The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer.

Takahashi K, Furukawa C, Takano A, Ishikawa N, Kato T, Hayama S, Suzuki C, Yasui W, Inai K, Sone S, Ito T, Nishimura H, Tsuchiya E, Nakamura Y, Daigo Y. 2006

[学会発表] Critical determinants of organ specific lung cancer metastasis.

Sone S. 2006

[雑誌論文] ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model.

Matsumori Y, Yano S, Goto H, Nakataki E, Wedge SR, Ryan AJ, Sone S. 2006

[学会発表] HM1. 24 (CD317) is a novel immunological target against lung cancer: implication for immunotherapy using anti-HM1. 24 antibody.

Nishioka Y, et al. 2006

[雑誌論文] Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages.

Kuniyasu H, Yano S, Sasaki T, Sasahira T, Sone S, Ohmori H. 2005

[雑誌論文] Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity.

Muguruma H, Yano S, Kakiuchi S, Uehara H, Kawatani M, Osada H, Sone S. 2005

[雑誌論文] Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer.

Furukawa C, Daigo Y, Ishikawa N, Kato T, Ito T, Tsuchiya E, Sone S, Nakamura Y. 2005

[学会発表] 肺がん転移の悪性化要因に対する分子標的治療の展開

曽根三郎 2005

[雑誌論文] Antitumor vascular strategy for controlling experimental metastatic spread of human small-cell lung cancer cells with ZD6474 in natural killer cell-depleted severe combined immunodeficient mice.

Yano S, Muguruma H, Matsumori Y, Goto H, Nakataki E, Edakuni N, Tomimoto H, Kakiuchi S, Yamamoto A, Uehara H, Ryan A, Sone S. 2005