がんの統合的ゲノム解析と個性診断法の開発 - MATCI 産学連携支援マッチング情報システム

研究課題番号	KAKENHI-PROJECT-17015012
研究種目	特定領域研究
研究分野
研究機関	東京医科歯科大学
代表研究者	稲澤譲治
研究分担者	橘逸勢
研究分担者	小崎健一
研究分担者	横井左奈
研究期間開始年月日	2005/4/1
研究期間終了年度	2009
研究ステータス	完了 (2009/4/1)
配分額（合計）	116,500,000 (直接経費 :116,500,000)
配分額（履歴）	2009年度：23,200,000 (直接経費 :23,200,000) 2008年度：23,400,000 (直接経費 :23,400,000) 2007年度：23,400,000 (直接経費 :23,400,000) 2006年度：23,400,000 (直接経費 :23,400,000) 2005年度：23,100,000 (直接経費 :23,100,000)
キーワード	がんゲノムエピゲノムマイクロアレイがん遺伝子がん抑制遺伝子マイクロRNA CGH 個性診断分子標的治療 CGHアレイ DNAメチル化 GhIP法 BAMCA法アレイCGH ChIP法

[雑誌論文] Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous-cell carcinoma.

Haruki S, Imoto I, Kozaki K, Matsui T, Kawachi H, Komatsu S, Muramatsu T, Shimada Y, Kawano T, Inazawa J 2010

[雑誌論文] Overexpression of NF-kappaB inducing kinase underlies constitutive NF-kappaB activation in lung cancer cells.

Saitoh Y, Martinez Bruyn VJ, Uota S, Hasegawa A, Yamamoto N, Imoto I, Inazawa J, Yamaoka S 2010

[学会発表] 食道扁平上皮癌における新規診断・治療標的遺伝子SMYD2の同定.

小松周平、井本逸勢、津田均、小崎健一、嶋田裕、市川大輔、大辻英吾、稲澤譲治 2009

[学会発表] 肝細胞癌においてエピゲノムで制御されるがん抑制遺伝子の統合的アレイ解析.

松村聡、井本逸勢、小崎健一、有井滋樹、稲澤譲治 2009

[雑誌論文] miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma.

Furuta M, Kozaki K, Tanaka S, Arii S, Imoto I, Inazawa J 2009

[雑誌論文] Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance.

Yamamoto S, Tsuda H, Honda K, Onozato K, Takano M, Tamai S, Imoto I, Inazawa J, Yamada T, Matsubara O 2009

[学会発表] ゲノムワイドな統合的DNAメチル化異常解析による肝癌抑制遺伝子候補探索

井本逸勢、稲澤譲治, その他 2009

[学会発表] 1p13増幅領域の標的遺伝子tripartite motif 33(TRIM33)は乳癌の予後不良因子である.

横井左奈、津田均、井本逸勢、稲澤譲治 2009

[学会発表] 口腔扁平上皮癌における19q13. 12-q13. 2増幅の新規標的遺伝子PAK4.

ベガムアスマ、井本逸勢、小崎健一、津田均、鈴木江美奈、天笠光雄、稲澤譲治 2009

[雑誌論文] Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous-cell carcinoma.

Komatsu S, Imoto I, Tsuda H, Kozaki K, Muramatsu T, Shimada Y, Aiko S, Yoshizumi Y, Ichikawa D, Otsuji E, Inazawa J 2009

[学会発表] 肝細胞癌において腫瘍特異的DNA過剰メチル化により発現抑制される癌抑制microRNA.

古田繭子、小崎健一、田中真二、有井滋樹、井本逸勢、稲澤譲治 2009

[雑誌論文] Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage.

Nishiyama N, Arai E, Chihara Y, Fujimoto H, Hosoda F, Shibata T, Kondo T, Tsukamoto T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y 2009

[学会発表] ヒト癌におけるLC3A variant 1の発現低下の意義.

白樺、井上純、井本逸勢、稲澤譲治 2009

[図書] がん化学療法・分子標的治療update

(分担)井本逸勢、稲澤譲治 2009

[学会発表] ゲノムワイドな統合的dnaメチル化異常解析による肝癌抑制遺伝子候補探索.

井本逸勢、松村聡、小崎健一、有井滋樹、稲澤譲治 2009

[雑誌論文] Identification of PAK4 as a putative target gene for amplification within 19q13. 12-q13. 2 in oral squamous-cell carcinoma.

Begum A, Imoto I, Kozaki K, Tsuda H, Suzuki E, Amagasa T, Inazawa J 2009

[雑誌論文] Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome.

Arai E, Ushijima S, Fujimoto H, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y 2009

[学会発表] がんの統合的ゲノム・エピゲノム解析

井本逸勢、稲澤譲治 2009

[雑誌論文] Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas.

Inoue J, Misawa A, Tanaka Y, Ichinose S, Sugino Y, Hosoi H, Sugimoto T, Imoto I, Inazawa J 2009

[雑誌論文] Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma.

Arai E, Ushijima S, Gotoh M, Ojima H, Kosuge T, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y 2009

[学会発表] 子宮体癌細胞株の機能的スクリーニングを用いたエピゲノム異常により発現抑制される癌抑制遺伝子型microRNAの探索.

鶴田智彦、小崎健一、平沢晃、阪杢浩司、進伸幸、井本逸勢、青木大輔、稲澤譲治 2009

[学会発表] 食道扁平上皮癌において高頻度に発現抑制される癌関連抑制遺伝子DESC1の同定.

春木茂男、井本逸勢、小松周平、村松智輝、松井毅、小崎健一、河内洋、嶋田裕、河野辰幸、稲澤譲治 2009

[雑誌論文] SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.

Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K, Imamura T: 2009

[図書] 造血器腫瘍アトラス-形態、免疫、染色体と遺伝子-改訂第4版

(分担)阿部達生、稲澤譲治、井本逸勢、井上純 2009

[学会発表] 食道扁平上皮癌におけるYAP1とそのisoformの癌遺伝子としての機能.

村松智輝、井本逸勢、松井毅、小崎健一、津田均、嶋田裕、稲澤譲治 2009

[雑誌論文]

Nakamura Y, Migita T, Hosoda F, Okada N, Gotoh M, Arai Y, Fukushima M, Ohki M, Miyata S, Takeuchi K, Imoto I, Katai H, Yamaguchi T, Inazawa J, Hirohashi S, Ishikawa Y, Shibata T 2009

[雑誌論文] Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer.

Kubo T, Kuroda Y, Shimizu H, Kokubo A, Okada N, Hosoda F, Arai Y, Nakamura Y, Taniguchi H, Yanagihara K, Imoto I, Inazawa J, Hirohashi S, Shibata T 2009

[雑誌論文] ASK1 amd ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

Iriyama T, Takeda K, Nakamura H, Motimoto Y, Kuroiwa T, Mizukami J, Umeda T, Noguchi T, Naguro I, Nishitoh H, Saegusa K, Tobiume K, Homma T, Shimada Y, Tsuda H, Aiko S, Imoto I, Inazawa J, Chiba K, Kamei Y, Kozuma S, Taketani Y, Matsuzawa A, Ichijo H 2009

[雑誌論文] Molecular cloning of t(2;7)(p24. 3;p14. 2), a novel chromosomal translocation in myelodysplastic syndrome-derived acute myeloid leukemia.

Fujita K, Sanada M, Harada H, Mori H, Niikura H, Omine M, Inazawa J, Imoto I 2009

[学会発表] Identification of a novel amplification-target gene in oral squamous cell carcinoma (OSCC) using array-CGH-assisted strategy.

Begum A, Suzuki E, Nakamura E, Imoto I, Kozaki K, Tsuda H, Amagasa T, Inazawa J 2008

[学会発表] 高密度オリゴアレイCGHを用いた新規食道扁平上皮癌関連癌抑制遺伝子の探索.

春木茂男、小松周平、井本逸勢、小崎健一、嶋田裕、河野辰幸、稲澤譲治 2008

[学会発表] 肝細胞癌において腫瘍特異的DNA過剰メチル化により発現抑制される癌抑制microRNA.

古田繭子、小崎健一、田中真二、有井滋樹、井本逸勢、稲澤譲治 2008

[学会発表] Silencing of tumor-suppressive microRNAs by DNA hypermethylation in oral squamous cell carcinoma.

Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J 2008

[雑誌論文] Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue.

Qi S, Mogi S, Tsuda H, Tanaka Y, Kozaki K, Imoto I, Inazawa J, Hasegawa S, Omura K 2008

[学会発表] 肝細胞癌において腫瘍特異的DNA過剰メチル化により発現抑制される癌抑制microRNA.

古田繭子、小崎健一、田中真二、有井滋樹、井本逸勢、稲澤譲治 2008

[学会発表] 食道癌発生におけるYes-associated protein 1(YAP1)増幅の意義.

村松智輝、井本逸勢、津田均、嶋田裕、小崎健一、稲澤譲治 2008

[雑誌論文] Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes.

Katsuki Y, Nakada S, Yokoyama T, Imoto I, Inazawa J, Nagasawa M, Mizutani S 2008

[雑誌論文] Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy.

Tanaka S, Arii S, Yasen M, Moqushi K, Su NT, Zhao C, Imoto I, Eishi Y, Inazawa J, Miki Y, Tanaka H 2008

[学会発表] 神経芽腫細胞でのLAPTM5遺伝子強制発現により誘導される細胞死の特性.

井上純、井本逸勢、稲澤譲治 2008

[雑誌論文] Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization: its association with DNA methylation alteration and patient outcome.

Arai E, Ushijima S, Tsuda H, Fujimoto H, Hosoda F, Shibata T, Kondo T, Imoto I, Inazawa J, Hirohashi S, Kanai Y 2008

[学会発表] アレイCGHを用いた甲状腺未分化癌のゲノム構造解析による新規増幅領域20q11. 22の標的候補遺伝子ITCHの同定.

石原孝也、津田均、小崎健一、吉田明、伊藤公一、井本逸勢、稲澤譲治 2008

[学会発表] エピジェネティック異常により発現抑制される子宮体がん関連癌抑制遺伝子のMPA療法における役割

鶴田智彦、井本逸勢、平沢晃、小崎健一、阪埜浩司、進伸幸、青木大輔、稲澤譲治 2008

[雑誌論文] POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17.

Zhao C, Inoue J, Imoto I, Otsuki T, Iidab S, Ueda R, Inazawa J 2008

[雑誌論文] Frequent inactivation of a putative conditional tumor-suppressor gene, angiopoietin-like protein 2, in ovarian cancer.

Kikuchi R, Tsuda H, Kozaki K, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I 2008

[学会発表] X-tilingアレイを用いたX染色体上の癌関連遺伝子群の探索.

坂本宙子、横井左奈、井本逸勢、稲澤譲治 2008

[学会発表] PRTFDCl, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation

井本逸勢、稲澤譲治 2008

[雑誌論文] Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer.

Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J 2008

[学会発表] 自作BACアレイを用いた未分化甲状腺癌細胞株のコピー数異常解析により検出された新規増幅領域20q11. 22の標的遺伝子候補ITCH.

石原孝也、津田均、堀田晶子、小崎健一、吉田明、吉村弘、伊藤公一、井本逸勢、稲澤譲治 2008

[学会発表] ゲノム構造解析による食道扁平上皮癌の標的遺伝子探索

井本逸勢、稲澤譲治 2008

[雑誌論文] Frequent silencing of a putative tumor suppressor gene melatonin receptor 1A (MTNR1A) in oral squamous-cell carcinoma.

Nakamura E, Kozaki K, Tsuda H, Suzuki, E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I 2008

[学会発表] 肺小細胞癌における1p13増幅領域の標的候補遺伝子tripartite motif33(TRIM33)の解析

横井左奈、井本逸勢、柴田龍弘、北川昌伸、廣橋説雄、稲澤譲治 2008

[学会発表] アレイCGH法による肺小細胞癌の潜在的ゲノムコピー数解析と癌関連遺伝子の同定

横井左奈、井本逸勢、柴田龍弘、北川昌伸、廣橋説雄、稲澤譲治 2008

[学会発表] Identification of a novel amplification-target gene in oral squamous cell carcinoma (OSCC) using array-CGH strategy.

Asma Begum、鈴木江美奈、中村恵理奈、井本逸勢、小崎健一、津田均、天笠光雄、稲澤譲治 2008

[学会発表] ヒト癌におけるゲノム一次構造異常領域から同定された増幅標的癌遺伝子候補としてのdual specificity phosphatase

井本逸勢、稲澤譲治 2008

[学会発表] Frequent inactivation of a putative conditional tumor-suppressor gene TSOVC1 in ovarian cancer.

Kikuchi R, Imoto I, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J 2008

[学会発表] エピゲノム異常で発現抑制を受ける新規口腔、食道扁平上皮癌抑制遺伝子候補の同定

井本逸勢、井上純、稲澤譲治 2008

[学会発表] 口腔癌において腫瘍特異的DNA過剰メチル化により発現抑制される癌抑制microRNA:miR-137とmiR-193a

小崎健一、井本逸勢、茂木世紀、小村健、稲澤譲治 2008

[雑誌論文] Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas.

Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, Kosuge T, Umaki T, Onozato K, Shitashige M, Yamaguchi U, Ono M, Tsuchida A, Aoki T, Inazawa J, Hirohashi S, Yamada T 2008

[雑誌論文] Identification of SMURF1 as a possible target for 7q21. 3-22. 1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.

Suzuki A, Shibata T, Murakami Y, Horii A, Shiratori K, Hirohashi S, Inazawa J, Imoto I 2008

[雑誌論文] Overexpressed NF-{kappa}B inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.

Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez BVJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S 2008

[雑誌論文] ITCH is a putative target for a novel 20q11. 22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization.

Ishihara T, Tsuda H, Hotta A, Kozaki K, Yoshida A, Jaeduk Yoshimura Noh, Ito K, Imoto I, Inazawa J 2008

[学会発表] Inactivation of LC3A gene in human cancers.

白樺、井上純、井本逸勢、稲澤譲治 2008

[学会発表] 食道扁平上皮癌における新規診断治療標的遺伝子OESC1の同定.

小松周平、井本逸勢、津田均、小崎健一、松井毅、嶋田裕、市川大輔、大辻英吾、稲澤譲治 2008

[学会発表] 神経芽腫細胞でのLAPTM5遺伝子強制発現により誘導される細胞死の特性

井上純、井本逸勢、稲澤譲治 2008

[学会発表] ゲノムアレイプラットフォームを用いた遺伝疾患研究の進展と臨床応用

井本逸勢、林深、本田尚三、稲澤譲治 2008

[学会発表] 自作BACアレイを用いた未分化甲状腺癌細胞株のコピー数異常解析により検出された新規増幅領域20q11. 22の標的遺伝子候補ITCH.

石原孝也、津田均、堀田晶子、小崎健一、吉田明、吉村弘、伊藤公一、井本逸勢、稲澤譲治 2008

[学会発表] エピゲノム異常で発現抑制を受ける新規口腔、食道扁平上皮癌抑制遺伝子候補の同定

井本逸勢、井上純、稲澤譲治 2008

[学会発表] In-house BAC array-based copy-number analysis revealed novel cancer-related genes in Anaplastic thyroid cancer.

石原孝也、于衛、井上純、音田正光、江見充、井本逸勢、稲澤譲治 2007

[雑誌論文] Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.

Katoh H, Ojima H, Kokubu A, Saito S, Kondo T, Kosuge T, Hosoda F, Imoto I, Inazawa J, Hirohashi S, Shibata T 2007

[雑誌論文] The suppression of aurora-A/STK15/BTAK expression enhances chemosensitivity to docetaxel in human esophageal squamous cell carcinoma.

Tanaka E, Hashimoto Y, Ito T, Kondo K, Higashiyama M, Tsunoda S, Ortiz C, Sakai Y, Inazawa J, Shimada Y 2007

[学会発表] MicoroRNA expression profiles in oral squamous cell carcinoma cell lines.

Kozaki K, Imoto I, Inazawa J 2007

[学会発表] CTGF is a tumor-suppressor gene frequently inactivated by promoter hypermethylation in ovarian cancer.

菊池良子、井本逸勢、津田均、金井弥栄、笠松高弘、千石一雄、広橋説雄、稲澤譲治 2007

[学会発表] Epigenetic silencing of TSOC25 by hypermethylation of the CpG island in oral cancer.

中村恵理奈、鈴木江美奈、中川貴之、津田均、山本剛、入江太朗、小崎健一、井本逸勢、立川哲彦、天笠光雄、稲澤譲治 2007

[学会発表] Exploration of cancer-related genes on X chromosome using X-tilling array-based copy-number analysis in human cancer.

坂本宙子、横井左奈、井本逸勢、稲澤譲治 2007

[雑誌論文] Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome.

Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, Ohki M, Inazawa J, Hirohashi S 2007

[雑誌論文] PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.

Suzuki E, Imoto I, Pimkhaokham A, Nakagawa T, Kamata N, Kozaki K, Amagasa T, Inazawa J 2007

[学会発表] 口腔扁平上皮癌においてDNAメチル化により発現抑制される癌抑制microRNAの単離

小崎健一、井本逸勢、茂木世紀、小村健、稲澤譲治 2007

[雑誌論文] Association of KLK5- overexpression with invasiveness of urinary bladder carcinoma cells.

Shinoda Y, Kozaki K, Imoto I, Obara W, Tsuda H, Mizutani Y, Shuin T, Fujioka T, Miki T, Inazawa J 2007

[学会発表] BAMCA(BAC-array based MCA)法による多発性骨髄腫DNAメチル化領域の網羅的探索.

中村紋子、横井左奈、井上純、井本逸勢、稲澤譲治 2007

[雑誌論文] Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma.

Tanaka K, Imoto I, Inoue J, Kozaki K, Tsuda H, Shimada Y, Aiko S, Yoshizumi Y, Iwai T, Kawano T, Inazawa J 2007

[学会発表] Long-range chromosomal interactions regulate the expression of novel E2F1 target gene.

横井左奈、井上純、井本逸勢、稲澤譲治 2007

[雑誌論文] Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation.

Kawanishi H, Takahashi T, Ito M, Matsui Y, Watanabe J, Ito N, Kamoto T, Kadowaki T, Tsujimoto G, Imoto I, Inazawa J, Nishiyama H, Ogawa O 2007

[雑誌論文] Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.

Kikuchi R, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I 2007

[学会発表] Cancer genomic and epigenomic analyses on a BAC-array platform.

井本逸勢、稲澤譲治 2007

[雑誌論文] RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.

Saigusa K, Imoto I, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J 2007

[図書] 最新医学 62巻増刊号臨床遺伝学

井本逸勢、稲澤譲治 2007

[学会発表] ChiP on BAC-arrayにより見出したE2F1標的遺伝子のクロマチン構造による転写制御.

横井左奈、井上純、井本逸勢、稲澤譲治 2007

[雑誌論文] Partial tandem duplication of GRIA3 in a male with mental retardation.

Chiyonobu T, Hayashi S, Kobayashi K, Morimoto M, Miyanomae Y, Nishimura A, Nishimoto A, Ito C, Imoto I, Sugimoto T, Jia Z, Inazawa J, Toda T 2007

[学会発表] A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.

Ishihara T, Yu W, Inoue J, Onda M, Emi M, Imoto I, Inazawa J 2007

[学会発表] Epigenetic silencing of TSOC25 by hypermethylation of the CpG island in oral cancer.

Nakamura E, Suzuki E, Nakagawa T, Tsuda H, Yamamoto G, Kozaki K, Irie T, Tachikawa T, Amagasa T, Imoto I, Inazawa J 2007

[学会発表] Inactivation of LC3A gene in human cancers.

井上純、井本逸勢、稲澤譲治 2007

[学会発表] Detection of aberrantly methylated genes in hepatocellulara carcinoma by BACarray based MCA(BAMCA)strategy.

趙晨、井本逸勢、井上純、田中信治、有井滋樹、田中博、稲澤譲治 2007

[学会発表] BCL2L2 is a probable target for novel 14q11. 2 amplification detected in a non-small cell lung cancer cell line.

河崎勉、横井左奈、和泉宏幸、井本逸勢、吉澤靖之、稲澤譲治 2007

[学会発表] Association of KLK5-overexpression with invasiveness of urinary bladder carcinoma cells.

篠田康夫、小崎健一、井本逸勢、執印太郎、藤岡知昭、三木恒治、稲澤譲治 2007

[図書] 細胞工学

井本逸勢、稲澤譲治 2007

[雑誌論文] Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas.

Sugino Y, Misawa A, Inoue J, Kitagawa M, Hosoi H, Sugimoto T, Imoto I, Inazawa J 2007

[雑誌論文] BCL2L2 is a probable target for novel 14q11. 2 amplification detected in a non-small cell lung cancer cell line.

Kawasaki T, Yokoi S, Tsuda H, Izumi H, Kozaki k, Aida S, Ozeki Y, Yoshizawa Y, Imoto I, Inazawa J 2007

[学会発表] RGC32, a novel p53-inducible tumor-suppressor gene, is located on centrosomes during mitosis and results in G2/M arrest.

Imoto I, Saigusa K, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J 2007

[雑誌論文] Non-incidental coamplification of Myc and ERBB2, and Myc and EGFR, in gastric adenocarcinomas.

Mitsui F, Dobashi Y, Imoto I, Inazawa J, Kono K, Fujii H, Ooi A 2007

[学会発表] Epigenetic silenciong of prostaglandin E receptor 2 is associated with progression of neuroblastmas.

杉野由里子、三沢あき子、井上純、北川正信、細井創、井本逸勢、杉本徹、稲澤譲治 2007

[雑誌論文] Multiplex PCR/Liquid chromatography assay for screening of subtelomeric rearrangements.

Udaka T, Imoto I, Aizu Y, Torii C, Izumi K, Kosaki R, Takahashi T, Hayashi S, Inazawa J, Kosaki K 2007

[学会発表] TSOVC2 is a putative conditional tumor-suppressor gene frequently inactivated by promoter hypermethylation in ovarian cancer.

Kikuchi R, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I 2007

[学会発表] Identigication of tumor suppressor microRNA silenced by DNA methylation in oral squamous cell carcinoma.

小崎健一、井本逸勢、茂木世紀、小村健、稲澤譲治 2007

[学会発表] Identification of tumor suppressor microRNA silenced by DNA methylation in oral squamous cell carcinoma.

Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J 2007

[学会発表] Identification of novel amplification-taeget genes in oral squamous cell carcinoma using array-CGH-assisted strategy.

Begum Asma、鈴木江美奈、中村恵理奈、井本逸勢、小崎健一、津田均、天笠光雄、稲澤譲治 2007

[学会発表] アレイCGH法による微細染色体異常症解析の評価

会津善紀、井本逸勢、林深、山口敏和、宮本力、稲澤譲治 2007

[学会発表] Frequent methylationassociated silencing of candidate tumor-suppressor, CRABP1 in esophageal squamous-cell carcinoma.

田中浩司、井本逸勢、井上純、小崎健一、津田均、嶋田裕、河野辰幸、岩井武尚、稲澤譲治 2007

[学会発表] RGC32, a novel p53-inducible tumor-suppressor gene, is located on centrosomes during mitosis and results in G2/M arrest.

Imoto I, Inazawa J, et. al. 2007

[学会発表] Cancer genomic and epigenomic analyses on BAC-array platform

井本逸勢、小崎健一、稲澤譲治 2007

[学会発表] Methylation-associated gene silencing of prostaglandin D2 receptor (PTGDR) and prostaglandin E receptor 2 (PTGER2) in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification (BAMCA).

Sugino Y, Inoue J, Misawa A, Hosoi H, Sugimoto T, Imoto I, Inazawa J 2006

[雑誌論文] Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers. Cancer Res.

Imoto I, Inazawa J, et al. 2006

[学会発表] Freeman Sheldon症候群におけるMYH3遺伝子の変異解析

井上奈都子、林深、井本逸勢、岡本伸彦、水野誠司、大山紀美栄、稲澤譲治 2006

[雑誌論文] Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers.

Imoto I, Izumi H, Yokoi S, Hosoda H, Shibata T, Hosoda F, Ohki M, Hirohashi S, Inazawa J 2006

[学会発表] Methylation-associated silencing of NR1I2 in advanced-type neuroblastomas, identified by BAC array-based methylated CpG island amplification (BAMCA).

Inoue J, Misawa A, Sugino Y, Hosoi H, Sugimoto T, Hosoda F, Ohki M, Imoto I, Inazawa J 2006

[学会発表] Identification of novel E2F1 target genes detected on a BAC-array platform.

Yokoi S, Inoue J, Imoto I, Inazawa J 2006

[学会発表] Detecting copy-number variation in the human genome using BAC-array based comparative genomic hybridization.

Imoto I, Hayashi S, Honda S, Inazawa J 2006

[学会発表] 口腔扁平上皮癌におけるPIK3CA遺伝子変異

小崎健一、長谷川正午、津田均、Atiphan Pimkhaokham、井本逸勢、小村健、稲澤譲治 2006

[学会発表] PIK3CA mutations in oral squamous cell carcinoma.

Kozaki K, Suzuki E, Pimkhaokham A, Imoto I, Inazawa J 2006

[雑誌論文] A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.

Yu W, Imoto I, Inoue J, Onda M, Emi M, Inazawa J 2006

[学会発表] 高密度ゲノムアレイにより発見された肺癌関連遺伝子候補の解析

河崎勉、横井左奈、和泉宏幸、井本逸勢、吉澤靖之、稲澤譲治 2006

[学会発表] 高精度ゲノムアレイを用いた甲状腺未分化癌関連遺伝子の解析.

石原孝也、于衛、井本逸勢、音田正光、江見充、稲澤譲治 2006

[学会発表] DNAメチル化により発現制御をうける新規口腔癌関連遺伝子候補TSOC10の解析.

鈴木江美奈、井本逸勢、井上純、中川貴之、Atiphan Pimkhaokham、細田文恵、大木操、天笠光雄、稲澤譲治 2006

[学会発表] Detection of altered DNA methylation patterns in oral cancer.

Nakagawa T, Yokoi S, Inoue J, Atiphan Pimkhaokham, Suzuki E, Kamata N, Omura K, Imoto I, Inazawa J 2006

[学会発表] BAC arrayを用いたエピゲノム解析

井上純、三沢あき子、横井左奈、中川貴之、杉野由里子、細井創、杉本徹、井本逸勢、稲澤譲治 2006

[雑誌論文] Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma.

Nakagawa T, Pimkhaokham A, Suzuki E, Omura K, Inazawa J, Imoto I 2006

[雑誌論文] The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase.

Kumada K, Yao R, Kawaguchi T, Karasawa M, Hoshikawa Y, Ichikawa K, Sugitani Y, Imoto I, Inazawa J, Sugawara M, Yanagida M, Noda T 2006

[学会発表] In house BACアレイを用いた癌のゲノム構造・機能異常解析からの分子標的探索.

井本逸勢、稲澤譲治 2006

[学会発表] Exploration of molecular targets based on the genomic and epigenomic characterization of human cancers using in-house BAC array system.

井本逸勢、稲澤譲治 2006

[学会発表] Array-CGH detecting Human Genome Variation in Japan.

Imoto I, Hayashi S, Honda S, Inazawa J 2006

[学会発表] 胃癌に認められる超低密度リポタンパク質受容体VLDLR発現抑制機序と意義.

高田久、井本逸勢、津田均、中西幸浩、阪倉長平、光藤章二、岡上武、広橋説雄、稲澤譲治 2006

[雑誌論文] Genomic loss and epigenetic silencing of very low density lipoprotein receptor involved in gastric carcinogenesis.

Takada H, Imoto I, Tsuda H, Nakanishi Y, Sakakura C, Mitsufuji S, Hirohashi S, Inazawa J 2006

[学会発表] 多発性骨髄腫細胞株で検出された11q23増幅の標的遺伝子候補POU2AF1のTNFRSF17転写制御を介する腫瘍細胞増殖促進作用.

趙晨、井上純、大槻剛巳、井本逸勢、稲澤譲治 2006

[雑誌論文] Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations.

Nakada S, Katsuki Y, Imoto I, Yokoyama T, Nagasawa M, Inazawa J, Mizutani S 2006

[学会発表] BAMCA(BAC array-based MCA)法による神経芽細胞腫抑制遺伝子PTGDRおよびPTGER2の同定

杉野由里子、井上純、降旗あき子、北川昌伸、細井創、井本逸勢、杉本徹、稲澤譲治 2006

[学会発表] 神経芽腫の自然退縮におけるLAPTM5遺伝子活性化の意義.

井上純、三沢あき子、杉野由里子、細井創、杉本徹、井本逸勢、稲澤譲治 2006

[学会発表] X-tilingアレイを用いたX染色体上の癌関連遺伝子群の探索.

坂本宙子、横井左奈、井本逸勢、稲澤譲治 2006

[学会発表] Frequent Silencing of the Candidate Tumor-suppressor PCDH20 by Epigenetic Mechanism in Non-Small Cell Lung Cancers.

Imoto I, Izumi H, Takada H, Tanaka K, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hosoda F, Ohki M, Hirohashi S, Inazawa J 2006

[学会発表] アレイCGH法による卵巣癌の潜在的ゲノムコピー数異常解析と癌関連遺伝子の同定.

菊池良子、井本逸勢、津田均、千石一雄、石川睦男、金井弥栄、広橋説雄、稲澤譲治 2006

[学会発表] Methylation-associated silencing of a candidate tumor suppression gene, TSEC1, in esophageal squamous-cell carcinoma, identified by bacterial artificial chromosome array-based methylated CpG island amplification (BAMCA).

Tanaka K, Imoto I, Inoue J, Tsuda H, Suzuki E, Shimada Y, Kawano T, Iwai T, Inazawa J: 2006

[学会発表] アレイCGH法による染色体解析.

井本逸勢 2006

[学会発表] BAMCA(BAC array-based methylated CpG island amplification)法による食道扁平上皮癌新規癌抑制遺伝子候補TSEC1の同定.

田中浩司、井本逸勢、井上純、津田均、嶋田裕、河野辰幸、岩井武尚、稲澤譲治 2006

[学会発表] ChIP on BAC array法を用いた新規E2F1標的遺伝子の解析.

横井左奈、井上純、井本逸勢、稲澤譲治 2006

[学会発表] In-house BACアレイを用いた癌のゲノム構造・機能異常解析からの分子標的探索.

井本逸勢、稲澤譲治 2006

[学会発表] 高密度・高精度ゲノムアレイにより発見された新規膀胱癌関連遺伝子の解析

篠田康夫、小崎健一、井本逸勢、藤岡知昭、執印太郎、三木恒治、稲澤譲治 2006

[学会発表] Exploration of molecular targets based on genomic copy-number aberrations in human cancers.

井本逸勢、稲澤譲治 2006

[学会発表] 口腔癌のアレイCGH解析により検出した新規ホモ欠失領域の標的癌関連遺伝子候補の解析.

中村恵理奈、鈴木江美奈、中川貴之、山本剛、入江太郎、小崎健一、井本逸勢、立川哲彦、天笠光雄、稲澤譲治 2006

[雑誌論文] PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.

Kozaki K, Imoto I, Pimkhaokham A, Hasegawa S, Tsuda H, Omura K, Inazawa J 2006

[学会発表] 口腔癌におけるBAC-arrayを用いたDNAメチル化領域の網羅的探索.

中川貴之、横井左奈、井上純、鈴木江美奈、Atiphan Pimkhaokham、鎌田伸之、小村健、井本逸勢、稲澤譲治 2006

[学会発表] 神経芽腫における1p35-p36候補癌抑制遺伝子TSNB1のエピゲノム解析.

井上純、降旗あき子、杉野由里子、細井創、杉本徹、井本逸勢、稲澤譲治 2005

[雑誌論文] The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma.

Tanaka E, Hashimoto Y, Ito T, Okumura T, Kan T, Watanabe G, Imamura M, Inazawa J, Shimada Y 2005

[学会発表] 高密度CGHマイクロアレイにより発見された新規肺癌抑制遺伝子候補の解析

和泉宏幸、井本逸勢、井上純、横井左奈、高橋隆、細田文恵、大木操、稲澤譲治 2005

[学会発表] 高密度・高精度ゲノムアレイにより発見された新規口腔癌関連遺伝子候補の解析

鈴木江美奈、井本逸勢、井上純、中川貴之、Atiphan Pimkhaokham、細田文恵、大木操、天笠光雄、稲澤譲治 2005

[学会発表] 口腔癌におけるBAC-arrayを用いたDNAメチル化領域の網羅的探索.

中川貴之、横井左奈、井上純、鈴木江美奈、Atiphan Pimkhaokham、鎌田伸之、小村健、井本逸勢、稲澤譲治 2005

[学会発表] Identification of novel gastrointestinal cancer-related genes through bacterial artificial chromosome (BAC)-array based analyses of cancer genome.

Imoto I, Inazawa J 2005

[学会発表] 染色体検査の補完・代替法としてのCGHアレイ法の実用化

会津善紀、林深、井本逸勢、宮本力、稲澤譲治 2005

[学会発表] Frequent Silencing of DBC1 is by Genetic or Epigenetic Mechanisms in Non-Small Cell Lung Cancers.

Imoto I, Izumi H, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hirohashi S, Inazawa J 2005

[雑誌論文] Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Takada H, Imoto I, Tsuda H, Sonoda I, Ichikura T, Mochizuki H, Okanoue T, Inazawa J 2005

[学会発表] X-tilingアレイの構築および同アレイによる癌におけるX染色体コピー数異常領域の探索

坂本宙子、水口真希、横井左奈、和泉宏幸、井本逸勢、稲澤譲治 2005

[学会発表] 高精度ゲノムアレイを用いた子宮内発育遅延児の潜在的ゲノム異常の解析.

小崎里華、奥山虎之、林深、井本逸勢、稲澤譲治 2005

[学会発表] BAMCA法とCHIP on chip法を用いた膵癌の異常メチル化領域の網羅的探索

鈴木文香、横井左奈、井上純、堀井明、白鳥敬子、井本逸勢、稲澤譲治 2005

[雑誌論文] Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: Identification of genetic indicators to predict patient outcome.

Katoh H, Shibata T, Kokubo A, Ojima H, Loukopoulos P, Kanai Y, Kosuge T, Fukayama M, Kondo T, Sakamoto M, Hosoda F, Ohki M, Imoto I, Inazawa J, Hirohashi S 2005

[学会発表] ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation.

Imoto I, Takada H, Tsuda H, Nakanishi Y, Ichikura T, Mochizuki H, Hosoda F, Hirohashi S, Ohki M, Inazawa J 2005

[雑誌論文] Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung.

Peng WX, Shibata T, Katoh H, Kokubu A, Matsuno Y, Asamura H, Tsuchiya R, Kanai Y, Hosoda F, Sakiyama T, Ohki M, Imoto I, Inazawa J, Hirohashi S 2005

[学会発表] 多発性骨髄腫におけるB細胞特異的転写共役因子BOB1増幅による活性化

趙晨、井上純、大槻剛巳、井本逸勢、稲澤譲治 2005

[学会発表] CGHマイクロアレイで診断された22q13. 3欠失例と重複例

岡本伸彦、中村豊、村上龍助、林深、井本逸勢、稲澤譲治 2005

[学会発表] Characterization of TSGL1, a candidate tumor suppressor gene for glioma frequently silenced by CpG island methylation, identified from 13q deletion lesion detected CGH-array analysis.

Saigusa K, Imoto I, Inoue J, Aoyagi M, Ohno O, Inazawa J 2005

[雑誌論文] Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Saigusa K, Hashimoto N, Tsuda H, Yokoi S, Maruno M, Yoshimine T, Aoyagi M, Ohno K, Imoto I, Inazawa J 2005

[学会発表] ゲノムアレイを用いた固形腫瘍の潜在的ゲノム異常解析からの新規癌関連遺伝子の同定

井本逸勢、稲澤譲治 2005

[学会発表] 高密度CGHアレイにより検出された新規胃癌抑制遺伝子候補の解析.

高田久、井本逸勢、津田均、中西幸浩、細田文恵、広橋説雄、大木操、稲澤譲治 2005

[学会発表] ヒトグリオーマ高頻度13q欠失領域から同定した新規癌抑制遺伝子候補TSGL1.

三枝邦康、井本逸勢、井上純、青柳傑、大野喜久郎、稲澤譲治 2005

[学会発表] CGHアレイによる卵巣癌の網羅的ゲノム解析

菊池良子、井本逸勢、千石一雄、石川睦男、稲澤譲治 2005

[学会発表] High-throughput screening of methylated DNA sequences at 1p35-p36 in neuroblastoma by using BAC array-based MCA method (BAMCA).

Inoue J, Misawa-Furihata A, Hosoi H, Sugimoto T, Imoto I, Inazawa J: 2005

[雑誌論文] Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16.

Kuroda H, Moritake H, Sawada K, Kuwahara Y, Imoto I, Inazawa J, Sugimoto T 2005

[雑誌論文] Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome arraybased methylated CpG island amplification.

Misawa A, Inoue J, Sugino Y, Hosoi H, Sugimoto T, Hosoda F, Ohki M, Imoto I, Inazawa J 2005

[学会発表] Epigenetic silencing of MCG22 by hypermethylation of the CpG island in gastric cancer.

Takada H, Imoto I, Tsuda H, Shibata T, Okanoue T, Hosoda F, Hirohashi S, Ohki M, Inazawa J 2005

[学会発表] 消化器癌の潜在的ゲノム異常の解析と新規癌関連遺伝子の同定.

井本逸勢、稲澤譲治 2005

[学会発表] 卵巣癌における染色体1q21-q22領域の増幅とPDZ domain containing1(PDZK1)遺伝子発現の意義

工藤一弥、井上純、高野政志、藤井和之、佐々木直樹、喜多恒和、菊池義公、井本逸勢、稲澤譲治 2005

[学会発表] BAMCA(BAC array-based MCA)法を用いた新規癌抑制遺伝子候補TSGL1.

杉野由里子、井上純、降旗あき子、細井創、杉本徹、井本逸勢、稲澤譲治 2005

[雑誌論文] Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features.

Shibata T, Uryu S, Kokubu A, Hosoda F, Ohki M, Sakiyama T, Matsuno Y, Tsuchiya R, Kanai Y, Kondo T, Imoto I, Inazawa J, Hirohashi S 2005

[雑誌論文] Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome- wide copy-number analysis.

Tanami H, Tsuda H, Okabe S, Iwai T, Sugihara K, Imoto I, Inazawa J 2005

[雑誌論文] Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.

Izumi H, Inoue J, Yokoi S, Hosoda H, Shibata T, Sunamori M, Hirohashi S, Inazawa J, Imoto I 2005

[学会発表] 甲状腺未分化がんの新規癌遺伝子NATA1の同定と機能解析.

干衛、井本逸勢、音田正光、江見充、稲澤譲治 2005

[学会発表] Establishment of "ChIP on chip" exploring of novel E2F1 target genes on a BAC-array platform.

Yokoi S, Inoue J, Imoto I, Inazawa J 2005

[雑誌論文] Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas.

Tanimoto T, Tsuda H, Imazeki N, Ohno Y, Imoto I, Inazawa J, Matsubara O 2005

[学会発表] CGHアレイ法による新規の膀胱癌関連遺伝子の探索.

篠田康夫、井本逸勢、三木恒治、稲澤譲治 2005

[雑誌論文] ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation.

Takada H, Imoto I, Tsuda H, Nakanishi Y, Ichikura T, Mochizuki H, Mitsufuji S, Hosoda F, Hirohashi S, Ohki M, Inazawa J 2005

[学会発表] BAMCA(BAC-array based MCA)法による食道癌DNAメチル化領域の網羅的探索.

田中浩司、井本逸勢、井上純、鈴木江美奈、横井左奈、嶋田裕、河野辰幸、岩井武尚、稲澤譲治 2005

[雑誌論文] DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung.

Shibata T, Kokubu A, Miyamoto M, Hosoda F, Gotoh M, Tsuta K, Asamura H, Matsuno Y, Kondo T, Imoto I, Inazawa J, Hirohashi S

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