研究成果

[雑誌論文] Insulin-Induced Ectodomain Shedding of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Adipocytes In Vitro.

Yamamoto T, Suganami T, Kiso-Narita M, Scherle PA, Kamei Y, Isobe M, Higashiyama S, Ogawa Y. 2010

[雑誌論文] Novel monoclonal antibodies recognizing the active conformation of epidermal growth factor receptor.

Ise N, Omi K, Miwa K, Honda H, Higashiyama S, Goishi K. 2010

[雑誌論文] Induction of striatal neurogenesis and generation of region-specific functional mature neurons after ischemia by growth factors.

Yoshikawa G, Momiyama T, Oya S, Takai K, Tanaka JI, Higashiyama S, Saito N, Kirino T, Kawahara N. 2010

[雑誌論文] Activation of epidermal growth factor receptor gene is involved in transforming growth factor-beta-mediated fibronectin expression in a chondrocyte progenitor cell line.

Takeda H, Inoue H, Kutsuna T, Matsushita N, Takahashi T, Watanabe S, Higashiyama S, Yamamoto H. 2010

[雑誌論文] Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells.

Akino Y, Teshima T, Kihara A, Kodera-Suzumoto Y, Inaoka M, Higashiyama S, Furusawa Y, Matsuura N 2009

[雑誌論文] Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection.

Schirrmeister W, Gnad T, Wex T, Higashiyama S, Wolke C, Iaumann M, Lendeckel U. 2009

[学会発表] A zinc finger transcription factor regulates vascular sprouting through the downregulation of Notch signaling in vascular endothelial cells.

Hidetaka Ohnuki, Hirofumi Inoue, Hironao Nakayama, Shinji Fukuda, Shigeki Higashiyama 2009

[雑誌論文] Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.

Myers TJ, Brennaman LH, Stevenson M, Higashiyama S, Russell WE, Lee DC, Sunnarborg SW 2009

[学会発表] 膜型増殖因子のEctodomain Shedding-分子機構から生理機能まで

東山繁樹 2009

[雑誌論文] Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice.

Oyagi A, Oida Y, Kakefuda K, Shimazawa M, Shioda N, Moriguchi S, Kitaichi K, Nanba D, Yamaguchi K, Furuta Y, Fukunaga K, Higashiyama S, Hara H 2009

[雑誌論文] Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation : involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands.

Uchiyama K, Saito M, Sasaki M, Obara Y, Higashiyama S, Nakahata N 2009

[雑誌論文] Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.

Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD, Williams BR 2009

[雑誌論文] BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers.

Hirata Y, Ogasawara N, Sasaki M, Mizushima T, Shimura T, Mizoshita T, Mori Y, Kubota E, Wada T, Tanida S, Kataoka H, Kamiya T, Higashiyama S, Joh T 2009

[雑誌論文] Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.

Uetani T, Inoue H, Higashiyama S 2009

[学会発表] Inner nuclear membrane targetmg of membrane anchored growth factors and transcriptional regulation (Invited)

Shigeki Higashiyama 2009

[雑誌論文] Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.

Myers TJ, Higashiyama S 2009

[学会発表] Nuclear signaling of membrane-anchored growth factors and cell growth regulation (Invited)

Shigeki Higashiyama 2009

[雑誌論文] Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.

Uetani T, Nakayama H, Okayama H, Okura T, Higaki J, Inoue H, Higashiyama S. 2009

[学会発表] A zine finger transcnption factorregulates vascular sproutmg hough the down egulaion of Notch signaling in vascular endothelial cells

Hidetaka Ohnuki, Shigeki Higashiyama, et.al. 2009

[学会発表] Inner nuclear membrane translocation and nuclear signaling of membrane-anchored growth factors

Shigeki Higashiyama 2009

[学会発表] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation (Invited).

Shigeki Higashiyama 2009

[雑誌論文] Localisation of endothelin B receptor variants to plasma membrane microdomains and its effects on downstream signalling.

Grossmann S, Higashiyama S, Oksche A, Schaefer M, Tannert A 2009

[雑誌論文] Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.

Xu D, Higashiyama S 2009

[学会発表] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation

Shigeki Higashiyama 2009

[雑誌論文] Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor.

Ozaki N, Ohmuraya M, Hirota M, Ida S, Wang J, Takamori H, Higashiyama S, Baba H, Yamamura K. 2009

[雑誌論文] Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice.

Oyagi A, Higashiyama S 2009

[雑誌論文] Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury.

Oya S, Yoshikawa G, Takai K, Tanaka JI, Higashiyama S, Saito N, Kirino T, Kawahara N. 2009

[学会発表] 膜型増殖因子EGFファミリー分子は細胞膜から核膜へ局在変化する

檜枝美紀、東山繁樹(他1名) 2008

[雑誌論文] Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane.

Hieda M, Higashiyama S 2008

[学会発表] 膜型填殖因子amphiregulinの細胞内輪送経路およびその解析

礒兼真由美、東山繁樹 (他2名) 2008

[雑誌論文] An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression.

Nanba D, Inoue H, Higashiyama S 2008

[学会発表] Plasma membrane anchored growth factors HB EGF and amphmegulm targeted to the inner nuclear membrane and regulate gene expression

Maynmi Isokane, Shigeki Higashiyama, et.al. 2008

[雑誌論文] Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands.

Higashiyama S 2008

[雑誌論文] Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription.

Isokane M, Hieda M, Higashiyama S 2008

[雑誌論文] he carboxyl-terminal fragment of pro-HB-EGF reverses Bcl6-mediated gene repression.

Kinugasa Y, Hieda M, Hori M, Higashiyama S 2007

[学会発表] Amphiregulin overexpressed in Oral Squamous Cell Carcinoma cell lines accumulates at the inner nuclear membrane.

Mayumi Isokane, Shigeki Higashiyama, et. al. 2007

[学会発表] Molecular target therapy for gastric cancer. suppression of proHb-EGF carboxy-terminal fragment nuclear translocation,

Takaya Shimura, Shigeki Higashiyama, et. al. 2007

[学会発表] The carboxy-terminal fragment of proHB-EGF reverses Bc16-mediated gene expression.

Yumi Kinugasa, Shigeki Higashiyama, et. al. 2007

[雑誌論文] The carboxy-terminal fragment of proHB-EGF reverses Bcl6-mediated gene expression.

Kinugasa, Y., Hieda, M., Hori, M., Higashiyama, S. 2007

[雑誌論文] Pbx1 is a major target of PLZF-mediated melanoma cell growth suppression.

Shiraishi, K., Yamasaki, K., Nanba, D., Inoue, H., Hanakawa, Y., Shirakata, Y., Hashimoto, K., Higashiyama, S. 2007

[学会発表] Membrane-anchored growth factor, HB-EGF targets to the nuclear membrane and regulates gene expression

Miki Hieda, Shigeki Higashiyama, etc. 2007

[学会発表] Membrane-anchored growth factor amphiregulin translocates to the inner nuclear memberane via retrograde membrane trafficking.

Mayumi Isokane, Shigeki Higashiyama, etc. 2007

[学会発表] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression

Miki Hieda and Shigeki Higashiyama 2007

[学会発表] Sheddingフィールド形成因子同定と増殖因子シグナル制御機構

中山寛尚、井上博文、東山繁樹 2007

[学会発表] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression

Miki Hieda and Shigeki Higashiyama 2007

[学会発表] Membrane-anchored growth factor amphiregulin translocates to the inner nuclear membrane via retrograde membrane trafficking.

Mayumi Isokane, Shigeki Higashiyama, et. al. 2007

[学会発表] 増殖因子切断による心筋細胞死誘導制御の解析

上谷晃由、井上博文、大蔵隆文、檜垣實夫、東山繁樹 2007

[雑誌論文] Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression.

Shiraishi K, Inoue H, Higashiyama S 2007

[雑誌論文] Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart valve malformation and cardiac hypertrophy.

Nanba, D., Kinugasa, Y., Morimoto, C., Koizumi, M., Yamamutra, H., Takahashi, K., Takakura, N., Mekada, E., Hashimoto, K., Higashiyama, S. 2006

[雑誌論文] Activity-dependent shedding of heparin-binding EGF-like growth factor in brain neurons.

Shishido, Y., Tanaka, T., Piao, Y.S., Araki, K., Takei, N., Higashiyama, S., Nawa H. 2006

[雑誌論文] PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation.

Kikugawa, T., Kinugasa, Y., Shiraishi, K., Nanba, D., Nakashiro K., Tanji, N., Yokoyama, M., Higashiyama, S. 2006

[図書] 細胞増殖因子と再生医療

松本邦夫, 田畑泰彦, 東山繁樹 他 2006

新規ユビキチンリガーゼ及びその利用法

新規ユビキチンチガーゼ複合体及びその利用法

血管新生制御剤, 及びそのスクリーニング方法、並びにスクリーニング用キット