トップ研究者を探すMorphometrical and quantitative transcriptome analyses of C-C chemokine receptor 5 in functional structure of osteoclasts

Morphometrical and quantitative transcriptome analyses of C-C chemokine receptor 5 in functional structure of osteoclasts

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16K20412
研究種目 若手研究(B)
研究分野 生物系
医歯薬学
歯学
形態系基礎歯科学
研究機関 愛媛大学
代表研究者 李 智媛
研究協力者 飯村 忠浩
研究期間 開始年月日 2016/4/1
研究期間 終了年度 2018
研究ステータス 完了 (2018/4/1)
配分額(合計) 3,900,000 (直接経費 :3,000,000、間接経費 :900,000)
配分額(履歴) 2017年度:1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
2016年度:1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード osteoclast
osteoblast
chemokine receptor 5
bone metabolism
chemokine
bone
CCR5
RANKL
chemokine receptor
RNA-sequence
histomorphometry

研究成果

[雑誌論文] 骨組織の顕微鏡研究

飯村 忠浩、李 智媛 2018

[雑誌論文] テリパラチドの高頻度投与は皮質骨空隙形成を誘導する

高倉 綾、李 智媛、 山根 宏志、高尾 亮子、飯村 忠浩 2018

[雑誌論文] PV1, a novel Plasmodium falciparum merozoite dense granule protein, interacts with exported protein in infected erythrocytes.

Morita Masayuki、Nagaoka Hikaru、Ntege Edward H.、Kanoi Bernard N.、Ito Daisuke、Nakata Takahiro、Lee Ji-Won、Tokunaga Kazuaki、Iimura Tadahiro、Torii Motomi、Tsuboi Takafumi、Takashima Eizo 2018

[学会発表] The HIV co-receptor CCR5 regulates cellular pathways required for osteoclast function

Lee JW 2018

[学会発表] HIV, co-receptor, CCR5 plays an essential role in bone-destructive conditions through the functional regulation of osteoclast

Lee JW 2018

[学会発表] The HIV co-receptor CCR5 regulates cellular pathways required for osteoclast function

Lee JW 2018

[学会発表] CCR5, a therapeutic target of HIV infection, is required for osteoclast differentiation and function, suggesting a skeletal merit of the CCR5 targeting HIV therapy.

Lee JW 2018

[学会発表] CCR5 is required for osteoclast function through regulating lysosomal vesicle trafficking

LEe JW, Iami Y, Iimura T 2018

[学会発表] HIV治療薬標的分子CCR5の破骨細胞機能分化における必須の機能-CCR5を標的としたHIV治療は骨吸収性疾患に対してもメリットをもたらす可能性がある-

李 智媛、飯村 忠浩 2017

[雑誌論文] Journal of Oral Biosciences

Tadahiro Iimura, Ji-Won Lee 2017

[雑誌論文] Shedding quantitative fluorescence light on novel regulatory mechanisms in skeletal biomedicine and biodentistry.

Lee JW, Iimura T 2017

[雑誌論文] Bone Research

Aya Tanaka, Ji-Won Lee, Kyoko Hirano, Yukihiro Isogai, Toshinori Ishizuya, Rhoko Takao-Kawabata, Tadahiro Iimura 2017

[学会発表] Novel regulatory mechanisms of osteoclast function, as revealed by combinatorial approaches of functional live-imaging and molecular omics

Lee JW 2017

[雑誌論文] Japanse Dental Science Review

Ji-Won Lee, Tadahiro Iimura 2017

[学会発表] Requirement of CCR5, a co-receptor of HIV, for the functional cellular architecture of osteoclasts, providing experimental evidences for the direct association between loss of CCR5 and resistance to bone loss

Lee JW, Inoue K, Uehara S, Kobayashi Y, Imai Y, Iimura T 2017

[学会発表] Role of chemokine-mediated signaling in architectural function of osteoclasts

Ji-Won Lee 2016

[学会発表] Novel regulatory mechanisms of osteoclast function, as revealed by combinatorial approaches of functional live-imaging and molecular comics

Ji-Won Lee 2016

[学会発表] C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal is required for architectural function of osteoclasts, thus for RANKL-induced bone destruction

Ji-Won Lee, Akiyoshi Hoshino, Yasuhiro Kobayashi, Shunsuke Uehara, Yuuki Imai, Tadahiro Iimura 2016

[学会発表] Unveiling novel regulatory mechanisms of osteoclasts by integrative approaches of bio-imaging and molecular comics

Ji-Won Lee 2016

[学会発表] Essential roles of C-C chemokine-mediated signaling in mature osteoclast function

Ji-Won Lee, Akiyoshi Hoshino, Yasuhiro Kobayashi, Shunsuke Uehara, Yuuki Imai, Tadahiro Iimura 2016

[学会発表] C-C chemokine receptor 5, a co-receptor of HIV, -mediated signal is required for geometric architecture and function of osteoclasts, thus for RANKL-induced bone destruction

Ji-Won Lee, Akiyoshi Hoshino, Kazuki Inoue, Shunsuke Uehara, Yasuhiro Kobayashi, Satoshi Ueha, Kouji Matsushima, Akira Yamaguchi, Yuuki Imai, Tadahiro Iimura 2016

[学会発表] Essential role of C-C chemokine-mediated signaling in mature osteoclast function

Ji-Won Lee 2016

[学会発表] 機能的生細胞イメージングとオミックス解析による破骨細胞調節機能の解明

Ji-Won Lee 2016