3種類のPNPLA3遺伝子改変マウスを用いたNASH発症病態の解明

トップ›研究者を探す›3種類のPNPLA3遺伝子改変マウスを用いたNASH発症病態の解明

代表研究者	越智経浩
研究課題番号	KAKENHI-PROJECT-16K19351
研究種目	若手研究(B)
研究分野	生物系医歯薬学内科系臨床医学消化器内科学
研究機関	高知大学
研究期間開始年月日	2016/4/1
研究期間終了年度	2018
研究ステータス	完了 (2018/4/1)
配分額（合計）	3,770,000 (直接経費 :2,900,000、間接経費 :870,000)
配分額（履歴）	2018年度：650,000 (直接経費 :500,000、間接経費 :150,000) 2017年度：1,040,000 (直接経費 :800,000、間接経費 :240,000) 2016年度：2,080,000 (直接経費 :1,600,000、間接経費 :480,000)
キーワード	NASH PNPLA3 PNPLA3 mutation XBP-1 肝臓学

研究成果

[学会発表] EVALUATION OF IMPAIRED FATTY ACID OXIDATION CAPACITY BY DYNAMIC LIVER SCINTIGRAPHY WITH 1231-BMIPP IS IMPORTANT IN THE DEVELOPMENT OF NONALCOHOLIC FATTY LIVER DISEASE IN NON-OBESE PATIENTS

Yamamoto S, Ono M, Masuda K, Nagano S, Yano Y, Kitagawa T, Hashiba M, Ochi T, Munekage K, Hirose A, Mizuta H, Saibara T 2018

[雑誌論文] Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS

Ochi T, Kawaguchi T, Nakahara T, Ono M, Noguchi S, Koshiyama Y, Munekage K, Murakami E, Hiramatsu A, Ogasawara M, Hirose A, Mizuta H, Masuda K, Okamoto N, Suganuma N, Chayama K, Yamaguchi M, Torimura T, Saibara T 2017

[雑誌論文] High fasting insulin concentrations may be a pivotal predictor for the severity of hepatic fibrosis beyond the glycemic status in non-alcoholic fatty liver disease patients before development of diabetes mellitus．

Masuda K，Noguchi S，Ono M，Ochi T，Munekage K，Okamoto N，Suganuma N，Saibara T 2017

[学会発表] Involvement of PNPLA3 function for hepatic lipids metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice

Nagano S，Ono M，Ochi T，Munekage K，Yano Y，Mizuta H，Ogasawara M，Hirose A，Nozalki Y，Okamoto N，Iwasaki S，Jude A ObenT，Saibara T 2017

[学会発表] Functional roles of AGE-RAGE system for the development of hepatic fibrosis of NASH

Ono M，Munekage K，Ochi T，Hirose A，Ogasawara M，Okamoto N，Saibara T 2017

[図書] 消化器疾患最新の治療2017-2018

越智経浩／西原利治 2017

[学会発表] INVOLVEMENT OF AGE-RAGE SYSTEM FOR THE DEVEL-OPMENT OF HEPATIC FIBROSIS IN NASH

Munegage K，Ono M，Ochi T，Ogasawara M，Hirose A，Fujimura Y ，Iwasaki S，Saibara T 2016

[図書] Mebio

越智経浩／小野正文／西原利治 2016

[学会発表] PNPLA3 IS INVOLVED IN HEPATIC LIPIDS METABOLISM THROUGH XBP1 AND MODUALATION OF ENDOPLASMIC RETICULUM SYRESS IN MICE

Ono M，Ochi T，Munegage K，Ogasawara M，Hirose A，Nozaki-Fujimura Y，Okamoto N， Iwasaki S，Oben J，Saibara T 2016