研究成果

[雑誌論文] β3-Adrenoceptors in the normal and diseased urinary bladder - what are the open questions?

Igawa Yasuhiko、Aizawa Naoki、Michel Martin C. 2019

[雑誌論文] Age-related changes in function and gene expression of the male and female mouse bladder

Kamei Jun、Ito Hiroki、Aizawa Naoki、Hotta Harumi、Kojima Toshio、Fujita Yasunori、Ito Masafumi、Homma Yukio、Igawa Yasuhiko 2018

[学会発表] RQ-00434739, a novel TRPM8 antagonist, inhibits prostaglandin-E2-induced hyperactivity of the primary bladder afferent nerves in rats.

Aizawa N, Ohshiro H, Watanabe S, Homma Y, Igawa Y. 2018

[学会発表] Preoperative ultrasound-guided pelvic floor muscle training promotes early recovery of urinary continence after robot assisted radical prostatectomy.

Yoshida M, Matsunaga A, Fujimura T, Shinoda Y, Niimi A, Aizawa N, Homma Y, Sanada H, Igawa Y. 2017

[雑誌論文] Characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction

Aizawa Naoki、Ichihara Koji、Fukuhara Hiroshi、Fujimura Tetsuya、Andersson Karl-Erik、Homma Yukio、Igawa Yasuhiko 2017

[雑誌論文] Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis

Niimi Aya、Igawa Yasuhiko、Aizawa Naoki、Honma Toshiki、Nomiya Akira、Akiyama Yoshiyuki、Kamei Jun、Fujimura Tetsuya、Fukuhara Hiroshi、Homma Yukio 2017

[学会発表] KPR-2579, a novel TRPM8 antagonist, inhibits hyperactivity of the primary bladder afferent nerves induced by acetic acid in rats

Aizawa N, Fujimori Y, Kobayashi J,Nakanishi O,Hirasawa H, Homma Y, Igawa Y 2017

[学会発表] Effects of tadalafil, a PDE type 5 inhibitor, on the bladder mechanosensitive afferent activities related to microcontractions in male rats with bladder outlet obstruction.

Aizawa N, Fukuhara H, Fujimura T, Homma Y, Igawa Y 2017

[雑誌論文] Toll-like receptor 7 is overexpressed in the bladder of Hunner-type interstitial cystitis, and its activation in the mouse bladder can induce cystitis and bladder pain

Ichihara Koji、Aizawa Naoki、Akiyama Yoshiyuki、Kamei Jun、Masumori Naoya、Andersson Karl-Erik、Homma Yukio、Igawa Yasuhiko 2017

[雑誌論文] Incontinence: How do β3-adrenoceptor agonists work in the bladder?

Igawa Yasuhiko、Aizawa Naoki 2017

[学会発表] Functional role of Transient Receptor Potential Melastatin 8 (TRPM8) channel in the rat urinary bladder assessed by using a novel potent antagonist.

Aizawa N, Ohshiro H, Watanabe S, Homma Y, Igawa Y. 2017

[学会発表] KPR-2579, a novel TRPM8 antagonist, inhibits acetic-acid-induced bladder hyperactivity via mechanosensitive afferent C-fibers in rats.

Aizawa N, Fujimori Y, Kobayashi J, Nakanishi O, Hirasawa H, Homma Y, Igawa Y. 2017

[雑誌論文] Pathophysiology of the underactive bladder.

Aizawa N, Igawa Y 2017

[学会発表] 前立腺全摘出術後の尿失禁重症度と骨盤底の形態・機能の関係：症例検討

吉田美香子、松永明子、藤村哲也、篠田裕介、新美文彩、亀井潤、相澤直樹、井川靖彦、本間之夫、真田弘美 2016

[学会発表] 雄性下部尿路閉塞ラットの膀胱微小収縮に同期した膀胱伸展受容一次求心性神経活動におよぼすシロドシンとイミダフェナシンの作用

相澤直樹、本間之夫、井川靖彦 2016

[学会発表] Ageing-related bladder dysfunction in mice: do they demonstrate detrusor hyperactivity with impaired contractility?

Jun Kamei、Hiroki Ito、Naoki Aizawa、Yoshiyuki Akiyama、Koji Ichihara、Harumi Hotta、Toshio Kojima、Yasunori Fujita、Masafumi Ito、Tetsuya Fujimura、Hiroshi Fukuhara、Yukio Homma、Yasuhiko Igawa 2016

[学会発表] Frequent expansion of clonal B-cells suggestive of specific immune responses in Hunner type interstitial cystitis.

Akiyama Y, Maeda D, Morikawa T, Niimi A, Nomiya A, Yamada Y, Kamei J, Aizawa N, Igawa Y, Fukayama M, Homma Y 2016

[学会発表] 前立腺全摘術患者における超音波検査装置を用いた骨盤底リハビリテーションのフィージビリティ検討

松永明子、吉田美香子、藤村哲也、篠田裕介、新美文彩、亀井潤、相澤直樹、真田弘美、芳賀信彦、井川靖彦、本間之夫 2016

[学会発表] 頻尿を伴う炎症性膀胱痛に対するTransient receptor potential (TRP) M2およびTRPA1チャネルの役割：ノックアウトマウスを用いたLPS膀胱内注入による検討

亀井潤、相澤直樹、中川貴之、秋山佳之、金子周司、本間之夫、井川靖彦 2016

[学会発表] GUANYLATE CYCLASE AND P2X PURINOCEPTOR SIGNALLING PATHWAYS CONTRIBUTE TO UROTHELIUM-DERIVED INHIBITION OF ΒADRENOCEPTOR-MEDIATED RELAXATION IN HUMAN DETRUSOR SMOOTH MUSCLE.

Kamei J, Aizawa N,Akiyama Y,Fujimura T, Fukuhara H, Homma Y,Igawa Y 2016

[学会発表] EFFECTS OF SILODOSIN AND IMIDAFENACIN ON THE BLADDER MECHANOSENSITIVE AFFERENT ACTIVITIES OF A-DELTA- AND CFIBERS RELATED WITH MICROCONTRACTIONS IN MALE RATS WITH BLADDER OUTLET OBSTRUCTION.

Aizawa N, Fukuhara H, Fujimura T, Homma Y,Igawa Y 2016

[学会発表] TRANSIENT RECEPTOR POTENTIAL MELASTATIN 2 (TRPM2) MEDIATES LIPOPOLYSACCHARIDE (LPS)-INDUCED INFRAMMATORY BLADDER PAIN AND FREQUENT VOIDING IN MICE.

Kamei J, Aizawa N,Nakagawa T, Akiyama Y, Kaneko S, Homma Y,Igawa Y 2016