トップ研究者を探す血漿マイクロRNAを用いた大腸癌肝転移Precision Medicineの構築

血漿マイクロRNAを用いた大腸癌肝転移Precision Medicineの構築

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16K10573
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
消化器外科学
研究機関 岡山大学
代表研究者 楳田 祐三
研究分担者 藤原 俊義
研究分担者 八木 孝仁
研究分担者 永坂 岳司
研究協力者 藤 智和
研究協力者 母里 淑子
研究協力者 安井 和也
研究期間 開始年月日 2016/4/1
研究期間 終了年度 2018
研究ステータス 完了 (2018/4/1)
配分額(合計) 4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額(履歴) 2018年度:910,000 (直接経費 :700,000、間接経費 :210,000)
2017年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2016年度:2,340,000 (直接経費 :1,800,000、間接経費 :540,000)
キーワード Precision medicine
大腸癌肝転移
Liquid Biopsy
マイクロRNA
Liquid biopsy
Precision Medicine
遺伝子解析

研究成果

[雑誌論文] Comparison of outcomes between symptomatic and asymptomatic patients with colorectal cancer: a propensity score-matched analysis of surgical invasiveness, medical costs and oncological outcomes.

Inada R, Nagasaka T, Watanabe A, Yagi T, Mori Y, Kondo Y, Kishimoto H, Umeda Y, Fujiwara T. 2018

[学会発表] De novo Malignancies after Liver Transplantation and a proposal for establishment of cancer screening

Yoshida K, Umeda Y, Yoshida R, Nobuoka D, Kuise T, Yasui K, Takaki A, Fujiwara T, Yagi T 2018

[学会発表] Prediction of salvage liver transplantation for hepatocellular carcinoma recurrence: when and for which patient should we decide transplant?

Umeda Y, Yagi T, Yoshida R, Nobuoka D, Kuise T, Yoshida K, Yasui K, Shirakawa Y, Fujiwara T 2018

[雑誌論文] A subclinical high tricuspid regurgitation pressure gradient independent of the mean pulmonary artery pressure is a risk factor for the survival after living donor liver transplantation.

Saragai Y, Takaki A, Umeda Y, Matsusaki T, Yasunaka T, Oyama A, Kaku R, Nakamura K, Yoshida R, Nobuoka D, Kuise T, Takagi K, Adachi T, Wada N, Takeuchi Y, Koike K, Ikeda F, Onishi H, Shiraha H, Nakamura S, Morimatsu H, Ito H, Fujiwara T, Yagi T, Okada H. 2018

[雑誌論文] The Outcome of Complex Hepato-Pancreato-Biliary Surgery for Elderly Patients: A Propensity Score Matching Analysis.

Takagi K, Umeda Y, Yoshida R, Nobuoka D, Kuise T, Fushimi T, Fujiwara T, Yagi T. 2018

[学会発表] 肝切除における血清アルブミン動態 -アルブミン製剤至適投与に向けて臨床指標を再考する-

吉田一博, 楳田祐三, 吉田龍一, 信岡大輔, 杭瀬 崇, 安井和也, 香川俊輔, 白川靖博, 八木孝仁, 藤原俊義 2018

[雑誌論文] Comparison of success rates in eye drop instillation between sitting position and supine position.

Naito T, Yoshikawa K, Namiguchi K, Mizoue S, Shiraishi A, Ichikawa Y, Fujiwara M, Miki T, Araki R, Umeda Y, Morizane Y, Shiraga F. 2018

[雑誌論文] Effect of an enhanced recovery after surgery protocol in patients undergoing pancreaticoduodenectomy: A randomized controlled trial.

Takagi K, Yoshida R, Yagi T, Umeda Y, Nobuoka D, Kuise T, Hinotsu S, Matsusaki T, Morimatsu H, Eguchi J, Wada J, Senda M, Fujiwara T. 2018

[雑誌論文] Clinical outcomes of women with ovarian metastases of colorectal cancer treated with oophorectomy with respect to their somatic mutation profiles.

Mori Y, Nyuya A, Yasui K, Toshima T, Kawai T, Taniguchi F, Kimura K, Inada R, Nishizaki M, Haraga J, Nakamura K, Umeda Y, Kishimoto H, Fujiwara T, Katata Y, Yamaguchi Y, Nagasaka T. 2018

[雑誌論文] Long-term Remission of Hepatitis-associated Aplastic Anemia Possibly due to Immunosuppressive Therapy after Liver Transplantation

Kanamitsu K, Chayama K, Washio K, Yoshida R, Umeda Y, Yagi T, Shimada A. 2018

[学会発表] Minimum requirement of Pancreatoduodenectomy for certified expert HBP surgeon: surgical outcome of 387 cases and the learning curve analysis

Yoshida K, Umeda Y, Yoshida R, Nobuoka D, Kuise T, Yasui K, Konishi D, Okabayashi H, Yagi T, Fujiwara T 2018

[学会発表] 大腸癌多発肝転移に対する治療戦略 -遺伝子変異解析を踏まえた術前化学療法の適応選別-

楳田祐三, 八木孝仁, 吉田龍一, 信岡大輔, 杭瀬 崇, 吉田一博, 安井和也, 香川俊輔, 白川靖博, 藤原俊義 2018

[学会発表] 大腸癌における新規 oncogenic small nucleolar RNA (oncSNOR) の探求

吉田一博, 重安邦俊, 楳田祐三, 吉田龍一, 信岡大輔, 杭瀬 崇, 安井和也, 香川俊輔, 白川靖博, 八木孝仁, Goel A, 藤原俊義 2018

[雑誌論文] Prognostic Factors for Pediatric Living Donor Liver Transplantation: Impact of Zero-mortality Transplant for Cholestatic Diseases

Morikawa T, Inada R, Nagasaka T, Mori Y, Kishimoto H, Kawai T, Umeda Y, Mishima H, Goel A, Fujiwara T. 2018

[学会発表] 大腸癌多発肝転移に対する肝切除~多回肝切除と化学療法を見据えたParenchymal sparing & skeletonized hepatectomy~

楳田祐三, 八木孝仁, 永坂岳司, 吉田龍一, 信岡大輔, 杭瀬 崇, 伏見卓郎, 香川俊輔, 白川靖博, 藤原俊義 2018

[学会発表] Liquid Biopsy has a potential to predict the colorectal cancer patients with destiny for recurrence after curative surgery

Toshima T, Nyuya A, Umeda Y, Yasui K, Yoshida K, Fujiwara T, Goel A, Nagasaka T 2018

[学会発表] 大腸癌多発肝転移におけるRAS/RAF変異の意義~生物学的悪性度から術前化学療法適応を見極める~

楳田祐三, 八木孝仁, 永坂岳司, 吉田龍一, 信岡大輔, 母里淑子, 杭瀬 崇, 高木弘誠, 河合 毅, 藤原俊義 2017

[学会発表] Gene expression signatures in BRAF V600E mutant colorectal cancer in relation to WNT signaling cascade

Yasui K, Nagasaka T, Nyuya A, Toshima T, Kawai T, Shigeyasu K, Yano S, Mori Y, Haraga J, Nakamura K, Umeda Y, Goel A, Fujiwara T 2017

[学会発表] Surgical outcomes of living donor liver surgery: technical knack for zero morbidity

Kuise T, Umeda Y, Yoshida R, Nobuoka D, Kumano K, Koujima T, Takagi K, Fujiwara T, Yagi T 2017

[学会発表] Gene expression profiles in BRAF V600E mutant colorectal cancer and association with SFRP2 methylation status

Yasui K, Nagasaka T, ToshimaT, Kawai T, Shigeyasu K, Mori Y, Haraga J, Nakamura K, Umeda Y, Tazawa H, Goel A, Fujiwara T 2017

[学会発表] 遺伝子変異情報に基づいた大腸癌肝転移の治療戦略―原発巣の左右局在とRAS/RAF 変異の意義―

楳田祐三, 永坂岳司, 母里淑子, 吉田龍一, 信岡大輔, 杭瀬 崇, 藤 智和, 河合 毅, 荒木宏之, 八木孝仁, 藤原俊義 2017

[学会発表] Prediction of salvage liver transplantation for hcc recurrence: when and which patient should we decide transplant?

Umeda Y, Yagi T, Yoshida R, Nobuoka D, Kuise T, Kumano K, Koujima T, Takagi K, Nagasaka T, Fujiwara T 2017

[学会発表] A novel circulating cell free DNA-based assay can predict tumor response to systematic chemotherapy

Toshima T, Nagasaka T, Mori Y, Kawai T, Yasui K, Fuji T, Taniguchi F, Kimura K, Kishimoto H, Umeda Y, Goel A, Fujiwara T 2017

[学会発表] StageIV大腸癌に対するPrecision Medicineの構築

河合 毅, 永坂岳司, 母里淑子, 楳田祐三, 稲田 涼, 谷口文崇, 安井和也, 戸嶋俊明, 岸本浩行, 藤原俊義 2017

[学会発表] Efficacious use of Tolvaptan for refractory ascites and hyponatremia in perioperative management in liver transplantation

Kuise T, Umeda Y, Yoshida R, Nobuoka D, Kumano K, Koujima T, Takagi K, Fujiwara T, Yagi T 2017

[学会発表] Clinical significance of radical lymphadenectomy for intrahepatic cholangiocarcinoma - analysis based on tumor location and recurrence pattern -

Kuise T, Umeda Y, Yoshida R, Nobuoka D, Kumano K, Koujima T, Takagi K, Araki H, Kajioka H, Fujiwara T, Yagi T 2017

[雑誌論文] Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Liver Transplantation

Takagi K, Yagi T, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Watanabe N, Kuise T, Fuji T, Araki H, Fujiwara T. 2017

[学会発表] Heterogenity of epigenetic and EMT marks observed in hepatocellular carcinoma with keratin 19 proficiency

Nagasaka T, Okada T, Yokomichi N, Taniguchi F, Toshima T, Yasui K, Fuji T, Mori Y, Kawai T, Umeda Y, Yagi T, Fujiwara T, Goel A 2017

[雑誌論文] Radiographic sarcopenia predicts postoperative infectious complications in patients undergoing pancreaticoduodenectomy.

Takagi K, Yoshida R, Yagi T, Umeda Y, Nobuoka D, Kuise T, Fujiwara T. 2017

[学会発表] Surgical approach to cirrhotic patients with hepatocellular carcinoma: splenectomy ameliorates liver function which could expand the chance of hepatectomy

Koujima T, Umeda Y, Watanabe N, Yoshida R, Nobuoka D, Kuise T, Kumano K, Takagi K, Araki H, Fujiwara T, Yagi T 2017

[学会発表] Hepatectomy for multiple colorectal liver metastasis - precise tumor removal and parenchymal sparing -

Kajioka H, Umeda Y, Yoshida R, Nagasaka T, Nobuoka D, Kuise T, Koujima T, Kumano K, Araki H, Fujiwara T, Yagi T 2017

[学会発表] Ovarian metastasectomy in colorectal cancer may improve the clinical outcomes of patients with metastatic colorectal cancer regardless of BRAF or KRAS mutational profiles

Mori Y, Nagasaka T, Tanioka H, Nyuya A, Kawai T, Toshima T, Yasui K, Shigeyasu K, Kishimoto H, Umeda Y, Fujiwara T 2017

[雑誌論文] Preoperative Controlling Nutritional Status (CONUT) Score for Assessment of Prognosis Following Hepatectomy for Hepatocellular Carcinoma.

Takagi K, Yagi T, Umeda Y, Shinoura S, Yoshida R, Nobuoka D, Kuise T, Araki H, Fujiwara T. 2017

[学会発表] 切除不能進行再発大腸がんの2次治療以降における Ramcirumab + FOLFIRI 療法の治療成績

永坂岳司, 母里淑子, 重安邦俊, 河合 毅, 矢野修也, 岸本浩行, 楳田祐三, 山口佳之, 藤原俊義 2017

[学会発表] Preoperative proximal splenic artery embolization: alternative portal modulation for prophylaxis of small-for-size syndrome

Umeda Y, Yagi T, Yoshida R, Nobuoka D, Kuise T, Kumano K, Koujima T, Takagi K, Nagasaka T, Fujiwara T 2017

[雑誌論文] Phase II clinical trial of peptide cocktail therapy for patients with advanced pancreatic cancer: VENUS-PC study.

Suzuki N, Hazama S, Iguchi H, Uesugi K, Tanaka H, Hirakawa K, Aruga A, Hatori T, Ishizaki H, Umeda Y, Fujiwara T, Ikemoto T, Shimada M, Yoshimatsu K, Shimizu R, Hayashi H, Sakata K, Takenouchi H, Matsui H, Shindo Y, Iida M, Koki Y, Arima H, Furukawa H, Ueno T, Yoshino S, Nakamura Y, Oka M, Nagano H. 2017

[雑誌論文] Living Donor Liver Transplantation for Acute Liver Failure : Comparing Guidelines on the Prediction of Liver Transplantation.

Yoshida K, Umeda Y, Takaki A, Nagasaka T, Yoshida R, Nobuoka D, Kuise T, Takagi K, Yasunaka T, Okada H, Yagi T, Fujiwara T. 2017

[学会発表] 安全で正確な系統的肝切除の実践に向けて:Knack & Pitfalls

楳田祐三, 八木孝仁, 吉田龍一, 信岡大輔, 杭瀬 崇, 國府島 健, 伏見卓郎, 香川俊輔, 白川靖博, 藤原俊義 2017

[学会発表] テロメラーゼ標的蛍光発現ウィルスを用いた腹腔内遊離膵癌細胞診断技術の開発

吉田龍一, 桒田和也, 楳田祐三, 信岡大輔, 杭瀬 崇, 國府島 健, 熊野健二郎, 伏見卓郎, 香川俊輔, 八木孝仁, 藤原俊義 2017

[学会発表] Is poor outcome of living donor liver transplantation for primary sclerosing cholangitis the nature of the disease itself or insufficient immunosuppression?

Yagi T, Nobuoka D, Umeda Y, Yoshida R, Kuise T, Takagi K, Kumano K, Fujiwara T 2017

[雑誌論文] Early Chimerism After Liver Transplantation Reflects the Clinical Course of Recurrent Hepatitis C.

Utsumi M, Takaki A, Umeda Y, Koike K, Napier SC, Watanabe N, Shinoura S, Yoshida R, Nobuoka D, Yasunaka T, Oto T, Araki M, Yamamoto K, Fujiwara T, Yagi T. 2017

[学会発表] 局所進行直腸癌に対する術前化学療法の有用性

母里淑子, 永坂岳司, 河合 毅, 重安邦俊, 矢野修也, 近藤喜太, 楳田祐三, 岸本浩行, 藤原俊義 2017

[雑誌論文] Primary pancreatic-type acinar cell carcinoma of the jejunum with tumor thrombus extending into the mesenteric venous system: a case report and literature review.

Takagi K, Yagi T, Tanaka T, Umeda Y, Yoshida R, Nobuoka D, Kuise T, Fujiwara T. 2017

[学会発表] Radical distal pancreatectomy with en block celiac axis resection and retroperitoneal dissection for advanced pancreatic cancer

Umeda Y, Yagi T, Yoshida R, Nobuoka D, Kuise T, Koujima T, Kumano K, Takagi K, Araki H, Kajioka H, Fujiwara T 2017

[雑誌論文] A novel intestinal rotation method for digestive reconstruction after combined pancreaticoduodenectomy and extended right hemicolectomy: A case report and surgical technique.

Takagi K, Yagi T, Umeda Y, Yoshida R, Nobuoka D, Kuise T, Kumano K, Kojima T, Fushimi T, Fujiwara T. 2017

[学会発表] Prediction of salvage liver transplantation for hepatocellular carcinoma recurrence: when and for which patient should we decide transplant?

Fushimi T, Umeda Y, Yoshida R, Nobuoka D, Kuise T, Takagi K, Yasunaka T, Takaki A, Fujiwara T, Yagi T 2017

[学会発表] 肝内胆管癌の外科治療~リンパ節郭清結果を踏まえ手術戦略を再考する~

渡辺信之, 楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 杭瀬 崇, 須井健太, 藤 智和, 高木弘誠, 木村裕司, 八木孝仁, 藤原俊義 2016

[学会発表] The Utility of Cadaver-Based Approaches for the Surgical Training in Hepatobiliary and Pancreatic Surgery

Nobuoka D, Yagi T, Kondo Y, Yoshida R, Umeda Y, Shinoura S, Takeda Y, Ohtsuka A, Fujiwara T 2016

[学会発表] Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer

谷口文崇, 永坂岳司, 藤 智和, 母里淑子, 岸本浩行, 河合 毅, 楳田祐三, 藤原俊義 2016

[学会発表] Efficacy of Tolvaptan for refractory ascites and hyponatremia in perioperative management in liver transplantation

Umeda Y, Yagi T, Takaki A, Shinoura S, Yoshida R, Nobuoka D, Yasunaka T, Watanabe N, Kuise T, Fuji T, Sui K, Takagi K, Nagasaka T, Fujiwara T 2016

[学会発表] Risk Factors for Recurrence in the Remnant Pancreas after Partial Pancreatectomy for Intraductal Papillary Mucinous Neoplasms (IPMNs)

Yoshida R, Fuji T, Shinoura S, Umeda Y, Nobuoka D, Watanabe N, Kuise T, Takagi K, Araki H, Yagi T, Fujiwara T 2016

[雑誌論文] Surgical Outcome of Patients Undergoing Pancreaticoduodenectomy: Analysis of a 17 Year Experience at a Single Center

Takagi K, Yagi T, Yoshida R, Shinoura S, Umeda Y, Nobuoka D, Kuise T, Watanabe N, Sui K, Fuji T, Fujiwara T 2016

[雑誌論文] Sarcopenia and American Society of Anesthesiologists Physical Status in the Assessment of Outcomes of Hepatocellular Carcinoma Patients Undergoing Hepatectomy

Takagi K, Yagi T, Yoshida R, Shinoura S, Umeda Y, Nobuoka D, Kuise T, Watanabe N, Fujiwara T 2016

[学会発表] 肝内胆管癌に対するリンパ節郭清の意義

楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 渡辺信之, 杭瀬 崇, 藤 智和, 高木弘誠, 八木孝仁, 藤原俊義 2016

[学会発表] MGMT Inactivation Arrest Tumor Growth and Serves As a Promising Predictive Biomarker for Treatment Response in Colorectal Cancer

Mori Y, Nagasaka T, Tazawa H, Umeda Y, Shigeyasu K, Yoshida K, Goel A, Fujiwara T 2016

[学会発表] Lynch症候群および家族性大腸腺腫症の系統的遺伝子解析

谷口文崇, 永坂岳司, 楳田祐三, 母里淑子, 河合 毅, 内海方嗣, 田中屋宏爾, 青木秀樹, 竹内仁司, 藤原俊義 2016

[学会発表] Comprehensive analysis of intrahepatic cholangiocarcinoma based on viral infections and mutational status in the IDH1/2 and KRAS genes

Yasui K, Nagasaka T, Umeda Y, Fuji T, Taniguchi F, Toshima T, Kimura K, Kawai T, Mori Y, Tazawa H, Yagi T, Goel A, Fujiwara T 2016

[学会発表] 膵癌切除症例における免疫チェックポイント分子の発現解析~膵癌切除例とTCGA dataを対象とした免疫チェックポイント機構の解析~

藤 智和, 楳田祐三, 永坂岳司, 母里淑子, 谷口文崇, 安井和也, 河合 毅, 八木孝仁, 藤原俊義 2016

[学会発表] Surgical technique for minimal invasiveness in living donor liver surgery: Knack & Pitfalls

Umeda Y, Yagi T, Shinoura S, Yoshida R, Nobuoka D, Watanabe N, Kuise T, Fuji T, Takagi K, Fujiwara T. 2016

[学会発表] IDH1/2 およびKRAS 遺伝子の変異ステータスによる肝内胆管癌の層別化

安井和也, 永坂岳司, 楳田祐三, 藤智和, 戸嶋俊明, 河合毅, 母里淑子, 八木孝仁, 藤原俊義 2016

[学会発表] Efficacy of enhanced alcoholism treatment program before a liver transplantation for patients with alcoholic liver cirrhosis

Yoshida R, Takaki A, Matsumoto Y, Yasuda Y, Takagi K, Sui K, Fuji T, Kuise T, Watanabe N, Nobuoka D, Umeda Y, Shinoura S, Yagi T 2016

[学会発表] 再肝切除における根治性確保と合併症軽減に向けた手術手技と工夫

楳田祐三, 八木孝仁, 篠浦 先, 吉田龍一, 信岡大輔, 渡辺信之, 杭瀬 崇, 藤 智和, 高木弘誠, 藤原俊義 2016

[学会発表] Prediction of salvage liver transplantation for hepatocellular carcinoma recurrence:until when are we tenacious of locoregional therapy?

Umeda Y, Yagi T, Nagasaka T, Shinoura S, Yoshida R, Nobuoka D, Watanabe N, Kuise T, Fuji T, Takagi K, Fujiwara T 2016

[学会発表] 安全で正確な肝切除:ICG 蛍光法によるfusion imagingとSoft凝固付CUSA による肝静脈露出

楳田祐三, 八木孝仁, 篠浦 先, 吉田龍一, 信岡大輔, 渡辺信之, 杭瀬 崇, 藤 智和, 高木弘誠, 荒木宏之, 藤原俊義 2016

[学会発表] 肝硬変合併肝細胞癌に対する脾摘の肝機能改善効果

渡辺信之, 楳田祐三, 篠浦 先, 吉田龍一, 信岡大輔, 杭瀬 崇, 藤 智和, 高木弘誠, 荒木宏之, 八木孝仁, 藤原俊義 2016