トップ研究者を探す脳内アミロイドβ排除による水頭症治療の可能性検証研究

脳内アミロイドβ排除による水頭症治療の可能性検証研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16K10212
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
精神神経科学
研究機関 高知大学
大阪大学
代表研究者 数井 裕光
研究分担者 貴島 晴彦
研究分担者 渡邉 嘉之
研究期間 開始年月日 2016/4/1
研究期間 終了年度 2018
研究ステータス 完了 (2018/4/1)
配分額(合計) 4,680,000 (直接経費 :3,600,000、間接経費 :1,080,000)
配分額(履歴) 2018年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2017年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2016年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
キーワード 特発性正常圧水頭症
アルツハイマー病
アミロイド
PADRE
歩行障害
記憶障害
シャント術
脳血流
水頭症
MRI
髄液バイオマーカー
アミロイドPET
臨床
老年精神医学

研究成果

[雑誌論文] Changes in brain morphology in patients in the preclinical stage of idiopathic normal pressure hydrocephalus.

Suehiro T, Kazui H, Kanemoto H, Yoshiyama K, Sato S, Suzuki Y, Azuma S, Matsumoto T, Kishima H, Ishii K, Ikeda M. 2019

[雑誌論文] EEG Resting-State Networks in Dementia with Lewy Bodies Associated with Clinical Symptoms.

Aoki Y, Kazui H, Pascal-Marqui RD, Ishii R, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Hata M, Canuet L, Iwase M, Ikeda M. 2019

[雑誌論文] Conversational assessment of cognitive dysfunction among residents living in long-term care facilities.

Oba H, Sato S, Kazui H, Nitta Y, Nashitani T, Kamiyama A 2018

[雑誌論文] 軽度認知障害の疫学と臨床的意味

樫林哲雄、数井裕光 2018

[学会発表] Identifying dementia patients based on behavioral markers in human-avatar interaction.

Ujiro T, Tanaka H, Adachi H, Kazui H, Ikeda M, Kudo T, Nakamura S 2018

[雑誌論文] Advantages of different care services for reducing neuropsychiatric symptoms in dementia patients.

Suzuki Y, Kazui H, Yoshiyama K, Azuma S, Kanemoto H, Sato S, Suehiro T, Ikeda M. 2018

[学会発表] “From DLB to long-term care; My experiences in DLB and long-term care”

Kazui H 2018

[雑誌論文] Alpha event-related synchronization after eye closing differs in Alzheimer's disease and dementia with Lewy bodies: a magnetoencephalography study.

Hata M, Kurimoto R, Kazui H, Ishii R, Canuet L, Aoki Y, Ikeda S, Azuma S, Suehiro T, Sato S, Suzuki Y, Kanemoto H, Yoshiyama K, Iwase M, Ikeda M 2018

[学会発表] Association between left pulvinar hypometabolism and sleep disturbances in patients with Lewy bodies.

Kanemoto H, Kazui H, Adachi H, Yoshiyama K, Wada T, Tokumasu Nomura K, Ikeda M 2018

[学会発表] Approaches to promote the spread of effective behavioural management techniques to informal caregivers of dementia patients in Japan

Kazui H 2018

[雑誌論文] Violation of Laws in Frontotemporal Dementia: A Multicenter Study in Japan.

Shinagawa S, Shigenobu K, Tagai K, Fukuhara R, Kamimura N, Mori T, Yoshiyama K, Kazui H, Nakayama K, Ikeda M 2017

[雑誌論文] Neural basis of apathy in patients with amnestic mild cognitive impairment.

Kazui H, Takahashi R, Yamamoto Y, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Azuma S, Suehiro T, Shimosegawa E, Ishii K, Tanaka T 2017

[雑誌論文] Use of T1-weighted/T2-weighted magnetic resonance ratio to elucidate changes due to amyloid-β accumulation in cognitively normal subjects.

Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Takahashi M, Nakagawara J, Iida H, Kishimoto T, Nagatsuka K 2017

[学会発表] 特発性正常圧水頭症におけるシャント術後でのDESH所見の経時的変化

末廣聖,数井裕光,松本拓也,東眞吾,佐藤俊介,鈴木由希子, 鐘本英輝,吉山顕次,山下典生,貴島晴彦,池田学 2017

[学会発表] Neuroanatomical bases of lower psychomotor speed and gait disturbance in idiopathic normal pressure hydrocephalus.

Sato S, Kazui H, Kanemoto H, Azuma S, Suehiro T, Suzuki Y, Matsumoto T, Yoshiyama K, Kishima H, Ikeda M 2017

[学会発表] The changes of brain morphology in the patients of the preclinical stage of idiopathic normal pressure hydrocephalus,

Suehiro T, Kazui H, Matsumoto T, Azuma S, Sato S, Kanemoto H, Yoshiyama K, Yamashita F, Kishima H, Ikeada M 2017

[学会発表] Cerebral metabolism related to sleep disturbances in patients with dementia with Lewy bodies: An open-label study.

Kanemoto H, Kazui H, Adachi H, Yoshiyama K, Wada T, Tokumasu Nomura K, Tanaka T, Ikeda M 2017

[雑誌論文] Disability risk or unimproved symptoms following shunt surgery in patients with idiopathic normal-pressure hydrocephalus: post hoc analysis of SINPHONI-2.

Yamada S,Kimura T,Jingami N,Atsuchi M,Hirai O,Tokuda T,Miyajima M,Kazui H,Mori E,Ishikawa M,SINPHONI-2 Investigators 2017

[雑誌論文] 認知症診療における連携と協同.

数井裕光 2017

[学会発表] Keynote Speech “Psychiatric and behavioral symptoms of iNPH”

Kazui H 2017

[雑誌論文] 認知症における問題行動

東眞吾, 数井裕光 2017

[学会発表] 治る認知症、iNPHを見逃さないために

数井裕光 2017

[雑誌論文] High amyloid-β deposition related to depressive symptoms in older individuals with normal cognition: A pilot study

Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Kosaka J, Kudo T, Iida H, Kishimoto T, Nagatsuka K 2017

[雑誌論文] Effects of donepezil on sleep disturbances in patients with dementia with Lewy bodies An open-label study with actigraphy.

Kazui H, Adachi H, Kanemoto H, Yoshiyama K, Wada T, Tokumasu Nomura K, Tanaka T, Ikeda M 2017

[学会発表] 精神科領域における特発性正常圧水頭症診療の現状と今後,

数井裕光 2017

[学会発表] 治る認知症、iNPHを見逃さないために

数井裕光 2017

[雑誌論文] 認知症診療におけるチーム医療

数井裕光 2016

[雑誌論文] 特発性正常圧水頭症の診断 治療の現況

数井裕光 2016

[雑誌論文] Disability risk or unimproved symptoms following shunt surgery in patients with idiopathic normal-pressure hydrocephalus: post hoc analysis of SINPHONI-2.

Yamada S,Kimura T,Jingami N,Atsuchi M,Hirai O,Tokuda T,Miyajima M, Kazui H,Mori E,Ishikawa M,SINPHONI-2 Investigators. 2016

[雑誌論文] A structural model of age, grey matter volumes, education, and personality traits.

Kitamura S,Yasuno F,Yamamoto A,Kazui H,Kudo T,Matsuoka K,Kiuchi K,Kosaka J,Nagatsuka K,Iida H,Kishimoto T. 2016

[雑誌論文] One-year outcome in patients with idiopathic normal-pressure hydrocephalus: comparison of lumboperitoneal shunt to ventriculoperitoneal shunt.

Miyajima M,Kazui H,Mori E,Ishikawa M,on behalf of the SINPHONI-2 Investigators. 2016

[雑誌論文] Bladder recovery relates with increased mid-cingulate perfusion after shunt surgery in idiopathic normal-pressure hydrocephalus: a single-photon emission tomography study.

Sakakibara R,Uchida Y,Ishii K,Hashimoto M,Ishikawa M,Kazui H,Yamamoto T,Uchiyama T,Tateno F,Kishi M,Tsuyusaki Y,Aiba Y,Tateno H,Nagao T,Terada H,Inaoka T,Members of SINPHONI (Study of Idiopathic Normal Pressure Hydrocephalus On Neurological Improvement). 2016

[雑誌論文] iNPH診療における医療連携

末廣聖、数井裕光 2016

[雑誌論文] Effect of lumbo-peritoneal shunt surgery on neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus.

Kanemoto H,Kazui H(CA),Suzuki Y,Sato S,Kishima H,Yoshimine T,Yoshiyama K. 2016

[学会発表] 特発性正常圧水頭症のprodromal stage

数井裕光 2016

[学会発表] Comparison of memory function between idiopathic normal pressure hydrocephalus and Alzheimer’s disease.

Matsumoto T,Kazui H,Yoshiyama K,Kanemoto H,Suzuki Y,Sato S,Azuma S,Suehiro S,Ikeda M. 2016

[雑誌論文] Electrical stimulation of the parahippocampal gyrus for prediction of posthippocampectomy verbal memory decline.

Tani N,Kishima H,Khoo HM,Yanagisawa T,Oshino S,Maruo T,Hosomi K, Hirata M,Kazui H,Nomura KT,Aly MM,Kato A,Yoshimine T. 2016

[雑誌論文] Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus.

Khoo HM,Kishima H,Tani N,Oshino S,Maruo T,Hosomi K,Yanagisawa T, Kazui H,Watanabe Y,Shimokawa T,Aso T,Kawaguchi A,Yamashita F,Saitoh Y,Yoshimine T. 2016

[雑誌論文] BPSDの対応に向けて

数井裕光 2016

[雑誌論文] Disease duration: the key to accurate CSF tap test in iNPH

Yamada S,Ishikawa M,Miyajima M,Atsuchi M,Kimura T,Kazui H,Mori E,SINPHONI-2 Investigators. 2016

[雑誌論文] Association between high biomarker probability of Alzheimer's disease and improvement of clinical outcomes after shunt surgery in patients with idiopathic normal pressure hydrocephalus.

Kazui H,Kanemoto H,Yoshiyama K,Kishima H,Suzuki Y,Sato S,Suehiro T,Azuma S,Yoshimine T,Tanaka T. 2016

[雑誌論文] 特発性正常圧水頭症における髄液シャント術の脳波NPV解析による効果予測

青木保典、数井裕光, 石井良平, 吉山顕次, 鐘本英輝, 鈴木由希子, 佐藤俊介, 東眞吾, 末廣聖, 松本拓也, 武者利光, 松崎晴康, 今城郁, 畑真弘, 池田俊一郎, 岩瀬真生, 池田学 2016