トップ›研究者を探す›アストログリアコネキシンの脳内免疫系賦活作用の抑制による多発性硬化症治療法の開発

アストログリアコネキシンの脳内免疫系賦活作用の抑制による多発性硬化症治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16K09694
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
神経内科学
研究機関 九州大学
代表研究者 山崎 亮
研究分担者 山口 浩雄
研究分担者 真崎 勝久
研究期間 開始年月日 2016/4/1
研究期間 終了年度 2018
研究ステータス 完了 (2018/4/1)
配分額（合計） 4,680,000 (直接経費 :3,600,000、間接経費 :1,080,000)
配分額（履歴） 2018年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
2017年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2016年度：1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
キーワード 多発性硬化症
実験的自己免疫性脳脊髄炎
コネキシン
アストログリア
ミクログリア
オリゴデンドログリア
動物モデル
マウスモデル

研究成果

[学会発表] 二次進行型多発性硬化症(SPMS)新規動物モデルの樹立と炎症性グリアを標的とした進行型多発性硬化症治療薬開発

吉良潤一、○山﨑 亮、松下拓也、篠田紘司、竹内英之、中川昌也 2019

[雑誌論文] Novel disease-modifying anti-rheumatic drug iguratimod suppresses chronic experimental autoimmune encephalomyelitis by down-regulating activation of macrophages/microglia through an NF-κB pathway

Guangrui Li, Ryo Yamasaki, Mei Fang, Katsuhisa Masaki, Hirofumi Ochi, Takuya Matsushita, Jun-ichi Kira 2018

[学会発表] Astroglial connexin (Cx)30 and Cx43 and oligodendroglial Cx47 differentially modulate acute and chronic experimental autoimmune encephalomyelitis

Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Hiroo Yamaguchi 2018

[学会発表] Oligodendroglia-specific conditional ablation of connexin 47 is sufficient to produce relapse and progression in demyelinating disease

Yinan Zhao, Ryo Yamasaki, Marion Wijering, Hiroo Yamaguchi, Jun-ichi Kira 2018

[学会発表] Oligodendroglia-specific connexin47 deletion produces a relapse-remitting multiple sclerosis model

Ryo Yamasaki MD, PhD, Yinan Zhao MD, Marion Wijering BS, Hiroo Yamaguchi MD, PhD, Jun-ichi Kira MD, PhD. 2018

[学会発表] Elucidation of the effects of gap junction protein connexin on the pathogenesis of multiple sclerosis model mice and development of new therapeutic options by functional modification ギャップ結合蛋白コネキシンが多発性硬化症モデルマウスの病態に及ぼす影響の解析

Ryo Yamasaki MD, PhD, Yinan Zhao MD, Marion Wijering BS, Mei Fang MD, Guangrui Li MD, PhD, Hayato Une MD, Hiroo Yamaguchi MD, PhD, Jun-ichi Kira MD, PhD. 2018

[学会発表] Revisiting glia; as a mother and guardian of central nervous system

Ryo　Yamasaki MD, PhD 2018

[学会発表] A novel secondary progressive multiple sclerosis model by oligodendroglia-specific inducible conditional knockout of connexin 47

Ryo Yamasaki MD, PhD, Yinan Zhao MD, Marion Wijering BS, Hiroo Yamaguchi MD, PhD, Jun-ichi Kira MD, PhD. 2018

[雑誌論文] Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis

Kobayakawa Yuko、Masaki Katsuhisa、Yamasaki Ryo、Shiraishi Wataru、Hayashida Shotaro、Hayashi Shintaro、Okamoto Koichi、Matsushita Takuya、Kira Jun-ichi 2018

[学会発表] Astroglial and oligodendroglial connexins differentially modulate acute and chronic experimental autoimmune encephalomyelitis

Ryo Yamasaki, Mei Fang, Yinan Zhao, Hayato Une, Hiroo Yamaguchi, Jun-ichi Kira 2017

[学会発表] T-05-040C Astrocytic connexin 30 deletion leads to hypersensitivity in a MPTP mouse model of Parkinson’s disease

Atsushi Fujita, MD,1 Hiroo Yamaguchi, MD, PhD,1 Ryo Yamasaki, MD, PhD,1 Yuta Matsuoka, PhD,2 Ken-ichi Yamada, PhD,2 Jun-ichi Kira, MD, PhD 2017

[学会発表] Elucidation of pathomechanistic effect toward central nervous system (CNS) demyelinating disorders by altered function of gap junction-consisting protein “connexins”

Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Kyoko Iinuma, Katsuhisa Masaki, Koji Shinoda, Hiroo Yamaguchi. 2017

[学会発表] "Astroglial and oligodendroglial connexins differentially modulate acute and chronic experimental autoimmune encephalomyelitis"

Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Kyoko Iinuma, Katsuhisa Masaki, Koji Shinoda, Hiroo Yamaguchi 2017

[学会発表] "Astroglial (Cx30, Cx43) and oligodendroglial (Cx47) connexins modulate acute and chronic experimental autoimmune encephalomyelitis (EAE) "

"Ryo Yamasaki, Fang Mei, Hayato Une, Zhao Yinan, Hiroo Yamaguchi, Jun-ichi Kira " 2017

[学会発表] "Astroglial and Oligodendroglial Connexins Differentially Influence Both Acute and Chronic Progressive Experimental Autoimmune Encephalomyelitis "

Jun-ichi Kira, Ryo Yamasaki, Hayato Une, Mei Fang, Yinan Zhao, Guangrui Li, Hiroo Yamaguchi 2017

[学会発表] Astroglial connexin 30 deletion leads to hypersensitivity in a MPTP mouse model of Parkinson’s disease

Atsushi Fujita, 〇Hiroo Yamaguchi, Ryo Yamasaki, Yuta Matsuoka, Ken-ichi Yamada, Jun-ichi Kira 2017

[学会発表] "Oligodendroglia-specific Connexin 47 deletion induced relapse-remitting EAE model mice"

"Ryo Yamasaki MD, PhD, Yinan Zhao, MD, Hiroo Yamaguchi MD, PhD, Jun-ichi Kira MD, PhD." 2017

[学会発表] Oligodendroglial Cx47 mediates myelin protective effects and plays a role in suppressing infiltration of inflammatory cells in autoimmune encephalomyelitis

"Yinan Zhao, Ryo Yamasaki, Hiroo Yamaguchi, Hayato Une, Yiwen Cui, Jun-ichi Kira " 2017

[学会発表] Connexin 30 欠損マウスにおける慢性進行期EAEの軽症化

"山﨑　亮、方　梅、李　広瑞、藤田 篤史、宇根 隼人、山口 浩雄、吉良 潤一 " 2017

[学会発表] コネキシン30欠損マウスにおける慢性進行期EAEの軽症化-治療標的としてのCx30の意義-

山崎　亮 2017

[学会発表] Functional analysis of connexin30 in experimental autoimmune encephalomyelitis

山崎　亮 2016