研究成果

[学会発表] The mechanism by which lifestyle-related diseases cause atherosclerosis: The role of innate immune system.

Daiju Fukuda, Masataka Sata. 2018

[学会発表] Inhibition of thrombin signaling by dabigatran, a direct thrombin inhibitor, attenuates endothelial dysfunction in diabetic mice.

Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Masataka Sata. 2018

[学会発表] A Deep Learning Approach for Automated Diagnosis of Regional Wall Motion Abnormality on Echocardiography.

Kusunose K, Abe T, Haga A, Yamada H, Fukuda D, Harada M, SataM. 2018

[学会発表] Inhibition of S1P2 receptor ameliorates endothelial dysfunction and prevents atherogenesis in apolipoprotein-E-deficient Mice.

Ganbaatar B, Fukuda D, Yagi S, Soeki T, Sata M. 2018

[学会発表] Single coronary 合併重症ASに対してTAVIを施行し救命し得た１例

Robert Zheng、伊勢孝之、川端豊、八木秀介、西條良仁、上野理絵、坂東美佳、伊藤浩敬、轟貴史、松浦朋美、楠瀬賢也、飛梅威、山口浩司、福田大受、山田博胤、添木武、若槻哲三、黒部裕嗣、藤本鋭貴、北川哲也、佐田政隆 2018

[学会発表] 未固定遺体において光干渉断層法で観察される冠動脈壁微小管腔構造と局所周囲脂肪炎症との関連

川端豊、若槻哲三、山口浩司、伊藤浩敬、福田大受、伊勢孝之、楠瀬賢也、松浦朋美、轟貴史、飛梅威、八木秀介、山田博胤、添木武、佐田政隆 2018

[学会発表] Atheroprotective effects of ticagrelor, a P2Y12 antagonist, in apolipoprotein-E-deficient mice.

Ganbaatar B, Fukuda D, Salim HM, Yagi S, Soeki T, Sata M. 2018

[雑誌論文] Predictors for the Treatment Effect of Sodium Glucose Co-transporter 2 Inhibitors in Patients with Type 2 Diabetes Mellitus

Yagi S、Aihara KI、Kondo T、Kurahashi K、Yoshida S、Endo I、Fukuda D、Nakaya Y、Suwaki K、Takeji T、Wada T、Salim HM、Hama S、Matsuura T、Ise T、Kusunose K、Yamaguchi K、Tobiume T、Yamada H、Soeki T、Wakatsuki T、Matsuhisa M、Shimabukuro M、Akaike M、Sata M 2018

[学会発表] 薬物治療が著効したＳＬＥ関連心筋炎の一例

Robert Zheng、數藤久美子、楠瀬賢也、松浦朋美、瀬野弘光、西條良仁、上野理絵、川端豊、坂東美佳、伊藤浩敬、轟貴史、伊勢孝之、飛梅威、山口浩司、八木秀介、福田大受、山田博胤、添木武、若槻哲三、佐田政隆 2018

[学会発表] Inhibition of Thrombin-PARs Signaling by Dabigatran, a Direct Thrombin Inhibitor, Attenuates Endothelial Dysfunction in Diabetic Mice.

Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M. 2018

[学会発表] 血液凝固因子と動脈硬化‐新規経口抗凝固薬の血管保護効果について‐

福田大受、佐田政隆 2018

[学会発表] Gender disparities of distribution of epicardial adipose tissue and its impact on coronary artery disease.

Maimaituxun G, Shimabukuro M, Fukuda D, Yagi S, Hirata Y, Iwase T, Matsuura T, Ise T , Kusunose K, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Sata M. 2018

[学会発表] Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers.

Ito H, Wakatsuki T, Yamaguchi K, Fukuda D, Kawabata Y, Todoroki T, Matsuura T, Ise T, Kusunose K, Tobiume T, Yagi S, Yamada H, Soeki T, Sata M. 2018

[学会発表] 活性型血液凝固第X因子が冠動脈硬化に与える影響

福田大受、山口浩司、楠瀬賢也、八木秀介、山田博胤、若槻哲三、添木武、佐田政隆 2018

[学会発表] 未固定遺体における冠動脈壁小管腔構造と局所心臓周囲脂肪内炎症との関連

伊藤浩敬、若槻哲三、山口浩司、福田大受、川端豊、伊勢孝之、楠瀬賢也、松浦朋美、轟貴史、飛梅威、八木秀介、山田博胤、添木武、佐田政隆 2018

[学会発表] Rivaroxaban, a Direct Inhibitor of Factor Xa, Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Mice Through the Inhibition of Protease-Activated Receptor 2 Signaling.

Phuong PT, Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Shimabukuro M, Sata M. 2018

[学会発表] C-type natriuretic peptide improves left ventricular diastolic dysfunction and ischemia/reperfusion injury-associated ventricular arrhythmias.

Soeki T, Uematsu E, Matsuura T, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Sata M. 2018

[雑誌論文] A novel lipoprotein (a) lowering drug, D-47, decreases neointima thickening after vascular injury

Nakaya Y, Fukuda D, Oyamada T, Ogawa K, Harada N, Nakagami H, Morishita R, Sata M, Sakaue, H. 2017

[雑誌論文] Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus.

Yagi S, Hirata Y, Ise T, Kusunose K, Yamada H, Fukuda D, Salim HM, Maimaituxun G, Nishio S, Takagawa Y, Hama S, Matsuura T, Yamaguchi K, Tobiume T, Soeki T, Wakatsuki T, Aihara KI, Akaike M, Shimabukuro M, Sata M. 2017

[学会発表] 自己DNA断片を介した自然免疫機構が心血管代謝性疾患の発症を促進する

福田大受、佐田政隆 2017

[学会発表] 血管の炎症と動脈硬化症におけるToll様受容体9の役割

西本幸子、福田大受、佐田政隆 2017

[学会発表] DPP-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and the development of atherosclerosis in apolipoprotein-E deficient mice.

Kunduziayi Aini, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata. 2017

[学会発表] Dabigatran, a direct thrombin inhibitor, attenuates endothelial dysfunction in diabetic mice

Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata. 2017

[学会発表] 心房細動アブレーション後の医原性心房中隔欠損残存により右心不全症状をきたした一例

矢野哲弘、松浦朋美、數藤久美子、瀬野弘光、西條良仁、上野理絵、川端豊、伊藤浩敬、轟貴史、伊勢孝之、楠瀬賢也、飛梅威、山口浩司、八木秀介、福田大受、山田博胤、添木武、若槻哲三、佐田政隆 2017

[学会発表] Ticagrelor, a P2Y21 inhibitor, attenuated vascular dysfunction and inhibited atherogenesis in apolipoprotein-E-deficient mice.

Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata. 2017

[学会発表] Canagliflozin, a novel selective SGLT2 inhibitor, ameliorated endothelial dysfunction and atherogenesis in diabetic mice.

Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata. 2017

[雑誌論文] Improved Exercise Capacity After Cardiac Rehabilitation Is Associated with Reduced Visceral Fat in Patients with Chronic Heart Failure

Takagawa Y, Yagi S. Ise T, Ishii A, Nishikawa K, Fukuda D, Kusunose K, Matsuura T, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Katoh S, Aihara KI, Akaike M, Sata M. 2017

[学会発表] Lipid-rich Coronary Plaque is Associated with Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadaveric Models.

伊藤浩敬、若槻哲三、山口浩司、福田大受、川端豊、轟貴史、松浦朋美、楠瀬賢也、伊勢孝之、飛梅威、八木秀介、山田博胤、添木武、佐田政隆 2017

[学会発表] The Tissue Characteristics of Coronary Plaque with Microluminal Structures Identified by OCT Associated with Local Inflammatory Response in Fresh Cadavers.

若槻哲三、山口浩司、伊藤浩敬、福田大受、川端豊、轟貴史、松浦朋美、伊勢孝之、楠瀬賢也、飛梅威、八木秀介、山田博胤、添木武、佐田政隆 2017

[学会発表] Local Epicardial Adipose Tissue Thickness in Left Anterior Descending Artery Provides a New Prediction Model for Coronary Artery Disease.

Gulinu Maimaituxun, Shimabukuro M, Hirata Y, Iwase T, Takao S, Matsuura T, Ise T, Kusunose K, Tobiume T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Soeki T, Wakatsuki T, Harada M, Sata M. 2017

[学会発表] picardial Adipose Tissue Thickness in Left Anterior Descending Artery Predictict Coronary Atherosclerosis.

マイマイチュクングリヌ、島袋充生、平田有紀奈、山口浩司、八木秀介、福田大受、山田博胤、添木武、原田雅史、佐田政隆 2017

[学会発表] Epicardial Adipose Tissue Produces Proinflammatory Cytokines and Influences the Pathogenesis of Atrial Fibrillation.

Soeki T, Matsuura T, Uematsu E, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Sata M. 2017

[雑誌論文] Low Serum Levels of Eicosapentaenoic Acid and Docosahexaenoic Acid are Risk Factors for Cardiogenic Syncope in Patients with Brugada Syndrome

Yagi S, Soeki T, Aihara KI, Fukuda D, Ise T, Kadota M, Bando S, Matsuura T, Tobiume T, Yamaguchi K, Kusunose K, Yamada H, Wakatsuki T, Shimabukuro M, Akaike M, Sata M. 2017

[学会発表] Dabigatran, a direct thrombin inhibitor, attenuates endothelial dysfunction in diabetic mice.

Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata. 2017

[学会発表] Ticagrelor, a P2Y12 antagonist, prevents endothelial dysfunction and the development of atherosclerosis in apolipoprotein-E deficient mice.

Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata. 2017

[学会発表] Activated Factor X Signaling Pathway via Protease-Activated Receptor-2 is a Novel Therapeutic Target to Prevent Atrial Fibrillation.

谷口実佑、添木武、松浦朋美、佐藤裕紀、飛梅威、原知也、楠瀬賢也、伊勢孝之、山口浩司、八木秀介、福田大受、山田博胤、若槻哲三、島袋充生、佐田政隆 2017

[学会発表] Ticagrelor, a P2Y12 Antagonist, Attenuates Vascular Dysfunction and Inhibits Atherogenesis in Apolipoprotein-E-deficient Mice.

Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata. 2017

[学会発表] Atheroprotective effects of Linagliptin, a DPP-4 inhibitor, in normoglycemic ApoE-/- mice.

Kunduziayi Aini, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata. 2017

[学会発表] Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and the development of atherosclerosis in normoglycemic apolipoprotein-E deficient mice.

Aini Kunduziayi, Daiju Fukuda, Hotimah Masdan Salim, Shusuke Yagi, Takeshi Soeki, Masataka Sata. 2017

[学会発表] 多価不飽和脂肪酸と動脈硬化性疾患

福田大受、佐田政隆 2017

[学会発表] ω３系不飽和脂肪酸の抗動脈硬化作用

高島啓, 福田大受, 田中君枝, 東邦康智, 平田陽一郎, 八木秀介, 添木武, 佐田政隆 2017

[学会発表] 診断から40年後に治療しえた著明なBroad Kent束を有するWPW症候群の一例

豊田直人、轟貴史、添木武、瀬野弘光、數藤久美子、西條良仁、上野理絵、川端豊、伊藤浩敬、松浦朋美、伊勢孝之、楠瀬賢也、飛梅威、山口浩司、福田大受、八木秀介、山田博胤、若槻哲三、佐田政隆 2017

[雑誌論文] n-3 Polyunsaturated Fatty Acids: Promising Nutrients for Preventing Cardiovascular Disease

Yagi S, Fukuda D, Aihara KI, Akaike M, Shimabukuro M, Sata M. 2017

[学会発表] 自然免疫機構が関与する慢性炎症と心血管代謝性疾患

福田大受 2017

[学会発表] 遊離核酸断片を介した自然免疫機構が脂肪組織の炎症とインスリン抵抗性の発症に与える影響

福田大受 2017

[学会発表] 新しい動脈硬化のメカニズムの解明～自己由来核酸断片による自然免疫機構の関与～

福田大受 2017

[雑誌論文] Long-chain monounsaturated fatty acid-rich fish oil attenuates the development of atherosclerosis in mouse models.

Yang ZH, Bando M, Sakurai T, Chen Y, Emma-Okon B, Wilhite B, Fukuda D, Pryor BV, Wakabayashi Y, Sampson M, Yu ZX, Sakurai A, Zarzour A, Miyahara H, Takeo J, Sakaue H, Sata M, Remaley AT. 2016

[学会発表] Genetic deletion of TLR9 promotes blood flow recovery in hind limb ischemia.

Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Sakaue H, Shimabukuro M, Sata M. 2016

[学会発表] Cell free DNA/Toll-like receptor 9 axis plays a pivotal role in chronic inflammation induced by metabolic disorders, leading to atherogenesis and insulin resistance.

Fukuda D, Nishimoto S, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M. 2016

[学会発表] 遊離核酸断片による血管の炎症と動脈硬化症発症機序の解明

福田大受、佐田政隆 2016

[学会発表] Adipocyte size distribution and depot-specific modulation of pro- and anti-atherosclerotic adipocytokines and innate immune molecules in human adipose tissue.

Shimabukuro M, Sato H, Izaki H, Fukuda D, Uematsu E, Hirata Y, Yagi S, Soeki T, Sakaue H, Kanayama H, Masuzaki H, Sata M. 2016

[学会発表] Increased local production of C-type natriuretic peptide in patients with vasospastic angina.

Soeki T, Matsuura T, Uematsu E, Bando S, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Sata M. 2016

[学会発表] Oral Direct Factor Xa Inhibitor Prevents Atrial Fibrillation by Inhibiting Inflammation in Rapidly Paced Spontaneously Hypertensive Rats.

Matsuura T, Soeki T, Uematsu E, Bando S, Tobiume T, Hara T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Sata M. 2016

[学会発表] Glycemic Control with Ipragliflozin, a Novel Selective SGLT2 Inhibitor, Ameliorated Endothelial Dysfunction in Obese and Non-Obese Diabetic Mice.

Salim HM, Fukuda D, Yagi S, Soeki T, Shimabukuro M, Sata M. 2016

[学会発表] ～心不全を予防する～ 遊離核酸断片を介した血管の炎症と動脈硬化症発症機序の解明.

福田大受、佐田政隆 2016

[学会発表] Glycemic control with canagliflozin, a SGLT2 inhibitor, inhibited inflammation in the vascular and adipose tissue, and ameliorated vascular complication in diabetic mice.

Salim HM, Fukuda D, Yagi S, Soeki T, Shimabukuro M, Sata M. 2016

[雑誌論文] Noninvasive quantitative tissue characterization of carotid plaque using color-coded mapping based on ultrasound integrated backscatter.

Bando M, Yamada H, Kusunose K, Fukuda D, Amano R, Tamai R, Torii Y, Hirata Y, Nishio S, Satomi J, Nagahiro S, Sata M. 2016

[学会発表] 動脈硬化発症におけるFXa-PARsシグナルのマクロファージ活性化調節機構の解明

福田大受 2016

[学会発表] Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice.

福田大受 2016

[学会発表] Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance.

福田大受 2016

[雑誌論文] PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.

Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabasi AL, Boothby M, Aikawa E, Singh SA, Aikawa M. 2016

[学会発表] Dabigatran, a direct thrombin inhibitor, prevents the development of endothelial dysfunction in diabetic mice.

Salim HM, Fukuda D, Yagi S, Soeki T, Shimabukuro M, Sata M. 2016