肥大型心筋症の病因遺伝子解析と病態形成機構の解明

トップ›研究者を探す›肥大型心筋症の病因遺伝子解析と病態形成機構の解明

代表研究者	久保亨
研究課題番号	KAKENHI-PROJECT-16K09440
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学循環器内科学
研究機関	高知大学
研究分担者	北岡裕章
研究期間開始年月日	2016/4/1
研究期間終了年度	2020
研究ステータス	完了 (2020/4/1)
配分額（合計）	4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額（履歴）	2020年度：910,000 (直接経費 :700,000、間接経費 :210,000) 2019年度：910,000 (直接経費 :700,000、間接経費 :210,000) 2018年度：910,000 (直接経費 :700,000、間接経費 :210,000) 2017年度：910,000 (直接経費 :700,000、間接経費 :210,000) 2016年度：910,000 (直接経費 :700,000、間接経費 :210,000)
キーワード	肥大型心筋症遺伝子解析サルコメア遺伝子変異突然死塞栓症心不全サルコメア遺伝子予後表現型拡張相肥大型心筋症ファブリー病遺伝子型

研究成果

[図書] 別冊・医学のあゆみ　遺伝性心血管疾患のすべて

久保亨 2020

[図書] U40世代が描く心不全診療の現状と未来

久保亨 2020

[雑誌論文] Sudden cardiac death-related events of hypertrophic cardiomyopathy in a regional Japanese cohort -Results from Kochi RYOMA Study.

Kubo T, Baba Y, Ochi Y, Takahashi A, Hirota T, Yamasaki N, Hamashige N, Yamamoto K, Kondo F, Bando K, Yamada E, Furuno T, Yabe T, Doi YL, Kitaoka H. 2020

[雑誌論文] Hypertrophic cardiomyopathy - A heterogeneous and lifelong disease in the real world.

Kitaoka H, Kubo T, Doi YL 2020

[雑誌論文] Elevation of high-sensitivity cardiac troponin T and left ventricular remodelling in hypertrophic cardiomyopathy.

Kubo T, Ochi Y, Baba Y, Sugiura K, Takahashi A, Hirota T, Yamanaka S, Yamasaki N, Doi YL, Kitaoka H. 2020

[雑誌論文] Lifelong Clinical Impact of the Presence of Sarcomere Gene Mutation in Japanese Patients With Hypertrophic Cardiomyopathy

Nakashima Y, Kubo T, Sugiuta K, Ochi Y, Takahashi A, Baba Y, Hirota T, Yamasaki N, Kimura A, Doi YL, Kitaoka H. 2020

[学会発表] Epidemiologic, genetic, and clinical features in Japanese HCM patients

久保亨 2020

[図書] 循環器ジャーナル基礎編

久保亨 2020

[図書] 循環器領域25の疑問

久保亨 2020

[学会発表] Prognostic impact of atrial fibrillation in patients with hypertrophic cardiomyopathy in a community-based Japanese cohort: Results from Kochi RYOMA Study

Toru Kubo 2020

[学会発表] 心尖部肥大型心筋症の遺伝子解析：pure-apical formとdistal-dominant formの違い

久保亨 2020

[図書] 循環器最新ガイドライン2021-2022

久保亨 2020

[雑誌論文] Short- and Long-Term Outcomes of Patients With Hypertrophic Cardiomyopathy After Noncardiac Surgery: A Single-Center Retrospective Study.

Yatabe T, Kubo T, Kitaoka H, Yokoyama M. 2019

[雑誌論文] Clinical Profile of Thromboembolic Events in Patients With Hypertrophic Cardiomyopathy in a Regional Japanese Cohort　― Results From Kochi RYOMA Study ―

Hirota T, Kubo T, Baba Y, Ochi Y, Takahashi A, Yamasaki N, Hamashige N, Yamamoto K, Kondo F, Bando K, Yamada E, Furuno T, Yabe T, Doi YL, Kitaoka H. 2019

[雑誌論文] Development of a Novel Risk Prediction Model for Sudden Cardiac Death in Childhood Hypertrophic Cardiomyopathy (HCM Risk-Kids)

Norrish G, Ding T, Field E, Olivotto I, Limongelli G, Toru-Kubo J, et al. 2019

[図書] 心不全のセット検査

久保亨 2019

[図書] 新しい臨床を開拓するための分子循環器病学

久保亨 2019

[学会発表] 肥大心の治療

久保亨 2019

[学会発表] 肥大型心筋症における遺伝子解析への期待と課題

久保亨 2019

[学会発表] 臨床的観点からの心筋症の遺伝子診断の意義と現状

久保亨 2019

[図書] Heart View 心筋症のいまを識る

久保亨 2019

[学会発表] 肥大型心筋症患者の突然死予防

久保亨 2019

[雑誌論文] Short- and Long-Term Outcomes of Patients With Hypertrophic Cardiomyopathy After Noncardiac Surgery: A Single-Center Retrospective Study.

Yatabe T, Kubo T, Kitaoka H, Yokoyama M. 2018

[雑誌論文] International External Validation Study of the 2014 European Society of Cardiology Guidelines on Sudden Cardiac Death Prevention in Hypertrophic Cardiomyopathy (EVIDENCE-HCM).

O'Mahony C, Jichi F, Ommen SR, Christiaans I, Cecchi F, Olivotto I, Kitaoka H, Gotsman I, Carr-White G, Mogensen J, Antoniades L, Mohiddin SA, Maurer MS, Tang HC, Geske JB, Siontis KC, Mahmoud KD, Vermeer A, Wilde A, Favalli V, Guttmann OP, Gallego-Delgado M, Dominguez F, Tanini I, Kubo T, Elliott PM. 2018

[雑誌論文] Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort　― Results From Kochi RYOMA Study ―

Kubo T, Hirota T, Baba Y, Ochi Y, Takahashi A, Yamasaki N, Hamashige N, Yamamoto K, Kondo F, Bando K, Yamada E, Furuno T, Yabe T, Doi YL, Kitaoka H. 2018

[学会発表] Genetic Basis and Clinical Significance of Hypertrophic Cardiomyopathy

Toru Kubo 2018

[学会発表] Management of Hypertrophic Cardiomyopathy in Lifelong Cardiology

久保亨 2018

[学会発表] Genotype and Phenotype of Hypertrophic Cardiomyopathy

Toru Kubo 2018

[学会発表] 同定された genetic variant のpathogenicity を考える

久保亨 2018

[学会発表] Sudden cardiac death relevant events of hypertrophic cardiomyopathy in a community-based Japanese cohort: Results from Kochi RYOMA Study.

Toru Kubo 2018

[学会発表] Genetic analysis of hypertrophic cardiomyopathy with apical phenotype: comparison of pure-apical form and distal-dominant form.

Toru Kubo 2018

[雑誌論文] Prevalence and clinical features of Fabry disease in Japanese male patients with diagnosis of hypertrophic cardiomyopathy.

Kubo T, Ochi Y, Baba Y, Hirota T, Tanioka K, Yamasaki N, Yoshimitsu M, Higuchi K, Takenaka T, Nakajima K, Togawa T, Tsukimura T, Sano S, Tei C, Sakuraba H, Kitaoka H. 2017

[雑誌論文] Prognostic Significance of Non-Dilated Left Ventricular Size and Mitral Regurgitation in Patients With Dilated Phase of Hypertrophic Cardiomyopathy

Kubo T, Baba Y, Hirota T, Tanioka K, Yamasaki N, Doi YL, Kitaoka H. 2017

[雑誌論文] Imaging of Left Ventricular Hypertrophy: a Practical Utility for Differential Diagnosis and Assessment of Disease Severity.

Kubo T, Kitaoka H. 2017

[学会発表] Clinical Course and Natural History of Hypertrophic Cardiomyopathy

Toru Kubo 2017

[学会発表] 地域在住肥大型心筋症患者の突然死関連因子の同定高知県心筋症ネットワーク～Kochi RYOMA Study～

久保亨 2017

[学会発表] An elevated serum concentration of high-sensitivity cardiac troponin T predicts progression into end-stage phase of hypertrophic cardiomyopathy

Toru Kubo 2017

[学会発表] Fabry disease and its cardiac involvement

久保亨 2017

[学会発表] Epidemiology and clinical profile of hypertrophic cardiomyopathy in an unselected regional Japanese cohort: Results from Kochi RYOMA Study

Toru Kubo 2016

[学会発表] 肥大型心筋症における拡張相への進展因子の検討

久保亨 2016