研究成果

[雑誌論文] Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-cholesterol Levels in J-MICC Study Participants

Nindita Y, Nakatochi M, Ibusuki R, Shimoshikiryo I, Nishimoto D, Shimatani K, Takezaki T, ..., Kuriki K, ... 2023

[雑誌論文] Association Between Nutrient Patterns and Fatty Liver Index: Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima, Japan

Nguyen Van Tien, Kokichi Arisawa, Hirokazu Uemura, Nahomi Imaeda, Chiho Goto, Sakurako Katsuura-Kamano 2022

[雑誌論文] Claudins and Gastric Cancer : An Overview.

Hashimoto I, Oshima T 2022

[雑誌論文] Association between germline pathogenic variants and breast cancer risk in Japanese women : the HERPACC study

Kasugai Y, Kohmoto T, Taniyama Y, Koyanagi YN, Usui Y, Iwase M, Oze I, Yamaguchi R, Ito H, Imoto I, Matsuo K. 2022

[雑誌論文] The association of reproductive history with hypertension and obesity according to menopausal status : the J-MICC Study.

Ohashi M, Miura K, Takashima N, Kadota A, Saito Y, Tsuji S, Murakami T, ... Kuriki K, et al. 2022

[学会発表] 成人男性におけるFatty Liver Indexと慢性炎症や動脈スティフネスとの関連

上村浩一、釜野桜子、有澤孝吉、J-MICC Study徳島地区 2021

[学会発表] 食事酸負荷とメタボリック症候群との関連 : J-MICC Study

有澤孝吉、釜野桜子、上村浩一、Nguyen Van Tien, J-MICC Study Group 2021

[学会発表] Association between nutrient patterns and fatty liver index : Baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima, Japan.

Nguyen Van Tien, Kokichi Arisawa, Hirokazu Uemura, Sakurako Katsuura-Kamano 2021

[図書] Clinical Neuroscience

間野 達雄, 岩田 淳 2021

[学会発表] 低酸素誘導因子HIF1A依存的オートファジーはαシヌクレイン病理を改善させる

間野達雄, 大友岳, 岩田淳, 戸田達史 2021

[学会発表] 朝食欠食および睡眠時間とメタボリック症候群との関連 : J-MICC Study

釜野桜子、有澤孝吉、Nguyen Van Tien、上村浩一、for the J-MICC Study Group 2021

[学会発表] Tau-induced Aggregation of BRCA1 in Tauopathies

Masanori Kurihara, Tatsuo Mano, Yuko Saito, Shigeo Murayama, Atsushi Iwata, Tatsushi Toda 2021

[学会発表] HIF1A-dependent autophagy mitigates alpha-synuclein pathology and cognitive impairment

Tatsuo Mano, Gaku Ohtomo, Atsushi Iwata, Tatsushi Toda 2021

[学会発表] HIF1α依存性オートファジーによるαシヌクレイン病理の分解促進

大友 岳, 間野 達雄, 岩田 淳, 戸田 達史 2021

[雑誌論文] Association between long-term alcohol consumption and insomnia symptoms in civil servants : Aichi Workers' Cohort Study.

Terabe M, Kitajima T, Ota A, Yatsuya H, Iwata N. 2021

[学会発表] Baseline Global DNA Hypermethylation Increase the Risk of Cerebrovascular Disease Mortality in Japanese Population

Yoshiki Tsuboi, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Keisuke Maeda, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki, et al. 2021

[学会発表] 血糖調節指標に対する血糖値の調節に関わる遺伝的要因と栄養素摂取量の横断的検討

橘 拓希、川島晃子、川畑春佳、伊東 葵、古郡かすみ、可児美月、後藤千穂、栗木清典 2021

[雑誌論文] Clinical Significance of PLA2G2A Expression in Gastric Cancer Patients who Receive Gastrectomy and Adjuvant S-1.

Hatori S, Sakamaki K, Kimura Y, Hiroshima Y, Hashimoto I, Saeki H, Miyagi Y, Oshima T. 2021

[学会発表] Gene and environmental factors for liver fibrosis among Japanese general population with NAFLD

Rie Ibusuki, Ippei Shimoshikryo, Daisaku Nishimoto, Hironori Miyahara, Koichi Tokushige, Toshiro Takezaki 2021

[雑誌論文] Clinical Significance of TAP1 and DLL4 Expression in Patients With Locally Advanced Gastric Cancer.

Segami K, Aoyama T, Hiroshima Y, Komori K, Hashimoto I, Miyagi Y, Saeki H, Oshima T. 2021

[学会発表] 内臓脂肪面積に対する脂肪酸摂取量と赤血球膜脂肪酸構成割合、遺伝的要因の横断的検討

川畑春佳、川島晃子、橘 拓希、伊東 葵、古郡かすみ、可児美月、後藤千穂、栗木清典 2021

[雑誌論文] Association between circulating vascular-related microRNAs and an increase in blood pressure : a 5-year longitudinal population-based study

Suzuki K, Yamada H, Fujii R, Munetsuna E, Ando Y, Ohashi K, Ishikawa H, Yamazaki M, Maeda K, Hashimoto S, Hamajima N. 2021

[学会発表] Association between dietary fatty acid intake, serum levels of fatty acids and ABCA1 DNA methylation

Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Yoshitaka Ando, Keisuke Maeda, Yoshiki Tsuboi, Kenji Wakai, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki, et al. 2021

[学会発表] Protective effect of common and rare variants of URAT1/SLC22A12 on gout

Toyoda Y, Kawamura Y, Nakayama A, Nakaoka H, .., Morimoto K, Uchida N, Shigesawa R, Takeuchi K, Inoue I, Ichida K, Suzuki H, Shinomiya N, Takada T, Matsuo H. 2021

[雑誌論文] Clinical Significance of Stanniocalcin2 mRNA Expression in Patients With Colorectal Cancer.

Watanabe T, Shiozawa M, Kimura Y, Hiroshima Y, Hashimoto I, Rino Y, Masuda M, Miyagi Y, Oshima T. 2021

[学会発表] 血糖値に対する緑茶・カテキン摂取量と腸内細菌叢の関連についての横断的検討

伊東 葵、古郡かすみ、橘 拓希、川島晃子、川畑春佳、後藤千穂、栗木清典 2021

[学会発表] Circulating microRNA and the development of hypertension : A five-year longitudinal population-based study

Koji Suzuki, Hiroya Yamada, Ryosuke Fujii, Eiji Munetsuna, Yoshitaka Ando, Keisuke Maeda, Yoshiki Tsuboi, Shuji Hashimoto, Nobuyuki Hamajima, et al. 2021

[学会発表] 肥満に対する高たんぱく質食品摂取量と腸内細菌叢の関連 : 四季食事調査の横断的検討

川島晃子、川畑春佳、橘 拓希、伊東 葵、古郡かすみ、可児美月、後藤千穂、栗木清典 2021

[学会発表] Association of drinking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population

Keisuke Maeda, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Koji Ohashi, Yoshiki Tsuboi, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki 2021

[学会発表] Estimated prevalence of metabolic syndrome components by simulated reducing amount and frequency of alcohol intake

Ippei Shimoshikiryo, Rie Ibusuki, Keiichi Shimatani, Daisaku Nishimoto, Toshiro Takezaki, For The Japan Multi-Institutional Collaborative Cohort Study Group 2021

[学会発表] 血清尿酸値の大規模ゲノムワイドメタ解析により23個の新規尿酸関連遺伝子座を同定した

中杤昌弘, 金井仁弘, 中山昌喜, 菱田朝陽, 河村優輔, 池崎裕昭, 島ノ江千里, 嶽崎俊郎, 尾崎悦子, 鈴木貞夫, 喜多義邦, 栗木清典, 有澤幸吉, 松尾恵太郎, 三上春夫, 四ノ宮成祥, 横田充弘, 若井建志, 岡田随象, 松尾洋孝 2020

[学会発表] アルツハイマー病の病態解明におけるエピゲノムアプローチ

間野 達雄, 岩田 淳 2020

[学会発表] 神経細胞特異的な転写制御機構から見える孤発性アルツハイマー病の病態

間野かがり, 間野達雄, 鈴木穣, 森島真帆, 村山繁雄, 戸田達史, 岩田淳 2020

[学会発表] ゲノムワイド関連解析による無症候性高尿酸血症患者からの痛風発症に関連する新規遺伝子座の同定

松尾洋孝、河村優輔、中岡博史、中山昌喜、岡田随象、山本健、清水徹、大山博司、長瀬満夫、清水聖子、高尾幹也、中島宏、中杤昌弘、有澤孝吉、嶽崎俊郎、田中恵太郎、若井建志、久保充明、井ノ上逸朗、四ノ宮成祥 2020

[学会発表] 朝食欠食および睡眠時間とメタボリック症候群との関連 : J-MICC Study

釜野桜子、有澤孝吉、Nguyen Van Tien、上村浩一 2020

[雑誌論文] Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study

Arisawa K, Katsuura-Kamano S, Uemura H, Tien NV, Hishida A, Tamura T, Kubo Y, …, Kuriki K, et al. 2020

[学会発表] EGFR signal induces T cell non-inflamed tumor microenvironment (TME) through suppression of chemokine production from human EGFRmt lung adenocarcinoma

Hidetoshi Sumimoto, Atsushi Takano, Koji Teramoto, Yataro Daigo 2020

[雑誌論文] Association between dietary inflammatory index and serum C-reactive protein concentrations in the Japan Collaborative Cohort Study.

Suzuki K, ShivappaN, Kawado M, Yamada H, Hashimoto S, Wakai K, Iso H, Okada E, Fujii R, Hebert JR, Tamakoshi A. 2020

[雑誌論文] Associations of Circulating MicroRNAs (miR-17, miR-21, and miR-150) and Chronic Kidney Disease in a Japanese Population

Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ohashi K, Ishikawa H, Keisuke Maeda K, Hagiwara C, Ando Y, Hashimoto S, Hamajima N, Suzuki K. 2020

[雑誌論文] A nobel multivariate index for cancer risk detection based on the serum trace elements : Metallo-Balance Method.

Okamoto N, Mikami H, Nakamura Y, Kusakabe M, Fujimoto S, Ueda M, Inagaki S, Miyagi Y, Nagase H, et al 2020

[学会発表] Novel neuropathologic findings of Gerstmann-Str€aussler-Scheinker disease with P102L mutation.

Kawai Y, Takao M, Hashimoto M, Mihara B, Kitamoto T, Yuzuriha T. 2020

[学会発表] A new method for detection of neoantigen-specific T cell clones based on clonal expansion using NGS of the TCRβ CDR3

Hidetoshi Sumimoto, Atsushi Takano, Koji Teramoto, and Yataro Daigo 2020

[雑誌論文] Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure.

Nakano M, Riku Y, Nishioka K, Hasegawa M, Washimi Y, Arahata Y, Takeda A, Horibe K, Yamaoka A, Suzuki K, Tsujimoto M, Li Y, Yoshino H, Hattori N, et al 2020

[雑誌論文] Association between dietary inflammatory index and serum C-reactive protein concentrations in the Japan Collaborative Cohort Study

Suzuki K, ShivappaN, Kawado M, Yamada H, Hashimoto S, Wakai K, Iso H, Okada E, Fujii R, H?bert JR, Tamakoshi A. 2020

[学会発表] 脂肪肝の簡易指標であるFatty liver indexと慢性炎症や動脈スティフネスとの関連

上村浩一、釜野桜子、岩崎夕貴、有澤孝吉 2019

[学会発表] 日常の身体活動および余暇時の運動とメタボリック症候群やその構成因子との関連の検討

上村浩一、釜野桜子、岩崎夕貴、有澤孝吉 2019

[雑誌論文] Association of genetic risk score and chronic kidney disease in a Japanese population

Fujii R, Hishida A, Nakatochi M, Furusyo N, Murata M, Tanaka K, Shimanoe C, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Takezaki T, Shimoshikiryo I, Arisawa K, Katsuura‐Kamano S, Takashima N, Turin T, Kuriki K, Endoh K, Mikami H, Nakamura Y, Oze I, Ito H, Kubo M, Momozawa Y, Kondo T, Naito M, Wakai K. 2019

[学会発表] 朝食欠食および睡眠時間とメタボリック症候群との関連 : J-MICC Study

釜野桜子、上村浩一、有澤孝吉 2019

[学会発表] 多施設共同トリオ解析による双極性障害の遺伝的構造の解明

西岡将基、酒井直美、数野安亜、池田匡志、早馬俊、渡部芳徳、岡敬、小森敦子、石渡みずほ、的場奈々、片岡宗子、藤井久彌子、松尾幸治、岩田仲生、高田篤、加藤忠史 2019

[学会発表] 日常の身体活動および余暇時の運動とメタボリック症候群やその構成因子との関連の検討

上村 浩一, 勝浦-釜野 桜子, 岩﨑 夕貴, 有澤 孝吉 2019

[学会発表] タウオパチー脳におけるDNA修復タンパクBRCA1の局在異常

栗原 正典, 間野 達雄, 村山 繁雄, 岩田 淳, 戸田 達史 2019

[学会発表] 脂肪肝の簡易指標であるFatty liver indexと慢性炎症や動脈スティフネスとの関連

上村 浩一, 勝浦-釜野 桜子, 岩﨑 夕貴, 有澤 孝吉 2019

[学会発表] 栄養素パターンとメタボリックシンドロームとの関連の検討

岩崎 夕貴, 釜野 桜子, 上村 浩一, 有澤 孝吉 2019

[学会発表] Mislocalization of DNA repair protein BRCA1 in human tauopathies

Masanori Kurihara, Tatsuo Mano, Shigeo Murayama, Atsushi Iwata, Tatsushi Toda 2019

[雑誌論文] Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases.

Yuta Murakami, Kiyoshi Saito, Hiromi Ito, Yasuhiro Hashimoto 2019

[学会発表] Relationship between n-3 polyunsaturated fatty acid intake and IGF1R rs4966025 related to kidney function on estimated glomerular filtration rate in Japanese adults : the J-MICC Sakura Diet Study

Nakano K, Kawata K, Kani M, Akimoto S, Goto C, Kuriki K. 2019

[雑誌論文] APOE4-mediated amyloid-βpathology depends on its neuronal receptor LRP1

Tachibana M, Holm ML, Liu CC, Shinohara M, Aikawa T, Oue H, Yamazaki Y, Martens YA, Murray ME, Sullivan PM, Weyer K, Glerup S, Dickson DW, Bu G, Kanekiyo T. 2019

[学会発表] Advancement of hepatic fibrosis among general women with/without NAFLD

R Ibusuki, I Shimoshikiryo, K Shimatani, D Nishimoto, S Maenohara, T Takezaki. 2019

[雑誌論文] Tau and TDP-43 accumulation of the basal nucleus of Meynert in individuals with cerebral lobar infarcts or hemorrhage.

Hatsuta H, Takao M, Nogami A, Uchino A, Sumikura H, Takata T, Morimoto S, Kanemaru K, Adachi T, Arai T, Hasegawa, M and Murayama S. 2019

[雑誌論文] Clinicopathological characteristics of distant metastases of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma : An autopsy study of older Japanese patients.

Matsuda Y, Seki A, Nonaka K, Kakizaki M, Wang T, Aida J, Ishikawa N, Nakano Y, Kaneda D, Takata T, Takahashi-Fujigasaki J, Murayama S, Takubo K, Ishiwata T, Sawabe M, Arai T. 2018

[雑誌論文] Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by <i>ALDH2</i> and <i>ADH1B</i> Polymorphisms in Japanese Men

Sasakabe Tae、Wakai Kenji、Kawai Sayo、Hishida Asahi、Naito Mariko、Suzuki Sadao、Nindita Yora、Arisawa Kokichi、Kita Yoshikuni、Hara Megumi、Kuriyama Nagato、Hirata Akie、Mikami Haruo、Oze Isao、Kubo Michiaki、Tanaka Hideo、Hamajima Nobuyuki 2018

[学会発表] 日本人男性における大豆食品摂取と動脈スティフネスとの関連

上村浩一、釜野桜子、Bahari Tirani、藤岡美穂、岩崎夕貴、有澤孝吉 2018

[学会発表] Tau-related dysfunction of BRCA1 lead to reduced neuronal plasticity in Alzheimer's disease

Tatsuo Mano, Atsushi Iwata, Takashi Nonaka, Airi Tarutani, Tadafumi Hashimoto, Masato Hasegawa, Takeshi Iwatsubo, Tatsushi Toda 2018

[学会発表] Neuron-specific histone modification analysis of Alzheimer's diseae brain

Kagari Mano, Tatsuo Mano, Atsushi Iwata, Shigeo Murayama, Tatsushi Toda 2018

[学会発表] Hepatic steatosis indexやFatty liver indexと慢性炎症や動脈スティフネスとの関連

上村浩一、釜野桜子、有澤孝吉 2018

[学会発表] Tau-related dysfunction of BRCA1 lead to reduced neuronal plasticity in Alzheimer's disease

Tatsuo Mano, Atsushi Iwata, Takashi Nonaka, Airi Tarutani, Tadafumi Hashimoto, Masato Hasegawa, Takeshi Iwatsubo, Tatsushi Toda 2018

[学会発表] Neuron-specific histone modification analysis of sporadic Alzheimer's disease

Kagari Mano, Tatsuo Mano. Atsushi Iwata, Shigeo Murayama, Tatsushi Toda 2018

[雑誌論文] Prednisolone-responsive Postpartum IgG4-related Hypophysitis.

Koide H, Shiga A, Komai E, Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi K, Yokote K, Tanaka T. 2018

[学会発表] Novel CSF biomarkers for diagnosing Spontaneous intracranial hypotension : combination of lipocalin-type prostaglandin D synthase & brain-type transferrin

Yuta Murakami, Koichi Takahashi, Kyoka Hoshi, Hiromi Ito, Kiyoshi Saito, Masakazu Miyajima, Hajime Arai, Tatuo Mima, Yasuhiro Hashimoto 2018

[雑誌論文] Lectin-based assay for glycoform-specific detection of ・2, 6sialylated transferrin and carcinoembryonic antigen in tissue and body fluid

Hiromi Ito, Kyoka Hoshi, Takashi Honda, Yasuhiro Hashimoto 2018

[雑誌論文] Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid

Yuta Murakami, Koichi Takahashi, Kyoka Hoshi, Hiromi Ito, Mayumi Kanno, Kiyoshi Saito, Kenneth Nollet, Yoshiki Yamaguchi, Masakazu Miyajima, Hajime Arai, Yasuhiro Hashimoto, Tatsuo Mima 2018

[雑誌論文] Association of subcutaneous and visceral fat with circulating microRNAs in a middle-aged Japanese population.

Munetsuna E, Yamada H, Ando Y, Yamazaki M, Tsuboi Y, Kondo M, Mizuno G, Ishikawa H, Sugimoto K, Osakabe K, Ichino N, Ohashi K, Hamajima N, Suzuki K. 2018

[学会発表] 神経細胞特異的DNAメチローム解析によるレビー小体病の新規病態の探索

土田剛行, 坂内太郎, 野間達雄, 永田健一, 山下 聡, 藤ヶ﨑純子, 村山繁雄, 西道隆臣, 牛島俊和, 辻 省次, 岩田 淳 2017

[学会発表] 経過11年の時間的分散や軸索再生像を伴ったアミロイドニューロパチーの76歳男性剖検例

北村明日香, 平賢一郎, 新井冨生, 池村雅子, 中村文彦, 岩田 淳, 清水 潤, 村山繁雄, 辻 省次 2017

[学会発表] LDL-C concentration is estimated by dietary factors with considering the genetic variation among Japanese : the J-MICC Sakura Diet Study.

Akimoto S, Endoh K, Wu. Re, Suzuki W, Goto C, Kuriki K. 2017

[学会発表] The brain bank for aging research project, Tokyo, Japan.

Murayama S, Sengoku R., Takada T, Matsubara T, Yamazaki M, Kobayashi M, Sakashita Y, Shibukara M, Morimoto S, Motoyama R, Hiroyoshi Y, Higashihara M, Nishina Y, Kanemaru K, Yanagisawa K, Saito Y 2017

[学会発表] Improvement of anti-tumor responses by targeting hypoxia-mediated immunosuppression

Teramoto K, Kataoka Y, Igarashi T, Sumimoto H, Daigo Y 2017

[学会発表] Dentification of candidate lung cancer neoantignes by systematic screening with next gencration sequencing

Sumimoto H, Takano A, Teramoto K, Daigo Y 2017

[学会発表] Association between objectively measured physical activity and methylation of PYCARD gene in the Japanese general population

Yuichiro Nishida, Yasuki Higaki, Naoto Taguchi, Megumi Hara, Kazuyo Nakamura, Hinako Nanri, Takeshi Imaizumi, Tatsuhiko Sakamoto Mikako Horita, Koichi Shinchi, Chisato Shimanoe, Ken Higashimoto, Hidenobu Soejima, and Keitaro Tanaka 2017

[雑誌論文] Simultaneous skin, nerve and muscle biopsy of neuronal intranuclear inclusion body disease.

Morimoto S, Takao M, Murayama S 2017

[学会発表] The color of the iris in patients with neuronal intranuclear hyaline inclusion disease will change.

Sengoku R, Shibukawa M, Morimoto S, Motoyama R, Sunakawa M, Kaneda D, Nishina Y, Kanemaru K, Murayama S : 2017

[学会発表] Development and validation of estimation model on LDL-C concentration according to dietary and genetic factors : the J-MICC Sakura Diet Study.

Akimoto S, Endoh K, Wu. Re, Suzuki W, Goto C, Kuriki K. 2017

[学会発表] Transthoracic echocardiography is useful to detect right-to-left shunt in the olderly.

Motoyama R, Morimoto S, Tanaka J, Murayama S 2017

[学会発表] Epigenetic Regulation of BRCA1 in Alzheimer's Disease. Evaluation of Post-Mortem Brain-and Model Mice Reveals Importance of Aggregated Tau

Mano T, Ohtomo R, Nagata K, Murayama S, Saido T. C, Yamashita S, Ushijima T, Hashimoto T, Tamaoka A, Iwatsubo T, Tsuji S, Iwata A 2016