トップ研究者を探すAIREの機能解析による自己免疫病態の解明

AIREの機能解析による自己免疫病態の解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16H05342
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
膠原病・アレルギー内科学
研究機関 徳島大学
代表研究者 松本 満
研究分担者 森本 純子
研究分担者 西嶋 仁
研究分担者 毛利 安宏
研究期間 開始年月日 2016/4/1
研究期間 終了年度 2018
研究ステータス 完了 (2018/4/1)
配分額(合計) 17,290,000 (直接経費 :13,300,000、間接経費 :3,990,000)
配分額(履歴) 2018年度:5,850,000 (直接経費 :4,500,000、間接経費 :1,350,000)
2017年度:4,940,000 (直接経費 :3,800,000、間接経費 :1,140,000)
2016年度:6,500,000 (直接経費 :5,000,000、間接経費 :1,500,000)
キーワード 自己免疫疾患
Aire
遺伝子改変マウス
I型糖尿病
胸腺
樹状細胞
自己免疫
AIRE

研究成果

[学会発表] A novel Aire-dependent subset of mTECs with tolerogenic functions is defined by Ly6 family protein expression

Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Hitoshi Nishijima 2018

[学会発表] Acquisition of the resistance to autoimmune diabetes by the expression of human AIRE in BM-derived APCs in NOD

Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto 2018

[学会発表] Transgenic human AIRE expression in peripheral antigen-presenting cells resulted in the acquisition of the resistance to the diabetes in NOD

Mitsuru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto 2018

[学会発表] Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity

Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto 2018

[学会発表] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells

Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto 2018

[学会発表] Amelioration of diabetes development in NOD by the transgenic human AIRE expression in DCs

Mitsuru Matsumoto 2018

[学会発表] "Transgenic human AIRE expression in NOD acquired resistance to T1D due to the impaired presentation of self-antigens"

Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto 2017

[学会発表] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells

Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto 2017

[学会発表] Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function

Morimoto, J., Nishikawa, Y., Nishijima, H., Matsumoto, M. 2017

[学会発表] Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice

Nishijima, H., Mouri, Y., Morimoto, J., Matsumoto, M. 2017

[学会発表] Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE

Nishijima, H., Mouri, Y., Morimoto, J., Matsumoto, M. 2017

[学会発表] Tissue-specific autoimmune response controlled by Aire

Mitsuru Matsumoto 2017

[学会発表] Augmented expression of the autoimmune regulator (AIRE) induces paradoxical development of polymyositis-like autoimmunity

Nishijima, H., Matsumoto, M. 2016

[学会発表] Massive infiltration of macrophages and eosinophils in the muscle of mice overexpressing Aire in thymic and peripheral antigen-presenting cells

Nishijima, H., Matsumoto, M. 2016

[学会発表] Possible defect in the Treg production in mice overexpressing AIRE/Aire which exhibit muscle-specific autoimmunity

Nishijima, H., Matsuoka, Y., Mouri, Y., Morimoto, J., Matsumoto, M. 2016

[学会発表] Immunological tolerance mediated by Aire

Matsumoto, M. 2016