研究成果

[雑誌論文] Persistent activation of calcium-sensing receptor suppresses bone turnover, increases microcracks and decreases bone strength

Bingzi Dong, Itsuro Endo, Yukiyo Ohnishi, Yukari Mitsui, Kiyoe Kurahashi, Mai Kanai, Masahiro Hiasa, Jumpei Teramachi, Hirofumi Tenshin, Seiji Fukumoto, Masahiro Abe, Toshio Matsumoto. 2019

[雑誌論文] Development of versatile non-homologous end joining-based knock-in module for genome editing.

Sawatsubashi S, Joko Y, Fukumoto S, Matsumoto T, Sugano SS 2018

[雑誌論文] Endothelial Nitric Oxide Synthase-Independent Pleiotropic Effects of Pitavastatin Against Atherogenesis and Limb Ischemia in Mice

Mitsuhashi T, Uemoto R, Ishikawa K, Yoshida S, Ikeda Y, Yagi S, Matsumoto T, Akaike M, Aihara KI 2018

[図書] Chapter 93. Eldecalcitol and Osteoporosis. In Feldman D, Editor-in-Chief. Vitamin D, 4th Ed.

Matsumoto T, Takahashi F. 2018

[雑誌論文] Grauer A 2018 FRAME Study: The Foundation Effect of Building Bone With 1 Year of Romosozumab Leads to Continued Lower Fracture Risk After Transition to Denosumab.

Cosman F, Crittenden DB, Ferrari S, Khan A, Lane NE, Lippuner K, Matsumoto T, Milmont CE, Libanati C, Grauer A 2018

[学会発表] FGF Receptor 1c Works as a Phosphate-Sensor to Regulate FGF23 Production

Yuichi Takashi, Yuka Kinoshita, Nobuaki Ito, Shun Sawatsubashi, Hidetaka Kosako, Masahiro Abe, Munehide Matsuhisa, Toshio Matsumoto, and Seiji Fukumoto 2018

[学会発表] Opposite effects of TRAIL on the Sp1-c-FLIP survival pathway in myeloma cells and osteoclasts.

Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Mohannad Ashtar, Kotaro Tanimoto, Iwasa Masami, Ariunzaya Bat-Erdene, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe. 2018

[学会発表] Disruption of a progressive vicious cycle between myeloma tumor growth and bone destruction by TAK1 inhibition

Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Asuka Oda, Ariunzaya Bat-Erdene, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Toshio Matsumoto and Masahiro Abe. 2018

[学会発表] Calcilytic, the calcium-sensing receptor antagonist, enhances bone remodeling and increases bone mineral density without increasing urinary calcium excretion

Bingzi Dong, Itsuro Endo, Yukiyo Ohnishi, Zhengju Fu, Toshio Matsumoto, Yangang Wang. 2018

[学会発表] Eldecalcitol Increases BMD More Than Alfacalcidol in Chinese Osteoporotic Patients without Vitamin D or Calcium Supplementation

Yan Jiang, Hai Tang, Xinlong Ma, Qun Cheng, Hua Lin, Xiaolan Jin, Zhenlin Zhang, Wei Yu, Shuli He, Tsuyoshi Kobayashi, Satomi Uehara, Toshio Matsumoto, Weibo Xia. 2018

[学会発表] Muscle-Specific Vitamin D Receptor (VDR) Ablation Results in Reduced Grip Power and Altered Gene Expression Pattern in Mice.

Maria K Tsoumpra, Itsuro Endo, Shun Sawatsubashi, Yuichi Takashi, Seiji Fukumoto and Toshio Matsumoto. 2017

[学会発表] Decreased bone strength induced by persistent activation of calcium-sensing receptor.

Itsuro Endo, Bingzi Dong, Yukiyo Ohnishi, Takeshi Kondo, Masahiro Hiasa, Jumpei Teramachi, Shinichi Aizawa, Toshio Matsumoto, Masahiro Abe and Seiji Fukumoto. 2017

[雑誌論文] Recent advances in the management of osteoporosis.

Fukumoto S, Matsumoto T 2017

[雑誌論文] Assessment criteria for vitamin D deficiency/insufficiency in Japan — proposal by an expert panel supported by Research Program of Intractable Diseases, Ministry of Health, Labour and Welfare, Japan, The Japanese Society for Bone and Mineral Research and The Japan Endocrine Society [Opinion]

Okazaki R, Ozono K, Fukumoto S, Inoue D, Yamauchi M, Minagawa M, Michigami T, Takeuchi Y, Matsumoto T, Sugimoto T 2017

[学会発表] TAK1 inhibition impairs myeloma cell-bone marrow interaction to reduce myeloma tumor growth and bone destruction.

umpei Teramachi, Masahiro Hiasa, Asuka Oda, Hirofumi Tenshin, Ryota Amachi, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Akihito Yamamoto, Tatsuji Haneji, Toshio Matsumoto and Masahiro Abe. 2017

[学会発表] FRAME Study: The Foundation Effect of Rebuilding Bone With One Year of Romosozumab Leads to Continued Lower Fracture Risk After Transition to Denosumab.

Felicia Cosman, Daria B Crittenden, Serge Ferrari, Aliya Khan, Nancy E Lane, Kurt Lippuner, Toshio Matsumoto, Cassandra E Milmont, Cesar Libanati, and Andreas Grauer. 2017

[学会発表] Alendronate ameliorates the risk of urinary stone formation of astronauts on the International Space Station for 6 months.

Okada A, Yasui T, Kohri K, Matsumoto T, LeBlanc A, Sibonga J, Spector E, Jones J, Shapiro J, Lang T, Shackelford L, Smith SM, Evans H, Ploutz-Snyder R, Keyak J, Ohshima H. 2017

[雑誌論文] Pim-2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma.

Teramachi J, Hiasa M, Oda A, Harada T, Nakamura S, Amachi R, Tenshin H, Iwasa M, Fujii S, Kagawa K, Miki H, Kurahashi K, Yoshida S, Endo I, Haneji T, Matsumoto T, Abe M 2017

[雑誌論文] A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration.

Amachi R, Hiasa M, Teramachi J, Harada T, Oda A, Nakamura S, Hanson D, Watanabe K, Fujii S, Miki H, Kagawa K, Iwasa M, Endo I, Kondo T, Yoshida S, Aihara KI, Kurahashi K, Kuroda Y, Horikawa H, Tanaka E, Matsumoto T, Abe M 2016

[学会発表] The regulatory mechanisms of FGF23 activity via GALNT3 by phosphate

Yuichi Takashi, Yuka Kinoshita, Nobuaki Ito, Maria K Tsoumpra, Shun Sawatsubashi, Toshio Matsumoto, Seiji Fukumoto. 2016

[学会発表] FGF23 enhances CYP24A1 transcription in Klotho-dependent way via ERK pathway

Maria K Tsoumpra, Shun Sawatsubashi, Yuichi Takashi, Toshio Matsumoto and Seiji Fukumoto. 2016

[学会発表] Bone Loss Countermeasures for Long Duration Spaceflight

E Spector, T Matsumoto, J Jones, J Shapiro, T Lang, L Shackelford, S M Smith, H Evans, R Ploutz-Snyder, J Sibonga, J Keyak, T Nakamura, K Kohri, H Ohshima, G Moralez, A LeBlanc. 2016

[雑誌論文] Total 25-hydroxyvitamin D levels predict fracture risk: Results from the 15-year follow-up of the Japanese Population-based Osteoporosis (JPOS) Cohort Study.

Tamaki J, Iki M, Sato Y, Kajita E, Nishino H, Akiba T, Matsumoto T, Kagamimori S 2016