トップ研究者を探す包括的マイクロアレイ解析を基盤とした食道癌の診断・治療の新規標的分子の同定

包括的マイクロアレイ解析を基盤とした食道癌の診断・治療の新規標的分子の同定

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16591300
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
消化器外科学
研究機関 東京医科歯科大学
代表研究者 橘 逸勢
研究分担者 稲澤 譲治
研究期間 開始年月日 2004/4/1
研究期間 終了年度 2005
研究ステータス 完了 (2005/4/1)
配分額(合計) 3,600,000 (直接経費 :3,600,000)
配分額(履歴) 2005年度:1,600,000 (直接経費 :1,600,000)
2004年度:2,000,000 (直接経費 :2,000,000)
キーワード 食道癌
アレイCGH
ゲノム
エピゲノム
DNAメチル化
組織アレイ
発現解析
分子標的
CGHアレイ
esophageal cancer
array-CGH
genome
epigenome
DNA methylation
tissue microarray
expression analysis
molecular target

研究成果

[雑誌論文] Frequent Silencing of the Candidate Tumor Suppressor PCDH20 by Epigenetic Mechanism in Non-Small-Cell Lung Cancers.

Imoto I, Inazawa J, et al. 2006

[雑誌論文] Frequent Silencing of the Candidate Tumor Suppressor PCDH20 by Epigenetic Mechanism in Non-Small-Cell Lung Cancers.

Imoto I, Inazawa J, et al. 2006

[雑誌論文] Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Saigusa K, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Methylation-associated silencing of the nuclear receptor 112 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification.

Misawa A, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.

Izumi H, Imoto I, Inazawa J, et al. 2005

[雑誌論文] ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation.

Takada H, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Takada H, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis.

Tanami H, Imoto 1, Inazawa J, et al. 2005

[雑誌論文] Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis.

Tanami H, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Detection of cryptic chromosome aberrations in a patient with a balanced t(1;9)(p34.2;p24) by array-based comparative genomic hybridization.

Hayashi S, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification.

Misawa A, Imoto I, Inazawa J, et al. 2005

[雑誌論文] Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.

Sonoda I, Imoto I, Inazawa J, et al. 2004

[雑誌論文] Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma

Sonoda I, Imoto I, Inazawa J, et al. 2004

[雑誌論文] Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13).

Yuki Y, Imoto I, Inazawa J, et al. 2004

[雑誌論文] Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.

Tanami H, Imoto I, Inazawa J, et al. 2004

[雑誌論文] Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers.

Sanada T, Imoto I, Inazawa J, et al. 2004

[雑誌論文] Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.

Inoue J, Imoto I, Inazawa J, et al. 2004