トップ›研究者を探す›特発性血小板減少性紫斑病におけるT細胞エピトープの同定と新たな免疫療法の開発

特発性血小板減少性紫斑病におけるT細胞エピトープの同定と新たな免疫療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16590942
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
血液内科学
研究機関 愛媛大学
代表研究者 羽藤 高明
研究分担者 安川 正貴
研究期間 開始年月日 2004/4/1
研究期間 終了年度 2005
研究ステータス 完了 (2005/4/1)
配分額（合計） 3,500,000 (直接経費 :3,500,000)
配分額（履歴） 2005年度：1,600,000 (直接経費 :1,600,000)
2004年度：1,900,000 (直接経費 :1,900,000)
キーワード 血小板
特発性血小板減少性紫斑病
GPIIb-IIIa
T細胞
自己免疫
インテグリン
エピトープ
platelet
ITP
GPIIb-IIIa
T cell
autoimmunity
integrin
epitope

研究成果

[雑誌論文] Patients with platelet dysfunction characterized by transient and reversible aggregation in response to ADP despite normal collagen-induced aggregation.

Iijima K, Yoshioka A, Matsumoto H, Hara A, Hato T. 2005

[雑誌論文] Novel RUNX1-PRDM16 fusion transcripts in a patient with acute myeloid leukemia showing t(1;21)(p36;q22).

Sakai I, Tamura T, Narumi H, Uchida N, Yakushijin Y, Hato T, Fujita S, Yasukawa M. 2005

[雑誌論文] Direct recognition and lysis of leukemia cells by WT1-specific CD4^+ T lymphocytes in an HLA class II-restricted manner.

Guo Y, Niiya H, Azuma T, Uchida N, Yakushijin Y, Saki I, Hato T, Takahashi M, Senju S, Nishimura Y, Yasukawa M 2005

[雑誌論文] Differential regulation of perforin expression in human CD4+ and CD8+ cytotoxic T lymphocytes.

Niiya H, Sakai I, Lei J, Azuma T, Uchida N, Yakushijin Y, Hato T, Fujita S, Yasukawa M. 2005

[雑誌論文] Identification of an epitope on glycoprotein IIb-IIIa that is recognized by HLA-DRB1^*0405-restricted CD4^+ T cells from a patient with immune thrombocytopenic purpura.

Yamanouchi J, Hato T, Tamura T, Fujita S, Yasukawa M. 2004

[雑誌論文] Suppression of integrin activation by the membrane-distal sequence of the integrin αIIb cytoplasmic tail.

Yamanouchi J, Hato T, Tamura T, Fujita S. 2004

[雑誌論文] Existence of leukemic clones resistant to both imatinib mesylate and rituximab before drug therapies in a patient with Philadelphia chromosome-positive acute lymphocytic leukemia.

Hato T, Yamanouchi J, Tamura T, Yasukawa M et al. 2004

[雑誌論文] Identification of an epitope on glycoprotein IIb-IIIa that is recognized by HLA-DRB1^*0405-restricted CD4^+ T cells from a patient with immune thrombocytopenic purpura.

Yamanouchi J, Hato T, Tamura T, Fujita S, Yasukawa M. 2004

[雑誌論文] Critical residues for ligand binding in blade 2 of the propeller domain of the integrin αIIb subunit.

Tamura T, Hato T, Yamanouchi J, Fujita S 2004

[雑誌論文] Suppression of integrin activation by the membrane-distal sequence of the integrin αIIb cytoplasmic tail.

Yamanouchi J, Hato T, Tamura T, Fujita S. 2004

[雑誌論文] Role of CD21 antigen in diffuse large B-cell lymphoma and its clinical significance

Otsuka M, Yakushijin Y, Hamada M, Hato T, Yasukawa M, Fujita S. 2004

[雑誌論文] Critical residues for ligand binding in blade 2 of the propeller domain of the integrin αIIb subunit.

Tamura T, Hato T, Yamanouchi J, Fujita S. 2004

[雑誌論文] Existence of leukemic clones resistant to both imatinib mesylate and rituximab before drug therapies in a patient with Philadelphia chromosome-positive acute lymphocytic leukemia.

Hato T, Yamanouchi J, Tamura T, Hojo N, Niiya Y, Kohno M, Bando S, Yakushijin Y, Takada K, Sakai I, Yasukawa M, Fujita S. 2004

[雑誌論文] Role of CD21 antigen in diffuse large B-cell lymphoma and its clinical significance

Otsuka M, Yakushijin Y, Hamada M, Hato T, Yasukawa M, Fujita S. 2004

[雑誌論文] Existence of leukemic clones resistant to both imatinib mesylate and retuximab before drug therapies in a patient with Philadelphia chromosome-positive acute lymphocytic leukemia.

Hato T et al. 2004