トップ研究者を探す肺および気道線維化のメカニズムの解明とその制御

肺および気道線維化のメカニズムの解明とその制御

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16590747
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
呼吸器内科学
研究機関 広島大学
代表研究者 横山 彰仁
研究分担者 河野 修興
研究分担者 近藤 圭一
研究期間 開始年月日 2004/4/1
研究期間 終了年度 2006
研究ステータス 完了 (2006/4/1)
配分額(合計) 3,400,000 (直接経費 :3,400,000)
配分額(履歴) 2006年度:1,000,000 (直接経費 :1,000,000)
2005年度:1,100,000 (直接経費 :1,100,000)
2004年度:1,300,000 (直接経費 :1,300,000)
キーワード 気管支喘息
線維芽細胞
サイトカイン
T細胞
インターフェロン
肺線維症
リモデリング
bronchial asthma
cytokine
fibroblast
T cells
interferon
pulmonary fibrosis
remodeling

研究成果

[雑誌論文] Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis

Shoda H, Yokoyama A, et al. 2007

[雑誌論文] Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis

Shoda H, Yokoyama A, Nishino R, Nakashima T, Ishikawa N, Haruta Y, Hattori N, Naka T, Kohno N. 2007

[雑誌論文] Prognostic Value of Circulating KL-6 in Idiopathic Pulmonary Fibrosis.

Yokoyama A, Kondo K, Nakajima M, Matsushima T, Takahashi T, Nishimura M, Bando M, Sugiyama Y, Totani Y, Ishizaki T, Ichiyasu H, Suga M, Hamada H, Kohno N. 2006

[雑誌論文] Anti-tumor effect of the anti-KL-6/MUC1 monoclonal antibody through exposure of surface molecules by MUC1 capping

Doi M, Yokoyama A, et al. 2006

[雑誌論文] Air Trapping in Patients with Asthma May Represent Remodeling of Small Airways.

Ito R, Yokoyama A, Hamada H, Yasuhara Y, Kohno N, Higaki J. 2006

[雑誌論文] Air Trapping in Patients with Asthma May Represent Remodeling of Small Airways.

Ito R, Yokoyama A, et al. 2006

[雑誌論文] Anti-tumor effect of the anti-KL-6/MUCI monoclonal antibody through exposure of surface molecules by MUC1 capping.

Doi M, Yokoyama A, Kondo K, Ohnishi H, Ishikawa N, Hattori N, Kohno N. 2006

[雑誌論文] Prognostic Value of Circulating KL-6 in Idiopathic Pulmonary Fibrosis

Yokoyama A, et al. 2006

[雑誌論文] Polymorphism of MUC1 mucin gene is associated with susceptibility and prognosis of lung adenocarcinoma

Mitsuta, K, Yokoyama A, et al. 2005

[雑誌論文] Adoptive Transfer of Th1 Clones Inhibits Eosinophilic Inflammation and Airway Hyperresponsiveness in a Murine Model of Asthma

Irifune K, Yokoyama A, et al. 2005

[雑誌論文] KL-6, a Human MUCI Mucin, Promotes Proliferation and Survival of Lung Fibroblasts.

Ohshimo S, Yokoyama A, Hattori N, Ishikawa N, Hirasawa Y, Kohno N. 2005

[雑誌論文] IL-10/IL-12軸を介した新たな気道過敏性の制御機構

横山彰仁 2005

[雑誌論文] Circulating aminopeptidase N/CD13 is an independent prognostic factor in patients with non-small cell lung cancer.

Murakami H, Yokoyama A, Kondo K, Nakanishi S, Kohno N, Miyake M. 2005

[雑誌論文] KL-6, a Human MUC1 Mucin, Promotes Proliferation and Survival of Lung Fibroblasts

Ohshimo S, Yokoyama A, et al. 2005

[雑誌論文] NKT細胞と気管支喘息:病態発現におけるNKT細胞の関与

横山彰仁 2005

[雑誌論文] Circulating aminopeptidase N/CD13 is an independent prognostic factor in patients with non-small cell lung cancer.

Murakami H, Yokoyama A, et al. 2005

[雑誌論文] Polymorphism of MUC1 mucin gene is associated with susceptibility and prognosis of lung adenocarcinoma.

Mitsuta K, Yokoyama A, Kondo K, Nakajima M, Kohno N. 2005

[雑誌論文] SOCS-1ノックアウトマウス

庄田浩康, 横山彰仁 2004

[雑誌論文] 気管支喘息とロイコトリエン拮抗薬の臨床

横山彰仁 2004

[雑誌論文] Circulating Natural Killer T Cells in Patients with Asthma Irifune K, Yokoyama A, Sakai K, Watanabe A, Katayama H, Ohnishi

Ikegami Y, Yokoyama A, Haruta Y, Hiyama K, Mendoza C, Kohno K. 2004

[雑誌論文] Circulating Natural Killer T Cells in Patients with Asthma

Ikegami Y, Yokoyama A, et al. 2004

[雑誌論文] Circulating KL-6/MUC1 mucin carrying sialyl Lewisa oligosaccharide is an independent prognostic factor in patients with lung adenocarcinoma

Inata J, Hattori N, Yokoyama A, et al.

[雑誌論文] Overexpression of Suppressor of Cytokine Signaling-5 Augments Eosinophilic Airway Inflammation in Mice

Ohshima M, Yokoyama A, Ohnishi H, Hamada H, Kohno N, Higaki J, Naka T.

[雑誌論文] Overexpression of Suppressor of Cytokine Signaling-5 Augments Eosinophilic Airway Inflammation in Mice

Ohshima M, Yokoyama A, et al.

[雑誌論文] Circulating KL-6/MUC1 mucin carrying sialyl Lewisa oligosaccharide is an independent prognostic factor in patients with lung adenocarcinoma

Inata J, Hattori N, Yokoyama A, et al.

[雑誌論文] Overexpression of Suppressor of Cytokine Signaling-5 Augments Eosinophilic Airway Inflammation in Mice

Ohshima M, Yokoyama A, et al.