トップ›研究者を探す›細胞間接触による内皮細胞の増殖と機能分化に関わるシグナル伝達網の解明

細胞間接触による内皮細胞の増殖と機能分化に関わるシグナル伝達網の解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16590695
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
循環器内科学
研究機関 九州大学
代表研究者 平野 真弓
研究分担者 平野 勝也
研究期間 開始年月日 2004/4/1
研究期間 終了年度 2005
研究ステータス 完了 (2005/4/1)
配分額（合計） 3,100,000 (直接経費 :3,100,000)
配分額（履歴） 2005年度：1,500,000 (直接経費 :1,500,000)
2004年度：1,600,000 (直接経費 :1,600,000)
キーワード 血管内皮細胞
細胞間接触
KIP^1遺伝子
転写活性
低分子量G蛋白質
Rac1
Kip1遺伝子
アポトーシス
Vascular endothelial cells
cell-cell contact
p27^<Kip1>
promoter region
small G protein
Rac1
transcription activity
growth arrest

研究成果

[雑誌論文] Involvement of G_<i/o> in the PAR-4-induced NO production in endothelial cells

Momota F, Hirano K, Hirano M, Nishimura J, Hideo Kanaide 2006

[雑誌論文] Involvement of Gi/o in the PAR-4-induced NO production in endothelial cells.

Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H: 2006

[雑誌論文] Involvement of Gi/o in the PAR-4-induced NO production in endothelial cells.

Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H 2006

[雑誌論文] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery

Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H: 2005

[雑誌論文] Rac1 regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells.

Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H 2005

[雑誌論文] Physiology and pathophy siology of proteinase-activated receptors (PARs) : Regulation o the expression of PARs

Hirano K, Yufu T, Hirano M, Nishimura J, Kanaide H: 2005

[雑誌論文] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery

Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H 2005

[雑誌論文] Racl regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells.

Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H: 2005

[雑誌論文] Physiology and pathophysiology of proteinase-activated receptors (PARs) : Regulation of the expression of PARs

Hirano K, Yufu T, Hirano M, Nishimura J, Kanaide H 2005

[雑誌論文] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery

Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H 2005

[雑誌論文] Inactivation of protease- activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells

Nakayama T, Hirano K, Hirano M, Nishimura J, Kuga H, Nakamura K, Takahashi S, Kanaide H 2004

[雑誌論文] A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells

Hirano K, Hirano M, Nishimura J, Kanaide H 2004

[雑誌論文] Regulation of myosin phosphorylation and myofilament Ca^<2+> sensitivity in vascular smooth muscle

Hirano K, Hirano M, Kanaide H: 2004

[雑誌論文] Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells

Koga M, Hirano K, Hirano M, Nishimura J, Kanaide H 2004

[雑誌論文] Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells

Koga M, Hirano K, Hirano M, Nishimura J, Kanaide H 2004

[雑誌論文] A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells

Hirano K, Hirano M, Nishimura J, Kanaide H: 2004

[雑誌論文] Facilitation of proteasomal degradation of p27^<Kip1> by N-terminal cleavage, and their sequence requirements

Hirano K, Ihara E, Hirano M, Nishimura J, Nawata H, Kanaide H 2004

[雑誌論文] Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells

Nakayama T, Hirano (co-1^<st>author), Hirano M, Nishimura J, Kuga H, Nakamura K, Takahashi S, Kanaide H: 2004

[雑誌論文] Facilitation of proteasomal degradation of p27^<Kip1> by N-terminal cleavage, and their sequence requirements

Hirano K, Ihara E, Hirano M, Nishimura J, Nawata H, Kanaide H 2004

[雑誌論文] Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells

Koga M, Hirano K, Hirano M, Nishimura J, Kanaide H: 2004

[雑誌論文] Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca^<2+> sensitivity in an intact coronary artery

Hirano K, Derkach DN, Hirano M, Nishimura J, Takahashi S, Kanaide H 2004

[雑誌論文] Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca^<2+> sensitivity in an intact coronary artery

Hirano K, Derkach DN, Hirano M, Nishimura J, Takahashi S, Kanaide H: 2004

[雑誌論文] Regulation of myosin phosphorylation and myofilament Ca^<2+> sensitivity in vascular smooth muscle

Hirano K, Hirano M, Kanaide H 2004

[雑誌論文] A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells

Hirano K, Hirano M, Nishimura J, Kanaide H 2004

[雑誌論文] Facilitation of proteasomal degradation of p27^<Kip1> by N-terminal cleavage, and their sequence requirements

Hirano K, Ihara E, Hirano M, Nishimura J, Nawata H, Kanaide H: 2004

[雑誌論文] Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca^<2+> sensitivity in an intact coronary artery

Hirano K, Derkach DN, Hirano M, Nishimura J, Takahashi S, Kanaide H 2004