トップ研究者を探す溶骨性骨転移における破骨細胞分化因子(RANKL)の役割

溶骨性骨転移における破骨細胞分化因子(RANKL)の役割

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16590313
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
基礎医学
実験病理学
研究機関 神戸大学
代表研究者 北澤 理子
研究期間 開始年月日 2004/4/1
研究期間 終了年度 2005
研究ステータス 完了 (2005/4/1)
配分額(合計) 3,300,000 (直接経費 :3,300,000)
配分額(履歴) 2005年度:1,100,000 (直接経費 :1,100,000)
2004年度:2,200,000 (直接経費 :2,200,000)
キーワード 骨転移
破骨細胞
RANKL
遺伝子プロモータ
転写制御
副甲状腺ホルモン関連蛋白
Runx2
CpGメチル化
Bone metastasis
Osteoclast
RANKL
Gene promoter
Gene transcription
PTHrP
Runx2
CpG methylation

研究成果

[雑誌論文] Expression profiles of genes related to osteoclastogenesis in mouse growth plate and articular cartilage.

Kishimoto K, Kitazawa R, Kurosaka M, Maeda S, Kitazawa S 2006

[雑誌論文] In situ detection of specific gene expression during and immediately after transcription at electron microscopic level.

Kitazawa S. et al. 2006

[雑誌論文] In situ detection of specific gene expression during and immediately after transcription at electron microscopic level.

Kitazawa S. et al. 2006

[雑誌論文] In situ detection of specific gene expression during and immediately after transcription at electron microscopic level

Kitazawa S, Kitazawa R 2006

[雑誌論文] Application trials of in situ hybridization at electron microscopic level.

Kitazawa S, Kondo T, Kitazawa R. 2005

[雑誌論文] Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression.

Fujimoto M, Kitazawa R, Maeda S, Kitazawa S. 2005

[雑誌論文] Ray tracing analysis of overlapping objects in refraction contrast imaging.

Hirano M, Yamasaki K, Okada H, Sakurai T, Kondoh T, Karafuchi T, Sugimura K, Kitazawa S, Kitazawa R, Maeda S, Tamura S. 2005

[雑誌論文] In situ hybridizatoin on calcified tissue : detection of RANKL mRNA in mouse osteolytic bone lesions

Kitazawa R. et al. 2005

[雑誌論文] Application trials of in situ hybridization at electron microscopic level.

Kitazawa S. et al. 2005

[雑誌論文] Estimation of Contrast of Refraction Contrast Imaging Compared with Absorption Imaging -Basic Approach.

Hirano M, Yamasaki K, Okada H, Kitazawa S, Kitazawa R, Ohno Y, Sakurai T, Kondoh T, Ohbayashi C, Katafuchi T, _Maeda S, Sugimura K, Tamura S. 2005

[雑誌論文] An autopsy case of type I Pene-Shokeir syndrome.

Mori K, Kitazawa R, Kondo T, Kishimoto K, Maeda S, Kitazawa S. 2005

[雑誌論文] Desmoid tumor with ossification in chest wall : possible involvement of BAMBI promoter hypermethylation in metaplastic bone formation.

Kitazawa S. et al. 2005

[雑誌論文] In situ hybridization on calcified tissue : Detection of RANKL mRNA in osteolytic bone lesion.

Kitazawa R, Kitazawa S. 2005

[雑誌論文] In situ Hybridization on Calcified Tissue : Detection of RANKL mRNA in Mouse Osteolytic Lesions.

Kitazawa R 2005

[雑誌論文] Desmoid tumor with ossification in chest wall : involvement of BAMBI promoter hypermethylation in metaplastic bone formation.

Kitazawa S, Kitazawa R, Obayashi C, Yamamoto T. 2005

[雑誌論文] Application Trials of in situ Hybridization at Electron Microscopic Level.

Kitazawa S 2005

[雑誌論文] Dominant negative N-cadherin inhibit osteoclast diiferentiatio in by interfering with b-catenin regulation of RANKL, independent of cell-cell adhesion.

Shin CS, Her SJ, Kim JA, Kim DH, Kim SW, Kim HC, Park KH, Kim JG, Kitazawa R, Cheng SL, Civitelli R. 2005

[雑誌論文] Transcriptional regulation mechanism of BMP genes

Kitazawa S., Kitazawa R 2005

[雑誌論文] In situ hybridization on calcified tissue : detection of RANKL mRNA in mouse osteolytic bone lesions

Kitazawa R. et al. 2005

[雑誌論文] An autopsy case of ulcerative colitis associated with pulmonary thrombus.

Fujimoto M, Kitazawa R, Hirata K, Yamada H, Kondo T, Maeda S, Kitazawa S. 2005

[雑誌論文] Desmoid tumor with ossification in chest wall : possible involvement of BAMBI promoter hypermethylation in metaplastic bone formation

Kitazawa S.et al. 2005

[雑誌論文] A case of ochronosis presenting acute destructive arthropathy

Kondo T, Kitazawa R, Hasegawa Y, Kitazawa S. 2005

[雑誌論文] A case of MEN type I and menin in parathyroid lesions.

Tobimatsu T, Kaji H, Naito J, Yo M, Sowa H, Yamauchi M, Tsukada T, Kitazawa R, Kitazawa S, Sugimoto T, Chihara K. 2005

[雑誌論文] T-138C polymorphism of matrix gla protein promoter alters its expression but is not directly associated with atherosclerotic vascular calcification.

Kobayashi N, Kitazawa R, Maeda S, Schurgers LJ, Kitazawa S. 2005

[雑誌論文] A case of geiant cell fibroblastome of nose.

Kondo T, Kitazawa S, Kitazawa R, Taguchi K. 2004

[図書] 組織細胞化学2004

北澤 荘平 2004

[雑誌論文] Menin in activation leads to loss of TGF-b inhibition of parathyroid cell proliferation and PTH secretion

Sowa H, Kaji H, Kitazawa R, Kitazawa S, Tsukamoto T, Yano S, Canaff L, Hendy JN, Sugimoto T, Chihara K. 2004

[雑誌論文] In vitro real-time imaging of TGFbeta-induced transcriptional activation of the RANK ligand gene in intraosseous prostate cancer.

Zhang J, Lu Y, Dai J, Yao Z, Kitazawa R, Kitazawa S, Zhao X, Hall DE, Pienta KJ, Keller ET. 2004

[雑誌論文] Application of ISH to research of regenerative medicine.

Kitazawa S, Kitazawa R. 2004

[雑誌論文] 1a,25 dihydoxyvitamin D3 rapidly regulates the mouse osteoprotegerin through dual pathway.

Kondo T, Kitazawa R, Maeda S, Kitazawa S. 2004

[雑誌論文] Gene expression in osteolytic lesion of cancer metastasis.

Kitazawa R, Kitazawa S. 2004

[雑誌論文] A case of colon tuberculosis preoperatively diagnosed as colon cancer.

Hayashi S, Takeda Y, Kitazawa R. 2004

[雑誌論文] Imaging of fine structure of bone sample with high coherence X-ray beam and high spatial resolution detector.

Hirano M, Yamasaki K, Kitazawa R, Kitazawa S, Okada H, Katafuchi T, Maeda S, Sakurai T, Kondoh T, Obayashi C, Sugimura K, Tamura S. 2004

[雑誌論文] Transcription factor.

Kitazawa S, Kitazawa R. 2004

[雑誌論文] Lung carcinosarcoma with liposarcoma element an autopsy case.

Kitazawa R, Kitazawa S, Nishimura Y, Kondo T, Obayashi C

[雑誌論文] A case of schizophrenia with spinal aspergillosis and tabes dorsalis.

Kondo T, Kitazawa R, Miyake M, Kitazawa S.

[雑誌論文] Transcriptional regulation of RANKL and OPG.

Kitazawa S, Kitazawa R, Mori K, Kondo T.

[雑誌論文] A case of uterine adenosarcoma presenting as endocerviacal polyp.

Kondo T, Kitazawa R, Yamasaki M, Kitazawa S.

[雑誌論文] Modulation of mouse RANKL gene expression by Runx2 and PKA pathway.

Mori K, Kitazawa R, Kondo T, Yamaguchi A, Maeda S, Kitazawa S

[雑誌論文] Expression and functional analysis of menin in a multiple endocrine neoplasia type I (MENI) patient with somatic loss of heterozygosity in chromosome 11q13 and unidentified germline mutation of the MEN1 Gene.

Naito J, Kaji H, Sowa H, Kitazawa R, Kitazawa S, Tsukada T, Hendy GN, Sugimoto T, Chihara K

[雑誌論文] MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.

Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Kasga M.