トップ研究者を探す尿細管・糸球体フィードバック活性の調節による新たな腎不全治療法の開発

尿細管・糸球体フィードバック活性の調節による新たな腎不全治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-16390158
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
境界医学
応用薬理学
研究機関 香川大学
代表研究者 安部 陽一
研究分担者 西山 成
研究分担者 木村 正司
研究期間 開始年月日 2004/4/1
研究期間 終了年度 2005
研究ステータス 完了 (2005/4/1)
配分額(合計) 13,200,000 (直接経費 :13,200,000)
配分額(履歴) 2005年度:3,300,000 (直接経費 :3,300,000)
2004年度:9,900,000 (直接経費 :9,900,000)
キーワード 尿細管・糸球体フィードバック
腎微小循環
腎不全
高血圧
ダール食塩感受性高血圧ラット
輸入細動脈
ATP
スラミン
P2受容体
Tubulo-glomerular feedback
Afferent arteriole
Nephropathy
Hypertension
Dahl salt-sensitive rats
ATP
P2 receptor
Suramin

研究成果

[雑誌論文] Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferat ion and deformability.

Nishiyama Akira 2005

[雑誌論文] Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability.

Nishiyama Akira 2005

[雑誌論文] Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability.

Nishiyama Akara 2005

[雑誌論文] D-allose, an all-cis aldo-hexose, suppresses development of salt-induced hypertension in Dahl rats.

Kimura Shoji 2005

[雑誌論文] D-allose, an all-cis aldo-hexose, suppresses development of salt induced hypertension in Dahl rats.

Kimura Shoji 2005

[雑誌論文] Mitochondria-derived reactive oxygen species and vascular MAP kinase : comparison of angiotensin II and diazoxide.

Kimura Shoji 2005

[雑誌論文] D-allose, an all-cis aldo-hexose, suppresses development of salt induced hypertension in Dahl rats.

Kimura Shoji 2005

[雑誌論文] Role of interstitial ATP and adenosine in the regulation of renal hemodynamics and microvascular function.

Nishiyama Akira 2004

[雑誌論文] Effects of AT1 receptor blockade on renal injury and mitogen-activated protein kinase activity in Dah1 salt-sensitive rats.

Nishiyama Akira 2004

[雑誌論文] The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats.

Nishiyama Akira 2004

[雑誌論文] The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats.

Nishiyama Akira 2004

[雑誌論文] Effects of AT1 receptor blockade on renal injury and mitogen-activated protein kinase activity in Dahl salt-sensitive rats.

Nishiyama Akira 2004

[雑誌論文] Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats.

Nishiyama Akira 2004

[雑誌論文] Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats.

Nishiyama Akira 2004

[雑誌論文] Time-dependent transition of tempol-sensitive reduction of blood pressure in angiotensin II-induced hypertension.

Kimura Shoji 2004